JP2000249711A - Fluid treatment device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a fluid treatment device which can save space, prevent the danger of a connecting error and also reduce cost. SOLUTION: A fluid system unit to be used in a hemocytometer comprises a sampling valve unit A, a first fluid circuit unit B, a second fluid circuit unit C, a third fluid circuit unit D and a syringe pump unit E. The three units B, C and D are connected fluidly and direct-joined structurally by a method wherein concave parts of oppositely arranged inflow/outflow ports P1a-P4a, P1b-P5b, P23a and P23b sandwich each corresponding convex parts thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fluid processing apparatus, and more particularly, to a fluid processing apparatus used for analyzing and counting particles suspended in a fluid. .

[0002]

2. Description of the Related Art Among fluid treatment apparatuses of this kind, the ones for the purpose of downsizing are as follows:
Japanese Patent No. 5838 and (b) Japanese Patent No. 2623322 are known.

[0003] Both of them constitute a compact and relatively simple fluid circuit. Therefore, in order to construct a slightly complicated fluid circuit, it is necessary to use a plurality of fluid processing units and fluidly connect these units. Connections between units are usually
This is achieved by connecting the corresponding inflow / outflow ports of a plurality of units via a plurality of fluid flow tubes.

[0004]

However, according to the connection through a plurality of tubes, not only a space for disposing the plurality of tubes is required, but also a plurality of tubes and a plurality of inflow / inflow tubes are required. Since many steps are required, such as connecting the outlet properly and connecting the tube to prevent the tube from coming off, there is a risk of connection mistakes such as forgetting to connect or incorrect connection, and cost reduction cannot be achieved. There was a problem.

[0005] The present invention has been made in view of such circumstances, and its object is to save space, prevent the possibility of connection errors, and reduce costs. It is an object of the present invention to provide a fluid processing apparatus capable of performing the above-mentioned operations.

[0006]

According to the present invention, a plurality of fluid processing units having a flow path and an inflow / outflow port connected thereto and having a predetermined fluid processing function are provided. A plurality of fluid processing units, each of which has a main body having a flow path formed in a predetermined pattern, and an opening / closing section for opening and closing the flow path of the main body. A fluid treatment device is provided, comprising a circuit unit, wherein the corresponding inlet and outlet are structurally directly connected for fluid connection by the connecting member.

Each of the fluid processing units includes one or a plurality of flow paths through which various fluids such as a sample and a cleaning liquid flow.
1 that connects to these flow paths and allows the same fluid to flow in and out
It has one or more inlets and outlets and has a predetermined fluid treatment function-suction, transfer, discharge, metering, mixing, dilution, etc.

The fluid processing unit includes a fluid circuit unit having a main body having a flow path formed in a predetermined pattern and an opening / closing section for opening and closing the flow path of the main body. In addition to the fluid circuit unit, it may further include a pump unit for quantitatively supplying a fluid, a sampling unit for quantitatively collecting a sample, and the like.

The connecting member is for connecting these fluid processing units. That is, the connecting member is for structurally directly connecting the corresponding inflow / outflow ports to each other in order to fluidly connect the plurality of fluid treatment units. Here, "the corresponding inflow
`` Connecting the outlets structurally directly '' means that the corresponding inlet and outlet are directly connected to each other by uneven fitting or bonding without using a tube or a similar fluid distribution member as in the past. Means to connect to

The corresponding inflow / outflow ports of these fluid circuit units are structurally directly connected, for example, by mounting the connecting member over a plurality of fluid treatment units. The plurality of fluid processing units are fluidly connected to each other.

Here, the corresponding inflow / outflow ports are, for example,
One of them has a connecting protrusion and the other has a connecting recess for receiving the protrusion.

The fluid circuit unit as an example of the fluid processing unit includes, for example, at least one unit having a penetrating portion having a penetrating portion at the center and one unit having no penetrating portion having no penetrating portion.

In this case, the connecting member has a cylindrical insertion portion penetrating through the penetrating portion of the unit having the penetrating portion, and an outer diameter larger than an inner diameter of the penetrating portion of the unit having the penetrating portion provided continuously with the inserting portion. One having a pressing cylindrical projection is preferably used.

The insertion portion of the connecting member is inserted into the penetrating portion of the unit with the penetrating portion and is coupled to the unit without the penetrating portion on the distal end side, and the projecting portion of the connecting member connects the unit with the penetrating portion to the unit without the penetrating portion. By pressing inward, the inflow / outflow ports of the plurality of fluid circuit units are directly connected to each other.

