JP2000235010A - Nuclear magnetic resonance device and liquid constituent inspection device using the device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an NMR device capable of limiting a temperature change in a constant- temperature chamber so that a change in a magnetic field can be kept at a minimum value of about 10-4% or less and provide a device for inspecting food with high accuracy and with high efficiency by automating the inspection of food using an NMR in a food inspecting system utilizing the NMR. SOLUTION: In this nuclear magnetic resonance device (NMR device), heat exchangers 59, 60, 61 are disposed close to permanent magnets 56 in a constant-temperature chamber in which the permanent magnets 56 and an electromagnetic coil 51 are disposed while a constant-temperature liquid producing device 62 is provided for producing a constant- temperature liquid controlled to a constant temperature, and the constant-temperature liquid producing device 62 is connected to the heat exchangers 59, 60, 61 by piping to circulate the constant-temperature liquid between the two, thereby keeping the interior of the constant- temperature chamber at a constant temperature. In a food inspecting device for measuring constituents of a sample liquid by the NMR device 100, a signal detected by magnetic resonance and sent from the NMR device 100 is converted into a frequency spectrum, a peak frequency thereof is detected, a current correcting value that makes the peak frequency equal to a reference frequency is found, and a correcting magnetic field is set up by the current correcting value for correcting the magnetic-field intensity of the magnets, thereby limiting a change in the magnetic-field intensity.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nuclear magnetic resonance apparatus for generating a nuclear magnetic resonance phenomenon and a liquid component inspection apparatus for measuring a liquid component using the nuclear magnetic resonance apparatus.

[0002]

2. Description of the Related Art A nuclear magnetic resonance apparatus (hereinafter referred to as an NMR apparatus) generates a nuclear magnetic resonance phenomenon by applying an electromagnetic wave to a static magnetic field generated by a permanent magnet installed in a thermostat by an electromagnetic coil. .

FIG. 4 is a configuration diagram showing one example of such a conventional NMR apparatus. In FIG. 4, reference numeral 8 denotes a constant temperature chamber having a constant temperature chamber 8a which is isolated from the outside by a heat insulating wall 7.
1, 1 are permanent magnets installed facing each other in the constant temperature chamber 8a. An electromagnetic coil 3 for generating magnetic resonance in a central portion between the permanent magnets 1, 1 and receiving the resonance signal. And a detection tube 2 for containing a liquid as a substance to be measured.

A shim coil 4 is provided between the permanent magnets 1 and 1 and the coil 3 to make the magnetic distribution uniform within the measurement range. 5 is a signal generator for transmitting an electromagnetic wave signal to the coil 3, and 6 is a signal processing unit for processing a measurement signal. Reference numeral 9 denotes an air conditioner, and the inside of the constant temperature chamber 8a is maintained at a predetermined constant temperature by the air conditioner 9.

In such an NMR apparatus, the inside of the constant temperature chamber 8a is maintained at a constant temperature by an air conditioner 9, and a static magnetic field is formed by the permanent magnets 1 and 1 in the room at the constant temperature. Then, the frequency f ₀ = δ (B ₀ / 2π) determined by the magnitude B _{0 of the} static magnetic field provided by the permanent magnets 1, 1 is applied to the substance to be measured placed in the static magnetic field.
An electromagnetic wave (where δ is the magnetic rotation ratio) is applied by the electromagnetic coil 3 via the signal generator 5 to generate a nuclear magnetic resonance phenomenon (hereinafter referred to as NMR).

Since the static magnetic field generated by the permanent magnets 1 and 1 changes with temperature (the magnetic field changes by 0.1 to 0.01% due to a temperature change of 1 ° C.), the air conditioner is used during the NMR measurement. 9, the inside of the constant temperature chamber 8a is maintained at a constant temperature, and the stability of the signal obtained by the NMR is maintained.

As a technique for maintaining the temperature in the constant temperature chamber 8a in which the permanent magnets are installed at a constant temperature, Japanese Utility Model Application Laid-Open Publication No.
No. 386 is provided. In this method, the thermostat is formed in a double-walled structure with double heat-insulating walls, and two chambers are individually controlled in temperature. An NMR device such as a permanent magnet is installed in the inner thermostat. By doing so, the inside and outside of the thermostat are completely thermally insulated.

