JP2000321246A - Molecule identifying device and method and ion trap - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a molecule identifying device and method with high accuracy in determination and an ion trap. SOLUTION: This molecule identifying device is formed of a decomposer 6 or 8 for decomposing part of a plurality of molecules into fragments and an accelerator 9 for accelerating the molecules and fragments electrically. The spectra of the original molecules and fragmented atoms and molecules become data for highly accurately specifying and identifying the substance. It is especially important for the decomposer to be an ion trap. The combination of condensation and excitation provides an extremely important technique for identifying a minor component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a molecular identification apparatus, a molecular identification method, and an ion trap, and more particularly, to an ion capable of detecting a trace amount of a chemical substance such as dioxin in a gas with high precision. The present invention relates to a flight-type molecule identification device, a molecule identification method, and an ion trap.

[0002]

2. Description of the Related Art Dioxin is extremely harmful to cells even in minute amounts. As a detector for detecting a trace amount of a chemical substance, a mass spectrum analyzer in which a resonance multiphoton ionizer and a time-of-flight mass analyzer are combined in series is known. As shown in FIG. 8, such a mass spectrum analyzer supplies a sample gas 1 from a pulse nozzle 2 to a vacuum chamber 3 as a (supersonic) free jet, and the free jet is cooled by adiabatic expansion. Due to such cooling, a gas whose vibration / rotation level is biased toward the low energy side and whose wavelength selectivity is increased efficiently absorbs a resonant multiphoton such as the laser 4 to increase its ionization efficiency. The molecules in the ionized gas are accelerated by the accelerating electrode 5, are given an acceleration inversely proportional to the mass, fly in the flight tube 6, are reflected by the reflectron 7, and are incident on the detector 8. By measuring the time of flight in the flight tube 6, the mass of the molecule or atomic particle is obtained by calculation,
From the comparison of the signal intensity of the detector 8, the concentration of the chemical substance to be measured becomes clear.

Such a mass spectrum analyzer is excellent in principle in that it can detect a trace substance, but has the following three problems. The first point is that when the temperature of the sample to be introduced is high, the sample gas is not sufficiently cooled and its wavelength selectivity is reduced. Such a decrease in wavelength selectivity simultaneously ionizes many types of molecules, making it difficult to identify target molecules.
Such difficulty is particularly remarkable in a substance having a high chlorine number such as dioxin. The second point is that when molecules having the same mass as the target molecule A are mixed, measurement of the target molecule becomes impossible. Such a phenomenon is particularly remarkable when measuring an ultra trace component such as dioxin. Third
The point is that when performing time-of-flight mass spectrometry starting from ionization with a pulse laser having excellent properties for ionizing introduced molecules, the oscillation frequency of the pulse laser is limited, and it is difficult to increase sensitivity.

[0004] In such a known measuring device, ionization is improperly performed due to a reduction in wavelength selectivity, and parameters important for determination are lost. It is desired that such important parameters remain to improve the determination accuracy. In particular, it is desirable that reliable identification be possible even when chemical substances having the same mass are mixed, and it is desirable that ionization be performed on a specific substance even if the wavelength selectivity is reduced.

[0005]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a molecular identification apparatus, a molecular identification method, and an ion trap with a high determination accuracy. Another subject of the present invention is:
An object of the present invention is to provide a molecule identification device, a molecule identification method, and an ion trap which can determine a substance having the same mass. Still another object of the present invention is to provide a molecular identification device, a molecular identification method, and an ion trap that can ionize a specific substance even if the wavelength selectivity is reduced. Still another object of the present invention is to provide a molecule identification device, a molecule identification method, and an ion trap that can decompose a substance to be measured without losing information necessary for high-precision determination. is there.

[0006]

Means for solving the problem are described as follows. The technical matters corresponding to the claims in the expression are appended with numbers, symbols, etc. in parentheses (). The number, the symbol, etc. are at least one of the technical matters corresponding to the claims and the plurality of embodiments.
Although the agreement / correspondence with the technical matters of the two forms is clarified, it is not intended to show that the technical matters corresponding to the claims are limited to the technical matters of the embodiment.

