JP2000154135A - Composition for skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition for skin lotion that includes an extract from jojoba leaves, as an essential component, in other words, contains a plant extract having the action to inhibit active oxygen as an excellent cosmetic additive from the view points of the price, irritations and effects, and is useful as a skin lotion or the like. SOLUTION: This composition contains, as an essential ingredient, an extract of jojoba leaves, preferably in an amount of 0.00001-5.0 wt.%, more preferably 0.001-0.5 wt.% on the dry basis. This extract is obtained by extracting raw or dried jojoba leaves, directly or after being crushed, with a solvent, for example, ethanol or the like at room temperature or under warming, when necessary, concentrating, filtering and purifying or the like the extract. The composition is useful as the basic cosmetics, for example, milky lotion, cream, pack or the like and as a make-up cosmetic, for example, foundation cosmetics or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin for preventing skin aging caused by active oxygen by eliminating active oxygen generated in the skin by ultraviolet rays and metabolism by incorporating an extract of jojoba leaves. It relates to an external preparation composition.

[0002]

2. Description of the Related Art The skin is the organ most exposed to active oxygen because of its contact with air and irradiation of ultraviolet rays as well as oxygen stress caused by the body. On the skin surface, active oxygen oxidizes sebum, causing deterioration of the skin surface condition. It is also said that in the dermis, collagen and elastin, which are constituent components, cause a decrease in elasticity due to cross-linking, and that hyaluronic acid has a low molecular weight, thereby causing a decrease in moisturizing ability. Such a change in the dermis component has been proposed as a cause of wrinkles. In addition, active oxygen is considered to be deeply involved in the formation of spots, and is therefore presumed to be the main cause of various skin aging. For these reasons, cosmetics that protect the skin from active oxygen have been developed. Among them, many active oxygen suppressing substances have been identified from natural products. Sesameol in sesame oil, sesamol, tocophenol in rice germ, oryzanol, caffeic acid in coffee beans, carnosol in rosemary, rosemary acid, curcumin in turmeric, and many other plant extracts. The inhibitory effect was confirmed, and it has been blended in cosmetics and the like.

On the other hand, in the jojoba according to the present invention, its seed oil is widely used as a cosmetic oil. However,
Until now, jojoba leaves have not been industrially used and have not been known to have an active oxygen scavenging effect.

[0004]

The isolated components in natural products which have been effective so far have the disadvantage that they are expensive and have strong skin irritation, and they are expensive, irritating and effective when formulated into cosmetics. There is a problem from the point of view. On the other hand, conventional plant extracts having an active oxygen-suppressing effect are weak in effect, and in order to obtain a sufficient effect, it is necessary to mix a large amount of the extract with cosmetics. However, it was not possible to obtain a preferable one in terms of the above.

[0005] Accordingly, an object of the present invention is to incorporate a plant extract having an excellent active oxygen suppressing effect as a cosmetic additive in view of price, irritation and effect, and to prevent skin aging caused by active oxygen. It is to provide a skin external preparation composition.

[0006]

Under such circumstances, the present inventors have conducted extensive studies on plant extracts existing widely in the natural world. As a result, the extract of jojoba leaves showed a high active oxygen suppressing action. And completed the present invention.

[0007] That is, the present invention provides a skin external preparation composition having an active oxygen scavenging action, characterized by containing a jojoba leaf extract.

Hereinafter, the skin external preparation composition of the present invention will be described in detail.

In the present invention, Jojoba [Buxus
chinensis (Link1822), Simm
ondsia california (Nuttall
1844), Simmondsia chinensi
s (Schneider 1907)] leaf extract is used as an essential component. Here, jojoba is an evergreen shrub that grows naturally in the arid region of the southwestern United States (Arizona, California) and northern Mexico (Sonora, Baja region). It is a dioecious plant, and is 3 m in height from 60 cm to 180 cm. Some reach. At present, it is cultivated and cultivated not only in the United States and Mexico but also in arid regions such as Israel, Australia and Argentina.