On the other hand, a technique for applying the NMR to a beverage component inspection system in a food production plant has recently been proposed. In such a food inspection system by NMR, conventionally, a sample is injected from outside the inspection device,
After measuring the components of the sample, the sample is allowed to flow out of the device,
Next, a procedure of causing a new sample to flow into the measuring device is manually performed by an operator.

[0009]

As described above, in the NMR apparatus, in order to prevent a change in the magnetic field of the permanent magnet,
It is necessary to make the temperature change inside the thermostat as small as possible. As described above, the magnetic field of the magnet changes by 0.1 to 0.01% with respect to a temperature change of 1 ° C.
It is necessary to improve to a minimum value of about ^0-4 %.

[0010] However, in an apparatus such as that shown in Fig. 4 in which the temperature inside the constant temperature chamber 8a is maintained at a predetermined temperature by the air conditioner 9, it is impossible to suppress such a minimal change in the magnetic field.

In the technique proposed in Japanese Utility Model Application Laid-Open No. 3-33386, the temperature change can be made smaller than that of the apparatus shown in FIG. Since the temperature in the room is only controlled by the heater, it is impossible to suppress the temperature change to the minimum value as described above even with this technique.

On the other hand, when the NMR is applied to the measurement of the components of a liquid beverage in a food inspection system, conventionally, the measurement of the sample components, the injection of the sample, and the outflow are semi-manually performed by an operator as described above. Therefore, inspection accuracy is low and work efficiency is low.

The present invention has been made in view of the above-mentioned problems of the prior art, and has as its first object to provide an NMR apparatus capable of suppressing a temperature change in a thermostatic chamber so that a change in a magnetic field can be maintained at a minimum value of about 10 ⁻⁴ % or less. The purpose of.

Further, a second object of the present invention is to provide a food inspection system utilizing NMR, which can automatically and automatically perform food inspection by NMR, thereby achieving high precision and high efficiency of food inspection. To provide an apparatus for performing the above.

[0015]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention is directed to an electro-optical device comprising: a magnetic field generated by a permanent magnet provided in a thermostatic chamber formed in a thermostat; A nuclear magnetic resonance apparatus that generates a nuclear magnetic resonance phenomenon by applying an electromagnetic wave by a coil, wherein a heat exchanger is installed in the constant temperature chamber by approaching or contacting at least the permanent magnet, and controlled at a constant temperature. A constant temperature liquid generator for generating a constant temperature liquid, wherein the constant temperature liquid generator and the heat exchanger are connected by piping so that the constant temperature liquid is circulated therebetween. A resonator is proposed.

According to a second aspect of the present invention, in addition to the first aspect, the inside of the constant temperature bath is provided with a nuclear magnetic resonance phenomenon generating portion such as the permanent magnet and the electromagnetic coil by the double outer and inner heat insulating walls. And a thermostatic chamber in which a heat exchanger is accommodated, and an external thermostatic chamber formed by separating the thermostatic chamber and the heat insulating wall, and heat connected to the thermostatic liquid generating device by a pipe to the external thermostatic chamber. An exchange is provided.

Preferably, nitrogen gas is sealed in the constant temperature chamber in addition to the invention described in claim 1 or 2.

According to the invention, the liquid controlled to a predetermined temperature by the constant temperature liquid generator is sent to the heat exchanger provided near or in contact with the permanent magnet in the constant temperature chamber, and supplies heat to the permanent magnet. Or from a permanent magnet. Thereby, the permanent magnet is maintained at the same predetermined temperature as the liquid temperature, and the temperature in the constant temperature chamber is also maintained at the predetermined temperature.

According to the second aspect of the present invention, the constant temperature chamber further surrounds the outside of the constant temperature chamber with another heat insulating wall,
Because it is configured to be surrounded by double heat insulating walls, even if the temperature outside the thermostatic chamber changes, the permanent magnets and the like in the thermostatic chamber are kept at the controlled temperature without being substantially affected by the temperature change. Is done.