[0007] The molecular identification apparatus according to the present invention comprises a decomposer (8) for decomposing a part of molecules of the plurality into fragments, and an accelerator (9) for electrically accelerating the molecules and fragments. ). The spectrum of atoms / molecules of the original molecule and fragment becomes data for specifying and identifying the substance with high accuracy.

[0008] The apparatus further comprises a detector for detecting a plurality of times of flight (t (N)) of molecules and fragments accelerated by the accelerator (9), and an ionizer for ionizing the molecules and fragments. The ionizer is preferably an ion trap (6) for concentrating molecules in a specific space region.
In this case, the ion trap (6) is also used as a decomposer (8).

Further, a measuring device (14) for measuring the number and the number of molecules and fragments detected by the detector and a measurement mass spectrum indicating the correspondence between the mass corresponding to the plurality and the time and the plurality and the number are prepared. And a creator (15) for performing the operation. In this case, the detector is a measuring device (1
4). Further, it is preferable to use a storage device in which a known specific mass spectrum of a molecule and a fragment of the molecule is stored in advance. Further, it is preferable that the apparatus further comprises a comparator (15) for identifying the molecule by comparing the measured mass spectrum with the specific mass spectrum.

Further, the ionizer (3 or 4) comprises an introducer (1) for continuously introducing the sample gas (2). Furthermore, it is preferable that the introducer (1) includes a nozzle (not shown) for jetting a sample and a heater (not shown) for heating the nozzle. It is preferable that a molecular adhesion preventing film (not shown) is formed on the inner surface of the nozzle. In addition, a carrier gas introducing device (not shown) for introducing a carrier gas into the ionizer (3) and a mixing device (not shown) for mixing a liquid sample into the carrier gas may be practical. Is preferred.

Further, the ionizer (3) is provided with a carrier gas introducing device for introducing a carrier gas and an evaporator (not shown) for evaporating a solid sample. Preferably, it is mixed with the carrier gas.

According to the method for identifying a molecule according to the present invention, a step of ionizing a part of the plurality of molecules and a step of decomposing the other number of molecules into fragments to ionize the fragments. And a step for electrically accelerating the molecules and fragments. By the above-described operation, the resolution is improved by an order of magnitude, and simultaneous measurement of a plurality of molecules is possible.

The method comprises the steps of detecting a plurality of times of flight of molecules and fragments accelerated by the step, and further comprises the step of concentrating the molecules in a specific space region. This concentration further improves the resolution and reduces the measurement time. The shortening of the measurement time and the improvement of the resolution enable real-time detection of a trace amount of dioxin, and provide a timely use technology.

[0014] It is preferable that the ionization be performed continuously to improve the accuracy. In the step for ionizing the molecule, it is very important that the molecule is continuously excited by resonant multiphotons. In the step for decomposing, the molecules can be excited successively by resonant multiphotons.
It is already clear from the above-mentioned matter that a laser that is a resonant multiphoton has a fixed mode, is capable of high repetition, and is an ultrashort pulse laser. For example, an ultrashort pulse is between picoseconds and femtoseconds.
It is also preferred that the laser reciprocate a plurality of times. For multiple reciprocations, a facing mirror (Fabry-Perot resonance mirror) is used.

In the step for ionizing the molecule,
It is also possible that the molecules are continuously excited by the electron flow. In this case, it is preferable that the energy of the electron beam has a repetition frequency. In the step for ionizing the molecules, the molecules are continuously excited under an RF electric field, resulting in gas enrichment.

[0016] The molecular identification method according to the present invention comprises the steps of enriching a plurality of specific molecules into a population, decomposing the enriched specific molecules, and electrically decomposing the specific molecules and the decomposed fragments. To measure values corresponding to individual masses from the law of motion. Concentration is a very important step.

