JP2000327509A - Slime-controlling agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a slime-controlling agent that has excellent stability and handleability with no risk and can retain a suitable solubility by press-forming a non-bleaching type antimicrobial agent and a specific base material. SOLUTION: The objective slime-controlling material is prepared by press- forming (A) a non-bleaching type antifungal and (B) a base material selected from calcium hydrogen phosphate dihydrate, anhydrous tricalcium phosphate, magnesium hydrogen phosphate trihydrate, magnesium hydrogen phosphate octahydrate, lactic acid, vanillin, calcium citrate tetrahydrate, calcium sulfate dihydrate, acetoacetic anilide, glycerol fatty acid monoester, alkyl sorbitol ester (of <=14 HLB). As a component A, are preferably cited an antifungal agent (for example, 5-chloro-2-methyl-4-isothiazoline-3-one), a clathrate compound of polymolecular host compound (for example, tetrakis-phenols), organic iodide antifungal agent or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a slime that is provided at a place where slime is generated by metabolites such as germs and molds, such as a kitchen sink or a drain of a bathroom, to remove slime and prevent the occurrence of slime. It relates to a controlling agent.

[0002]

2. Description of the Related Art The main component of slime at the drain of a kitchen sink or bathroom is a polysaccharide that is secreted by bacteria when foodstuffs, surfactants, soap, human scum, etc. become a nutrient source of bacteria. .

[0003] As a method for removing such a slime component,
An oxidizing agent is widely used for commercially available slime removal. Among them, a method of chemically decomposing and removing slime using a chlorine-based bleaching powder, and a method of sterilizing germs and mold are used.
Further, in many cases, similar effects are obtained by using sodium percarbonate generally used as a non-chlorine oxidizing agent.

[0004]

However, in the bleaching powder-based slime remover as described above, the hypochlorous acid-based substance as an active ingredient has a strong oxidizing power, and corrodes the sink and the surrounding metal. Releases toxic chlorine gas. In particular, when it reacts with an acidic substance such as vinegar, the amount of generated chlorine gas increases, resulting in a dangerous state. In addition, an isocyanuric acid-based chemical containing trichloroisocyanuric acid as an active ingredient may generate explosive nitrogen trichloride gas when it comes into contact with an alkaline detergent or a sodium hypochlorite-based detergent.

[0005] Further, sodium percarbonate, which is a non-chlorine oxidizing agent, has a high solubility and dissolves quickly when it comes into contact with water. An object of the present invention is to provide a slime control agent which does not have the above-mentioned danger, is excellent in safety and handleability, and maintains appropriate solubility.

[0006]

Means for Solving the Problems The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, have found that an antibacterial agent, particularly an inclusion compound comprising an antibacterial agent and a multimolecular host compound, and a specific substrate The press-formed product with the above does not have such a danger,
The present inventors have found that the present invention is excellent in safety and handleability, retains appropriate solubility, and has a slime control effect, and has completed the present invention.

That is, the present invention relates to an inclusion compound comprising an antibacterial agent such as 5-chloro-2-methyl-4-isothiazolin-3-one and a multimolecular host compound such as tetrakisphenol, and an organic iodine. Non-bleachable antibacterial agents such as antibacterial agents, calcium hydrogen phosphate dihydrate, tricalcium phosphate anhydride, magnesium hydrogen phosphate trihydrate, magnesium hydrogen phosphate octahydrate, lactose, vanillin, calcium citrate 4 Hydrate, calcium sulfate dihydrate, calcium sulfate hemihydrate, acetoacetic anilide, acetoacetic acid-o
-Toluidide, acetoacetic acid-p-toluidide, acetoacetic acid-o-anisidide, sorbitol, glycerin monofatty acid ester, alkyl sorbitan ester (H
LB14 or less, and sucrose fatty acid ester (HLB14 or less).

