JP2000086449A - Scalp-improving hair tonic, and hair-mother cell- improving hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject hair tonic designed to activate hair-mother cells and capable of manifesting hair-fostering and hair-growing activities as a synergetic effect of inhibition of testosterone, inhibition of lipase and the like by constituting the hair tonic of materials comprising a testosterone- inhibiting material, a lipase-inhibiting material or the like, and acting on and improving the surface of the scalp. SOLUTION: This hair tonic is composed of materials comprising at least three kinds of a testosterone-inhibiting material (e.g. Scutellaria root extract, Aloe and Glycyrrhiza extract), a lipase-inhibiting material (e.g. Sapindus mukurossi and Glycyrrhiza extract), a lipid peroxide-inhibiting material (e.g. Scutellaria root), a dermal secretion-inhibiting material (e.g. fucus, vitamin B6, royal jelly), and a material for normalizing the isoelectric point (e.g. hinokitiol, vitamin B complex and Glycyrrhiza component), and acting on and improving the surface of the scalp.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growing / hair-growing agent using plant-derived components, and more particularly to a combination of two hair-growing agents useful for improving the scalp and activating hair matrix cells. It relates to a hair restorer.

[0002]

2. Description of the Related Art Various hair nourishing agents for improving the scalp have been researched and released. And, as cosmetics, it stimulates the scalp, improves blood circulation in the scalp, enhances skin function, makes the hair roots tonic (TONIC), and furthermore, by its bactericidal activity, reduces bacterial and scalp diseases from bacterial diseases. An important cosmetic that protects hair is tonic.

[0003]

In general, in the case of symptoms such as thinning of the hair, the hair growth effect is not recognized even when the above hair growth agent is used, or when the scalp itself is weak and allergic, the hair growth agent is used. Because of the synthetic chemical components contained in
Many had side effects and problems. In addition, hair tonics have a refreshing sensation because they are based on 40-90% alcohol, but the hair growth effect cannot be expected at present. In general, fluctuations in the secretion of sebum are closely related to the keratinization of the epidermis (that is, keratinization), and the regulation of secretions is hormones such as testosterone (male hormone), estrogen (estrogen hormone), pituitary hormone, and kidney. It is known that there is a close relationship with cortical hormones and the like. Especially in sebaceous glands and hair follicles, the secretion of testosterone, a male hormone, and its reduction (metabolism)
It is believed to be dependent on the production of the type of dehydrotestosterone and the like. That is, abnormally increased production of dehydrotestosterone is linked to increased secretion of sebum, and the result is thought to be one of the triggers for seborrheic dermatitis, seborrheic alopecia or acne vulgaris . In addition, testosterone 5α-reductase (TSR), which is an enzyme, is very involved in the production of dehydrotestosterone and the like. Therefore, in the present invention, in particular, a hair restorer containing a substance having a component having an inhibitory effect on testosterone 5α-reductase (TSR) production has been developed to prevent abnormal production of dehydrotestosterone. The purpose is. For hair growth, if the condition of the scalp cannot be improved, the effect cannot be expected even if a substance having a component having a testosterone 5α-reductase (TSR) production inhibitory action is used. Therefore, the present invention also provides a scalp improving hair restorer containing a substance which improves scalp from the viewpoint of lipase inhibition, suppression of lipid peroxide, suppression of sebum secretion, normalization of isoelectric point, and the like. is there.

[0004]

BEST MODE FOR CARRYING OUT THE INVENTION The term "improvement of action on the scalp surface" referred to in the present invention means that lipase is inhibited, the production of free fatty acids is prevented from increasing, and the suppression of lipid peroxide (antioxidant / SOD-like activity) is given. Decomposition of sebum, suppression of excessive sebum excretion, formation of saturated solution of unsaturated fatty acids. Normalization of isoelectric point (weak acid) .. Anti-allergic (hyaluronta) that cleanses the scalp by sterilization, anti-inflammatory, and astringent action. Inhibition). Activation of a hair matrix (hair matrix) in the present invention means activation of cells, activation of hair roots, hair follicles, scalp and hair matrix promotion, hair growth promoting action by the activity of enhancing enzymes, 5α- Reductase inhibitory activity (anti-5α-DH against male hormones)
T action) promotion of keratinization (keratinization) and promotion of amino acid synthesis. Decomposition of sebum, suppression of excessive sebum content ・ ・ Saturated solution of unsaturated fatty acids, hair growth, hair loss prevention, hair growth due to anti-inflammation around hair root and scalp, supply of nutrients ・ Promotion of blood flow, Blood supply, activation of nutrient metabolism, promotion of blood circulation of skin, enhancement of oxidative function, hair growth by vasodilation, etc.,
Hair loss prevention, hair growth and the like. Testosterone inhibitory substance of scalp improving hair restorer
Aloe, licorice extract, clove, hibamata and the like can be mentioned. Examples of the testosterone inhibitory substance of the hair matrix improving hair restorer include licorice extract, clove, carrot extract, carrot extract, emicou, sansho, nicotinic acid and the like. Substances that improve the effect on the scalp surface include vitamin B complex, natural vitamin E, dokudami, mukuroji, nicotinic acid, yeast, royal jelly, and the like. Carrot extract, NMF (amino acids, etc.) are used as hair matrix improving hair restorer , Vitamin B complex and the like. By using both of these hair restorers, a synergistic effect can be expected.