A step for concentrating the plurality of specific molecules into a population, a step for decomposing the concentrated specific molecules, and a law of motion by electrically accelerating the specific molecules and the fragments obtained by decomposing the specific molecules. A step for measuring a value corresponding to each individual mass from, a step for measuring the number of specific molecules and fragments, and a step for creating a measured mass spectrum formed from the value and the number corresponding to the mass Consists of

Further, the enriched specific molecule contains a first type molecule and a second type molecule whose masses are substantially the same, and an unknown concentration Ca in the known mass spectrum Sa (I) of the first type molecule. Is represented by CaSa (I), and the second
The value obtained by multiplying the known mass spectrum Sb (I) of the seed molecule by the unknown concentration Cb is expressed as CbSb (I), where I indicates a value corresponding to the mass, and the measured mass spectrum is S ( I) and represented by S (I)-(CaS
a (I) + CbSb (I)) and a step for determining the concentration Ca and the concentration Cb at which the concentration becomes minimum. Coupling allows identification of molecules that were previously impossible.

The ion trap according to the present invention comprises a container (6) into which a molecular gas is introduced, and an RF electric field generator (24) for applying an RF electric field to the molecular gas in the container (6). The electric field generator (24) includes a notch imparting device (not shown) for imparting a notch to the specific frequency to make the electric field intensity at a specific frequency corresponding to the mass of the target molecule smaller than the intensity at other frequencies. The container (6) has a hole (22) through which an energy beam for decomposing a part of the molecule of interest enters the container (6). Preferably, there are a plurality of notches. As already mentioned, it is particularly preferred that the energy beam is a laser.

It is particularly preferred that the laser is pulsed. It is additionally preferred that the laser has a wavelength that selectively decomposes the molecule of interest. Further, an ion lens (not shown) for guiding ions of a target molecule into the container.
Consists of

[0021]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Corresponding to the drawings, the embodiment of the molecular identification apparatus according to the present invention is provided with a sample introduction nozzle. The sample introduction nozzle 1 includes a valve nozzle (not shown) that can eject the free jet 2. A free jet 2 as a sample is jetted into a vacuum chamber 3. Free jet 2 is expanded in vacuum chamber 3.

A first laser oscillator 4 is fixedly provided in the vacuum chamber 3. The laser emitted from the first laser oscillator 4 is used as an ionization laser, and the free jet 2 is orthogonal to the flow of the free jet 2.
To ionize the free jet 2. The free jet 2 may contain a chemical substance belonging to dioxin. The inside of the vacuum chamber 3 is evacuated by a vacuum pump 5. An ion trap 6 is fixedly provided in the vacuum chamber.

The ion trap 6 is provided with both electrodes and has a repetition frequency (voltage) whose frequency is continuously variable.
Can be generated. In the vacuum chamber 3, a second laser oscillator 8 for generating a fragment (laser) generating laser 7 is fixedly provided. Second
The fragment generation laser 7 generated by the laser oscillator 8 can further ionize the mixed and mixed molecules of the gas ionized in the ion trap 6 to decompose the gas molecules into fragments.

An acceleration electrode 9 is fixedly provided in front of the ion trap 6. In front of the vacuum chamber 3,
The flight tube 11 is arranged. A reflectron 12 is arranged in the flight tube 11. The reflectron 12 is used to increase the resolution (temporal microscopic function for extending the time-of-flight t described later to increase the resolution of the time-of-flight difference). Flying at constant speed in flight tube 11 and reflectron 1
The atoms and molecules, which are the ionized particles that collided with 2, are reflected by the local repulsion. In the flight tube 11,
An ion detector 14 is provided.

The ion detector 14 includes the reflectron 12
There is provided an ion detector 14 which receives the charge by collision of the ions reflected by the. The ion detector 14 can generate one pulse each time one ion strikes the ion detector. A signal processing device 15 is connected to the ion detector 14. The signal processing device 15 includes the ion detector 14
Detects electrical pulses generated by ions that collide with
In addition, it is possible to detect the flight time of the ions from when the acceleration voltage is applied to the acceleration electrode 9 until the ions collide with the ion detector 14.

