JP2000178156A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavities, exhibiting a high microorganism adhesion-inhibiting effect, capable of effectively inhibiting the formation of dental plaques, and useful for preventing oral cavity diseases by adding a carboxymethyldextrane. SOLUTION: This composition for oral cavities contains a carboxymethyldextrane of the formula [R is CH2COOM (M is H or the like)] and, preferably, further xylitol. The carboxymethyldextrane preferably has an average mol. wt. of 5,000-1,000,000, and preferably contains the carboxymethyl groups in an amount of 0.1-1.0 group per unit structure. The carboxymethyldextrane and the xylitol are preferably contained in amounts of 0.01-5 wt.% and 0.1-25 wt.%, respectively, in the composition. When the composition is a dentifrice such as a tooth paste, the composition may be mixed with a polishing agent (for example, crystalline silica), a binder (for example, carboxymethylcellulose) and a thickener (fot example, sorbitol).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oral composition having a plaque-suppressing effect.

[0002]

2. Description of the Related Art Conventionally, there have been proposed the following oral composition-related proposals using a technique of coating a tooth surface with a specific agent or the like to suppress the adhesion of microorganisms and inhibit plaque formation. ing. An antiplaque oral composition comprising a purple fluoroalkyl surfactant and a vehicle (JP-A-1-96115). An oral composition containing an acrylic acid polymer (JP-A-3-14511). Oral composition containing a specific peptide
261717, 3-261717). An oral composition containing a fluoroalkyl phosphate (JP-A-3-38517). Oral composition containing silicone derivative
-120014). An oral composition containing a specific alkyl betaine (JP-A-4-134025). However, the oral composition does not sufficiently satisfy the effect of suppressing the adhesion of microorganisms to the tooth surface, and therefore,
It has been desired to develop an oral composition having a higher effect of suppressing the adhesion of microorganisms.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a composition for oral cavity which exhibits a high effect of inhibiting the adhesion of microorganisms and is effective for preventing oral diseases which can effectively inhibit plaque formation. And

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, by containing carboxymethyl dextran which is highly safe, the effect of suppressing the adhesion of microorganisms to the tooth surface has been confirmed. It was also found that the addition of carboxymethyl dextran and xylitol resulted in a higher effect of suppressing the adhesion of microorganisms to the tooth surface, and thus completed the present invention. That is, according to the present invention, there is provided an oral composition comprising carboxymethyl dextran and, if necessary, xylitol.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The oral composition of the present invention contains carboxymethyl dextran, which is represented by the following general formula (1).

Embedded image In the above formula, R represents a carboxylmethyl group represented by —CH ₂ COOM or —H. In this case, M represents hydrogen or a salt-forming cation. Salt-forming cations include:
Alkali metal ions such as sodium, potassium, and lithium; alkaline earth metal ions such as calcium and magnesium; ammonium ions; and organic ammonium ions derived from organic amines.

The carboxymethyl dextran used in the present invention has an average molecular weight of 1,000 to 300.
10,000, more preferably 5000 to 1,000,000, and the ratio of the carboxymethyl group is 0.05 to
2.0, more preferably 0.1 to 1.0. Generally, carboxymethyl dextran is sold in terms of viscosity having carboxymethyl groups within this range. Such carboxymethyl dextran includes CMD sold by Meito Sangyo Co., Ltd.
There is.

The amount of CMD to be added to the oral composition of the present invention is 0.005 to 10% by weight, especially 0.01 to 10% by weight in the composition.
If the content is less than 0.005% by weight, a sufficient effect may not be obtained. If the content is more than 10% by weight, the viscosity increases and the composition becomes difficult to mix. The composition of the present invention preferably contains xylitol, and the amount of the xylitol is 0.01 to 30% by weight, more preferably 0.1 to 25% by weight.

