JP2000109427A - Skin patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin patch having excellent adhesion even in the case of application to a curved part such as heel, knee, elbow, shoulder, the circumference of eye, etc., not only causing no release and no rolling up but also reducing no commercial value followed by twist and shift, for example, even in the case of being stored in a longitudinal placing on display at a salesroom, etc., having excellent workability in production and handleability in patch. SOLUTION: This skin patch comprises a hydrous tacky agent layer formed on one side of a substrate 2. The surface of the hydrous tacky agent layer is covered with a facing. The hydrous tacky agent layer has >=5-1 mm gel strength, bending resistance of the facing is 20-150 mm and the substrate 2 is of unusual shape.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin patch which can be suitably used as a patch to be applied to a curved portion.

[0002]

2. Description of the Related Art Conventionally, a skin patch mainly intended for application to a curved portion has been devised in various shapes and the like in order to reduce peeling and curling. For example, it has been proposed to cut out the shape of the edge, make a cut, or make the shape elliptical.

[0003] However, in the case of a patch having the above-mentioned shape, a sense of stability is poor when stored vertically, and in any case, twist or misalignment is likely to occur in a vertical display at a sales floor, and further cuts and cuts are formed. However, there are problems that the pressure-sensitive adhesive layers adhere to each other at the time of application and that the facing that covers the surface of the pressure-sensitive adhesive layer is difficult to peel off.

As means for solving such a problem,
Means such as thickening the facing that covers the surface of the pressure-sensitive adhesive layer or using a hard material to supplement the rigidity of the entire patch can be considered, but in this case, the facing material is limited And the workability during production and the handling of the patch have deteriorated.

The present invention has been made in view of the above circumstances. For example, even if the present invention is applied to a curved portion such as a heel, a knee, an elbow, a shoulder, or the periphery of an eye, the adhesive has good adhesiveness and does not cause peeling or curling. For example, even if it is stored vertically, such as when displaying at a sales floor, it does not cause twisting or misalignment and does not reduce its commercial value, and it has good workability during production and good handling of patches. It is intended to provide a patch.

[0006]

Means for Solving the Problems and Embodiments of the Invention To achieve the above object, the present inventors have formed a water-containing pressure-sensitive adhesive layer on one side of a support, and the surface of the water-containing pressure-sensitive adhesive layer has a face. A skin patch covered with a shingle, wherein the hydrous pressure-sensitive adhesive layer has a gel strength of 5 mm ^-1 or more, and the facing has a softness of 20 to 150 mm, and the support has an irregular shape. A skin patch is provided. Here, it is more preferable that the shape of the support is such that a cut is formed on at least one side of a polygon. Further, if the support has a rounded corner, More preferred.

[0007] That is, the skin patch of the present invention has excellent operability and ease of handling of the patch in the manufacturing process because the softness of facing is in the above range, and there is a wide range of choice of facing material. Further, by defining the gel strength of the pressure-sensitive adhesive layer of the skin patch to a predetermined strength, not only peeling and turning up when the skin patch is applied to the curved portion can be reduced, but also by storing vertically. Also, twisting and displacement can be prevented, and the commercial value is not impaired. Further, since the support has an irregular shape, the fit of the skin patch at the curved portion can be improved.

Furthermore, if the support has a shape in which a cut is formed on at least one side of a polygon, the support is reduced in peeling and curling due to the presence of the cut, and
The fit at the curved part is further improved, and the usability (when pasted)
Feeling of discomfort is reduced. If the corners of the support are rounded, peeling and turning up when the skin patch is applied to a rapidly moving curved portion can be reduced more effectively.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to the drawings.

FIG. 1 and FIG. 2 illustrate one structural example of the skin patch 1 of the present invention. This skin patch 1
A hydrated pressure-sensitive adhesive layer 3 is formed on one surface of the support 2, and the surface of the hydrated pressure-sensitive adhesive layer 3 is covered with a facing 4. As shown in FIG. 2, the support 2 has rounded corners 5a, 5a, 5a, 5a, and a vertex 6 in the middle of the four sides 5b, 5b, 5b, 5b.
a, 6a, 6a, 6a have a triangular shape toward the center of the square, and the vertices 6a, 6a, 6a, 6a are formed with cutouts 6, 6, 6, 6 rounded. ,
In addition, cutouts 6 are formed in the four sides 5b, 5b, 5b, 5b.
The corners formed by 6, 6, 6 also have rounded shapes, and the shape of the support 2 is substantially the shape of the pressure-sensitive adhesive layer 3 formed on one surface thereof. But also
By adopting the specific shape as described above, the sticking property and the effect of preventing twisting and misalignment during vertical storage can be further improved without impairing ease of use during sticking.