When ions collide with the ion detector 14 at the same time, the ion detector 14 generates a voltage obtained by integrating the plurality of pulses. Alternatively, the signal processing device 15 has a resolution capable of detecting the collision time of a plurality of particles with high accuracy and resolving the time of the plurality of particles colliding substantially simultaneously to resolve all the pulses. .

A part of the free jet 2 is ionized by the first laser oscillator 4, and is preferably focused by an ion lens disposed immediately before the ion trap 6 and enters the ion trap 6. Most of the atoms and molecules ionized by the first laser oscillator 4 maintain the original state of the molecules and atoms. The atoms and molecules that have entered the ion trap 6 receive an RF electric field.

An atom / molecule that has received an electric field of a specific frequency resonates with the electric field frequency, and its floating position is fixed with high precision. The position fixation is determined by the electric field frequency and the mass of the atom / molecule. Other atoms and molecules having a mass number that does not match the mass number jump out of the ion trap 6, and atoms and molecules having a specific mass number are concentrated at a high concentration in the ion trap 6.

Particles having a specific mass number are further subjected to ionization energy by the fragment generation laser 7 for a time shorter than the average ion life (several seconds) until the decay of the ion. The fragment generation laser 7, which is a resonant multiphoton, functions as one photon, which is a collection of countless waves. Many molecules that make electromagnetic contact with the one photon are each broken down into smaller molecules and atoms.
The distribution pattern of fragments generated when an incident molecule is decomposed by one photon, two photons (double waves), and n photons of the laser energy sufficiently reflects the characteristics of the original molecule. For such reflection, decomposition by irradiation with the fragment generation laser 7 within a time shorter than the time (within several seconds) during which ions can be captured by the ion trap 6 increases the accuracy of the mass spectrum. Is preferred.

When the specific ions are concentrated and captured in the ion trap 6 and have the highest concentration, the fragment generating laser 7 is irradiated. Irradiation at such timing maximizes the accuracy of the mass spectrum of the decomposed atoms and molecules. Immediately thereafter, an appropriate positive voltage is applied to the acceleration electrode 9. Due to the applied voltage, the atoms and molecules are accelerated all at once and are instantaneously accelerated toward the reflectron 12, travel toward the reflectron 12 at a substantially constant speed, are reflected by the reflectron 12, and travel toward the ion detector 14. The time t between the application of the voltage of the acceleration electrode 9 and the collision with the ion detector 14 corresponds to the mass number (N) of each atom / molecule. That is, t = t
(N). This is the mass spectrum.

FIG. 2 shows the details of the ion trap 6. The main body of the ion trap 6 is an elliptical container 21.
It is. The container 21 is divided into two parts, one and the other of which form a bipolar electrode.
An F electric field is applied. Small holes 22 and 23 are formed in both electrodes facing the center of the ellipsoid in the short axis direction. An ion stream enters from one of the holes 22, and fragments decomposed in the ion trap 6 exit from the hole 23. An ion of a certain mass gathers at the approximate center region of the ion trap 6 at a voltage frequency corresponding to the mass, and ions of another mass exit from both holes 22 and 23 or are collected at the center region. Is bounced off. Ions of a particular mass collect in high concentrations in its central region.

The ions which have entered the hole 22 and have not been decomposed remain as such for a few seconds, but are decomposed into a group of fragment ions having a unique mass spectrum by irradiation of the fragment generation laser 7. . Since the fragment generation laser 7 is irradiated in a state where the original ions maintain their ion form, the original ions include the original ions.
At the same time (within 2 to 3 seconds) when a group of fragments in which the original ions have been decomposed is generated, the fragment generation laser 7 is irradiated.

FIG. 3 shows a mass spectrum for a specific ion A. In the figure, the horizontal axis shows the flight time corresponding to the mass number, and the vertical axis shows the number of molecules and atoms. The ions A have already been decomposed into three fragments while entering the ion trap 6. An ion composed of such three fragments is called an original ion state.
Laser 7 for fragment generation in ion trap 6
Of the ion A which has been subjected to the irradiation, one of its fragments is further decomposed into two fragments.