As for jojoba, only jojoba seed oil (ester) has been used so far. Native people such as Arizona and Sonora are said to have used them for medicine and cooking, and jojoba oil and its derivatives are currently used as oils for cosmetics.

However, jojoba leaves have hardly been used at all, and no studies on their usefulness have been published.

When an extract of jojoba leaves, which is an essential component of the present invention, is used, a raw or dried extract may be used as it is or pulverized, and the preparation method is not particularly limited. Using a suitable solvent at room temperature or under heating.

Specific examples of the extraction solvent include water, lower monohydric alcohols such as methanol and ethanol, glycerin,
Liquid polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; vegetable oils such as olive oil and jojoba oil; One or a mixture of two or more of these can be used. Among them, it is preferable to use water or a water-soluble solvent, in particular, one or a mixed solvent of water, ethanol, glycerin, propylene glycol, and 1,3-butylene glycol.

As the extract, the extract obtained by extraction as described above may be used as it is, or may be further subjected to concentration, filtration, etc., if necessary. In addition, the extract is subjected to a conventional method, for example, a column chromatography method, a countercurrent distribution method, or the like.
It can be used after fractionation and purification. In particular, it is preferable to use a column chromatography method.

The extract may be concentrated or lyophilized under reduced pressure, and then prepared in a powder or paste form.

The content of the jojoba leaf extract, which is an essential component of the present invention, is preferably 0.000% in terms of dry solids.
01 to 5.0% by weight (hereinafter simply indicated as "%"), particularly preferably 0.001 to 0.5%. When an extract is used, the extract concentration and the like are not particularly limited as long as the content of the dry solid content as a solute is within the above range.

The composition for external use on skin of the present invention is used in combination with antioxidants such as plant extracts such as ascorbic acid, α-tocophenol, rosemary extract, sage extract, and clove extract, in addition to the above essential components. By doing so, the effect of eliminating active oxygen can be enhanced.

The composition for external use on the skin of the present invention contains surfactants, oils and fats, polyhydric alcohols, lower alcohols, thickeners, ultraviolet absorbers / scatterers, which are generally used as cosmetic ingredients. Preservatives, antioxidants, chelating agents, p
An H adjuster, a fragrance, a dye, and the like can be appropriately compounded.
Specific examples of these additional components are as follows.
Examples of the surfactant include anionic surfactants such as higher fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, acyl N-methyl taurate, alkyl ether phosphates, and N-acyl amino acid salts. Cationic surfactants such as alkyltrimethylammonium, dialkyldimethylammonium chloride, benzalkonium chloride, amino alcohol fatty acid organic silicone resin, alkyldimethylaminoacetic acid betaine, alkylamidodimethylaminoacetic acid betaine, 2-
Amphoteric surfactant such as alkyl-N-carboxy-N-hydroxyimidazolinium betaine, polyoxyethylene alkyl ether, polyoxyethylene branched alkyl ether, sorbitan ester, polyoxyethylene sorbitan ester, glycerin fatty acid ester, polyoxyethylene Glycerin fatty acid ester, polyoxyethylene cholesterol ester, polyoxyethylene hydrogenated castor oil fatty acid ester, glycerin alkyl ether, polyoxyethylene glycerin alkyl ether,
Nonionic surfactants such as polyglycerin fatty acid esters, and natural surfactants such as lecithin, lanolin, cholesterol, saponin and the like. As fats and oils, olive oil, camellia oil, macadamian nut oil, castor oil, sesame oil, safflower oil, vegetable oils such as peanut oil, pistachio oil, animal oils such as mink oil, egg yolk oil, jojoba oil, carnaubaroe, candelilla wax , Beeswax, waxes such as lanolin, liquid paraffin, paraffin, vaseline, ceresin, microcrystalline wax, hydrocarbons such as squalane, lauric acid, myristic acid, stearic acid, higher fatty acids such as isostearic acid, cetyl alcohol,
Stearyl alcohol, isostearyl alcohol, 2
Octyldodecanol, higher alcohols such as jojoba alcohol, isopropyl myristate, 2-octyldodecyl myristate, cetyl 2-ethylhexanoate,
Esters such as diisostearyl malate; silicone oils such as methylpolysiloxane and methylphenylpolysiloxane; Polyhydric alcohols include ethylene glycol, polyethylene glycol, propylene glycol,
1,3-butylene glycol, glycerin, polyglycerin, glucose, maltose, fructose, xylitol, sorbitol, maltotriose, erythritol and the like. Examples of the thickener include sodium alginate, xanthan gum, quince seed extract, guar gum, locust bean gum, sodium hyaluronate, collagen, casein, sodium carboxymethylcellulose, carboxyvinyl polymer and the like.

