JP2000218172A - Pipet end part - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a pipet end part which has a sealable end and can be easily handled and further, can be applied to a microtitration plate by arranging a sealing surface on the terminal and arranging a pressure-applying annular surface under the sealing surface so that the max. outside diameter of the pipet end part is equivalent to a specific value or below. SOLUTION: A pipet end part has a flat sealing surface 1 of an annular ring shape with a machined head, formed on the end face. The pipet end part also has a pressure-applying surface 2 formed under the sealing surface 1 so that the max. outside diameter of the pipet end part is 4.5 mm or below. In addition, the surface 2 oppresses F the pipet end part to an interface part 6 in such a manner that the surface 2 is fricationally stopped by a pressure applying element 5, so that the surface 2 is stepped. Further, an elastomer 4 with which the end face of the pipet end part comes into contact is fixed on the surface of the interface part 6. In addition, the outlet 3 of the pipet end part is shaped so that it can be used in the narrow recess of a microtitration plate with, for example, 1,536 dents. This pipet end part can be manufactured in an injectable plastic such as polypropylene or fluoropolymer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION Pipette ends are often used as disposable products in routine laboratory work. The use of manual and motorized pipettes allows particularly easy handling of liquids. Multi-groove pipettes are used similarly to so-called microtiter plates. For example, COSTAR, GREINER, E
See company catalogs such as Ppendorf or Labsystems.

[0002]

In the prior art, there are two principles of forming a seal between the pipette end and the pipette. The most common methods on the market, such as squeezing the pipette end onto a cone, can ultimately be divided into two technical solutions. Some manufacturers use an O-ring on the cone and some manufacturers form a sealing lip on the inside surface opposite the mounted cone. Sealing the pipette end from the end, as is well known in German Utility Model G9204388,
It is a completely different type of seal. The advantage of this principle is that
A large number of pipette ends can be simultaneously connected to the pipetting device in a sealed state with little effort.

[0003]

All pipetting systems that have disposable ends and are compatible with microtiter plates are based on microtiter plates with a 9 mm pattern, and in the case of multi-groove pipettes this pattern is Implemented in a linear or two-dimensional arrangement.

Since the introduction of 384-well and 1536-well microtiter plates, various pipetting systems have been able to handle these plates with multiple pipettes in a 9 mm pattern. This is of course done at the expense of speed.

Therefore, Labsystems Co.
mpany has a special pipette end, 4.5 mm
Provide a manual pipette with 16 grooves, which can be arranged in series at intervals of. Although this pipette end is pushed onto a cone, it is difficult to push all of these pipettes simultaneously in one step to actually seal these pipette ends.

[0006]

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a seal at the end, ease of handling, use in 384 and 1536 well microtiter plates, and particularly in two-dimensional continuous Multiple ends, for example
To produce a pipette end that can be used as 384 ends.

[0007]

FIG. 1 shows an end which is shaped such that the head has a flat sealing area 1 in the form of a machined annular ring on its end face. At the lower end of the head there is a pressure application area 2 which is stepped in order to squeeze the pipette end against the interface 6 with the pressure application element 5 frictionally locked (F). It is in the form of a manufactured circular ring. The elastomer 4 is fixed on the interface 6 so that the end face of the end of the pipette comes into contact. There are various possibilities for shaping the pipette end under the head. FIG.
Shows a structure that allows the plunger to enter the pipette end by half the length of the pipette end.

Furthermore, the outlet 3 at the end of the pipette is shaped so that it can be used in the narrow recess of a 1536 microtiter plate.

This construction complies with the requirements of injection molded products, and the products of the present invention can be manufactured from an injectable plastic such as polypropylene or fluoropolymer.

According to the present invention, in order to form a seal between the pipette and the pipette end, an annular ring-shaped sealing area is formed on the head end face of the pipette end, and a pressure applying area is formed on the lower end of the head. The pressure application element presses the pipette end against the interface in a frictionally locked condition.

[Brief description of the drawings]

FIG. 1 shows an end which is shaped such that the head has a flat sealing area 1 in the form of a machined annular ring on its end face.

FIG. 2 shows the end face of the pipette end viewed from above.

FIG. 3 shows the outlet side of the pipette end as viewed from below.

FIG. 4 shows a spatial representation of the structure of the pipette end.

FIG. 5 illustrates the use of a pipette end.

[Explanation of symbols]

 F-Pressing force 1-Sealing area 2-Pressure applying area 3-Outlet 4-Elastomer 5-Pressure applying element 6-Boundary part

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Thomas More, Germany Day 07751 Dr. Kendorf Stadt Jena Zur Rämerleide 15 (72) Inventor Peter Zimmerman Germany Day 07747 Jena Salvador Allende Platz 5

Claims (6)

[Claims] 1. A pipette end in which a sealing surface 1 is arranged at the end and a pressure applying annular surface 2 is arranged below the sealing surface such that the maximum outer diameter of the pipette end is less than 4.5 mm. . 2. The pipette end according to claim 1, wherein the pipette end is manufactured from an injection-moldable plastic. 3. The pipette end according to claim 2, wherein the pipette end is manufactured from a fluorine-containing thermoplastic resin. 4. The pipette end according to claim 2, wherein the pipette end is made from polypropylene. 5. The method as claimed in claim 2, which has a hydrophobic coating.
Pipette end as described. 6. A pipette end structure shown and described in the figures.