[0008] The present invention also relates to the calcium sulfate 0.5
The slime-controlling agent, wherein the hydrate is β-type calcium sulfate pentahydrate, and the slime-controlling agent is a C ₁₄ such as stearic acid or lauric acid as a dissolution regulator.
It slime control agent and which is characterized in containing the saturated fatty acids -C _24, relating to the slime control agent, characterized in that the maximum length is pressed into tablets is 30mm or less.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION As the non-bleachable antibacterial agent in the present invention, any one can be used as long as it does not generate chlorine gas by reacting with an acidic substance or the like at the time of use. And compounds known as general fungicides or antibacterial agents, and natural oils known to have antibacterial activity. As the fungicide or antibacterial agent, for example, 5-chloro-2-
Methyl-4-isothiazolin-3-one, 2-methyl-
4-isothiazolin-3-one, 4,5-dichloro-3
-N-octyl-isothiazolin-3-one, 1,2-
Benzisothiazolin-3-one, 2-methoxycarbonylbenzimidazole, 2,3,5,6-tetrachloro-4-methanesulfonylpyridine, 2-thiocyanomethibenzothiazole, 2,2-dithio-bis- (pyridine- 1-oxide), 3,3,4,4-tetrahydrothiophene-1,1-dioxide, 4,5-dichloro-1,2-dithiolan-3-one, 5-chloro-4-
Phenyl-1,2-dithiolan-3-one, N-methylpyrrolidone, phenyl- (2-cyano-2-chlorovinyl) sulfone, methylenebisthiocyanate, 2-bromo-2-nitropropane-1,3-diol, 2,2-
Dibromo-2-ethanol, 2-bromo-4'-hydroxyacetophenone, dibromonitrilepropionamide, 2-bromo-2-bromomethylglutarnitrile,
Sodium percarbonate, potassium persulfate, sodium perborate, orthophenylphenol, diphenyl, 2-isopropyl-5-methylphenol, parachloromethaxylenol, n-butyl parahydroxybenzoate, ethyl parahydroxybenzoate, parahydroxybenzoic acid Methyl, benzalkonium chloride, benzethonium chloride, chlorohexidine hydrochloride, chlorohexidine gluconate, 2-
Pyridinethiol-1-oxide, 2-pyridinethiol-1-oxide zinc salt, 2-pyridinethiol-1
-Oxide sodium, N, N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide), 4,4 '-(tetramethylenediamino) bis (1
-Decylpyridinium bromide) and the like.

Examples of natural oils include cineol, hinokitiol, menthol, terpineol, borneol, nopol, citral, citronellal, citronellol, geraniol, linalool, dimethyloctanol, thymol and the like.

Further, as the non-bleachable antibacterial agent in the present invention, an iodine antibacterial agent can be exemplified, and among them, a solid antibacterial agent is particularly preferable. Examples of the iodine antibacterial agent include 2,3,3-triiodoallyl alcohols, 2,3,3-triiodoallyl ethers,
3,3-triiodoallylazoles, 3-iodo-2
-Propargylbutylcarbamic acid, 4-chlorophenyl (3-iodopropargyl) formal, iodopropargylazoles, diiodo-para-trisulfone, popidone iodine, benzyliodoacetate and paranitrobenzyliodoacetate. .

These non-bleachable antibacterial agents may be used alone or
A mixture of more than one species can be used. In addition, these non-bleached powder antibacterial agents can be guest compounds of a multimolecular host compound, for example, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4. An inclusion compound is formed by using -isothiazolin-3-one or the like as a guest compound, and these can be used as a non-exposed powder antibacterial agent.

In the present invention, the base material used together with the non-bleached antibacterial agent is calcium hydrogen phosphate dihydrate, tricalcium phosphate anhydride, magnesium hydrogen phosphate trihydrate, magnesium hydrogen phosphate octahydrate, lactose. , Vanillin,
Calcium citrate tetrahydrate, calcium sulfate dihydrate, calcium sulfate hemihydrate, acetoacetic anilide, acetoacetic-o-toluidide, acetoacetic-p-
Nonionic surfactants such as toluidide, acetoacetic acid-o-anisidide, sorbitol, alkyl sorbitan ester (HLB14 or less), glycerin mono fatty acid ester, and sucrose fatty acid ester (HLB14 or less) are used alone. Or two or more kinds can be used in combination, but it can be determined in consideration of the impact on tableting properties when formed under pressure, solubility in water, disintegration, and stability of antibacterial agents. desirable.