As the ultraviolet absorber, 2-hydroxy-
Benzophenone derivatives such as 4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, paraaminobenzoic acid derivatives such as paraaminobenzoic acid and octyl paradimethylaminobenzoate, octyl paramethoxycinnamate and mono-diparamethoxycinnamate
Methoxycinnamic acid derivatives such as glyceryl 2-ethylhexanoate, and salicylic acid derivatives such as homomenthyl salicylate. Preservatives include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, benzalkonium chloride, hinokitiol, resorcinol, ethanol and the like. Examples of antioxidants include tocophenol, ascorbic acid, butylhydroxyanisole, dibutylhydroxytoluene, and gallic esters. Examples of the chelating agent include sodium ethylenediaminetetraacetate, sodium polyphosphate, and citric acid.

Further, a plant extract having a physiologically active action such as antibacterial activity, cell activation, moisturizing, suppression of sebum secretion, inflammation, promotion of blood circulation, astringency, antioxidation, whitening and the like, and a combined use of these extracted fractions and purified products. You can also.

Further, the skin external preparation composition of the present invention is not limited to general skin cosmetics but includes quasi-drugs, cosmeceuticals and the like. The dosage form of the skin external preparation composition of the present invention may be any of a soluble type, an emulsifying type, a powdered dispersing type, etc., and the application is a basic cosmetic such as a lotion, an emulsion, a cream, a pack, and a makeup such as a foundation. It does not matter what kind of ingredients, eyeliner, bath agent, etc.

The thus obtained external composition for skin containing the jojoba leaf extract of the present invention as an essential component is excellent in active oxygen scavenging action, enhances skin function, prevents skin wrinkles,
It is highly effective for making fine and firm skin, and is useful as an antiaging cosmetic.

[0023]

Next, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

(Production Example 1 of Jojoba Leaf Extract) 3 kg of a 50 vol% ethanol solution was added to 100 g of dried jojoba leaves.
And stirred and extracted at 60 ° C. for 8 hours. After cooling, the mixture is filtered to obtain about 2800 g of extract A.

(Production example 2 of jojoba leaf extract) 3 kg of purified water was added to 200 g of dried jojoba leaves,
Stir and extract for hours. After cooling, the mixture was filtered and the extract B was about 2,600.
g. Furthermore, 50 vol% ethanol 3 was added to the filtration residue.
Then, the mixture is stirred and extracted at 600 ° C. for 5 hours. After cooling,
Filter to obtain about 2800 g of extract C. Further, 3 kg of 95 vol% ethanol is added to the filtration residue, and the mixture is stirred and extracted at 50 ° C. for 5 hours. After cooling, the mixture was filtered, and the extract D was about 2800 g.
Get.

(Production Example 3 of Jojoba leaf extract) After the extract B was concentrated to about 200 g under reduced pressure, the extract was treated with a column filled with the synthetic adsorbent Diaion HP-20, and 10 vol% after washing with water. Ethanol solution eluate, 15vol
% Ethanol solution eluate and 20 vol% ethanol solution eluate are obtained. Each eluate is concentrated under reduced pressure to 50 g, and 50 g of ethanol is added to obtain extracts E, F and G.