Here, as the material for forming the above-mentioned support 2, those used for the support of ordinary patches can be used. Examples of such materials include thick weave, yarn weave, and gauze. Woven fabrics, such as knitted fabrics, coal heavens and flannels, knitted fabrics made by flat knitting, rubber knitting, tack knitting, double knitting, etc., and nonwoven fabrics made by spun lace, spun bond, thermal bond, chemical bond, needle punch, etc. Among them, a nonwoven fabric is particularly preferably used. The material of the nonwoven fabric is not particularly limited, but it is preferable to use thermoplastic fibers alone or to mix thermoplastic fibers and non-thermoplastic fibers.
Examples of the thermoplastic fiber include polyester fiber, polyethylene fiber, polypropylene fiber, polyamide fiber,
Polyvinyl chloride fiber, polyurethane fiber and the like,
Non-thermoplastic fibers include, for example, rayon, cupra,
Hemp, silk, etc. can be mentioned. The thickness of the support is not particularly limited.

The stretchability of the support is not particularly limited, but from the viewpoint of the present invention, for example, when the stretchability is represented by a 50% elongation recovery ratio described below, the short side Direction recovery rate is more than 30%, especially 40
% Or more, and the recovery rate in the long side direction is 40% or more, especially 5%.
Desirably, it is 0% or more. If the 50% stretch recovery is too low, for example, when a skin patch is applied to the heel,
It may not be able to follow the movement during walking, or even if it can follow the movement, the backing of the support may not be enough, so that the skin patch may easily float from the skin, resulting in a decrease in usability May occur. On the other hand, when the elasticity of the support is expressed as a 50% modulus value described below, the 50% modulus value in the short side direction is 100 to 1000.
0 g / 50 mm, especially 200 to 5000 g / 50 mm, and a 50% modulus value in the long side direction of 10 to 100.
It is preferably 0 g / 50 mm, particularly preferably 30 to 500 g / 50 mm. If each modulus value is too low, it may be difficult to set appropriate conditions in the spreading step of the water-containing adhesive, while if each modulus value is too high, for example, when a skin patch is applied to the heel, Since the ability to follow the movement of the feet is reduced, the skin patch is more likely to float up from the surroundings, and as a result, there is a possibility that the feeling of use may be reduced.

Here, the 50% elongation recovery rate and 50%
The modulus value is measured as follows. That is, with respect to a test piece having a test length of 150 mm and a width of 50 mm, the test length is grasped at a pinch interval of 100 mm using a tensile strength tester, and the pinch interval is 100 mm to 15 mm at an extension speed of 200 mm / min.
Stretch to 0 mm and record the stress (g) at that time (50% modulus value). Furthermore, the trial length B (m) of the knob interval when returning to the original position at the same speed
m), read the initial length A (mm) and calculate from the following equation.

50% elongation recovery rate (%) = 100 − ｛(B
-A) / 50 ° × 100 In the case of the present invention, the shape of the support 2 is changed to a different shape as shown in FIG. The shape is not limited to the above shape as long as it is a different shape, square, rectangle,
Any shape other than a circular shape may be used. Examples of such an irregular shape include an elliptical shape, a gourd shape, a crescent shape, a bay shape (D-shape), a mandama shape, and a butterfly. Examples include polygons such as molds, trapezoids, parallelograms, rhombuses, stars, and crosses, and multi-leaves such as four-leaf, three-leaf, and two-leaf types. As shown in FIG. 2, if the shape of the support 2 is such that a cut is formed on at least one side of the polygon including a rectangle and a square, it is difficult for the adhesives to adhere to each other at the time of application and that the facing is difficult to peel off. This is more preferable because a situation can be prevented.

In the case of the present invention, the corners 5a, 5a, 5a of the triangle are rounded as shown in FIG. 3, and the vertices 6a, 6b, 6b, 6b are located in the middle of the three sides 5b, 5b, 5b.
a, 6a has a triangular shape toward the center of the triangle,
Furthermore, notches 6, 6, 6 with roundness are formed at the vertices 6 a, 6 a, 6 a, and three sides 5 b, 5 b,
5b also has a rounded shape at the corners formed by the cutouts 6, 6, 6 and, as shown in FIG. 4, in the shape shown in FIG. Two each on four sides, rounded at each corner,
As shown in FIG. 5, in the shape shown in FIG. 2, a notch 6 similar to the above is formed on each side using a hexagon instead of a square, and each corner is rounded. It can be suitably used.

Here, the shape of the cut is not particularly limited, and may be a cut or a cutout in an appropriate shape. The length (h in the figure) of the cut from the periphery of the support toward the inside is not particularly limited, but is preferably 5 to 50 mm, particularly preferably 10 to 30 mm. If the length is too short, the effect of the cut may not be sufficiently obtained. If the length is too long, the handleability at the time of sticking may be deteriorated or the support may be easily torn.