[0015] The fluid treatment apparatus according to the present invention preferably comprises:
A pump unit is further provided, and the pump unit is arranged inside the connecting member. That is, this pump unit has an inflow / outflow port, and the inflow / outflow port is
It is structurally directly connected to the corresponding inlet and outlet of one fluid circuit unit for a fluid connection. And this pump unit supplies various fluids in a fixed amount.

The fluid treatment apparatus according to the present invention preferably comprises:
The apparatus further includes a sampling valve unit, and the sampling valve unit is attached to the fluid circuit unit. In other words, this sampling valve unit has an inflow / outflow port, and the inflow / outflow port is 1
It is structurally directly connected to the corresponding inlet and outlet of the two fluid circuit units for a fluid connection. Preferably, in the fluid treatment apparatus according to the present invention, the inner wall of the flow path of the fluid circuit unit is coated with a water-resistant substance such as a water-resistant solution. This coating makes it possible to impart water resistance to the inner wall of the flow path of the fluid circuit unit. Preferably, in the fluid processing apparatus according to the present invention, the fluid circuit unit is formed by a stereolithography method. By this stereolithography,
It becomes possible to manufacture a fluid circuit unit requiring a complicated circuit configuration as a precise three-dimensional structure having an arbitrary shape.

[0017]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described below in detail with reference to the drawings. Note that the present invention is not limited to this.

Apparatus Configuration A fluid system unit as a fluid processing apparatus according to one embodiment of the present invention is used in a blood cell counter, and as shown in FIG. 1, a sampling valve unit A, a first fluid It comprises a circuit unit B, a second fluid circuit unit C, a third fluid circuit unit D, and a syringe pump unit E. As shown in FIG. 2, the units AE are fluidly connected and directly connected structurally.

The sampling valve unit A has a function of collecting a fixed amount of the liquid sample sucked from the pipette 14, and has three elements 10 and a drive for rotating (rotating) these elements 10 by a certain angle. And part 18.

Each of the three fluid circuit units B, C, and D has a function of constituting a predetermined fluid circuit, and has three fluid circuit blocks 30, 50, and 50 formed with inflow and outflow ports as inflow and outflow ports. 70, and a valve as an opening / closing unit for opening / closing an internal flow path formed inside each of them.

The syringe pump unit E has a function of supplying a predetermined amount of liquid to the fluid circuit units B, C, D and the sampling valve unit A, and has a piston which is moved up and down by a drive source.

In the sampling valve unit A, three elements 10 each having a plurality of passages are housed in a housing in close contact with each other. As shown in FIG. 13, each of these elements 10 is composed of a fixed element 11, a movable element 12, and a fixed element 13, all of which have a disc shape. The movable element 12 is fixed with respect to the fixed elements 11 and 13 by the arm member 15 provided on a part of the periphery thereof being rotated by being engaged with a driving section 18 driven by a motor 22. Rotate by an angle.

The fixed element 13 has one suction pipette 1
4 and a plurality of nipples (not shown) functioning as fluid inflow / outflow ports. The housing in which the three elements 10 are housed is driven by a drive unit 18 by a set screw 19.
, A sampling valve unit A is configured. At this time, the suction pipette 14 and each nipple protrude toward the first fluid circuit unit B through the small holes 21 of the substrate of the drive unit 18. The sampling valve unit A is connected to the fluid circuit block 30 of the first fluid circuit unit B by a set screw 20.

As shown in FIGS. 3 to 5, the fluid circuit block 30 has a columnar convex portion 31 whose one end surface (upper surface) is flat and the other end surface (lower surface) protrudes downward. It is a resin-made disk-shaped block (unit without a penetrating portion). A cutout 34 having a V-shaped planar shape is provided in a part of the fluid circuit block 30. This notch 3
4, the suction pipette 14 of the sampling valve unit A is located.

The six nipples which are ports of the sampling valve unit A are connected via O-rings (not shown).
Six ports P13b, P14b, P15b, and P16b formed at the center of the upper surface of the first fluid circuit block 30
• Connected to P17b and P18b, respectively. These nipples and ports are connected such that one convex part fits into the other concave part.