(Production Example 4 of Jojoba Leaf Extract) 4 kg of 30 vol% ethanol was added to 200 g of dried jojoba leaves, and the mixture was extracted with stirring at 60 ° C. for 5 hours. After cooling, the mixture is filtered, and the obtained filtrate is concentrated under reduced pressure to 200 g. The concentrated solution is treated with a column packed with octadecylsilylated silica gel for column chromatography, fractions eluted with 10 to 20% by volume of ethanol are combined, concentrated under reduced pressure, and dried under reduced pressure to obtain about 15 g of powdered extract H. .

(Test Example 1) Measurement of active oxygen scavenging action SOD-like activity action The SOD-like activities of the extracts A to H were measured. SOD
Activity was determined by the NBT method (Beau in combination with the XOD system).
Champs et al .: Anal. Biochem. ,
44, 276-287, 1971). Table 1 shows the results.

[0029]

[Table 1]

(Test Example 2) Panel test The following external composition for skin of the present invention and the external composition for control skin were applied to 50 women aged 20 to 39 years (average age 23.7 years) twice a day. (Morning, Evening) Table 2 shows the sensory evaluation of the results of application and use on the face for three consecutive months. Sensory evaluation was made on four items: moisture, texture, wrinkles, spots and freckles. The jojoba leaf extract used in the test was prepared by dissolving the extract H shown in Production Example 4 in a 50% 1,3-butylene glycol solution at a ratio of 1% (weight ratio).
As a control, a 50% 1,3-butylene glycol solution was used.

External composition for skin used in panel test Jojoba leaf extract 5.0% (control: 50% 1,3-butylene glycol solution) Glycerin 5.0% Ethanol 5.0% Paraoxybenzoate 0.2 % Purified water 84.8%

As is clear from Table 2, the composition for external use on the skin of the present invention showed high efficacy, and the effect was derived from the jojoba leaf extract of the present invention.

[0033]

[Table 2]

(Test Example 3) Patch test Men 29 from 20 to 51 years old (average age 27.1 years)
A total of 60 healthy volunteers consisting of 31 women were used. As a test substance, the extract A of the above Production Example 1 and the extract used in the panel test were used.
A 1,3-butylene glycol solution and physiological saline were used. In the test, a 24-hour blockage application test was performed. Fin body chamber for human body sticking test (diameter 11mm, Taisho Pharmaceutical)
After applying 0.1 mL of each test substance using
It was immediately attached to the back of the subject and left for 24 hours. Then, the fin chamber was removed 24 hours later, and the skin reaction was observed 30 minutes later and the next day (48 hours later) according to the criteria.

The criterion was in accordance with the criterion of the Japanese Patch Test Study Group. No response ・ ・ ・ ・ ・ (−) Slight erythema ・ ・ ・ ・ ・ (±) Obvious erythema ・ ・ ・ ・ ・ (+) Erythema + swelling ・ ・ ・ ・ ・ (++) Erythema + swelling + papule or small Water bubble ···· (++) Large water bubble ···· (++++)

Table 3 shows the test results. No example showing a positive reaction (+ or more) was found. In addition, the case where slight erythema (±) occurred was 50% 1,3-
The frequency was almost the same as in the case of using butylene glycol solution or physiological saline. Therefore, the skin irritation was considered to be low, and it was clarified that there was no problem in terms of safety when blended into an external preparation for skin.