Further, the substrate is a neutral substance,
It is preferable that mixing with a commercially available cleaning agent containing hypochlorous acid does not increase the generation of chlorine gas. In particular, when an inclusion compound is used as the non-bleachable antibacterial agent, sorbitol, lactose, acetoacetate-o-toluidide, and calcium sulfate hydrate are preferred. Furthermore, when calcium sulfate is used as the base material, calcium sulfate hemihydrate is preferred from the viewpoint that moldability and solubility can be easily controlled, and among calcium sulfate hemihydrate, Β-type ones produced by normal-pressure calcination are preferred over α-type ones produced by pressure-sintering because they are less likely to lose their shape due to water absorption. When .pentahydrate is used, it is more preferable to use it in combination with lactose from the viewpoint of controlling the moldability and solubility.

In the present invention, the multimolecular host compound interacts with an antibacterial agent serving as a guest by an intermolecular force such as a hydrogen bond to form a crystalline complex (clathrate compound) having a regular arrangement. It refers to a compound, and is not particularly limited as long as it is a compound having the above properties. For example, the following compounds can be exemplified. (1) Tetrakisphenols (2) 1,1,6,6-tetraphenyl-2,4-hexadiyne-1,6-diol (3) 1,6-bis (2-chlorophenyl) -1,6 −
Diphenylhexane-2,4-diyne-1,6-diol (4) 1,1,4,4-tetraphenyl-2-butyne-
1,4-diol (5) 2,5-bis (2,4, dimethylphenyl) hydroquinone (6) 1,1-bis (2,4, dimethylphenyl) -2
-Propyn-1-ol (7) 1,1,2,2-tetraphenylethane-1,2
-Diol (8) 1,1'-bi-2-naphthol (9) 9,10-diphenyl-9,10-dihydroxyanthracene (10) 1,1,6,6-tetra (2,4-dimethylphenyl) -2,4-hexadiyne-1,6-diol (11) 9,10-bis (4-methylphenyl) -9,
10-dihydroxyanthracene (12) 1,1-bis (4-hydroxyphenyl) cyclohexane (13) N, N, N ', N'-tetrakis (cyclohexyl)-(1,1'-biphenyl) -2-2' -Dicarboxamide (14) 4,4'-sulfonylbisphenol (15) 4,4'-butylidenebis (3-methyl-6-
tert-butylphenol) (16) 2,2'-methylenebis (4-methyl-6-t
tert-butylphenol) (17) 4,4'-thiobis (4-chlorophenol) (18) 2,2'-methylenebis (4-chlorophenol) (19) deoxycholic acid (20) cholic acid (21) α, α, α ′, α′-tetraphenyl-1,
1'-biphenyl-2,2'-dimethanol (22) t-butylhydroquinone (23) 2,5-di-tert-butylhydroquinone (24) granular corn starch (25) 1,4-diazabicyclo- (2, 2,2) -octane