A flow path 33 is formed inside the first fluid circuit block 30. At the center of the other end surface (lower surface) of the first fluid circuit block 30, a columnar convex portion 31 projecting downward is formed, and the end surface (lower surface) of the convex portion 31 has three ports P10a. P11a and P12a are provided. These ports P10a, P11a,
P12a includes three nipples P10b, P11b, and P12, which are ports of a syringe pump unit E described later.
b are connected via O-rings (not shown).

Eight rectangular concave portions 35 are provided on the lower surface of the first fluid circuit block 30 so as to surround the convex portions 31, and quadrangular prism-shaped solenoids SV are fitted into these concave portions 35 respectively. .

Rubber solenoids are respectively attached to the ends of the plungers of these solenoids SV. Each valve element is provided in a state of invading the inside of the fluid circuit block 30 from each recess 35. Eight valves V10, V11, V12, V13, V17, V18, and V for opening and closing the internal flow path 33 by moving the valve body up and down.
19 · V21.

On the lower surface of the first fluid circuit block 30, nine ports P1a, P2a, P3
a ・ P4a ・ P5a ・ P6a ・ P7a ・ P8a ・ P9a
Are distributed. These ports P1a to P9a
Are the nine ports P of the second fluid circuit unit C described later.
1b ・ P2b ・ P3b ・ P4b ・ P5b ・ P6b ・ P7
b, P8b, and P9b.

In order to form a complicated flow path 33 inside the first fluid circuit block 30, the fluid block 30 was manufactured by a stereolithography method. The optical shaping method is also called rapid prototyping, and irradiates a liquid surface of an ultraviolet-curable liquid resin with an ultraviolet laser beam to form a three-dimensional structure having an arbitrary shape.

As shown in FIGS. 6 to 8, the fluid circuit block 5 of the second fluid circuit unit C (unit with a penetrating portion)
No. 0 has a through portion 52 having a circular planar shape at the center.
On the upper surface of the fluid circuit block 50, the fluid circuit block 3
Ports P1b to P9b that are fitted to and fluidly connected to the P0a ports P1a to P9a are provided so as to protrude upward by a length of several cm.

By pressing the two fluid circuit blocks 30 and 50 toward each other, the corresponding ports P1a to P9
a · P1b to P9b are fluidly connected to each other, and both fluid blocks 30 and 50 (fluid circuit units B and
C) They are directly connected structurally.

The ports P1a to P9a and P1b to P
As for the connection and connection between 9b, as shown in FIG.
A tall stainless steel hexagonal column nipple 56 is fitted in the flow path of one fluid block 50 (30), the tip of the nipple 56 is made thin and stepped, and the tip of the nipple 56 is flowed into the other fluid block 30 (50). It may be realized by inserting it into the path 39.

On the lower surface side of the second fluid circuit block 50,
Eight square pole solenoids are attached so as to surround the through portion 52, and eight valves V for opening and closing the internal passage are provided.
1, V2, V7, V14, V15, V16, V20, V
22 are configured.

On the lower surface of the second fluid circuit block 50, ten ports P19, P20, P
21, P22, P23a, P24, P25a, P26a
P27 and P28 are distributed.

Of the ten ports, three of the ports P23a, P25a, and P26a are connected to ports P23b, P25b, and P26b of a third fluid circuit unit D described later, respectively.

The other seven ports P19, P20, P21
As shown in the fluid circuit in FIG. 16, P22, P24, P27, and P28 are connected to other fluid units and fluid components by tubes. That is, these ports P19 to P28 are connected to the hemolytic agent container 112 containing the hemolytic agent for white blood cells and hemoglobin, the white blood cell / hemoglobin (WBC / HGB) detecting unit 121, the stirring chamber Mix. C, red blood cell (RBC) detection unit 120,
It is connected to the diluting liquid container 113, the cleaning unit 114 for cleaning the suction pipette 14, and the sampling valve unit A.

As shown in FIGS. 6 to 8, a concave portion 53 is further provided on the lower surface of the second fluid circuit block 50, and a convex portion 73 at the tip of a leg 71 of a third fluid circuit block 70 described later is provided therein. Is fitted. The flow path is formed in a complicated manner inside the second fluid circuit block 50, and a flow path having a large inner diameter is formed as the bubble removal chamber 54.

As shown in FIGS. 9 to 11, the fluid circuit block 70 (unit with a penetrating portion) of the third fluid circuit unit D also has a penetrating portion 72 at the center. On the upper surface of the third fluid circuit block 70, the third fluid circuit block 50
Ports P23a, P25a, and P26a, and three ports P23 that are respectively fluidly connected thereto.
b, P25b and P26b are erected.

