JP2000119149A - Toothpaste - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain tooth paste hardly causing the solidification or the like with time even if hydroxyapatite and sodium chloride are compounded so as to form high concentrations, and having stabilized physical properties. SOLUTION: This tooth paste contains hydroxyapatite and sodium chloride, and characterized by formulating neither a calcium salt of phosphoric acid nor a calcium salt of carbonic acid. The physical properties of the tooth paste can be improved by compounding at least one kind selected from a starch, a synthetic aluminum silicate, a natural aluminum silicate, and a crystalline cellulose, therewith.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a toothpaste, and more particularly, it contains hydroxyapatite and sodium chloride, has stable physical properties, has a whitening effect,
The present invention relates to a toothpaste having an excellent remineralization effect.

[0002]

2. Description of the Related Art Hydroxyapatite is a substance that is blended in toothpaste as an abrasive. The abrasive removes extraneous matter on the tooth surface without damaging the tooth surface and gives the tooth a natural luster. It is known that hydroxyapatite has a further excellent plaque removing effect and has an effect of whitening and beautiful teeth. Commonly used abrasives include calcium carbonate, dibasic calcium phosphate, etc., which are excellent as toothpaste abrasives in terms of hardness, particle size, taste, price, etc., and are generally used for toothpaste. I have. Even toothpastes containing hydroxyapatite as an abrasive generally use calcium carbonate, calcium phosphate or the like as an abrasive.

[0003] Sodium chloride has a firming effect on gums,
It has a preventive effect on alveolar pyorrhea and gingivitis, and is a substance that is added to toothpaste for this purpose.

As an example of mixing hydroxyapatite and sodium chloride in toothpaste at the same time, toothpaste in which magnesium chloride is further added in addition to hydroxyapatite and sodium chloride is known (Japanese Patent Publication No. 1-3).
No. 4966).

[0005] However, when hydroxyapatite and sodium chloride are simultaneously added to a conventional toothpaste at a high concentration, there is a disadvantage that solidification of the toothpaste itself and denaturation over time such as roughness of the toothpaste surface occur. This tendency becomes remarkable as the amount of hydroxyapatite and sodium chloride increases. For example, a conventional toothpaste containing 20% each of hydroxyapatite and sodium chloride causes solidification and the like after about one month at 40 ± 1 ° C. and RH75 ± 5%.

[0006]

SUMMARY OF THE INVENTION The present invention solves the above-mentioned drawbacks of the conventional toothpaste, and has a physical property that, even when hydroxyapatite and sodium chloride are blended at a high concentration, denaturation such as solidification does not occur over time. An object of the present invention is to provide a stable toothpaste.

[0007]

A means for solving the above-mentioned problems is a toothpaste containing hydroxyapatite and sodium chloride, and free of calcium salts of phosphoric acid and calcium carbonate. The toothpaste is
The physical stability can be further improved by blending at least one selected from the group consisting of starch, synthetic aluminum silicate, natural aluminum silicate and crystalline cellulose.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention comprises at least hydroxyapatite and sodium chloride,
And, toothpaste not containing calcium carbonate and calcium phosphate, and at least one selected from the group consisting of hydroxyapatite and sodium chloride and starch, synthetic aluminum silicate, natural aluminum silicate and crystalline cellulose. A toothpaste having at least a calcium carbonate salt and a calcium phosphate salt.

The content of hydroxyapatite in the toothpaste is 1 to 40% by weight, preferably 3 to 2%.
0% by weight. The content of hydroxyapatite is
The content is appropriately determined from the above range so as to be 100% by weight together with other components.

[0010] The content of sodium chloride in the toothpaste is 1 to 40%, preferably 10 to 30%. The content of sodium chloride is 10
The content is appropriately determined from the above range so as to be 0% by weight.

The toothpaste is required to contain hydroxyapatite and sodium chloride and not to contain calcium carbonate and calcium phosphate, but it is further required that starch, synthetic aluminum silicate, It is desirable to contain at least one selected from the group consisting of natural aluminum silicate and crystalline cellulose. Starch, synthetic aluminum silicate, natural aluminum silicate and crystalline cellulose are chemically inert and do not react with the other ingredients in the toothpaste, thus making toothpaste prolonged. Even if it is stored, it does not change its properties and properties, and in addition to hydroxyapatite and sodium chloride, brushing when brushing teeth with this toothpaste gives a soft touch and damages gums There is a technical effect that there is no. Examples of the starch include corn starch, rice starch, potato starch, wheat starch and the like.

[0012] The starch content in the toothpaste is 5-8.
0%, preferably 10 to 60%. The starch content is appropriately determined from the above range so as to be 100% by weight together with other components.