The tetrakisphenols in the above-mentioned multimolecular host compound include, for example, 1,1,2,2-
Tetrakis (4-hydroxyphenyl) ethane, 1,
1,2,2-tetrakis (3-fluoro-4-hydroxyphenyl) ethane, 1,1,2,2-tetrakis (3
-Chloro-4-hydroxyphenyl) ethane, 1,1,
2,2-tetrakis (3-methyl-4-hydroxyphenyl) ethane, 1,1,2,2-tetrakis (3-methoxy-4-hydroxyphenyl) ethane, 1,1,2,2
2-tetrakis (3,5-dimethyl-4-hydroxyphenyl) ethane, 1,1,3,3-tetrakis (4-hydroxyphenyl) propane, 1,1,3,3-tetrakis (3-fluoro-4- (Hydroxyphenyl) propane, 1,1,3,3-tetrakis (3-chloro-4-hydroxyphenyl) propane, 1,1,3,3-tetrakis (3-methyl-4-hydroxyphenyl) propane, 1,1 , 3,3-tetrakis (3-methoxy-4-
(Hydroxyphenyl) propane, 1,1,3,3-tetrakis (3,5-dimethyl-4-hydroxyphenyl)
Propane, 1,1,4,4-tetrakis (4-hydroxyphenyl) butane, 1,1,4,4-tetrakis (3
-Fluoro-4-hydroxyphenyl) butane, 1,
1,4,4-tetrakis (3-chloro-4-hydroxyphenyl) butane, 1,1,4,4-tetrakis (3-
Methyl-4-hydroxyphenyl) butane, 1,1,
4,4-tetrakis (3-methoxy-4-hydroxyphenyl) butane, 1,1,4,4-tetrakis (3,5
-Dimethyl-4-hydroxyphenyl) butane, 1,
1,5,5-tetrakis (4-hydroxyphenyl) pentane, 1,1,5,5-tetrakis (3-fluoro-
4-hydroxyphenyl) pentane, 1,1,5,5-
Tetrakis (3-chloro-4-hydroxyphenyl) pentane, 1,1,5,5-tetrakis (3-methyl-4
-Hydroxyphenyl) pentane, 1,1,5,5-tetrakis (3-methoxy-4-hydroxyphenyl) pentane, 1,1,5,5-tetrakis (3,5-dimethyl-4-hydroxyphenyl) pentane and the like Tetrakis (hydroxyphenyl) alkanes can be specifically exemplified.

The clathrate compound used in the present invention is usually
A non-bleachable antibacterial agent to be a guest and a host compound,
In some cases, at room temperature to 1 in the presence of water or an organic solvent.
It can be easily obtained by stirring and reacting at 00 ° C. for several minutes to several hours.

In the present invention, the mixing ratio of the non-bleachable antibacterial agent to the base material is arbitrary between 1 to 99 parts by weight of the non-bleachable antibacterial agent and 99 to 1 part by weight of the base material because of various usage conditions. The mixing ratio can be varied, but preferably 5 to 20 parts by weight of a non-exposed powder antibacterial agent,
0 parts by weight. When an inclusion compound is used as the non-bleachable powder antibacterial agent, a mixing ratio of 2 to 30 parts by weight of the inclusion compound and 98 to 70 parts by weight of the base material is preferable.

The slime-controlling agent of the present invention can be obtained by press-molding a non-bleachable antibacterial agent and a base material. In press-forming, if necessary, calcium stearate, magnesium stearate, Lubricants such as sodium stearate, sodium benzoate, orthoboric acid,
A binder such as hydroxypropylcellulose, sodium alginate, polyvinyl alcohol, or polyvinylpyrrolidone is added at a ratio of 0.1 to 5 parts by weight to 100 parts by weight of the total slime control agent with respect to 100 parts by weight of the total slime control agent. By adding at a ratio of up to 15 parts by weight, pressure molding can be facilitated.