On the upper surface of the third fluid circuit block 70, a leg 71 having no flow path is provided upright in the same shape and size. This leg 71 is provided with two fluid circuit blocks 5
0.70 (fluid circuit units C and D) are additionally provided to further ensure the structural connection between them.

On the lower surface side of the third fluid circuit block 70,
Five square pole solenoids are attached so as to surround the penetrating portion 72, and five valves V3, V4, V5, V6, and V9 for opening and closing the internal passage are configured.

On the lower surface of the third fluid circuit block 70, seven ports P29 and P3
0, P31, P32, P33, P34, and P35 are distributed. These ports P29 to P35
As shown in the fluid circuit in FIG. 6, it is connected to other fluid system units and fluid components. That is, the port P29
P35 to red blood cell (RBC) detection unit 120, white blood cell / hemoglobin (WBC / HGB) detection unit 1
21. Peristaltic pump 110 connected to sampling valve unit A, valve V8, and waste liquid container 111
Connected to.

The syringe pump E has a motor, a rotary cylinder having a bottomed cylindrical shape and having a connection portion on the bottom lower surface capable of connection with a speed reducer, and a screw portion formed on an inner circumference portion; And a guide for guiding the movable member in the axial direction of the rotating cylinder by regulating the rotation of the movable member when the rotating cylinder rotates through the connecting portion. A pump of the type comprising means, a piston rod disposed on the mover, and a cylinder in which the piston rod moves.

Next, connection and connection of the fluid units A to E configured as described above will be described.

As shown in FIG. 1, first, the insertion portion 100a
Cylindrical connecting member 100 having
The two fluid circuit blocks 50 and 70 are inserted into the through portions 52 and 72. Here, the insertion portion 100a is a portion that penetrates the penetration portions 52 and 72 of the fluid circuit blocks 50 and 70, and the overhang portion 100b is provided so as to be continuous with the insertion portion, and the penetration portions 52 and 72 of the fluid circuit blocks 50 and 70. 72 is a portion having an outer diameter larger than the inner diameter. As shown in FIG. 2, on the inner surface of the distal end of the insertion portion 100a of the connecting member 100,
A female screw 101 screwed to a male screw 32 provided on the outer peripheral surface of the convex portion 31 of the first fluid circuit block 30 is provided, and the two 30 and 100 are connected by screwing.

Next, as shown in FIG.
The syringe pump unit E is inserted into the cylinder of the syringe pump unit E, and three nipples (ports) P10b, P11b, and P1 at the distal end of the syringe head 92 of the syringe pump unit E.
2b and three ports P10a of the first fluid circuit unit B
P11a and P12a are connected respectively.

A female screw 1 is provided on the inner surface of the proximal end of the connecting member 100.
03 is provided. A fixing member 104 provided with a male screw 105 screwed to the female screw 103 presses the syringe pump unit E from the drive source 90 side to the first fluid circuit unit B side, so that the first, second, and third fluids are provided. The circuit units B, C, D and the syringe pump unit E are fluidly connected and structurally connected and integrated.

Such a fluid system unit A, B, C, D
A fluid circuit as shown in FIG. 16 was constructed using E.
In FIG. 16, portions indicated by four types of oblique lines and one type of horizontal line are portions realized by the fluid system units A to E. Reference numeral 122 denotes a red blood cell detector having micropores.
Is a leukocyte detector having micropores, and 124 is a flow cell for measuring hemoglobin.

Sequence of Fluid Circuit The sequence of the fluid circuit in the fluid units A to E will be described below mainly with reference to FIG.

(1) First, the syringe pump E is driven (the sample suction piston 94 having a diameter of 4 mm is lowered), and the sample suction pipette 14 of the sampling valve unit A is moved.
Can be used to remove 50 microliters of blood as a sample (μ
l) Aspirate. This blood flows from the pipette 14 to the passage Q1 to Q7 to Q3 to the port P14a as shown in FIG. On the other hand, the discharge pump 110 is driven to discharge the liquid in the mixing chamber 130 and the liquid in the WBC / HGB detection unit 121 to the waste liquid container 111.

(2) Next, the syringe pump E is driven (the diluting liquid piston 93 having a diameter of 10 mm is raised) to supply the diluting liquid to the unit 121 as a cleaning liquid. This diluent is supplied to the port P15 as shown in FIGS.
a → passage Q4 → Q9 → unit 121. After that, the discharge pump 110 is driven to discharge the washed waste liquid to the waste liquid container 111.