Further, in the case of the present invention, as shown in FIG. 2, when the corners 5a, 6a and the like of the support 2 are rounded,
Peeling or curling when applied to a curved portion can be more effectively prevented. Here, although the degree of roundness is not particularly limited, for example, roundness is represented by r, and r is the major axis a and the minor axis b.
When the a: b ratio indicates 1:
1000-1000: 1, preferably 1: 100-10
0: 1, more preferably 1:10 to 10: 1, and b is 1 mm or more, preferably 1 to 100 mm, more preferably 1 to 80 mm. Outside the above range, the effect of preventing peeling and turning-up due to the roundness of the corner of the patch when applied to the curved portion may not be sufficiently obtained.

In the case of the present invention, the proportion of the rounded corners is not particularly limited, but as shown in FIGS. When you attach
More effective.

Here, the size of the support 2 of the present invention is not particularly limited. However, in the case of the present invention, it is considered that the patch is prevented from being twisted or displaced when stored vertically. If it is large enough to be packed in a packaging material without folding when commercializing, considering that it is more useful, the longest diameter of the support is 300 mm or less, preferably 10 to 10 mm. 300 mm, more preferably 30
To 200 mm, and the area is 90,000 mm ² or less, preferably 500 to 90,0 mm.
00 mm ² , more preferably 1,500 to 20,000
mm ² is desirable.

The water-containing pressure-sensitive adhesive which is spread on one side of the support 2 and forms the water-containing pressure-sensitive adhesive layer 3 may be one which has been conventionally used as a water-containing pressure-sensitive adhesive (plaster) for a skin patch. Can be, for example, a water-soluble polymer compound, a curing agent,
A water-containing pressure-sensitive adhesive (plaster) in which a curing modifier, a mineral powder, a fragrance, a dye, water and the like are sufficiently kneaded can be used. Here, as the water-soluble polymer compound, for example, gelatin, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, sodium alginate, xanthan gum, Gum arabic, gum tragacanth,
Karaya gum, maleic anhydride copolymer, and the like. These can be used alone or in appropriate combination of two or more kinds. In the case of the present invention, in particular, polyacrylic acid and / or sodium polyacrylate and sodium carboxymethylcellulose are mixed with another polymer compound. It is desirable to use it.

The amount of the water-soluble polymer compound in the water-containing pressure-sensitive adhesive of the present invention can be appropriately selected depending on the type of the polymer compound to be selected and the degree of polymerization thereof.
1 to 40% by weight, preferably 3 to 30% by weight of the whole water-containing adhesive
%, More preferably about 5 to 20% by weight. If the amount is too small, sufficient cohesion may not be obtained, and if it is too large, the viscosity may be too high, leading to a decrease in productivity.

Next, the type of the curing agent is not particularly limited, and those which have been conventionally used for water-containing pressure-sensitive adhesives can be used. In the case of the present invention, the water-containing pressure-sensitive adhesive is used in the subsequent spreading step. From the viewpoint of uniformly applying the pressure-sensitive adhesive, those which act gradually rather than those which act immediately are preferable. As such a curing agent, for example, magnesium aluminate silicate, magnesium hydroxide alumina magnesium, magnesium metasilicate aluminate , Synthetic hydrotalcite, dihydroxyaluminum aminoacetate, etc., and these can be used alone or in an appropriate combination of two or more.

The amount of the above-mentioned curing agent in the water-containing pressure-sensitive adhesive of the present invention can be appropriately selected depending on the type thereof, the type of the water-soluble polymer compound used in combination, and the like. 005-3% by weight, preferably 0.
It is about 03 to 1% by weight. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, it may be difficult to adjust the curing speed.

The type of the curing regulator for controlling the curing by the curing agent is not particularly limited, and those which have been conventionally used for water-containing pressure-sensitive adhesives can be used. For example, citric acid, malic acid, tartaric acid, disodium edetate and the like can be mentioned, and these can be used alone or in an appropriate combination of two or more. The blending amount of the curing regulator can be appropriately selected, and usually, the amount of the curing regulator is 0.1% of the whole water-containing pressure-sensitive adhesive.
About 001 to 10% by weight is suitable. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, it may be difficult to adjust the curing speed.

The type of the mineral powder is not particularly limited, and those conventionally used for water-containing adhesives can be used. Examples of such a mineral powder include kaolin, bentonite, and the like. Montmorillonite, zinc oxide, titanium oxide, silicic anhydride and the like,
These can be used alone or in combination of two or more. The blending amount of the mineral powder can be appropriately selected, but is usually 5% by weight based on the total weight of the water-containing adhesive.
The degree is preferred. If the amount is too large, the water-containing pressure-sensitive adhesive may become too hard to spread.