Addition of a C ₁₄ -C ₂₄ saturated fatty acid such as stearic acid for the purpose of imparting lubricity during molding and at the same time improving the stability of the agent in water (the ability to prevent swelling and collapse). Can be. In particular, when calcium sulfate is used as a base material, it is preferable to add a C ₁₄ -C ₂₄ saturated fatty acid as a dissolution regulator. The amount of the C ₁₄ -C ₂₄ saturated fatty acid to be added is 1 to 10 with respect to 100 parts by weight of the whole slime control agent.
Used in parts by weight. Although 10 parts by weight or more can be added, the dissolution rate becomes slow. Although the saturated fatty acids C ₁₄ -C ₂₄ can include stearic acid and lauric acid Specifically, metal salts of saturated fatty acids of C ₁₄ -C ₂₄ such as calcium stearate as the lubricant is If used in a proportion of 1 part by weight or more with respect to 100 parts by weight of the whole slime control agent, the moldability may be impaired,
It is not suitable for use as a dissolution regulator. Further, depending on the purpose, corrosion inhibitors such as alkylthiourea-based and triazole-based can be added to suppress corrosion of metal parts such as piping. Also, by adding diatomaceous earth, sulphate clay and the like, an antistatic effect can be imparted during molding. Further, by adding various surfactants, the active ingredient can be widely diffused on the surface where slime is generated.
In addition, by adding a bitterness-imparting component, it is possible to prevent accidental eating of infants and infants, and by adding a deodorant and an aromatic agent, it is possible to prevent kitchen garbage and an odor at a drain.

As one embodiment of the slime control agent of the present invention, a small slime control agent formed into a tablet having a maximum length of 30 mm or less by pressure molding can be exemplified. Such a small slime control agent can take various known shapes, but from the viewpoint of ease of pressure molding and ease of installation in a narrow place, a disk shape, a square-cut square shape, an elliptical shape. , A flat sphere, a sphere and the like are preferably selected. The size of the longest part is 30 mm or less, preferably 20 mm or less, and particularly preferably 15 mm or less so that it can be installed in a narrow container such as various drainage pipes or kitchen trash receptacles.

The small-sized slime control agent of the present invention can be used in the form of being stored in a water-permeable container in order to prevent outflow when the device is further downsized by dissolution. As the water-permeable container, a container formed of various known water-permeable materials and a container formed of a non-water-permeable material can prevent the outflow of miniaturized tablets and have an appropriate water permeability. Any container provided with an opening having an opening can be used, and a nonwoven fabric or a resin film having pores is preferably used.

The above water-permeable container is provided with various known materials such as a thread, a string, a metal wire, a resin stopper, an adhesive, etc., in order to install the container in a drainage control pipe or a trash receiving container in a kitchen or the like. , And preferably those provided with a locking tool such as an adhesive tape portion. In addition, a water-permeable container provided with a placement section where no tablet exists between two tablet storage sections, and such a placement section is placed at the upper end of the periphery of a kitchen garbage container (commonly called a triangular corner). To control slime.

[0024]

EXAMPLES The present invention will be described below with reference to Examples and Comparative Examples.
Although described more specifically, the technical scope of the present invention is not limited to these examples. Examples and Comparative Examples (Preparation of Samples) Each sample consisting of a cylindrical molded product having a diameter of 30 mm was prepared from each mixture having the compounding ratio shown in Table 1 by pressure molding. In Table 1, “TEP · CMI” is 2 mol of 5-chloro- as an antibacterial agent serving as a guest compound.
Inclusion compound obtained by reaction of 2-methyl-4-isothiazolin-3-one with 1 mol of 1,1,2,2-tetrakis (4-hydroxyphenyl) ethane as a polymolecular host compound "Bronopol" represents the antimicrobial agent 2-bromo-2-nitropropane-1,3-diol, "TIAA" represents 2,3,3-triiodoallyl alcohol, and "HPC" represents the binder hydroxy. Represents propylcellulose.

[0025]

[Table 1]

(Tabletting / Disintegration Test) A tablet having a weight of 12 g was tableted at a tableting pressure of 8 t / cm ² by setting it on a continuous hydraulic tableting machine equipped with a Φ30 mm mold, and cracking, capping and lubricity were observed. When a "tabletability" test for adhesion and the like was performed, the tabletability of all the samples was evaluated as "O", and none of the samples showed tableting failure. One tablet of these samples was placed in a 200 ml polycup, and distilled water 2
After adding 00 ml and observing the state of collapse of the molded product after standing at room temperature for 24 hours, none of the samples collapsed.