(3) Next, the drive source 22 (shown in FIG. 1) of the sampling valve unit A acts on the movable operation section 15 of the movable element 12 so that the movable element 12 in the state of FIG. It is rotated in the rotation direction by a certain angle (until the state of FIG. 14 is reached). Then, the syringe pump E is driven (the piston 93 is raised) to transfer 2 μl of blood in the passage Q1 to the mixing chamber 130 with 998 μl of the diluent. That is, the diluent is supplied to the port P13a.
→ The passage Q1 → Q8 → flows to the mixing chamber 130. As a result, a sample diluted 500 times is produced.

(4) After that, the syringe pump E is driven (piston 93 is raised) to transfer 3 μl of blood in the passage Q3 to the unit 121 with 997 μl of the diluting liquid, and a hemolytic agent piston having a diameter of 8 mm. 95 is raised to supply 500 μl of the hemolytic agent to the unit 121. As a result, 500 times diluted WBC and HGB
A measurement sample is prepared.

As shown in FIG. 14, the diluent is supplied to the port P1
5a → passage Q3 → Q9 → unit 121 flows. In the meantime, the discharge pump 110 is driven to introduce a predetermined amount of the 500-fold diluted sample into the sampling valve unit A from the lower part of the mixing chamber 130. This 50
The 0-fold diluted sample is mixed in the mixing chamber 130 → passage Q11.
→ Q5 → Flow to port P17a.

(5) Thereafter, the drive source 22 of the sampling valve unit A acts on the movable operation section 15 of the movable element 12 to move the movable element 12 in the state of FIG. Reverse rotation (until state 15). On the other hand, by driving the discharge pump 110, the RB
The liquid in the C detection unit 120 is discharged to the waste liquid container 111.

(6) Further, by driving the discharge pump 110, the liquid in the mixing chamber 130 is discharged into the waste liquid container 111.
Discharge to Further, the syringe pump E is driven (the piston 93 is raised), and 30 μl of the 500-fold diluted sample in the passage Q5 is diluted with 1470 μl of the diluting liquid into the unit 120.
Transfer to Diluent is port P16a → passage Q5 → Q7
→ It flows to the unit 120. As a result, a sample for RBC measurement diluted 25,000 times is produced.

(7) Next, the syringe pump E is driven (the piston 93 is raised) and the discharge pump 110
By driving the diluent into the washing tank 114,
The outer surface of the pipette 14 is cleaned.

(8) Thereafter, the syringe pump E is driven (the piston 93 is raised) to supply the diluting liquid to the mixing chamber 130 as a cleaning liquid. This diluent is supplied from the port P13a → the passage Q2 → Q8 → the mixing chamber 130.
Flows to

(9) Further, the inner surface of the pipette 14 is cleaned by driving the syringe pump E (elevating the piston 93) and supplying the diluting liquid to the pipette 14 as a cleaning liquid. Diluent is port P14a → passage Q3 → Q7 →
It flows from Q1 to pipette 14.

(10) Thereafter, the discharge pump 110 is driven to remove the liquid in the mixing chamber 130 from the waste liquid container 11.
Discharge to 1.

(11) Next, the syringe pump E is driven (the piston 93 is moved down), the measurement sample is sucked from the detector 123 of the unit 121 through the valve V2, and the number of white blood cells is counted. On the other hand, the syringe pump E is driven (the piston 94 is lowered) to aspirate the measurement sample from the detector 122 of the unit 120 via the valve V1, and count the number of red blood cells or the number of red blood cells and platelets.
In the flow cell 124, the hemoglobin concentration is measured.

(12) Thereafter, the discharge pump 110 is driven to discharge the liquid in the unit 121 and the liquid in the unit 120 to the waste liquid container 111.

(13) Further, the syringe pump E is driven (the piston 93 is moved up), and the valves V10 and V11
, The diluent is supplied to the units 121 and 120 as a cleaning liquid.

[0064]

According to the first aspect of the present invention, there is provided a liquid processing apparatus including a plurality of fluid processing units having a flow path and an inflow / outflow port connected thereto and having a predetermined fluid processing function, and A connecting member for connecting the units, a plurality of fluid treatment units, a main body having a flow path formed in a predetermined pattern, and an opening / closing section for opening and closing the flow path of the main body. The corresponding inlet and outlet are structurally directly connected for fluid connection by the connecting member. Therefore, since a plurality of connection tubes as in the related art are not required, space can be saved, the risk of connection error can be prevented, and the cost can be reduced.