[0005]

Embodiment 1 An embodiment 1 (corresponding to claim 1) of the present invention will be described with reference to FIGS. First, this example is a hair tonic containing an effective substance for improving the scalp. FIG. 1 is a conceptual diagram showing scalp care for improving the hair growth effect. The component ratio in 100 ml of the scalp improving hair restorer of the present invention is described below. Ougon 0.4 ml Aloe 0.4 ml Licorice extract 1.0 ml Clove 0.2 ml Melissa 1.5 ml Dokudami 1.0 ml Mukuroji 0.1 ml Vitamin B6 0.4 ml Natural vitamin E 0.25 ml 0.2 ml seaweed (Hibamata) 0.3 ml royal jelly 1.5 ml yeast 0.02 ml nicotinic acid 0.2 ml hinokitiol 0.25 ml Here, each component will be described. Ougon: SOD-like activity, anti-inflammatory, antioxidant Aloe: 5α-reductase inhibitory, sun protection, moisturizing, cell activating, anti-inflammatory Licorice extract: β-glycyrrhizic acid, dipotassium glycyrrhizinate The closed flower buds and dried buds of the small conical symmetrical evergreen tree belonging to it are crisp and strong aromatic flavors. Melissa: Hair growth, antioxidant, blood flow promoting and effective. Melissa: Perennial herb of Lamiaceae. Promotes sweating and digestion. Japanese name Western Yamakka Dokudami: A perennial herb in the family of the swelling family. Leaves are effective when affixed to tumors. Vegetable B6: Hair growth, prevention of hair loss, improved activation of hair root function, prevention of skin disorders, softening of keratin Natural vitamin E: nourishes scalp Prevents lipid peroxidation, tissue Suppresses the breakdown of vitamin A in the body, anti-inflammatory,
Helps heal wounds, protects cell membranes, and inhibits nitrosamine form. Menthol: Seaweed Inflammation Seaweed (Hibamata): A reaction between halogens, mainly iodine, and unsaturated fatty acids, which is a saturated solution of fatty acids. Hair growth effect by action, abundant minerals, affect metabolism, destruction and absorption of pathological tissues and contribute to regeneration of healthy cell tissues, penetrate into epidermis and hair, suppress water release In addition, it has the effect of regulating the outside air temperature and keeps moisture. Royal jelly: A protein complex containing high vitamin B. Yeast: Fermentation action, ie, decomposes sugar into alcohol and carbon dioxide. Nicotinic acid: Peripheral vasodilator action, blood circulation promotion action. Involved in nutrient supply and energy metabolism to hair cells, promoting hair growth, preventing rough skin, and preventing inflammation of the skin. Le: A tropolone compound contained in the essential oil of Hiba and Taiwan cypress, which is used as a bactericide due to its broad antibacterial spectrum, and many clinical cases have been observed for its hair growth effect. Substances include gongon extract, aloe, licorice extract, clove, hibamata, etc., and the lipase inhibitor is mukuroji, licorice extract,
As a substance that inhibits lipid peroxide, it is gongon, as a substance that inhibits sebum secretion, is Hibamata, biamine B6, royal jelly, and as a substance that normalizes the isoelectric point (weakly acidic), it is hinokitiol, a vitamin B complex, a licorice component, a natural vitamin. E and so on.