The type of the fragrance is not particularly limited, and those which have been conventionally used as fragrances for water-containing adhesives can be used. Examples of such fragrances include anise, angelica, benzoin, immortel, Chamomile, garlic, cardamom, galvanum, caraway, carrot seed, guaiac wood, grapefruit, cypress, sandalwood, cedarwood, juniper, star anise, sage, geranium,
Celery, thyme, tarragon, turpentine, spruce, frankincense,
Violet, pine, parsley, birch, patchouli,
Rose, hyssop, fennel, black pepper, bodaige flower, myrrh, marigold, yarrow, lemon, lemongrass, rosemary, laurel, spirea,
Peach, cornflower, eucalyptus, yuzu, lavender and other herbal essential oils or extracts, other lower alcohols,
Aldehydes and the like can be mentioned, and these can be used alone or in an appropriate combination of two or more. The blending amount of the fragrance can be appropriately selected, but is usually preferably about 0.0001 to 1% by weight based on the whole water-containing pressure-sensitive adhesive. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if it is too large, skin irritation may occur.

The type of the dye is not particularly limited, and those conventionally used in water-containing pressure-sensitive adhesives can be used.
No. 3, Red No. 3, Red No. 102, Red No. 104, Red No. 10
No. 5, Red No. 106, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206
No., Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219
No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228
Red No. 230 (1), Red No. 230 (2), Red No. 231, Red No. 232, Red No. 401, Red No. 404
No., Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506
No. 4, Yellow No. 5, Yellow No. 5, Yellow No. 201, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 401, Yellow No. 402
No. Yellow 403 (1), Yellow No. 404, Yellow 405
No., Yellow No. 406, Yellow No. 407, Green No. 3, Green No. 20
No. 1, green 202, green 204, green 205, green 401, green 402, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204
No. Blue No. 205, Blue No. 403, Blue No. 404, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205
No., Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Brown No. 201, Purple No. 201
No. 1, Purple No. 401, Black No. 401, etc., and these can be used alone or in an appropriate combination of two or more. The amount of the dye can be appropriately selected, but is usually 0.00000 with respect to the entire water-containing pressure-sensitive adhesive.
5 to 0.1% by weight, particularly 0.0001 to 0.01% by weight
The degree is preferred. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, the color tone may be too strong. In addition, when blending the pigment in the water-containing adhesive,
It is preferable to dissolve the pigment in water, oils and fats, alcohol and the like, and then knead it with other components so that the coloring and the spotting of the pigment do not occur when the water-containing pressure-sensitive adhesive is spread.

The water-containing pressure-sensitive adhesive of the present invention is particularly effective when a medicinal component is further added in addition to the above-mentioned components. The types of medicinal ingredients that can be blended are not particularly limited. For example, allantoin, methyl salicylate, glycol salicylate, indomethacin, ketoprofen,
Flurbiprofen, ibuprofen, diclofenac sodium, mefenamic acid and its derivatives, flufenamic acid and its derivatives, bufexamac, ibufenac, alclofenac, prednisolone, hydrocortisone acetate, dexamethasone, l-menthol, dl-
Camphor, crotamiton, diphenhydramine hydrochloride, chlorpheniramine maleate, thymol, tocopherol acetate, vanillyl amide nonylate, naproxen, piroxicam, capsaicin, etc .; Herbal medicine dry extract, herbal extract such as assembly extract, herbal tincture such as arnica tincture, peppermint oil,
Essential oils such as cinnamon oil and the like can be mentioned. Of these, methyl salicylate, glycol salicylate, l-menthol, dl-camphor, thymol and the like, which are particularly easily volatilized, are useful. The above-mentioned medicinal ingredients can be used alone or in an appropriate combination of two or more. The compounding amount can be appropriately selected, but is usually about 0.01 to 20% by weight of the whole hydrous adhesive. Is preferred. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if it is too large, skin irritation may occur.

In the water-containing pressure-sensitive adhesive of the present invention, in addition to the above components, a humectant such as glycerin, sorbitol, propylene glycol, polyethylene glycol, polysorbate 80, polyoxyethylene hydrogenated castor oil, in addition to the above-mentioned components, are not impaired. And surfactants such as polyoxyethylene fatty acid esters can be added in appropriate amounts.

Furthermore, it is more preferable that the water-containing pressure-sensitive adhesive of the present invention further contains, in addition to the above-mentioned components, an animal or plant extract component having a function of imparting elasticity and flexibility by, for example, imparting moisture to the skin. Here, the animal and plant extracted component is a component of the living body of the animal and plant, and includes a component extracted from the animal and plant and a component obtained by synthesis. Examples of such animal and plant extract components include NMF-related components, acidic mucopolysaccharides, functional proteins, plant polysaccharides, natural polysaccharides, phospholipids, biological extracts, steroid compounds, plant extracts, sebum and keratinocytes Interlipid components or lipid components belonging thereto can be exemplified, and these can be used alone or in an appropriate combination of two or more.