[0037]

[Table 3]

(Example 1) Cream The following components (1) to (10) and, separately, the following components (11) to (15) are heated and dissolved at 75 ° C. to obtain solution A and solution B, respectively. The solution A was added to the solution A, emulsified, cooled to 50 ° C. while stirring, and the component (16) was added to prepare a cream. (Components) (% by weight) (1) Jojoba oil 3.0% (2) Squalane 2.0% (3) Methylpolysiloxane 0.5% (4) Stearyl alcohol 0.5% (5) Cetyl alcohol 5% (6) glyceryl tri (capryl / caprate) 12.5% (7) glyceryl monostearate 5.0% (8) 1.5% diglyceryl monostearate (9) decaglyceryl monostearate 0% (10) Propyl parahydroxybenzoate 0.1% (11) Xanthan gum 0.1% (12) Jojoba leaf extract A (Production Example 1) 2.5% (13) 1,3-butylene glycol 2.5 % (14) Methyl paraoxybenzoate 0.2% (15) Purified water 66.0% (16) Fragrance 0.1%

Example 2 Lotion The following components (5) to
Solution (8) is mixed and dissolved to obtain solution A. Separately, the following components (1) to (4) and (9) are mixed and dissolved to obtain solution (B), and solution A and solution B are uniformly mixed. , Got a lotion. (Components) (% by weight) (1) Quince seed extract 8.0% (2) Glycerin 3.0% (3) 1,3-butylene glycol 5.0% (4) Jojoba leaf extract E (Production Example 3) 2.0% (5) Polyoxyethylene sorbitan laurate 1.2% (6) Ethyl alcohol 5.0% (7) Preservative 0.2% (8) Fragrance 0.1% (9) Purified water 75.5%

Example 3 Emulsion The following components (1) to (1)
0), separately, the following components (11) to (14) and (16) were dissolved by heating at 75 ° C.
Solution, add solution B to solution A, emulsify, and stir for 50
After cooling to ℃, component (15) was added to prepare an emulsion. (Ingredients) (% by weight) (1) Jojoba oil 1.0% (2) Squalane 2.0% (3) Behenyl alcohol 1.0% (4) Tri (caprylic / capric acid) glyceryl 2.0% (5) Tetraglycerin condensed ricinoleic acid 0.1% (6) Propylene glycol monooleate 0.5% (7) Glyceryl monostearate 1.0% (8) Hexaglyceryl monomyristate 1.0% (9) Monomyristate Decaglyceryl 0.5% (10) Propyl parahydroxybenzoate 0.1% (11) Quince seed extract 5.0% (12) Jojoba leaf extract C (Production Example 2) 3.0% (13) 1,3 -Butylene glycol 3.0% (14) Methyl paraoxybenzoate 0.1% (15) Fragrance 0.1% (16) Purified water 79.6%

(Example 4) Cleansing gel The following components (1) to (3), and separately from this, the following component (4)
(6) and (8) are heated and dissolved at 70 ° C. to obtain solution A and solution B, respectively, and solution B is added to solution A and stirred until uniform. While stirring, the mixture was cooled to 50 ° C., and the component (7) was added to prepare a cleansing gel. (Components) (% by weight) (1) Hexaglyceryl monomyristate 20.0% (2) Liquid paraffin 59.7% (3) Paraoxybenzoate 0.3% (4) Jojoba leaf extract B (Production Example) 2) 5.0% (5) Concentrated glycerin 5.0% (6) Sorbitol 5.0% (7) Flavor 0.1% (8) Purified water 4.9%

[0041]

As described in detail above, the jojoba leaf extract of the present invention exhibits an excellent active oxygen suppressing effect, and a composition for external use on the skin containing the same contains active oxygen which causes aging of the skin. It suppresses generation and is also excellent in safety.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 C F-term (Reference) 4C083 AA111 AA112 AA122 AC022 AC072 AC122 AC422 AC482 AD152 AD352 CC04 CC05 DD31 EE12 EE13 4C088 AB12 AC05 BA08 MA63 NA14 ZA89

Claims (2)

[Claims] 1. A jojoba [Buxus chinensi]
s (Link 1822), Simmondiac
Alifornia (Nuttall 1844), S
immondsia chinensis (Schne
der 1907)] A skin external preparation composition comprising a leaf extract as an essential component. 2. The composition for external use on skin according to claim 1, wherein the composition for external use on skin is a cosmetic having an active oxygen scavenging action.