According to a second aspect of the present invention, in the liquid processing apparatus, the fluid circuit unit includes at least one unit having a penetrating portion having a penetrating portion at a central portion and one unit having no penetrating portion having no penetrating portion. And the connecting member is
A cylindrical insertion portion that penetrates the penetration portion of the unit with the penetration portion,
A pressurized tubular projection having an outer diameter larger than the inner diameter of the penetrating part of the unit with the penetrating part, the insertion part of the connecting member having the penetrating part of the unit with the penetrating part. Into the unit without penetrating part at the distal end side, and the projecting part of the connecting member presses the unit with penetrating part toward the unit without penetrating part, so that the inflow / outflow of a plurality of fluid circuit units The two are connected. Therefore, by a simple configuration and a simple operation of connecting the unit with the penetrating part and the unit without the penetrating part by the cylindrical insertion part and the cylindrical protrusion of the connecting member, the inflow / outflow of a plurality of fluid circuit units is achieved. The two can be connected directly structurally for a fluid connection.

The liquid processing apparatus according to the third aspect of the present invention has an inflow / outflow port, and the inflow / outflow port is structurally connected to the corresponding inflow / outflow port of one fluid circuit unit for fluid connection. The apparatus further includes a pump unit directly connected to supply a constant amount of the fluid, and the pump unit is disposed inside the connecting member. Therefore, this pump unit can save space and supply various fluids in a constant amount.

A liquid processing apparatus according to a fourth aspect of the present invention has an inflow / outflow port, and the inflow / outflow port is structurally connected for fluid connection to a corresponding inflow / outflow port of one fluid circuit unit. The apparatus further includes a sampling valve unit that is directly connected to sample a fixed amount of the sample, and the sampling valve unit is attached to the fluid circuit unit. Therefore, with the sampling valve unit, the effect of the liquid processing apparatus according to the third aspect of the invention can be more reliably assured.

The flow path of the fluid circuit unit of the liquid processing apparatus according to the present invention has an inner wall coated with a water-resistant substance. Therefore, the coating makes it possible to impart water resistance to the inner wall of the flow path of the fluid circuit unit.

In the liquid processing apparatus according to the present invention, the fluid circuit unit is formed by a stereolithography method. Therefore, it is possible to manufacture a fluid circuit unit requiring a complicated circuit configuration as a precise three-dimensional structure having an arbitrary shape.

[Brief description of the drawings]

FIG. 1 is an exploded perspective view of a fluid system unit according to one embodiment of the present invention.

FIG. 2 is a longitudinal sectional view of the fluid system unit of FIG.

FIG. 3 is a top view of a first fluid circuit unit constituting the fluid system unit of FIG. 1;

FIG. 4 is a bottom view of the first fluid circuit unit of FIG. 3;

FIG. 5 is a cross-sectional view of the first fluid circuit unit of FIG. 3 taken along line XX.

FIG. 6 is a top view of a second fluid circuit unit constituting the fluid system unit of FIG. 1;

FIG. 7 is a bottom view of the second fluid circuit unit of FIG. 6;

8 is a cross-sectional view of the second fluid circuit unit of FIG. 6, taken along line YY.

FIG. 9 is a top view of a third fluid circuit unit constituting the fluid system unit of FIG. 1;

FIG. 10 is a bottom view of the third fluid circuit unit of FIG. 9;

11 is a cross-sectional view of the third fluid circuit unit of FIG. 9 taken along the line ZZ.

FIG. 12 is a longitudinal sectional view showing another example of the connection between the first fluid circuit unit and the second fluid circuit unit constituting the fluid system unit of FIG. 1;

FIG. 13 is an exploded perspective view showing a case where three elements which are a part of a sampling valve unit constituting the fluid system unit of FIG. 1 are at a sample suction position.

FIG. 14 is an exploded perspective view showing a case where the three elements of FIG. 13 are at a sample first-stage dilution position.

FIG. 15 is an exploded perspective view showing a case where the three elements of FIG. 14 are at a sample second dilution position.

16 is a configuration explanatory view showing a fluid circuit in which the fluid system unit of FIG. 1 is incorporated.