The four fragments (one of which is an ion of the molecule and not decomposed) are instantaneously accelerated by the accelerating electrode 9 having the same voltage, and t (N) is measured by the ion detector 14 for each. The signal is then processed by the signal processing device 15. The signal intensity that the ion detector 14 measures for each fragment is determined by the individual (i
Corresponding to the number n of fragments. The mass spectrum represented by the following equation is obtained.

Ni = ti (Ni). Here, i is 1 to 4. In the graph of FIG. 3, the original ion state has three peak values, but after decomposing into fragments, has four peak values. Such two forms of mass spectrum, before and after decomposition, correspond to each other and are unique to the original molecule. For the known substance A, a mass spectrum has been obtained in advance with high precision by the same apparatus. The known spectrum is registered in the signal processing device 15 or a computer connected to the signal processing device 15 in advance.

FIG. 4 shows a mass spectrum of another specific ion B. The ions B are not decomposed at all and remain in the state of the ions as they enter the ion trap 6. Ions B irradiated by the fragment generation laser 7 in the ion trap 6
Is broken down into four fragments. The four fragments are instantaneously accelerated by the equal-voltage accelerating electrode 9 and each has t
(N) is measured by the ion detector 14.

Ni = ti (Ni). Here, i is 1 to 4 as in FIG. In the graph of FIG. 4, the original ion state has one peak value, but after decomposing into fragments, has four peak values. The two forms of mass spectrum before and after decomposition are as follows:
They are correspondingly unique to the original molecule. Known substance B
The mass spectrum was previously obtained with high accuracy by the same apparatus. The known spectrum is
It is registered in the signal processing device 15 or a computer connected to the signal processing device 15.

When the masses of the known substance A and the other known substance B are the same or similar (substantially the same), both substances are concentrated in the ion trap 6, and
If the mass spectra of both substances after decay are similar, if both mass spectra exceed the range of the resolution of the device, it becomes impossible or difficult to identify and identify both substances. .

The mass spectrum of the ion A is represented by n1 (t
1). Let the mass spectrum of ion B be n2 (t
2). The ion concentrations processed by the signal processing device 15 are represented by C1 for ions A and C2 for ions B. The mass spectrum of a mixed gas of ions A and B having substantially the same mass number is represented by n. FIG.
Shows the mass spectrum when the substance A and the substance B are mixed. The error of the signal strength is expressed by the following equation.

Δn = n− (C1 · n1 (t1) + C2 ·
n2 (t2)). C1 and C2 obtained by simultaneous equation calculation so as to minimize this value Δn correspond to the concentrations of ions A and B. The concentration determined by such calculation is determined with higher accuracy because the spectra of the original ions A and B are included in the calculation process. Conversely,
Conventionally, a mass spectrum (three peak values on the right side of FIG. 5) can be obtained only for the original ion.
And substance B cannot be distinguished, and furthermore, it cannot be determined whether the gas is a mixed gas or a single gas.

According to the present invention, as shown in FIG. 5, the mass spectrum S2 before the decomposition and the mass spectrum S
1 is obtained, and from the simultaneous linear equations containing both spectra as coefficients, both substances are specified and the mixing ratio thereof is also clarified.

The improvement of the accuracy by the simultaneous formation contributes to the ionization by the concentration process and the selective absorption. The best embodiment of the enrichment process is an ion trap, the best embodiment of selective absorption is a laser, but a multi-stage reflector can be used instead of an ion trap, and energy is used instead of a laser. An electron beam having a specified energy and a plasma-forming apparatus for supplying constant energy can be used.

One photon passing through the enriched gas is the synthesis of an enormous number of waves, with many molecules near the passage decomposing into fragments of a unique pattern while the one photon passes. , Lasers (multiphoton resonance beams) are the best means. More preferably, the pulse width of the laser is short. Pulse widths can be from picoseconds to femtoseconds with the latest technology. The laser passes through the concentrated gas instantaneously,
In addition, several laser pulses excite a gas of the same quantum mechanical level in a very short time, so that it is broken down into highly precise pattern fragments. The measurement is substantially continuous, and statistically higher accuracy is achieved.

