JP2000178152A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a technique capable of effectively reducing the irritation and pungency of an L-menthol-containing liquid composition for oral cavities, wherein the irritation and pungency are remarkably enhanced by the addition of ethanol in a high concentration. SOLUTION: This liquid composition for oral cavities contains 0.5-2 wt.% of L-menthol, 15-40 wt.% of ethanol and 1-20 wt.% of xylitol. In spite of the large contents of an oral odor-preventing ingredient, L-menthol and a solvent ethanol, the unpleasant irritation and pungency of the composition during or after its employment are reduced, and the palatability is remarkably improved.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for a liquid oral cavity such as a liquid oral freshener and a mouthwash, and more particularly, to an unpleasant odor-preventing component despite its large amount of l-menthol. The present invention relates to a composition for a liquid oral cavity which has no irritating sensation and spiciness and has markedly improved palatability.

[0002]

2. Description of the Related Art Conventionally, oral hygiene products such as oral fresheners and mouthwashes have been used for the purpose of preventing bad breath. These oral hygiene products usually contain l- as an active ingredient for preventing bad breath.
Menthol or peppermint oil (main component is l-menthol) is blended. Further, the product dosage form is preferably liquid. The liquid dosage form has the advantage that the active ingredient can quickly spread through the mouth when used, as compared to the solid form or the paste form. Ethanol is usually used as a solvent.
In consideration of the solubility of the active ingredient and other effects, the amount of ethanol contained in a commercially available oral hygiene product ranges from 15 to 40% by weight.

When l-menthol is used in a large amount, high efficacy is promised. On the other hand, the irritation and spiciness of l-menthol itself appear during and after use, resulting in poor palatability. There is a problem that comes. This disadvantageous property is particularly remarkable in oral hygiene products (especially oral fresheners) in which the blending amount of ethanol is as high as 15 to 40% by weight. Accordingly, various proposals have been made regarding techniques for reducing the irritation and hotness of l-menthol of these oral hygiene products. However, the fact is that there is almost no effect in a system with a high concentration of ethanol, and the development of an effective technique to reduce irritation and spiciness in a system containing a large amount of l-menthol and ethanol has been desired. .

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a technique for effectively reducing the irritation and spiciness of a liquid oral composition containing l-menthol which has been significantly enhanced by a high concentration of ethanol. It is.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that 0.5 to 2% by weight of l-menthol and 15 to 40% by weight of ethanol are used. By mixing 1 to 20% by weight of xylitol to the contained liquid oral composition, irritation and spiciness during use and after use are significantly reduced, and furthermore, l-menthol has a preventive property against bad breath and a pleasant refreshing sensation. It was found that both performances were maintained, and the present invention was accomplished. That is, according to the present invention, 0.5 to 2% by weight of l-menthol and 15 to 40% by weight.
A liquid oral composition is provided, which contains 1% by weight of ethanol and 1 to 20% by weight of xylitol.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The composition for liquid oral cavity according to the present invention can be applied to oral hygiene products such as liquid mouthwash, liquid dentifrice, water dentifrice, mouthwash, liquid gargle and medicine. . In particular, it is suitable for a liquid mouth freshener which tends to contain a large amount of ethanol.

[0007] The first component of the present invention is l-menthol. It is an active ingredient for preventing bad breath and has a secondary effect such as giving a refreshing feeling. As l-menthol, those manufactured and sold as a single item can be used. Also, peppermint oil whose main component is l-menthol can be used. Commercially available essential oils containing such l-menthol are well known in the oral hygiene field. These can be used alone or in combination of two kinds. The content of l-menthol is 0.5 to 2% by weight of the whole liquid oral composition. It is more preferably from 0.7 to 1.7% by weight, particularly preferably from 1.0 to 1.6% by weight. 0.5% by weight
If the amount is less than the above, an effective effect of preventing bad breath is not exhibited, and if the amount exceeds 2% by weight, irritation and spiciness become extremely strong and the effect of the present invention cannot be expected.