The calcium carbonate and calcium phosphate include calcium carbonate, monobasic calcium phosphate (calcium dihydrogen phosphate), dibasic calcium phosphate (calcium hydrogen phosphate), tertiary calcium phosphate (tricalcium phosphate), Calcium pyrophosphate and the like can be mentioned. In the present invention, the calcium salt of phosphoric acid is
This is a concept excluding hydroxyapatite.

The toothpaste of the present invention includes, for example, abrasives, excipients, wetting agents, surface active agents other than the above-mentioned calcium carbonate salt and phosphoric acid calcium salt which are usually contained in toothpaste. Agents, binders, sweeteners, preservatives, flavoring agents, solvents, anti-inflammatory agents, tissue activators, enzyme agents, fluorine compounds, bactericides, coloring agents and the like may be contained.

Examples of the polishing agent excluding the calcium salt of carbonic acid and the calcium salt of phosphoric acid include aluminum hydroxide, silicic anhydride, and ultrafine silica.

Examples of the excipient include starch, synthetic aluminum silicate, natural aluminum silicate, and crystalline cellulose, as described above.

Examples of the wetting agent include glycerin, sorbitol, propylene glycol, polyethylene glycol and the like.

Examples of the surfactant include sodium laurate, alkyl phosphate, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, and glycerin fatty acid ester.

Examples of the binder include dextran, dextrin, hydrolyzed reduced starch, sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, gum arabic, carrageenan, xanthan gum, tragacanth gum, karaya gum, pectin,
Examples thereof include sodium alginate, sodium chondroitin sulfate, sodium caseinate, and carboxyvinyl polymer.

Examples of the sweetener include saccharin, saccharin sodium, aspartame, stevia extract, xylitol, sorbitol, palatinose,
Panose, mannitol, maltitol, lactose,
Lactitol, fructooligosaccharide, sucrose, glucose, fructose and the like can be mentioned, and saccharin, sodium saccharin, aspartame, stevia extract, xylitol, sorbitol, palatinose, panose, mannitol, maltitol, lactose, lactitol, particularly for the purpose of preventing caries. , And fructooligosaccharides can be suitably employed.

The preservatives include, for example, alkyl diaminoethyl glycine hydrochloride, methyl parahydroxybenzoate (methylparaben), ethyl paraoxybenzoate (ethylparaben), and paraoxybenzoic acid esters (paraben) such as butyl paraoxybenzoate (butylparaben). ), Sodium salicylate, sodium benzoate and the like.

As the flavoring agent, for example, T-shaped oil,
Fruit flavors such as spearmint oil, peppermint oil, menthol, and lemon oil, anethole, wintergreen, cinnamon, clove, vanilla, and cashmere can be used.

Examples of the solvent include purified water, ethanol and the like.

Examples of the anti-inflammatory agent include anti-plasmin agents such as dihydrocholesterine, epidihydrocholesterine, allantoin and its derivatives, allantoin dihydroxyaluminum, glycyrrhizin and its derivatives, steering lithyl retinate, tranexamic acid and the like. be able to.

Examples of the tissue excipient include hinokitiol, sodium copper chlorophyllin and the like.

Examples of the enzyme include lysozyme and lysozyme chloride.

Examples of the fluorine compound include sodium monofluorophosphate, stannous fluoride, sodium fluoride and the like.

Examples of the bactericide include chlorhexidine, isopropylmethylphenol and the like.

The toothpaste of the present invention can be manufactured, for example, as follows.

A predetermined amount of said hydroxyapatite and said sodium chloride, or a predetermined amount of said hydroxyapatite, said sodium chloride and said starch;
The excipients, wetting agents, surfactants, binders, sweeteners, preservatives, flavoring agents, solvents, anti-inflammatory agents, tissue activators, enzyme agents,
A predetermined amount of a raw material selected from a fluorine compound, a bactericide, a coloring agent and the like is weighed. The weighed raw materials are mixed by a mixing stirrer or the like to form a coarse paste. This rough paste is subjected to a vacuum defoaming treatment. This is filled in a predetermined container such as a tube.

[0031]

EXAMPLES (Example 1) After mixing and defoaming the raw materials shown in the following toothpaste formulation, a tube was filled to prepare a toothpaste sample.

Sodium chloride 20% by weight Hydroxyapatite 20% by weight Maize starch 30% by weight Tocophenol acetate 0.5% by weight Glycerin 5% by weight Sodium lauryl sulfate 1% by weight Methyl paraben 0.2% by weight Xanthan gum 1% by weight Stevia extract 0. 5% by weight Flavoring agent 1% by weight Water Remaining amount 100% by weight Using the prepared sample, a test for examining physical change with time was conducted. The sample was observed at a temperature of 40 ° C. and a humidity of 75% for 0 days, 1 week, 2 weeks, 1 month, 2 months, 4 months, and 8 months. Table 1 shows the results.

