JP2000226373A5 - - Google Patents
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- Publication number
- JP2000226373A5 JP2000226373A5 JP1999100828A JP10082899A JP2000226373A5 JP 2000226373 A5 JP2000226373 A5 JP 2000226373A5 JP 1999100828 A JP1999100828 A JP 1999100828A JP 10082899 A JP10082899 A JP 10082899A JP 2000226373 A5 JP2000226373 A5 JP 2000226373A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- artificial sequence
- biphenylyl
- residue
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- IDGZWZOGXPFMAL-UHFFFAOYSA-N 1-(2-bromoethyl)-4-phenylbenzene Chemical compound C1=CC(CCBr)=CC=C1C1=CC=CC=C1 IDGZWZOGXPFMAL-UHFFFAOYSA-N 0.000 description 2
- -1 3- (N, N-dimethylamino) methyl-1- [ 2- (3-indolyl) acetyl] -1,2,3,4-tetrahydroquinoline hydrochloride Chemical compound 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- CLGLKAAXNFFWON-UHFFFAOYSA-N 2-(4-phenylphenyl)ethanol Chemical compound C1=CC(CCO)=CC=C1C1=CC=CC=C1 CLGLKAAXNFFWON-UHFFFAOYSA-N 0.000 description 1
- QHZNASNYQBXKCO-UHFFFAOYSA-N 2-(4-phenylphenyl)ethyl thiocyanate Chemical compound C1=CC(CCSC#N)=CC=C1C1=CC=CC=C1 QHZNASNYQBXKCO-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- JFFNCAIQLZBVNY-UHFFFAOYSA-N C(C(=O)O)(=O)O.CN(C)C1C(N(C2=CC=CC=C2C1)C(CC1CC2=CC=C(C=C2CC1)OC)=O)C Chemical compound C(C(=O)O)(=O)O.CN(C)C1C(N(C2=CC=CC=C2C1)C(CC1CC2=CC=C(C=C2CC1)OC)=O)C JFFNCAIQLZBVNY-UHFFFAOYSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 229940116357 potassium thiocyanate Drugs 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11100828A JP2000226373A (ja) | 1998-04-08 | 1999-04-08 | アミン誘導体、その製造法および剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9642298 | 1998-04-08 | ||
| JP10-345328 | 1998-12-04 | ||
| JP10-96422 | 1998-12-04 | ||
| JP34532898 | 1998-12-04 | ||
| JP11100828A JP2000226373A (ja) | 1998-04-08 | 1999-04-08 | アミン誘導体、その製造法および剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000226373A JP2000226373A (ja) | 2000-08-15 |
| JP2000226373A5 true JP2000226373A5 (cg-RX-API-DMAC7.html) | 2006-04-27 |
Family
ID=27308094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11100828A Abandoned JP2000226373A (ja) | 1998-04-08 | 1999-04-08 | アミン誘導体、その製造法および剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000226373A (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130023381A (ko) * | 2003-07-17 | 2013-03-07 | 플렉시콘, 인코퍼레이티드 | Ｐｐａｒ 활성 화합물 |
| ATE547415T1 (de) * | 2007-09-21 | 2012-03-15 | Janssen Pharmaceutica Nv | Inhibitoren der wechselwirkung zwischen mdm2 und p53 |
| US8759539B2 (en) * | 2008-11-17 | 2014-06-24 | Merck Sharp & Dohme Corp. | Substituted bicyclic amines for the treatment of diabetes |
| CA3204409A1 (en) * | 2021-01-29 | 2022-08-04 | Chan Sun Park | Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
-
1999
- 1999-04-08 JP JP11100828A patent/JP2000226373A/ja not_active Abandoned
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