More specifically, examples of NMF-related components include lactate, pyrrolidone carboxylate, glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, and asparagine. Acid, glutamic acid, arginine, histidine,
Examples include amino acids such as lysine and their derivatives, salts and the like, and urea. Examples of acidic mucopolysaccharides include sodium hyaluronate, sodium chondroitin sulfate, and heparin.

Further, functional proteins include, for example, collagen, elastin, keratin, soy protein, wheat protein,
Whey and the like, vegetable polysaccharides, for example, pectin, carrageenan, sodium alginate, trehalose, aloe extract, quince seed extract, rice bran extract, etc., as natural polysaccharides, for example, chitin derivatives, chitosan derivatives, phospholipids, For example, yolk phospholipids, soybean phospholipids, and the like, biological extracts such as placenta, ceramide, and the like, as steroid compounds,
For example, cholesterol, cholesterose ester, phytosterin and the like can be mentioned.

Examples of the plant extract include betaine, ashitaba extract, sensyaku extract, avocado extract, amacha extract, altea (below oil) extract, arnica extract, almond extract, aloe extract, aloe juice powder, ginkgo extract, Nettle extract,
Fennel extract, turmeric extract, age extract, gougon extract, oakaku extract, spinach extract, hypericum extract, scotch extract, dutch mustard extract, cuckoo extract, chamomile (chamomile) extract, kawagomugi extract, licorice extract, cucumber extract, kyounin extract, raspberry extract Extract, Kiwi extract, Kina extract, Gardenia extract, Kumazasa extract, Clara (Kudin) extract, Walnut shell extract, Clematis (Kobotduru) extract, Mulberry (Sohakuhi) extract, Grapefruit extract, Gentian extract, Gennoshoko extract, Tea extract, Comfrey ( Valerian extract, Burdock extract, Psychic extract, Sabonsou extract, Hawthorn extract, Sansho extract, Peony extract, Ubu root extract, shiitake mushroom extract,
Shikon extract, Perilla extract, Rosewood extract (Europea americana) extract, Spiraea biloba extract, Birch (birch) extract, Jio extract, honeysuckle extract, Aesculus extract, Sage (Salvia) extract, Siberian quinta (Ivy) extract, Sawberry hawthorn extract, Aesculus officinalis, Aesculus carp Extracts, Yarrow Extract, Common Menaceae Extract, Common Mistletoe Extract, Senkyu Extract, Assembly Extract, Common Mallow (Usvenia Mallow) Extract, Tassou (jujube)
Extract, Thyme (Wildzyme, Tachikosou) Extract, Cha Extract, Cha Dry Distillate, Clove Extract, Chimney Extract, Tubula Extract, Touki Extract, Calendula Extract, Towanin Extract, Spruce Extract, Tomato Extract, Tormentilla Extract, Dokudami Extract, Carrot Extract , Garlic extract, nobara extract, hamamelis (wich hazel) water, hamamelis extract, rose extract, parsley extract, Hioki sorghum (prolonged life grass) extract, loquat leaf extract, coltsfoot poppo extract, syllium extract, grape leaf extract, loofah extract, safflower extract, hop Extract, button extract, pine extract, horse chestnut (horse radish) extract, mukuroji extract, melissa extract, melilot extract, peach leaf extract, cornflower extract, saxifrage , Yuriekisu iodide garlic extract, Coix extract, mugwort extract, lavender extract, oil-soluble coix seed extract, licorice extract powder, licorice flavonoid, like rice bran ferment extract.

Further, the extract of animals and plants also includes allantoin and its derivatives.

In the case of the present invention, among these animal and plant extracts, NMF-related components, plant polysaccharides, plant extracts and the like are preferably used, and plant extracts are more preferably used.

The blending amount of the above-mentioned animal and plant extract components is not particularly limited, but is usually 0.0% of the total amount of the water-containing pressure-sensitive adhesive.
01 to 15% by weight, preferably 0.01 to 10% by weight,
More preferably, it is 0.01 to 5% by weight. If the amount is too small, the moisturizing property may be sufficiently improved and the effect may not be sufficiently maintained. If the amount is too large, the effect of further compounding may not be obtained.