[0008] The second component of the present invention is the solvent ethanol. Denatured ethanol may be used as long as the effects of the present invention are not inhibited. Aqueous ethanol may be used in consideration of sterility. In any case, the ethanol content is 15 to 40% by weight of the whole liquid oral composition. More preferably, it is 30 to 40% by weight. If the amount is less than 15% by weight, not only the stability over time of the preparation decreases, but also the feeling of use in a mouth freshener and the like deteriorates. On the other hand, if it exceeds 40% by weight, inconveniences such as excessive irritation to the oral mucosa become apparent, which is not preferable.

[0009] The third component of the present invention is xylitol. Xylitol is one of sugar alcohols having high safety, and commercially available products are available from, for example, Towa Kasei Co., Ltd. and Carta Food Science Co., Ltd. The xylitol content in the present invention is 1 to 20% by weight of the whole liquid oral composition. More preferably, it is 2 to 10% by weight. If it is less than 1% by weight, the stimulating effect and the spiciness reducing effect of the l-menthol / ethanol blending system are not sufficiently exhibited, and if it exceeds 20% by weight, the bitter taste of xylitol remains after use, which is not preferable.

[0010] The liquid oral composition of the present invention is usually used in the preparation of oral hygiene products of this type and the function imparting function, as long as it does not inhibit the stimulating effect on l-menthol and the effect of improving hotness. Ingredients such as wetting agents, surfactants, solvents, buffers, preservatives, bactericides, flavors, sweeteners, pigments, enzyme agents and the like can be incorporated.

Examples of the wetting agent include polyhydric alcohols that are widely used. Specifically, for example, glycerin, sorbitol, propylene glycol, polyethylene glycol, maltitol, erythritol, id, talit, dursit alit, arabit,
Adnit and others. Especially glycerin, sorbitol,
One or more polyhydric alcohols selected from propylene glycol, polyethylene glycol, maltitol, and erythritol can be suitably used. When polyethylene glycol is selected, it is preferable to use one that is colorless and transparent at room temperature. The amount of the polyhydric alcohol varies depending on the oral hygiene product, but is usually 0.05 to 3%.
0 weight range.

The surfactant is a commonly used surfactant such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, sucrose fatty acid ester, sorbitan fatty acid ester, and glycerin fatty acid. ester,
Polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene alkyl ether phosphoric acid and its salts, polyoxyethylene alkyl ether sulfate salt,
Polyoxyethylene phytosterol and phytostanol, polyoxyethylene alkyl phenyl ether phosphoric acid and its salt, polyoxyethylene lanolin and lanolin alcohol, polyoxyethylene alkylamine and fatty acid amide, polyoxyethylene alkylphenyl formaldehyde condensate, polyoxyethylene poly Oxypropylene alkyl ethers, polyoxyethylene alkyl phenyl ethers and fatty acid ethanolamides are exemplified. In particular, polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, sorbitan fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, fatty acid ethanolamide Nonionic surfactants such as are preferred. The amount of the surfactant varies depending on the oral hygiene product, but is usually in the range of 0.1 to 10% by weight.

[0013] Purified water is generally used as the solvent.

As the buffer, conventionally known compounds such as citric acid, malic acid, phosphoric acid and salts thereof can be used alone or in combination of two or more. Usually, the amount is in the range of 0.01 to 1.0% by weight.

[0015] Preservatives and fungicides include benzoic acid and its salts, salicylic acid and its salts, parabens, cetylpyridinium chloride, decalinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, isopropylmethylphenol. , Triclosan, hinokitiol, phenol and the like. Usually, the compounding amount is 0.
001 to 0.5% by weight.

As the fragrance, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Natural flavors such as lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, marjoram oil, bay oil, lemongrass oil, orina gum oil, pine needle oil and carvone, anethole, cineole, methyl salicylate, Cinnamaldehyde,
Eugenol, thymol, linalool, linalool acetate, limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, etc.
Further ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate,
Ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, etc., and a strawberry flavor, a apple flavor, a banana flavor, a pineapple flavor of a compounded flavor containing natural flavors and / or other natural flavors. Known flavors used for oral hygiene products such as grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, and fruit mix flavor can be used, and are not limited to the flavors described in Examples. . Usually, the amount is in the range of 0.00001 to 1% by weight.

As sweeteners, sodium saccharin,
Stevioside, aspartame, sucrose, fructose and the like may be added. If necessary, a dye, an enzyme agent and other components may be added.