FIG. 6 shows the measurement results for monochlorobenzene. The peak value at the right end of the mass spectrum indicates n (= t (N)) of monochlorobenzene. The spectrum composed of the other peak values is the mass spectrum of carbon, chlorine, hydrogen, and nitrogen atoms, and the molecular fragments made of these atoms, generated by the decomposition of monochlorobenzene.

FIG. 7 shows the measurement results of DCDD (dichlorobenzodioxin). The peak value indicated by an arrow in the figure of the mass spectrum indicates n (= t (N)) of monochlorobenzene. A spectrum S3 including a plurality of other peak values is a mass spectrum of an atom / molecule fragment generated by decomposition of monochlorobenzene.

When a laser is used to ionize the concentrated gas, the repetition frequency of the laser is not limited, and the sensitivity is improved. By performing the concentration, the ionization of the introduced sample can be made continuous, and in this respect, the sensitivity is improved. Conventionally, only one molecule can be measured per measurement, but according to the present invention, simultaneous measurement of a plurality of molecules is possible, and the measurement time can be reduced.

[0047]

The resolution of the molecular identification device, the molecular identification method and the ion trap according to the present invention is increased by an order of magnitude by concentration. In particular, it is possible to identify a trace substance with high accuracy. The use of lasers for the ionization of enriched gases increases the accuracy of trace substance identification by orders of magnitude.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view with a circuit block showing an embodiment of a molecular identification device according to the present invention.

FIG. 2 is a sectional view showing an embodiment of an ion trap.

FIG. 3 is a mass spectrum for a specific sample.

FIG. 4 is a mass spectrum for a specific sample.

FIG. 5 is a mass spectrum for a mixed gas.

FIG. 6 is a mass spectrum showing a measurement result.

FIG. 7 is a mass spectrum showing another measurement result.

FIG. 8 is a cross-sectional view showing a known mass spectrum analyzer.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... Introducer (sample introduction nozzle) 2 ... Sample gas (molecular flow) 3 ... Ionizer (vacuum chamber) 6 ... Ion trap (concentrator, container) 8 ... Decomposer (2nd laser oscillator) 9 ... Accelerator (acceleration) Electrode) 14 ... Measuring instrument (ion detector) 15 ... Creater (including signal processing device and comparator) 22 ... Hole 24 ... RF electric field generator t (N) ... Flight time (mass spectrum) Sa (I), t1 (n1): mass spectrum Ca, Cb: concentration Sb (I): mass spectrum

Claims (30)