It is more preferable to add an oily component to the water-containing pressure-sensitive adhesive of the present invention because the oily component in the water-containing pressure-sensitive adhesive can seal the skin and prevent the evaporation of water. Examples of such oily components include oils and fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, silicone oils, and the like.
These can be used alone or in combination of two or more. Specifically, examples of fats and oils include olive oil, camellia oil, macadamia nut oil, castor oil, hazelnut oil, grape seed oil, safflower oil, corn germ oil, sunflower oil, sweet nut oil, rosehip oil, avocado oil, apricot kernel Oil, sasanqua oil, sweet almond oil, meadowhome oil, soybean oil,
Cottonseed oil, sesame oil, peanut oil, rapeseed oil, rice bran oil, rice germ oil, wheat germ oil, barley oil, grape seed oil, carrot oil, evening primrose oil, cocoa butter, linseed oil,
Examples include plant-derived fats and oils such as coconut oil, palm oil and clove oil, and animal-derived fats and oils such as mink oil and egg yolk oil.

Examples of the waxes include jojoba oil, beeswax, carnauba wax, candelilla wax and the like. Examples of the hydrocarbon include squalane, liquid paraffin, paraffin, petrolatum, ceresin and the like, and these may be derived from natural products or synthetic products. As higher fatty acids, capric acid, lauric acid,
Myristic acid, palmitic acid, stearic acid, isostearic acid, hydroxystearic acid, oleic acid, linoleic acid, ricinoleic acid, behenic acid, and the like.Examples of higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, and cetostearyl alcohol. , Stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, octyl alcohol, decyl alcohol, aralkyl alcohol, 2-hexyldecanol, 2-octyldecanol, decyltetradecanol, lanolin alcohol and the like.

Examples of the esters include isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate. , Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like. Examples of the silicone oil include methyl polysiloxane, stearoxymethyl polysiloxane, stearoxytrimethylsilane, methyl hydrogen polysiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, tetrahydrosiloxane Examples thereof include tetramethylcyclotetrasiloxane, methylcyclopolysiloxane, dodecamethylcyclohexasiloxane, methylphenylpolysiloxane, and trimethylsiloxysilicic acid.

In the case of the present invention, among these, the above-mentioned fats and oils, waxes, hydrocarbons and the like are preferably used, and furthermore, the skin is well adapted, the feeling of use is excellent, the irritation is small, and the safety is excellent. For this reason, plant-derived fats and oils, waxes, hydrocarbons derived from natural products and the like are more preferably used, and in particular, plant-derived fats and oils such as olive oil, castor oil and evening primrose oil, waxes such as jojoba oil, Hydrocarbons derived from natural products such as squalane are more preferably used.

The amount of the oily component is 0.001 to 15% by weight, preferably 0.01 to 10% by weight of the whole water-containing pressure-sensitive adhesive.
% By weight, more preferably 0.01 to 5% by weight. If the amount is too small, the moisturizing property cannot be sufficiently improved, and the effect may not be sufficiently maintained. If the amount is too large, the cohesive force of the water-containing pressure-sensitive adhesive may decrease.

It is more preferable to add an extract from seaweed to the water-containing pressure-sensitive adhesive of the present invention as an active ingredient having a sustained effect of improving moisturizing properties. Such seaweeds include, for example, Ulvaceae and Ulgonaceae (Gra).
ciariaceae), Acrophoridae (Gelidi)
aceae), Myrinaceae (Solieriacea)
e), Laminariaceae, Laminariaceae (Aliariaceae), Laminariaceae (Sargassaceae), Laminariaceae (Fuca)
ceae), Funori family (Gloiopeltidace)
ae), Monostromataceae
ae), Milliaceae (Codiaceae), Bossaceae (Bangiaceae), Gibberium (Gigart)
inaceae), Bonemiso (Bonnemaiso)
niaceae), Ibarnaceae (Hypneacea)
e), Nagamatsumoe (Chordariaceae),
Nervaceaceae, Durvilleaceae, Lessoniaceae (L
essoniacae and Rhodym (Rhodim)
enlaceae), and
These seaweed extracts can be used alone or in an appropriate combination of two or more.

The amount of the above seaweed extract is 0.001 to 20% by weight, preferably 0.001% by weight of the whole water-containing adhesive.
-15% by weight, more preferably 0.001-10% by weight
It is preferable that If the amount is too small, the moisturizing property cannot be sufficiently improved, and sufficient sustainability of the effect may not be obtained. If the amount is too large, no further effect can be expected.

The water content of the water-containing pressure-sensitive adhesive of the present invention is from 40 to 85% by weight, especially from 45 to 8% by weight of the whole water-containing pressure-sensitive adhesive.
It is preferably 0% by weight. If the water content is too small, the absorbability of the medicinal component will be poor, and the feeling of use will also be reduced. If the water content is too large, the adhesive will tend to sag and stain on the back.

The water-containing pressure-sensitive adhesive of the present invention can be produced by adding an appropriate amount of water together with the above components and kneading the mixture by a known method until the mixture becomes uniform.