(Dissolution Test) One tablet is placed in a commercially available slime-removing storage case, and a commercially available pipette washer having a diameter of 18 cm and a height of 58 cm (washing water amount: 14.75 L, washing water temperature: 35 to 40 ° C., washing) (Water contact time: 3 minutes, washing interval: 6.6 minutes / time) At a position of 25 to 29 cm in water depth, the entire storage case was hung with a string and continuously washed to measure the dissolution rate. The numerical values in Table 1 represent the time until the molded product is completely dissolved.

(Performance Test) Each sample (molded product) was placed in a commercially available storage case for removing slime, and fixed by being hooked to a drain of a kitchen of a general household with a string. One month after the use, the odor at the time of use (salad powder odor) and the degree of adhesion of the slime were visually observed. Table 1 shows the results. As can be seen from Table 1, except for the sample of Comparative Example 2, there was no smelling powdery smell. As for the amount of slime adherence after one month, the sample of Example 5 showed slight adhesion of slime in the evaluation “△”, but the other samples showed no adhesion of slime in the evaluation of “○”. .

(Chlorine gas generation test when mixed with hypochlorous acid-based cleaning agent) 1 g of a sample was placed in a 100 ml beaker, 100 ml of distilled water was added, and the pH of the dissolved solution was measured with a pH meter. The following were used as a measure for generating chlorine gas by mixing with a commercially available hypochlorous acid-based cleaning agent. Table 1 shows the results. As can be seen from Table 1, the samples of Examples 1 to 5 have no risk of chlorine gas generation in the evaluation "O", the samples of Comparative Examples show pH 5 or less, and the samples of Examples 1 to 5 have the risk of chlorine gas generation in the evaluation "X". I found that there was.

(Disintegration test of clathrate when clathrate is used: dissolution test of antibacterial agent from clathrate) In order to see the effect of the base material on the stability of the clathrate, the following A disintegration test of the contact compound was performed. 1 g of each base material shown in Table 2 and 98 g of distilled water were put into a 200 ml beaker, stirred with a magnetic stirrer for 3 hours, and dissolved to a saturated state, and then 1 g of the above TEP was included as an inclusion compound.
-CMI was added, the mixture was stirred with a magnetic stirrer for 24 hours, and then the solution was filtered through a 0.2 µ membrane filter to measure the amount of the antibacterial agent eluted in the clathrate compound. As a blank, water with no added base material was used. Table 2 shows the results. In Table 2, "degree of clathration disintegration (%)" means the dissolution ratio of the antibacterial agent from the clathrate compound. And, as can be seen from Table 2, the base material used in the present invention had the same degree of inclusion disintegration as the blank, but the polyethylene oxide used for comparison showed that the inclusion compound was disintegrated at a high rate. From this point of view, the base material used in the present invention was found to be excellent also from the viewpoint of the degree of inclusion disintegration.

[0031]

[Table 2]

[0032]

EFFECT OF THE INVENTION The slime control agent of the present invention has no problem of chlorine odor or corrosion, is excellent in safety and handleability, enables stable elution of active ingredients, and can be used in kitchen sinks, bathroom drains, etc. As described above, it is provided at a place where slime is generated due to metabolites such as germs and fungi, thereby removing slime and preventing the generation of slime.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 31/08 A01N 31/08 35/04 35/04 37/02 37/02 37/06 37/06 37 / 36 37/36 37/42 37/42 43/16 43/16 A 59/06 59/06 Z 59/26 59/26 C11D 7/34 C11D 7/34 (72) Inventor Takashi Yoshihara Ichihara, Chiba Goi South Coast 12-54 Nippon Soda Co., Ltd. Chiba Factory (72) Inventor Eiji Takemura 2-2-1 Otemachi, Chiyoda-ku, Tokyo Nippon Soda Co., Ltd. F-term (reference) 4H003 AB03 BA09 CA20 DA08 DA17 DA01 DB01 EA11 EA12 EB03 EB07 EB08 EB09 EB17 EB21 EB27 EB41 FA34 4H011 AA02 BA01 BB03 BB04 BB10 BC03 BC05 BC06 BC18 DA03 DC11 DD07 DE17 DF02 DG03 DG05 DH10