[Claims] 1. A molecule identification apparatus comprising: a decomposer for decomposing a part of molecules of a plurality into fragments; and an accelerator for electrically accelerating the molecules and the fragments. 2. The apparatus according to claim 1, further comprising: a detector for detecting a plurality of flight times of the molecule and the fragment accelerated by the accelerator; and an ionizer for ionizing the molecule and the fragment. Wherein the ionizer is an ion trap for concentrating the molecule in a specific space region. 3. The molecular identification device according to claim 2, wherein the ion trap is also used as the decomposer. 4. The apparatus according to claim 2, further comprising: a measuring instrument for measuring a plurality and a number of the molecules and the fragments detected by the detector; a mass corresponding to the plurality and the time; and the plurality and the number. And a creator for creating a measured mass spectrum indicating the correspondence between the two. 5. The molecular identification apparatus according to claim 4, further comprising a storage device in which a known specific mass spectrum of the molecule and a fragment of the molecule is stored in advance. 6. The molecule identification apparatus according to claim 4, further comprising a comparator for comparing the measured mass spectrum with the specific mass spectrum to identify the molecule. 7. The molecular identification apparatus according to claim 2, further comprising an introducer for continuously introducing a sample gas into said ionizer. 8. The molecular identification apparatus according to claim 7, further comprising a nozzle for injecting the sample, and a heater for heating the nozzle. 9. The molecular identification device according to claim 8, wherein a molecular adhesion preventing film is formed on an inner surface of the nozzle. 10. The apparatus according to claim 2, further comprising a carrier gas introducing device for introducing a carrier gas into said ionizer, and a mixing device for mixing a liquid sample into said carrier gas. Molecular identification device. 11. The apparatus according to claim 2, further comprising: a carrier gas introducer for introducing a carrier gas into the ionizer; and an evaporator for evaporating a solid sample, wherein the sample evaporated by the evaporator is provided. A molecule identification device mixed with the carrier gas. 12. A step of ionizing some of the plurality of molecules, and a step of decomposing the other number of molecules of the plurality into fragments to ionize the fragments. A molecule identification method comprising: electrically accelerating the molecule and the fragment; and detecting a plurality of times of flight of the molecule and the fragment accelerated by the step. 13. The method according to claim 12, further comprising the step of enriching said molecule in a specific space region. 14. The molecular identification method according to claim 13, wherein the ionization is performed continuously. 15. The molecular identification method according to claim 12, wherein in the step of ionizing the molecule, the molecule is continuously excited by resonant multiphotons. 16. The molecular identification method according to claim 12, wherein in the step of decomposing, the molecules are continuously excited by resonant multiphotons. 17. The molecular identification method according to claim 15, wherein the laser that is the resonant multiphoton is a laser having a fixed mode, capable of high repetition, and an ultrashort pulse. 18. The molecular identification method according to claim 17, wherein the ultrashort pulse is between picoseconds and femtoseconds. 19. The molecular identification method according to claim 17, wherein the laser reciprocates a plurality of times. 20. The molecular identification method according to claim 12, wherein in the step of ionizing the molecule, the molecule is continuously excited by an electron flow. 21. The molecular identification method according to claim 12, wherein in the step of ionizing the molecule, the molecule is continuously excited under an RF electric field. 22. A step for concentrating the plurality of specific molecules into a population, a step for decomposing the concentrated specific molecules, and electrically accelerating the specific molecules and fragments in which the specific molecules are decomposed. Measuring a value corresponding to each mass from the law of motion. 23. A step of concentrating the plurality of specific molecules into a population, a step of decomposing the concentrated specific molecules, and electrically accelerating the specific molecules and the fragments in which the specific molecules are decomposed. Measuring the values corresponding to individual masses from the law of motion, measuring the number of the specific molecules and the fragments, and forming from the value corresponding to the mass and the number. A step for creating a measured mass spectrum. 24. The mass spectrometer according to claim 23, wherein the enriched specific molecule further comprises a first type molecule and a second type molecule having substantially the same mass, and a known mass spectrum of the first type molecule. Sa
The value obtained by multiplying the unknown concentration Ca by (I) is represented by CaSa (I), and the value obtained by multiplying the known mass spectrum Sb (I) of the second type molecule by the unknown concentration Cb is CbSb.
(I), wherein I indicates a value corresponding to the mass, and the measured mass spectrum is represented by S (I);
A method for identifying a molecule, comprising the steps of determining the concentration Ca and the concentration Cb that minimize S (I)-(CaSa (I) + CbSb (I)). 25. A container into which a molecular gas is introduced, and an RF for applying an RF electric field to the molecular gas in the container.
An RF electric field generator, wherein the RF electric field generator is provided with a notch for giving a notch to the specific frequency to make the electric field intensity at a specific frequency corresponding to the mass of the target molecule smaller than the intensity at other frequencies. An ion trap, characterized in that the container has a hole through which an energy beam for decomposing a part of the target molecule is incident into the container. 26. The ion trap according to claim 25, wherein the number of the notches is plural. 27. The ion trap according to claim 25, wherein said energy beam is a laser. 28. The ion trap according to claim 27, wherein the laser is a pulse. 29. The ion trap according to claim 27, wherein the laser has a wavelength for selectively decomposing the target molecule. 30. The ion trap according to claim 25, further comprising an ion lens for guiding ions of the target molecule into the container.