In the case of the present invention, the gel strength of the water-containing pressure-sensitive adhesive (usually aged for one week to one month after kneading at room temperature) when it is spread on the support 2 to form the water-containing pressure-sensitive adhesive layer Has a gel strength of 5 mm ^-1 or more, preferably 2
0 to 100 mm ^-1 , more preferably 40 to 80 mm ^-1 ,
Particularly preferably, it is necessary to be 50 to 70 mm ^-1 . If the gel strength is too low, it is not possible to sufficiently prevent the skin patch from twisting or displacing due to backing of the support, curling, and vertical storage. If the gel strength is too high, the adhesive strength of the water-containing pressure-sensitive adhesive layer may deteriorate.

Here, the gel strength of the water-containing pressure-sensitive adhesive of the present invention can be determined as follows. That is, about 200 g of the water-containing adhesive was packed into a bottle having an inner diameter of 50 mm and a depth of 100 mm without any gap, and an acrylic rod having a diameter of 10 mm was loaded with a load of 3 mm.
The acrylic rod was inserted at 0 g at a penetration speed of 20 mm / min, and the distance x (mm) at which the acrylic rod was inserted was measured, and the gel strength was calculated by the following equation. The preparation and measurement of the sample are both performed at room temperature (15 to 25 ° C.). Gel strength = 1 x 100 (mm ^-1 )

The water-containing pressure-sensitive adhesive thus obtained is uniformly coated on the support by a known method,
The water-containing pressure-sensitive adhesive layer 3 can be formed. Here, the weight of the water-containing pressure-sensitive adhesive layer 3 is not particularly limited and can be appropriately selected, but is usually 5 to 30 g / 140 c.
It is preferred to be about m ² . If the layer thickness is too thin, the effect of applying the skin patch may not be sufficiently obtained, and if it is too thick, not only the feeling of use of the skin patch is impaired, but also the workability in the manufacturing process deteriorates. There are cases.

The facing 4 covering the surface of the water-containing pressure-sensitive adhesive layer 3 has a stiffness of 20 to 20 as a stiffness described in detail below.
It needs to be 150 mm, preferably 30-130 mm, more preferably 40-110 mm. If the softness of the facing 4 is too high, problems such as poor workability in the manufacturing process and easy handling of the patch occur, and the effects intended by the present invention cannot be obtained. On the other hand, when the softness is too low, the thickness of the facing 4 is inevitably too thin, and the volatilization of moisture or the like may not be sufficiently prevented.

Here, in the present invention, the method of measuring the softness can be determined by the following method based on the softness A method (45 ° Cantilever method) of JIS L 1085. That is, 2 cm × 20 per sample (facing)
5 cm specimens were taken in each of the vertical and horizontal directions, and placed on a smooth horizontal table with a 45 ° slope at one end using a cantilever type test apparatus, with the short side aligned with the baseline of the scale. Thereafter, the test piece is gently slid in the direction of the slope by an appropriate method, and when the center of one end of the test piece contacts the slope, the position of the other end of the test piece is read by a scale. The bending resistance is indicated by the extruded length (mm) of the test piece, each of the five sides was weighed, the average value in the vertical and horizontal directions was obtained, and the average value in the vertical and horizontal directions was further averaged. The value is defined as the bending resistance of the present invention.

For the facing 4 of the present invention, as long as the above softness can be obtained, a plastic film used for a normal skin patch can be used. A plastic material obtained at an appropriate thickness is suitable, and for example, polyester, polypropylene, polyvinyl chloride, polyvinyl acetate and the like can be suitably used. The thickness of the film is not particularly limited as long as the above-mentioned bristles are obtained, but in consideration of the object of the present invention, the thickness is 10 to 200 μm, preferably 20 to 150 μm, more preferably 30 to 120 μm. Is preferably used. If it is too thin, volatilization of moisture or the like may not be sufficiently prevented, and if it is too thick, not only the workability in the manufacturing process may decrease, but also the handling of the patch may deteriorate.

In producing the skin patch 1 of the present invention, a uniform water-containing pressure-sensitive adhesive layer 3 can be formed on one surface of the support 2 cut into the above-mentioned predetermined shape as described above. In consideration of the production efficiency in the case of mass production, an uncut support having a uniform water-containing pressure-sensitive adhesive layer 3 formed on one surface and covered with the facing 4 is used as an original sheet. It is desirable to cut into a predetermined shape.

Here, the skin patch 1 of the present invention is desirably packaged without being folded as described above for its commercialization, for example, for heels, elbows, knees, shoulders, and around the eyes. When two or four sheets are used as a unit, they are packed in a packaging material capable of maintaining airtightness and sealed. In this case, as the packaging material, the shape and material are not particularly limited as long as airtightness can be maintained, but a laminated film using aluminum is suitably used, and a three-sided seal or a four-sided seal is used when packaging a skin patch. Thereby, the sheet agent can be effectively sealed.

