JP2000271130A - Syringe fixing/injecting device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a syringe fixing/injecting device capable of injecting different quantities of two medicinal liquids always at a constant ratio at the same time using universal low cost syringes without requiring manufacture of exclusive syringes. SOLUTION: This device comprises the main body 1 for fixing the barrels 22 of two syringes 21 and pressing parts 3 to be mounted at the rear end of the plunger 23 of each syringe. The device also has guide parts 6 for supporting two plungers 23 from the outer sides at both sides of the main body 1 in the rear end, and two gears with different outer diameters are mounted between the plungers 23 so that each gear is engaged with each other. A rack gear 9 to be engaged with the gear 8 moving together with each plunger 23 is mounted on the inner side of each plunger 23 in the pressing part 3. Since the ratio between the outer diameters of the gears 9 is set to be contrast to the ratio between the quantities of medicine to be injected in the syringes 21 adjacent to the gears 9, the quantities of progress of the plungers 23 are always in a constant ratio.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for injecting a tissue adhesive mainly applied as a two-component preparation, and more particularly to a method for reducing the volume ratio of a thrombin solution to a high-concentration fibrinogen solution. The present invention relates to a syringe-fixed injection device for a tissue adhesive, which is suitable for forming a high concentration of fibrin and obtaining a high closing effect.

[0002]

BACKGROUND OF THE INVENTION Fibrinogen is a coagulation factor that plays a very important role in the final stages of the so-called blood clotting cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes a significant contribution to hemostasis and wound healing, for example, in the activation of the blood coagulation system after injury. Tissue adhesives utilizing the principle of the final phase of blood coagulation have been developed and used in surgical operations as adhesives for suture replacement of soft organs such as liver or spleen or as suture aids. At the same time, it is applied in a wide range of clinical settings.
2. Description of the Related Art In recent years, a spray coating method in which a fibrinogen solution and a thrombin solution stored in two syringes are simultaneously ejected, and the two ejected solutions are atomized and mixed by using aseptic gas has begun to spread. . A suitable example of such a device is described, for example, in WO 94-07420. However, even if such a spray coating method is used, in cases where a strong adhesive / closing effect is required, such as treatment of large blood vessels or treatment of air leak in the lungs, it is not until the tissue adhesive exerts a sufficient effect. There were still problems to overcome.

On the other hand, it has been confirmed that it is effective to increase the fibrinogen concentration by changing the mixing ratio of the fibrinogen solution and the thrombin solution as a method for enhancing the effect of the tissue adhesive. A device that applies to these tissue adhesives,
That is, as a device for simultaneously injecting a fibrinogen solution and a thrombin solution in different volumes, Japanese Patent Application Laid-Open No.
JP-A-293443 and WO97-33633 disclose the use of two syringes having different cross-sectional areas shown in FIG. 3 as effective strokes of equal length. However, there are no general-purpose syringes having different cross-sectional areas and the same effective stroke, and a new syringe must be manufactured specifically for this purpose. Therefore, cost increases have been unavoidable in the field of syringes that are mass-produced and inexpensive.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to solve such a conventional problem, and a general-purpose low-cost syringe can be used without specially preparing a special-purpose syringe. Another object of the present invention is to provide an injecting device capable of simultaneously injecting two liquid solutions of different capacities at a fixed ratio at the same time in order to maximize the effect of the tissue adhesive.

[0005]

In other words, the present invention provides an apparatus in which at least two or more syringes of the same size are fixed and a drug solution can be simultaneously injected from each syringe, so that different volumes can always be injected at a fixed ratio. A syringe-fixing injection device, in which plunger movement strokes and movement speeds of the respective syringes are different from each other and a fixed ratio is maintained, and more specifically, a main body for fixing a barrel, and two syringes. And a pressurizing portion attached to the end of the plunger of the syringe, a guide portion holding the two plungers from the outer side surface at both ends on the rear end side of the main body portion, and an outer diameter inside the plunger. Are mounted so as to mesh with each other, and a rack gear meshing with the gear co-running with the plunger is provided on the pressurizing portion. Are installed on the side, the ratio of the outer diameter of each gear is a syringe fixed injection device is set to be inversely proportional to the ratio of different liquid injection volume of the syringe that is adjacent to the gear.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings. FIG. 1 is a three-dimensional perspective view showing the structure of a syringe fixed injection device according to one embodiment of the present invention, and FIG. 2 is a side view showing the arrangement before injection and after injection of the syringe fixed injection device according to one embodiment of the present invention. FIG. As shown in FIG. 1, the syringe fixed injection device for injecting an unequal amount of drug solution according to the present invention comprises two barrels (2) of the same size syringe (21).
It is basically composed of a main body (1) for holding 2) and two pressurizing sections (2) and (3) attached to the ends of the plunger (23) of the syringe (21). . The main body (1) has a plurality of barrel receivers (4) for holding the barrel (22) of the syringe (21), and a flange receiver (4) to which a flange (24) is fitted and fixed at the rear end of the barrel receiver (4). 5), and a guide portion (6) for holding two plungers (23) from the outer side surface at both ends at the rear end, and two gears (7) having different outer diameters on the inner side. ) And (8) are mounted so as to mesh with each other. The pressing portions (2) and (3) are provided with a U-shaped groove (11) into which a flange at the end of the plunger (23) is fitted, and the gear (7) running in parallel with the plunger (23) is provided on the front side. ), Rack gears (9), (10) meshing with (8)
Are located inside each plunger (23). The ratio of the outer diameters of the two gears (7) and (8) is set to be inversely proportional to the target injection amount of the chemical. For example, if the ratio of the injection amount of the chemical is 1: 3, the gear (7) The ratio of the outer diameter of (8) to the outer diameter of (8) is also set to 3: 1.