Further, since a heat exchanger connected to the constant temperature liquid generator is installed in the outside constant temperature chamber formed between the double heat insulating walls, the outside constant temperature chamber is controlled as described above. Kept at temperature. As described above, according to the invention, a change in the magnetic field due to a temperature change in the thermostatic chamber where the nuclear magnetic resonance signal is measured can be suppressed to a minimum value, and a stable magnetic resonance signal can be obtained.

According to a fourth aspect of the present invention, there is provided a liquid component inspection apparatus for inspecting a liquid beverage using the nuclear magnetic resonance apparatus. The components of the sample solution are detected by a nuclear magnetic resonance generator (NMR device) that puts the sample solution into a magnetic field formed between a pair of magnets surrounded by an adiabatic tank and generates a nuclear magnetic resonance phenomenon. Liquid component testing device,
A conversion unit for converting a detection signal of the sample solution by nuclear magnetic resonance from the NMR apparatus into a frequency spectrum, and detecting a peak frequency of the frequency spectrum so that the peak frequency becomes the same as a preset reference frequency. Arithmetic processing means for obtaining a large current correction value; and
And a correction coil for generating a correction magnetic field for correcting the magnetic field strength of the magnet with the current correction value.

According to a fifth aspect of the present invention, in addition to the fourth aspect of the present invention, a sample liquid temperature controller for controlling the temperature of the sample liquid to a predetermined temperature is provided in a supply path of the sample liquid to the NMR apparatus. And a circulating fluid pipe through which a circulating fluid for supplying heat to the magnet or removing heat from the magnet flows between the magnet and the heat insulating wall in the NMR apparatus. And a circulating fluid temperature controller for controlling the temperature of the circulating fluid to a predetermined temperature. According to a sixth aspect of the present invention, in the fourth or fifth aspect, the liquid component is a component of a beverage liquid flowing in a beverage liquid supply pipe in the liquid beverage manufacturing apparatus.

According to this invention, the sample liquid to be measured is adjusted to a predetermined set temperature by the sample liquid temperature controller and the NM
R is sent to the R
The magnet temperature change in the MR device can be suppressed to a minimum value. In addition, the inside of the NMR apparatus in which the magnet is housed is surrounded by a heat insulating wall, and the circulating fluid controlled to a predetermined constant temperature by the circulating fluid temperature controller circulates around the magnet, so that the outside air temperature changes. The effect on the magnet temperature due to is minimized.

When a change in the magnetic field intensity is caused by a change in the magnet temperature due to the injection of the sample solution, the detection signal of the sample solution component incorporating the change in the magnetic field intensity is converted into a frequency spectrum by frequency conversion means. And
The peak frequency of the frequency spectrum is calculated by the arithmetic processing means, and the peak frequency is matched with a preset reference frequency to obtain a current correction value such that the peak frequency becomes the reference frequency. The current correction value is applied to a correction coil, and the correction coil generates a magnetic field corresponding to the current correction value to correct a change in magnetic field intensity due to a temperature change of the magnet.

Therefore, according to the invention, the temperature of the sample liquid is maintained at a predetermined set temperature by the sample liquid temperature control device, and the magnet temperature is not affected by the outside air temperature by the heat insulating wall and the circulating water temperature control device. By maintaining the set temperature, a change in the magnetic field strength due to a change in the temperature of the sample liquid and a change in the outside air temperature can be suppressed to a minimum value.

Further, a change in magnetic field strength caused by a small temperature change due to injection of a sample solution, etc.
Converting the measurement signal into a frequency spectrum, obtaining a current correction value such that the peak frequency obtained by the conversion is adjusted to the reference frequency, applying the current correction value to the auxiliary coil, and suppressing a change in the magnetic field intensity by a correction magnetic field generated from the auxiliary coil. it can.
This makes it possible to continuously obtain a stable NMR measurement signal of the liquid sample.