Claims (9)

[Claims] 1. A non-bleached powder antibacterial agent, calcium hydrogen phosphate dihydrate, tricalcium phosphate anhydride, magnesium hydrogen phosphate trihydrate, magnesium hydrogen phosphate octahydrate, lactose, vanillin, calcium citrate 4 Hydrate, calcium sulfate dihydrate, calcium sulfate hemihydrate, acetoacetate anilide, acetoacetate-o-toluidide, acetoacetate-p-toluidide, acetoacetate-o-anisidide, sorbitol, glycerin mono fatty acid A slime control agent obtained by pressure molding one or more base materials selected from esters, alkyl sorbitan esters (HLB 14 or less), and sucrose fatty acid esters (HLB 14 or less). 2. The slime control agent according to claim 1, wherein the non-bleachable antibacterial agent is an inclusion compound comprising an antibacterial agent and a multimolecular host compound. 3. The multimolecular host compound is one or two selected from the group consisting of the following compounds (1) to (25):
3. The slime control agent according to claim 2, which is a compound of at least one kind. (1) Tetrakisphenols (2) 1,1,6,6-tetraphenyl-2,4-hexadiyne-1,6-diol (3) 1,6-bis (2-chlorophenyl) -1,6 −
Diphenylhexane-2,4-diyne-1,6-diol (4) 1,1,4,4-tetraphenyl-2-butyne-
1,4-diol (5) 2,5-bis (2,4, dimethylphenyl) hydroquinone (6) 1,1-bis (2,4, dimethylphenyl) -2
-Propyn-1-ol (7) 1,1,2,2-tetraphenylethane-1,2
-Diol (8) 1,1'-bi-2-naphthol (9) 9,10-diphenyl-9,10-dihydroxyanthracene (10) 1,1,6,6-tetra (2,4-dimethylphenyl) -2,4-hexadiyne-1,6-diol (11) 9,10-bis (4-methylphenyl) -9,
10-dihydroxyanthracene (12) 1,1-bis (4-hydroxyphenyl) cyclohexane (13) N, N, N ', N'-tetrakis (cyclohexyl)-(1,1'-biphenyl) -2-2' -Dicarboxamide (14) 4,4'-sulfonylbisphenol (15) 4,4'-butylidenebis (3-methyl-6-
tert-butylphenol) (16) 2,2'-methylenebis (4-methyl-6-t
tert-butylphenol) (17) 4,4'-thiobis (4-chlorophenol) (18) 2,2'-methylenebis (4-chlorophenol) (19) deoxycholic acid (20) cholic acid (21) α, α, α ′, α′-tetraphenyl-1,
1'-biphenyl-2,2'-dimethanol (22) t-butylhydroquinone (23) 2,5-di-tert-butylhydroquinone (24) granular corn starch (25) 1,4-diazabicyclo- (2, 2,2) -octane 4. The non-bleached powder antibacterial agent is 5-chloro-2.
The slime control agent according to claim 2 or 3, which is -methyl-4-isothiazolin-3-one. 5. The slime control agent according to claim 1, wherein the non-bleachable antibacterial agent is an organic iodine antibacterial agent. 6. The slime control agent according to claim 1, wherein the calcium sulfate hemihydrate is β-type calcium sulfate hemihydrate. 7. A slime control agent comprising C ₁₄ as a dissolution regulator.
Slime control agent according to any of claims 1 to 6, characterized in that it contains saturated fatty acids -C _24. 8. The slime-controlling agent according to claim 7, wherein the C ₁₄ -C ₂₄ saturated fatty acid is stearic acid or lauric acid. 9. The slime control agent according to claim 1, wherein the tablet is press-molded into a tablet having a maximum length of 30 mm or less.