(Comparative Examples 1 to 4) In Example 1, calcium monophosphate, calcium carbonate, calcium pyrophosphate and calcium tertiary phosphate were added instead of corn starch, and samples prepared in the same manner as in Example 1 were prepared. Comparative Examples 1 to 4 are provided.

The same tests as in Example 1 were conducted for Examples 2 to 4. Table 1 shows the results.

Example 2 A sample was prepared in the same manner as in Example 1 by using the raw materials shown in the following toothpaste formulation.
The same test was performed. Table 1 shows the results.

Sodium chloride 3% by weight Hydroxyapatite 2% by weight Natural aluminum silicate 40% by weight Glycerin 7% by weight Sorbite 3% by weight Sodium lauryl sulfate 1% by weight Ethyl paraben 0.2% by weight Carrageenan 1% by weight Sodium carboxymethylcellulose 0. 5% by weight Flavoring agent 1% by weight Chlorhexidine hydrochloride 0.0005% by weight Water Remaining total 100% by weight (Comparative Examples 5 to 8) In Example 2, monobasic calcium phosphate, calcium carbonate, pyrocarbon was used instead of natural aluminum silicate. Calcium phosphate and tricalcium phosphate were respectively added, and samples prepared in the same manner as in Example 1 were designated as Comparative Examples 5 to 8, respectively, and the same test as in Example 1 was performed. Table 1 shows the results.

Example 3 A sample was prepared in the same manner as in Example 1 by using the raw materials shown in the following toothpaste formulation.
The same test was performed. Table 1 shows the results.

Sodium chloride 30% by weight Hydroxyapatite 5% by weight Synthetic aluminum silicate 20% by weight Glycerin 5% by weight Sorbite 3% by weight Sodium lauryl sulfate 1% by weight Sodium monofluorophosphate 0.5% by weight Lauroyl sarcosine sodium 0.5% by weight Hydrochloric acid Alkyl diamino ethyl glycine 0.1% by weight Traganto gum 1.5% by weight Saccharin sodium 0.03% by weight Flavoring agent 0.5% by weight Water remaining amount 100% by weight (Comparative Examples 9 to 12) In Example 3, synthetic aluminum silicate Calcium phosphate, calcium carbonate, calcium pyrophosphate, and calcium tertiary phosphate were added in place of the above, and the samples prepared in the same manner as in Example 1 were referred to as Comparative Examples 9 to 12, and the same test as in Example 1 was performed. Was. Table 1 shows the results.

Example 4 A sample was prepared in the same manner as in Example 1 using the raw materials shown in the following toothpaste formulation.
The same test was performed. Table 1 shows the results.

Sodium chloride 3% by weight hydroxyapatite 25% by weight crystalline cellulose 20% by weight glycerin 7% by weight polyethylene glycol 2% by weight sodium lauryl sulfate 1% by weight glycyrrhizin 0.1% by weight ethyl paraben 0.1% by weight methyl paraben 1% by weight Gum arabic 1% by weight Xylitol 3% by weight Flavoring agent 0.8% by weight Water remaining amount 100% by weight (Comparative Examples 13 to 16) In Example 4, monobasic calcium phosphate and calcium carbonate were used instead of rice starch. , Calcium pyrophosphate and tricalcium phosphate were added, and samples prepared in the same manner as in Example 1 were designated as Comparative Examples 13 to 16, respectively, and the same test as in Example 1 was performed. Table 1 shows the results.

(Evaluation of the state of the sample after storage) ○ Little change in state compared to the start of storage × No change in state such as solidification compared to the start of storage

[0042]

[Table 1] Table 1

[0043]

According to the present invention, even if hydroxyapatite and sodium chloride are mixed at a high concentration for a long period of time, calcium carbonate and calcium phosphate which interact with hydroxyapatite and sodium chloride are not included. Thus, it is possible to provide a toothpaste having a gum tightening effect, a whitening effect of teeth, and the like, without causing any modification such as solidification.

Since starch is inert to other components in toothpaste, the incorporation of starch provides a toothpaste containing hydroxyapatite and sodium chloride that does not denature over a longer period of time. be able to.
In addition, since starch is contained, brushing becomes a soft touch and does not damage the gums.

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Claims (2)

[Claims] 1. A toothpaste comprising hydroxyapatite and sodium chloride, and free of calcium salts of phosphoric acid and calcium carbonate. 2. The toothpaste according to claim 1, which is at least one selected from the group consisting of starch, synthetic aluminum silicate, natural aluminum silicate and crystalline cellulose.