[0018]

According to the liquid oral composition of the present invention,
Despite containing a large amount of the bad breath preventive component l-menthol and the solvent ethanol, the use of xylitol reduces the unpleasant irritability and spiciness during and after use, and also enhances the refreshing feeling of l-menthol. Because it is maintained, its palatability is significantly improved. Also, naturally, a large amount of l-menthol is excellent in the effect of preventing bad breath.

[0019]

EXAMPLES The present invention will be described below in detail with reference to experimental examples and examples, but the present invention is not limited to these examples.

[Experimental Example] A liquid oral composition (oral freshener) was prepared by a conventional method using the components shown in Table 1, and filled into a PET container equipped with a sprayer. After spraying 05 g, the taste was subjected to a sensory evaluation of taste according to the following evaluation criteria. Table 1 shows the results. The l-menthol was used alone, the flavor was a prepared flavor not containing l-menthol, and the surfactant was polyoxyethylene (EO60) hydrogenated castor oil. Palatability rating ：: There is no irritation and spiciness peculiar to l-menthol, and the refreshing feeling is extremely good. ：: Stimulation and spiciness peculiar to l-menthol are suppressed, and the refreshing feeling is also good. X: Strong irritation and spiciness peculiar to l-menthol, and unpleasant.

[0021]

[Table 1]

Next, oral hygiene products having the following composition were prepared, and their palatability was evaluated in the same manner as in the experimental examples. As a result, all of them had good palatability. Table 2 shows the composition of the used fragrance. It should be noted that when the other fragrances (six types) in Table 2 were used instead of the fragrances described in the respective examples, good taste was obtained. Furthermore, instead of the * compounded flavor (banana flavor) described in Table 2, a group of flavors prepared with strawberry flavor, apple flavor, pineapple flavor, tropical fruit flavor, butter flavor, milk flavor, fruit mix flavor, and peach flavor were used. In each case, the palatability evaluation was good.

Example 1 (Mouth freshener) 1-menthol 1.0% by weight Ethanol 30 Xylitol 10 Polyoxyethylene (EO60) hydrogenated castor oil 1.5 Perfume A 0.9 Purified water Balance meter 100% by weight

Example 2 (Mouth freshener) l-menthol 1.0% by weight ethanol 30 xylitol 5 polyoxyethylene (EO60) hydrogenated castor oil 2.0 polyethylene glycol 10 perfume B 0.9 purified water balance meter 100% by weight

[Example 3] (Mouth freshener) l-menthol 2.0% by weight ethanol 40 xylitol 5.0 polyoxyethylene (EO60) hydrogenated castor oil 1.5 glycerin 10 fragrance C 0.9 purified water balance meter 100% by weight

Example 4 (Mouth freshener) l-menthol 2.0% by weight ethanol 40 xylitol 20 polyoxyethylene (EO60) hydrogenated castor oil 1.2 citric acid 0.05 sodium citrate 0.25 fragrance D 1.5 Purified water balance meter 100% by weight

[Example 5] (Mouth freshener) Peppermint oil (1-menthol ratio: 45% by weight) 2.0% by weight Ethanol 35 Xylitol 7 Polyoxyethylene (EO60) hydrogenated castor oil 1.8 Polyethylene glycol 8. 0 Perfume E 0.7 Purified water Balance meter 100% by weight

Example 6 (Mouth freshener) 1-menthol 0.5% by weight Peppermint oil (l-menthol ratio: 45% by weight) 0.8% by weight Ethanol 32 Xylitol 4 Polyoxyethylene (EO60) cured castor Oil 1.6 Glycerin 12 Fragrance F 0.7 Water making Balance meter 100% by weight

Example 7 (Mouth freshener) 1-menthol 0.5% by weight Peppermint oil (l-menthol ratio: 45% by weight) 0.4% by weight Ethanol 20 Xylitol 1.0 Polyoxyethylene (EO60) Hardened castor oil 2.0 Glycerin 5.0 Perfume G 0.5 Purified water Balance meter 100% by weight

[0030]

[Table 2]

Claims (2)

[Claims] 1. 0.5 to 2% by weight of l-menthol,
A liquid oral composition comprising 15 to 40% by weight of ethanol and 1 to 20% by weight of xylitol. 2. The liquid oral composition according to claim 1, wherein the liquid oral composition is a liquid oral freshener.