[0027]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will now be described in detail with reference to the drawings. However, the dimensions, materials, shapes, relative arrangements, and the like of the components described in this embodiment are not intended to limit the scope of the present invention unless otherwise specified, and are merely illustrative examples. Only.

FIG. 1 is a configuration diagram of a nuclear magnetic resonance apparatus 100 (hereinafter referred to as an NMR apparatus) according to a first embodiment of the present invention. In FIG. 1, reference numeral 70 denotes a constant temperature bath, which is constituted by a double heat insulating wall of an outer heat insulating wall 57 and an inner heat insulating wall 58. An outer constant temperature chamber 65 is formed between the inner surface of the outer heat insulating wall 57 and the outer surface of the inner heat insulating wall 58, and an inner constant temperature chamber 66 is formed inside the inner heat insulating wall 58. The inner constant temperature chamber 66 and the outer constant temperature chamber 65 are filled with nitrogen (N ₂ ) gas.

Two permanent magnets 5 are provided in the inner constant temperature chamber 66.
At the center between the permanent magnets 56, a detection tube 50 for containing a liquid to be measured and an electromagnetic coil 51 around the detection tube 50 are provided. ing. The electromagnetic coil 51 generates an electromagnetic wave for causing a nuclear magnetic resonance phenomenon (hereinafter referred to as NMR) and receives the electromagnetic wave after resonance.

Numerals 55, 55 are shim coils provided between the electromagnetic coil 51 and the detection tube 50 and the pair of permanent magnets 56, 56 to correct and uniform the magnetic distribution within the measurement range. Reference numeral 52 denotes a transmitter for transmitting an electromagnetic wave and transmitting the electromagnetic wave to the electromagnetic coil 51. Reference numeral 53 denotes a distributor, and reference numeral 54 denotes a signal processor. Nuclear magnetic resonance signals received by the coil 51 are sent to the signal processor 54 via the distributor 53.

Heat exchangers 59, 60 are attached to the back surfaces of the pair of permanent magnets 56, 56 in close contact with each other. Further, a heat exchanger 61 is also mounted in the outer constant temperature chamber 65 surrounded by the inner and outer heat insulating walls 58 and 57. In the heat exchangers 59 and 60, a liquid of a constant temperature generated by a constant temperature water generator 62 to be described later flows, and the heat exchangers 59 and 60 maintain the permanent magnets 56 and 56 at a constant temperature by the liquid. The temperature in 66 is also maintained at a constant temperature. Further, the heat exchanger 61 maintains the inside of the outer thermostat 65 at a constant temperature by the liquid.

A constant-temperature water generator 62 generates a liquid controlled at a constant temperature.
2 is connected to the three heat exchangers 59, 60 and 61 by liquid pipes 63a and 63b.
The constant-temperature water generated in the above is connected to the liquid pipes 63a and 63b.
Through the heat exchangers 59, 60, 61. As the liquid, water, ethylene glycol and the like are preferable.

In the NMR apparatus 100 having such a configuration, the constant temperature water generator 62 generates a liquid controlled to a predetermined temperature. This liquid is a liquid pipe 63
a through the heat exchangers 59 and 60, the permanent magnets 56, 56 are cooled or heated in the heat exchangers 59 and 60 so as to be maintained at a predetermined temperature controlled by the constant temperature water generator 62. The predetermined temperature is maintained by supplying or removing heat from inside the constant temperature chamber 66.

Further, the liquid is guided to the heat exchanger 61 and supplies or removes heat to the outside constant temperature chamber 65, thereby keeping the inside of the chamber at the predetermined temperature. And
The liquid that has exited the heat exchanger 61 is returned to the constant temperature water generator 62 via a liquid pipe 63b, adjusted to the constant temperature, and sent to the heat exchangers 59, 60, 61 again.

As described above, since the liquid controlled at a predetermined constant temperature by the constant temperature water generator 62 is circulated through the three heat exchangers, the temperatures of the permanent magnets 56 and 56 and other NMR devices are installed. In addition, the temperature of the inner constant temperature chamber 66 can be maintained at the controlled constant temperature, and the temperature of the outer constant temperature chamber 65 can also be maintained at the constant temperature.