The material and molding method of the main body (1), the pressurizing parts (2) and (3), the gears (7) and (8) are generally manufactured by injection molding of plastic or the like. There is, but not particularly limited. Further, as long as the gears (7) and (8) are used in a fixed chemical solution injection ratio, it is more cost-effective to fix the mounting positions of the gears (7) and (8) and mount the gears (7) and (8) in advance. However, if the injection ratio is appropriately changed and used, prepare multiple combinations of gears, and if multiple installation positions are installed, the user must change the chemical injection ratio and use it. This is also one of the preferred embodiments because it becomes possible.

Next, the mechanism of the syringe fixed injection device for injecting an unequal amount of drug solution according to the present invention will be described with reference to FIG. FIG.
(A) is a side view showing an arrangement before injecting a chemical solution, (b) is a side view showing an arrangement after injecting a chemical solution, and (c) is a diagram showing a cross-sectional view of a designated position in (b). The attached left and right syringes (21) have a capacity of 3 ml, and are fitted with gears (7) and (8) having an outer diameter ratio of 1: 3, and 3 ml and 1 ml.
3 shows an example of injection. The chemical liquid injection starts from the arrangement shown in FIG. 2 (a), and the rack gear (9) moves forward by pressing the pressurizing portion (2) to rotate the gear (7) in the right direction. In the direction shown in FIG.
The arrangement is as shown in FIG. At this time, each gear (7),
Since the ratio of the outer diameter of (8), that is, the ratio of the number of gear teeth, is 1: 3, the ratio of the forward distance of each of the rack gears (9) and (10) is inversely proportional to the ratio. The chemical is injected at a ratio of 1.

[0009]

As described above, the syringe fixed injection device for injecting an unequal amount of drug solution according to the present invention has a mechanism that can always advance the plungers of two different syringes at a constant rate. Because of this, it is possible to perform different drug injections using a general-purpose low-cost syringe without preparing a specially-designed special-purpose syringe, especially a tissue adhesive injection device suitable for forming a high concentration of fibrin and obtaining a high closing effect Useful as

[Brief description of the drawings]

FIG. 1 is a three-dimensional perspective view showing the structure of a syringe-fixed injection device for injecting an unequal amount of a drug solution according to an embodiment of the present invention.

FIG. 2 is a view showing a mechanism of a syringe fixed injection device for injecting an unequal amount of a drug solution according to one embodiment of the present invention, wherein (a) shows the arrangement before the injection of the drug solution and (b) shows the arrangement after the injection of the drug solution. In the side view shown, (c) is a sectional view in which the position of (b) is designated.

FIG. 3 is a side view showing a mechanism of a conventional syringe fixed injection device for injecting an unequal amount of drug solution.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Main body part 2 Pressing part 3 Pressing part 4 Barrel receiver 5 Flange receiver 6 Guide part 7 Gear 8 Gear 9 Rack gear 10 Rack gear 11 U-shaped groove part 21 Syringe 22 Barrel 23 Plunger 24 Flange

Claims (4)

[Claims] 1. A syringe-fixing and injecting device in which two syringes are fixed and a drug solution can be simultaneously injected from each of the syringes. 2. The syringe fixed injection device according to claim 1, wherein the plunger movement stroke and the movement speed of each syringe are different from each other, and a fixed ratio is maintained. 3. A main body for fixing the barrel, and a pressurizing part attached to the ends of the plungers of the two syringes. Two gears having different outer diameters are mounted on the inside of the guide portion and the plunger held from the side so as to mesh with each other, and a rack gear meshing with the gear running in parallel with the plunger is mounted on the pressing portion. The syringe according to claim 1, wherein the syringe is provided inside the plunger, and a ratio of an outer diameter of each gear is set to be inversely proportional to a ratio of a different chemical injection amount of a syringe adjacent to the gear. Fixed injection device. 4. The mounting position of the two gears on the main body is adjustable, and the gears are removable.
A syringe-fixed injection device as described.