The skin patch of the present invention is not limited to the above-mentioned constitution, and may be variously modified without departing from the gist of the present invention.

Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

[Examples 1 to 5 and Comparative Examples 1 to 4] After kneading the plaster compositions shown in Table 1 by a conventional method, a non-woven fabric of needle-punched 100% polyester fiber was used as a support. 16 per 140 x 100 mm
g to form a water-containing pressure-sensitive adhesive layer, and then the surface was covered with a plastic film shown in Table 1 as facing to obtain a patch original sheet. Next, patches having the shapes shown in Table 1 were cut from the original patch sheet to obtain skin patches of Examples and Comparative Examples. In Table 1, the size of the skin patch is the length of each side (5b in the figure) of the original polygon, the notch depth is the length of h in the figure, and CPP is uniaxially stretched polypropylene, PET. Means polyethylene terephthalate, and OPP means biaxially oriented polypropylene.

[0057]

[Table 1]

For each of the above patches, the following methods were used to evaluate the sticking property, the longitudinal storage stability, and the handling property at the time of sticking. <Pasteability> The skin patch was evaluated for peeling and curling when applied to the heels of 10 adult female panelists for 6 hours according to the following evaluation criteria. Table 2 shows the results. Evaluation Criteria 5 Peeling and no turnover 4 The skin patch was slightly turned around 3 1/4 to 1/3 of the whole skin patch was turned 2 2/3 to 1/2 of the whole skin patch Part turned up 1 Skin patch peeled off

[0059]

[Table 2]

<Vertical Storage Test> The above skin patches were enclosed in a bag made of a polyethylene / aluminum foil laminated film as a set of two skin patches, and kept standing for one month at a temperature of 50 ° C. Stored (test performed at n = 5). The condition of each skin patch after storage was observed and evaluated according to the following evaluation criteria. Table 3 shows the results. In addition, in the case of Comparative Example 2, although the result of the vertical storage test was good,
Workability was poor. Evaluation Criteria 5 Wrinkles and twists were not found at all. 4 Slight wrinkles and twists were found. 3 Wrinkles and twists were found but were usable. 2 Significant wrinkles and twists were found. Unusable condition 1 Unusable condition due to severe wrinkles and twists

[0061]

[Table 3]

<Handling test at the time of application> The above-mentioned skin adhesive was evaluated according to the following evaluation criteria for the ease of application when 10 adult female panelists applied to the heel.
Table 4 shows the results. Evaluation criteria 5 It was very easy to stick 4 It was easy to stick 3 It was difficult to stick 2 It was very difficult to stick 1 The plasters stuck together and could not stick

[0063]

[Table 4]

[0064]

EFFECT OF THE INVENTION The skin patch of the present invention has good adhesiveness even when applied to a curved portion, and not only does not peel off or turn up, but is also stored vertically, for example, at the time of display at a sales floor. Also, the commercial value is not reduced due to twisting and displacement, the workability at the time of manufacture, the handling of the patch is also good, for example, for the purpose of keratinization treatment and moisturizing, heel,
It is useful as a skin patch to be applied to curved parts such as elbows, knees, shoulders and around the eyes.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of a skin patch illustrating a first configuration example of the present invention.

FIG. 2 is a plan view of a support of the skin patch.

FIG. 3 is a plan view of a support for a skin patch of the second configuration example of the present invention.

FIG. 4 is a plan view of a support for a skin patch of a third configuration example of the present invention.

FIG. 5 is a plan view of a support for a skin patch of a fourth configuration example of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Skin patch 2 Support 3 Hydrous adhesive layer 4 Facing 5a Corner 6 Notch (notch)

Continued on the front page F term (reference) 4C076 AA73 AA74 AA77 AA78 BB31 CC18 DD28 DD28A DD30A DD37T DD38 DD38A DD45A DD49A DD59A EE06A EE09A EE23A EE32A EE42A FF36 GG11

Claims (3)

[Claims] 1. A skin patch wherein a water-containing pressure-sensitive adhesive layer is formed on one surface of a support, and the surface of the water-containing pressure-sensitive adhesive layer is covered with facing, and the gel strength of the water-containing pressure-sensitive adhesive layer is 5 m.
m ⁻¹ or more, and the rigidity of the facing is 20
皮膚 150 mm, and the support is irregular in shape. 2. The skin patch according to claim 1, wherein the support has a shape in which a cut is formed on at least one side of a polygon. 3. The skin patch according to claim 1, wherein a corner of the support is rounded.