[0008] In addition to the above components, the oral composition of the present invention may contain appropriate components in accordance with the dosage form. Specifically, in the case of dentifrices such as toothpastes, crystalline silica, amorphous silica, other silica-based abrasives, aluminosilicate, aluminum oxide,
Aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, dibasic calcium phosphate dihydrate, heavy calcium carbonate, light calcium carbonate (normally 3 to 99 wt%), carboxymethylcellulose as a binder, Cellulose derivatives such as methylcellulose, hydroxymethylcellulose and sodium carboxymethylhydroxymethylcellulose; synthetic binders such as polyvinyl alcohol and polyvinylpyrrolidone; .5-
10 wt%), sorbit, glycerin as a thickener,
Ethylene glycol, propylene glycol, 1,3-
Butylene glycol, polyethylene glycol, polypropylene glycol, maltitol, lactit, and the like (usually 1 to 50% by weight) can be added.

The composition of the present invention may contain a surfactant. Examples of the surfactant include anionic salts such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, and sodium α-sulfofatty acid alkyl ester. Surfactants, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, non-ionic surfactants such as alkyldimethylamine oxide, Betaine acetate-type amphoteric surfactants such as betaine alkyldimethylaminoacetate and betaine fatty acid amidopropyldimethylaminoacetate; N-fatty acyl-N
An imidazoline-type amphoteric surfactant such as -carboxymethyl-N-hydroxyethylethylenediamine salt can be added as long as the effects of the present invention are not impaired.

Further optional components include, for example, saccharin sodium, stevioside, neohesperidihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanine methyl ester, P
-Sweeteners such as methoxycinamic aldehyde, sucrose, fructose, sodium saccharinate, spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, eucalyptus oil, sage oil, mayonnaise oil,
Flavors such as thyme oil, lemon oil, orange oil, 1-menthol, carvone, anethole, methyl salicylate, etc., bactericides such as triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, epsilon aminocaproic acid, tranexamic acid, dextro Nase, amylase, protease, mutanase, lysozyme, lytic enzyme, enzymes such as litechenzyme, chlorohexidine salts, hydrocholesterol, glycyrrhetin salts,
Glycyrrhetinic acid, chlorophyca, caropeptides, vitamins, azulene, lysozyme chloride, anti-calculus agents, anti-plaque agents, potassium nitrate, aluminum lactate and the like can be added. In addition, the addition amount of these oppressive components can be a usual amount within a range that does not impair the effects of the present invention.

[0011]

EFFECT OF THE INVENTION The oral composition of the present invention has an excellent effect of suppressing the adhesion of microorganisms to the tooth surface and can effectively inhibit plaque formation, and can be effectively used for the prevention of oral diseases. it can. The oral composition of the present invention includes various products applied in the oral cavity. Examples of such agents include mouthwashes, liquid preparations such as periodontal pocket preparations, toothpastes, liquid dentifrices, mouth fresheners, detergents, aqueous gel bases for oral cavity, chewing gums and the like.

[0012]

The present invention will be specifically described below with reference to examples. In addition, CMD sold by Meito Sangyo Co., Ltd. was used as carboxymethyl dextran blended in Examples 1 to 12. It has a viscosity of about 600 cps (1%, 20 ° C.) and a carboxymethyl group ratio of about 0.7 / unit structure as measured by the present inventors.

Examples 1 to 5 and Comparative Example 1 As an experiment for inhibiting plaque formation on the tooth surface by microorganisms, Streptococcus gordonii on a saliva-coated hydroxyapatite plate was prepared using a sample solution having a component composition (% by weight) shown in Table 1. The growth inhibitory effect of ATCC10558 was evaluated by the following method. Table 1 shows the results. (1) Hydroxyapatite pieces (manufactured by Asahi Optical Industry Co., Ltd.) were used as tooth models and immersed in filtered human saliva at 37 ° C. for 2 hours. (2) The sample was immersed in a sample solution having the composition shown in Table 1 for 30 minutes, and then washed with distilled water. (3) Streptococcus Gorudoni OD ₅₅₀ = 0.
Buffer (0.05 M KC1, 1 mM
KH ₂ PO ₄ , 0.1 mM CaC ₁₂ , 0.1 mM
(MgCl ₂ ) at 37 ° C for 18 hours to adhere bacteria. (4) After washing with distilled water, the cells were stained with fuchsin, and the area of cell attachment was calculated by image analysis. (5) The bacterial adhesion inhibition rate with respect to the control was determined by calculation according to the following equation.