[Explanation of symbols]

 Reference Signs List A sampling valve unit B first fluid system unit C second fluid system unit D third fluid system unit E syringe pump unit 10 three elements 11 fixed element 12 movable element 13 fixed element P1a port (inflow / outflow port) P2a port ( Inflow / outflow port P3a port (inflow / outflow port) P4a port (inflow / outflow port) P5a port (inflow / outflow port) P6a port (inflow / outflow port) P7a port (inflow / outflow port) P8a port (inflow / outflow port) Outflow port P9a port (inflow / outflow port) P1b port (inflow / outflow port) P2b port (inflow / outflow port) P3b port (inflow / outflow port) P4b port (inflow / outflow port) P5b port (inflow / outflow port) P6b port (inflow / outflow) P7b port (inflow / outflow) P8b port (inflow / outflow) Port) P9b port (inlet / outlet) P10a port (inlet / outlet) P11a port (inlet / outlet) P12a port (inlet / outlet) P13b port (inlet / outlet) P14b port (inlet / outlet) P15b port (inlet / outlet) P16b port (inlet / outlet) P17b port (inlet / outlet) P18b port (inlet / outlet) P19 port (inlet / outlet) P20 port (inlet / outlet) P21 port (Inflow / outlet) P22 port (inflow / outflow) P23a port (inflow / outflow) P23b port (inflow / outflow) P24 port (inflow / outflow) P25a port (inflow / outflow) P25b port (inflow)・ Outflow port P26a port (inflow / outflow port) P26b port (inflow / outflow port) P27 port ( Inflow / outflow port P28 Port (inflow / outflow port) 30 First fluid circuit block (unit without penetrating portion) 31 Convex portion 33 Channel 50 Second fluid circuit block (unit with penetrating portion) 52 Penetrating portion 70 Third fluid Circuit block (unit with penetrating part) 72 Penetrating part 100 Connecting member 100a Insertion part 100b Overhang part

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Kaoru Asano 1-5-1, Wakihama Kaigandori, Chuo-ku, Kobe F-term within Sysmex Corporation (reference) 2G058 BA01 EA03 EA14 EB01 EC05 FA08 FB05 FB09 FB12

Claims (6)

[Claims] A fluid processing unit having a flow path and an inflow / outflow port connected thereto and having a predetermined fluid processing function; and a connecting member for connecting the fluid processing units to each other. The plurality of fluid treatment units include a main body having a flow path formed in a predetermined pattern, and a fluid circuit unit having an opening / closing section for opening and closing the flow path of the main body,
Corresponding inflow and outflow, by the connecting member,
A fluid treatment device that is structurally directly connected for fluid connection. 2. The fluid circuit unit includes at least one unit with a penetrating portion having a penetrating portion at a central portion and one unit without a penetrating portion having no penetrating portion, and the connecting member is a unit of the unit with a penetrating portion. It has a cylindrical insertion portion penetrating the penetration portion, and a pressing cylindrical projection portion provided outside of the penetration portion of the unit with the penetration portion and provided with the outside diameter larger than the inside diameter of the penetration portion of the unit with the penetration portion. The insertion part of the member is inserted into the penetrating part of the unit with the penetrating part and is coupled to the unit without the penetrating part at the distal end side, and the projecting part of the connecting member presses the unit with the penetrating part toward the unit without the penetrating part. The fluid processing apparatus according to claim 1, wherein the inflow / outflow ports of the plurality of fluid circuit units are connected to each other. 3. An inflow / outflow port having an inflow / outflow port that is structurally directly connected to a corresponding inflow / outflow port of one fluid circuit unit for fluid connection to supply a fixed amount of fluid. The fluid processing apparatus according to claim 2, further comprising a pump unit, wherein the pump unit is disposed inside the connecting member. 4. An apparatus according to claim 1, further comprising an inflow / outflow port, wherein said inflow / outflow port is structurally directly connected to a corresponding inflow / outflow port of one fluid circuit unit for fluid connection, thereby obtaining a fixed amount of a sample. The fluid processing apparatus according to claim 3, further comprising a sampling valve unit, wherein the sampling valve unit is attached to the fluid circuit unit. 5. The fluid processing apparatus according to claim 1, wherein an inner wall of the flow path of the fluid circuit unit is coated with a water-resistant substance. 6. The fluid processing apparatus according to claim 1, wherein the fluid circuit unit is formed by a stereolithography method.