Further, since the thermostat 70 is constituted by double inner and outer heat insulating walls 58 and 57, even if the temperature around the thermostat 70 changes, the permanent magnets 56 and 56, the electromagnetic coil The inside of the constant temperature chamber 66 in which the chamber 51 and the like are housed is maintained at a constant temperature controlled as described above, with almost no influence of the temperature change.

As described above, according to this embodiment, N
The temperature change in the constant temperature chamber 66 where the MR is generated can be maintained so that the change in the magnetic field is not more than a minimum value of about 10 ^-4 %, and a stable nuclear magnetic resonance signal can be obtained.

FIGS. 2 and 3 show a second embodiment of the present invention. FIG. 2 is a configuration diagram of a beverage liquid component inspection device, and FIG. 3 is a diagram showing a Fourier transform spectrum. This embodiment is a beverage liquid component inspection apparatus in which the nuclear magnetic resonance apparatus (NMR apparatus) 100 as shown in the first embodiment is applied to a liquid beverage inspection apparatus in a food production plant (beverage production plant).

FIG. 2 shows a main part of the nuclear magnetic resonance apparatus (NMR apparatus) 100 in a cross section including the axis of the detection tube 50. Reference numeral 1 denotes a main pipe of a beverage manufacturing plant, in which a product liquid of a beverage to be inspected, that is, a sample liquid for NMR measurement flows continuously or as needed. Reference numeral 2 denotes a bypass pipe branched from the main pipe 1, and reference numeral 3 denotes a sample pipe. The sample liquid in the main pipe 1 is divided. 9c is a liquid valve for opening and closing the inlet of the bypass tube 2, 9b is a liquid valve for opening and closing the outlet of the sample tube 3, and 9a is a sample liquid temperature controller 4 for the sample tube 3 which will be described later.
This is a liquid valve that opens and closes the downstream part. Reference numeral 4 denotes a sample liquid temperature control device provided at the connection between the bypass pipe 2 and the sample pipe 3 for controlling the temperature of the sample liquid to a predetermined temperature (Ts).

Numeral 100 denotes a nuclear magnetic resonance apparatus (NMR apparatus). The bypass pipe 2 and the sample pipe 3 are branched from the main pipe 1 to supply a sample liquid for inspection to the detection pipe 50, and then to the main pipe 1. It merges into one.

12 is an amplifier connected to the signal detector 10, 13 is a Fourier transform calculator, 14 is an arithmetic processor,
Reference numeral 15 denotes a DC power supply driver, and 16 denotes a DC power supply. An output terminal of the DC power supply 16 is connected to the correction coil 8.

In the beverage component inspection apparatus having such a configuration, the liquid valve 9c is opened at a certain timing, and the product liquid flowing in the main pipe 1, that is, the sample liquid for NMR measurement is caused to flow into the sample liquid temperature controller 4. After that, the liquid valve 9c
Close. Then, the temperature of the sample liquid flowing in is adjusted by the sample liquid temperature controller 4 to a predetermined set temperature Ts. Next, the liquid valves 9a and 9b are opened, the sample tube 3 is passed through, and N
After flowing into the MR device 100, the liquid valves 9a and 9b are closed.

On the other hand, the magnet 56 of the NMR apparatus 100
Is surrounded by a circulating water pipe 6 through which circulating water adjusted to the same temperature as the set temperature Ts of the sample liquid by the circulating water temperature controller 11 flows. Thus, the magnet 56 housed in the heat insulating wall 58 is maintained at the set temperature Ts without being affected by the outside air temperature.

However, by injecting the sample solution,
A slight temperature change occurs in the magnet 56, which causes
6 often cause a change in the magnetic field strength. However, in the present embodiment, a change in the NMR measurement signal due to the magnetic field temperature change is suppressed by the following means, and a stable NMR measurement signal is obtained.