Bacterial adhesion inhibition rate (%) = (AB) / A × 100 A: Bacteria adhesion area of control B: Bacteria adhesion area of sample

[0015]

[Table 1]

From the results in Table 1, it can be seen that the oral composition of the present invention greatly reduces bacterial adhesion to the tooth surface, whereby the oral composition containing carboxymethyl dextran inhibits plaque formation, It was confirmed that the composition was an oral composition that was effective for the prevention of caries (caries prevention and periodontal disease prevention).

Examples 6 to 12 are shown below, and these compositions also have a good plaque control effect.

Example 6 (Toothpaste) Aluminum hydroxide 45 (% by weight) Sorbit 20 Xylitol 10 Sodium lauryl sulfate 1.0 Polyoxyethylene (60) hardened castor oil 0.5 Saccharin sodium 0.1 Propylene glycol 5 Fragrance 1.3 Carboxymethyl dextran 1.5 Water balance

Example 7 (Toothpaste) Dicalcium phosphate dihydrate 40 (% by weight) Sorbit 20 Glycerin 10 Sodium lauryl sulfate 0.9 Saccharin sodium 0.1 Propylene glycol 5 Fragrance 1.3 Sodium monomonofluorophosphate 0 .05 Triclosan 0.05 Carboxymethyldextran 0.5 Sodium gluconate 1 Water Remaining amount

Example 8 (Toothpaste) Silica 20 (% by weight) Sorbit 60 Pluronic F-108 2 Decaglycerin monolaurate 1 Saccharin sodium 0.15 Propylene glycol 5 Fragrance 1.5 Polyvinylpyrrolidone 0.5 NaF 0.1 Polio Kidiethylene glycol # 4000 0.5 Carboxymethyl dextran 1.0 Triclosan 0.1 Trisodium citrate 1 Water Remaining amount

Example 9 (Mouthwash) Denatured ethanol 7 (% by weight) Citric acid 0.01 Trisodium citrate 0.3 Sodium saccharin 0.1 Carboxymethyldextran 0.2 Fragrance 0.5 Glycerin 5 Xylitol 5 Water balance amount

Example 10 (Mouthwash) Ethanol 10 (% by weight) Saccharin sodium 0.05 Dye 0.01 Sodium benzoate 0.05 Antioxidant 0.01 Fragrance 0.3 Pluronic F127 0.5 Monofluorophosphoric acid Sodium 0.05 Carboxymethyldextran 0.5 Water Remaining

Example 11 (Mouthwash) 90% ethanol 20 (% by weight) Pluronic F108 0.5 Fragrance 1.5 Sodium monofluorophosphate 0.05 Carboxymethyldextran 0.2 Water Remaining amount

Example 12 (Chewing gum) Gum base 20 (% by weight) Fragrance 1 Ginger syrup 20 Xylitol 30 Glucose 20 Carboxymethyldextran 1 Trisodium citrate 1.5 Water Remaining amount

Continued on front page F term (reference) 4C083 AB052 AB172 AB222 AB282 AB292 AB472 AC102 AC122 AC131 AC132 AC302 AC312 AC422 AC432 AC782 AC812 AC862 AD042 AD052 AD072 AD211 AD212 AD222 AD242 AD352 CC41 DD22 DD23 DD27 DD50 EE32 EE33 EE36

Claims (2)

[Claims] 1. An oral composition comprising carboxymethyl dextran. 2. The oral composition according to claim 1, which comprises xylitol.