That is, the detection signal obtained by detecting the components of the sample liquid introduced into the NMR apparatus 100 by the signal detecting section 10 by the NMR phenomenon is amplified by the amplifier 12 and then input to the Fourier transform calculator 13. . The Fourier transform calculator 13 converts the detection signal of the sample liquid component into a frequency spectrum. This frequency is the chemical shift,
That is, it corresponds to the static magnetic field strength received by the magnet 56 by the sample liquid.

FIG. 3 is a frequency spectrum showing the relationship between the strength and voltage of the magnetic field Fourier-transformed by the Fourier-transform calculator 13. This frequency spectrum is input to the arithmetic processing unit 14, in the calculation processor 14, the maximum peak frequency f _0n processes the frequency spectrum shown in FIG. 3, butt and a reference value f ₀₀ of predetermined frequency Then, a correction voltage value and a current value are determined so that the maximum peak frequency f _0n becomes the reference frequency f ₀₀ , and these are input to the DC power supply driver 15.

The DC power supply driver 15 operates the DC power supply 16 based on the current correction value to provide the correction coil 8 with the current correction amount. Thereby, the correction coil 8 generates a magnetic field corresponding to the current correction value, and
The magnetic field intensity change due to the temperature change of 6 is corrected.

As described above, the current correction amount corresponding to the change in the magnetic field strength of the magnet 56 due to the temperature change of the magnet 56 accompanying the injection of the sample solution is obtained, and the correction coil 8 generates the correction magnetic field. A stable NMR measurement signal can be obtained by suppressing a change in magnetic field intensity due to the sample liquid injection.

As described above, according to this embodiment,
The outer wall of the NMR apparatus 100 is constituted by double heat insulating walls 57 and 58, and circulating water adjusted to a predetermined set temperature Ts by the circulating water temperature controller 11 is caused to flow around the magnet 56 so that magnets due to a change in outside air temperature are generated. Minimize the effect of 56 on temperature.

On the other hand, before the sample solution flows into the NMR apparatus 100, the sample solution temperature controller 4 adjusts the temperature of the magnet 56 to the set temperature Ts, which is the same as the temperature of the magnet 56. Minimize the effect on temperature.

Further, a change in magnetic field intensity caused by a small change in magnet temperature due to the injection of the sample solution or the like is measured by NMR measurement (detection) from the signal detection unit 10.
On a frequency spectrum obtained by Fourier transforming the signal in the arithmetic unit 13, the maximum peak frequency f is calculated in the arithmetic processing unit 14.
And _0n, against a reference frequency f ₀₀ which is set in advance, the f _0n seeks current correction value such that f _00. Then, the current correction value is given to the magnetic field correction coil 8 via the DC power supply driver 15 and the DC power supply 16,
By correcting the magnetic field strength corresponding to the magnetic field strength change, the above-described change in the magnetic field strength is suppressed. As described above, a stable NMR measurement signal can be continuously obtained.

[0052]

As described above, according to the first to third aspects of the present invention, a heat exchanger is provided near a permanent magnet in a constant temperature chamber, and an outer constant temperature chamber surrounded by a double heat insulating wall. The liquid controlled at a predetermined temperature is circulated in the constant-temperature liquid generator, and the constant-temperature bath is surrounded by double insulating walls. Can be maintained at a constant temperature.
As a result, a change in the magnetic field due to a temperature change can be suppressed to a minimum value, and a stable magnetic resonance signal can be obtained.

According to the invention of claims 4 to 6,
The temperature of the sample liquid is maintained at a predetermined set temperature by the sample liquid temperature control device, and the magnet temperature is maintained at the set temperature without being affected by the outside air temperature by the heat insulating wall and the circulating water temperature control device. A change in magnetic field strength due to a temperature change and a change in outside air temperature can be suppressed to a minimum value.

Further, the change in the magnetic field strength caused by a small temperature change due to injection of a sample solution or the like is determined by NMR.
Converting the measurement signal into a frequency spectrum, obtaining a current correction value such that the peak frequency obtained by the conversion is adjusted to the reference frequency, applying the current correction value to the auxiliary coil, and suppressing a change in the magnetic field intensity by a correction magnetic field generated from the auxiliary coil. it can.
Thereby, a stable measurement signal of the liquid beverage can be obtained automatically and continuously, and highly accurate measurement can be performed with high work efficiency.

[Brief description of the drawings]

FIG. 1 is a configuration diagram of a nuclear magnetic resonance apparatus according to a first embodiment of the present invention.

FIG. 2 is a configuration diagram of a liquid beverage component inspection apparatus including a nuclear magnetic resonance apparatus according to a second embodiment of the present invention.

FIG. 3 is a diagram showing a frequency spectrum in the second embodiment.

FIG. 4 is a configuration diagram of a nuclear magnetic resonance apparatus according to a conventional technique.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Main piping 2 Bypass pipe 3 Sample pipe 4 Sample liquid temperature controller 6 Circulating water pipe 8 Correction coil 9a, 9b, 9c Liquid valve 10 Signal detector 11 Circulating water temperature controller 12 Amplifier 13 Fourier transform arithmetic unit 14 Arithmetic processor 15 DC Power supply driver 16 DC power supply 50 Detection tube 51 Electromagnetic coil 52 Transmitter 53 Distributor 54 Signal processing unit 55 Shim coil 56 Permanent magnet 57 Outer heat insulating wall 58 Inner heat insulating wall 59, 60, 61 Heat exchanger 62 Constant temperature water generator 63a, 63b Liquid piping 65 Outer thermostat 66 Inner thermostat 70 Thermostat 100 NMR equipment

Claims (6)

[Claims] 1. A nuclear magnetic resonance apparatus which generates a nuclear magnetic resonance phenomenon by applying an electromagnetic wave by an electromagnetic coil to a static magnetic field by a permanent magnet installed in a constant temperature chamber formed in a constant temperature chamber, In addition, at least a heat exchanger is installed by approaching or contacting the permanent magnet, and a constant temperature liquid generator that generates a constant temperature liquid controlled at a constant temperature is provided, and the constant temperature liquid generator and the heat exchanger are provided. A nuclear magnetic resonance apparatus, wherein the apparatus is connected by a pipe so as to circulate the constant temperature liquid therebetween. 2. A constant temperature chamber in which a nuclear magnetic resonance phenomenon generating portion such as a permanent magnet and an electromagnetic coil and a heat exchanger are accommodated by a double heat insulating wall on the outside and inside of the constant temperature bath. 2. The nuclear magnetic resonance according to claim 1, wherein the nuclear magnetic resonance is partitioned into a chamber and an outer thermostatic chamber formed by separating the heat insulating wall, and the outer thermostatic chamber is provided with a heat exchanger connected to the thermostatic liquid generator by a pipe. apparatus. 3. The nuclear magnetic resonance apparatus according to claim 1, wherein nitrogen gas is sealed in the constant temperature chamber. 4. A component of the sample liquid by a nuclear magnetic resonance generator (NMR apparatus) which generates a nuclear magnetic resonance phenomenon by putting the sample liquid into a magnetic field formed between a pair of magnets surrounded by a heat insulating tank. A liquid component inspection apparatus configured to detect a peak frequency of the frequency spectrum, and a conversion unit configured to convert a detection signal of the sample liquid by nuclear magnetic resonance from the NMR apparatus into a frequency spectrum. An arithmetic processing means for calculating a current correction value such that a peak frequency becomes the same as a preset reference frequency; and a correction attached to the magnet and generating a correction magnetic field for correcting the magnetic field strength of the magnet with the current correction value. A liquid component inspection device comprising a coil. 5. A sample solution temperature control device for controlling a temperature of the sample solution to a predetermined temperature in a supply path of the sample solution to the NMR device, further comprising: a magnet and the heat insulating wall in the NMR device. A circulating fluid pipe through which circulating fluid for supplying heat to the magnet or removing heat from the magnet flows, and controlling a temperature of the circulating fluid to the circulating fluid pipe to a predetermined temperature. The liquid component inspection apparatus according to claim 4, further comprising an apparatus. 6. The liquid component inspection device according to claim 4, wherein the liquid component is a component of a beverage liquid flowing in a beverage liquid supply pipe in the liquid beverage production device.