[0006] Such a hair restorer is used for the following five people.
As a result, surprisingly, everyone had some effect
Was.Type age sex Symptoms Passage  ・ Seborrheic hair loss 23-year-old female 5 years before the top of the head Hair loss was reduced on the 10th day Hair loss was increased on the 30th day Hair grew on the 30th day Hair growth on the 75th day ・ Male-type hair loss 40-year-old male 9-year-old head Hair loss increased on day 10 Hair loss increased on day 30 Gray hair turned brown on day 30 Hair growth on day 60 ・ Male hair loss 64 years old Male 9 years ago on top of head more than 10 years Hair loss decreased on day 10 Hair loss on day 30 Brown hair on day 30 Hair growth on day 60-Seborrheic alopecia 56-year-old male 10-year-old parietal hair on the 27th day Black short hair develops on the 27th day Settled 6 months after transplantation Suppuration Hair growth, good results Overall hair loss scalp redness (see FIG. 2 (b)) (see FIG. 2 (a)) This will be described with reference to FIG.
First, the present Example shows an effect substance on the activation of hair matrix cells.
FIG. 3, which is a hair-containing hair restorer, shows 3
It is the conceptual diagram demonstrated from two viewpoints. The present invention hair mother
Describe the component ratio in 100 ml of activated hair restorer
You. Confectionery 0.5 ml Citrus quista 0.25 ml Licorice extract 0.5 ml Clove 0.1 ml Odorikosou 0.3 ml NMF 0.25 ml Dokudami 0.5 ml Mukuro 0.05 ml Burdock 0.1 ml Vitamin B6 0.2 ml Natural vitamin E 0.1 ml Assembly 0.25 ml Menthol 0.15 ml Seaweed (Hibamata) 1.0 ml Royal jelly 1.0 ml Yeast 0.01 ml Carrot 0.25 ml Pine 0.1 0.1 ml nicotinic acid 0.1 ml Hinokitiol 0.1 ml Chlorella 0.5 ml Clara 0.1 ml Emmeisorum 0.5 ml Arnica 0.1 ml Touki 0.5 ml Rosemary 0.25 ml Sansho 0.1 ml chamomile 0.2 ml takanal (photosensitizer) 0.01 ml where one component One will be described (Example 1
Are omitted). Conflict: Anti-inflammatory, cell activating effect
Nodal action NMF: Moisturizing effect Burdock: Antiseborrheic effect, moisturizing effect, dandruff / hair loss
Anti-carrot: shows strong anti-inflammatory effect on scalp
At the same time, it penetrates directly into the pores to eliminate waste and
Eliminate excess water to restore scalp and hair to normal. Hair
The effect of dilating blood vessels and increasing blood flow is very strong. Prolapse
Not only does it slow down hair, it also prevents hair from whitening,
Protects against dihair. Prevents dry skin. Pine: Hair growth and blood flow promotion effects Chlorella: High protein content and amino acids
Contains moisturizing and metabolism-promoting action that contains a lot of lysine etc. Clara: Promotes hair growth, antibacterial action.
Enlarges capillaries, suppressing the generation of scalp microbes
Nourish hair roots and promote hair growth. Arnica: Remove subcutaneous hyperemia and regenerate tissue
To promote S. pyogenes from sweat glands and sebaceous glands on the skin
Staphylococcus invades the skin and causes rapid
And malignant swelling) and acne are also effective. Touki: Shows a sedative effect on the scalp and vitamin B
And biotin promotes hair growth. Rosemary: Bacteriostatic, antiperspirant, SOD-like effects Sansha: Testosterone 5α reductase inhibition
Action, seborrheic as seen by hormonal modulation
Prevents hair loss associated with skin (acne) and seborrheic scalp / hair.
Indicating licorice extract, assembly, sansho
There are cormorants, butterflies, etc.

[0007] Such a hair restorer is used for the following four people.
As a result, almost everybody had some effect similar to the first embodiment.
Admitted.Type age sex Symptoms Passage  ・ Circular, 49-year-old woman 25 years ago, total hair loss on the 26th day, hair loss on the frontal hair on the 26th day, alopecia partial white short hair, and the amount of hard hair on the 62nd day increased (see FIG. 4 (a)). It is becoming denser on the 220th day (see Fig. 4 (b))-Male-type male 5 years ago Frontal hair on the 67th day Hair loss occurred on the 67th day Forehead, anterior apical hair loss on day 60 Seborrheic 36 years old Sparse hair loss Hair growth on day 84 ・ Pityless hair loss Male 6 months ago Totally unchanged until 4 days 20 years old Many hair loss 25 days on hair loss Hair growth

Example 3 The use of both the above Example 1 and Example 2 agents provides
It can be expected to have a further multiplicative effect.
Used for several months to obtain data.Type age sex Symptoms Passage  -Male type 45-year-old male Frontal, frontal, occipital 72 days hair loss, hair loss overall. Wig use Multiple / Pitylessness 29-year-old male 5 years ago, anterior crest 108 days, multiple hairs, seborrhea, occipital hair loss Others, vellus hair 161 days, good growth, curly hair 185 days, 9cm diameter (see Fig. 5 (a)) (See Fig. 5 (b)) ・ Circular 24-year-old female Two years ago, monetary size-reduced hair loss on day 79 (malignant) Many up to pediatric palm size Short hairs occurred in one place Hair loss increased again on day 135 270 days Almost part of the circular hair growth-Male type 31-year-old male 7 years ago, hair loss on the front of the head 7 days Reduction of hair growth on the 20th day Hair growth per day on the 60th day-Male type 18-year-old male 7 days after birth 20 days Eye pores are conspicuous Circular (malignant) Partial hair loss is repeated Biman hair growth on day 45
It is inferred that there is a synergistic effect of both hair nourishes.

As described above, the scalp improving hair restorer and the hair matrix active hair restorer of the present invention protect the condition of the scalp from drying and inhibit sebum by inhibiting lipase, suppressing lipid peroxide, By suppressing secretory substances and inhibiting testosterone, the hair matrix is activated, and as a synergistic effect thereof, hair growth and hair growth effects are recognized.

[Brief description of the drawings]

FIG. 1 is a conceptual diagram showing scalp care by a scalp improving agent of the present invention.

FIG. 2 is an explanatory view showing the state of the scalp before and after use of the scalp improving agent of the present invention, wherein (a) shows a state before treatment and (b) shows a state after treatment for 73 days.

FIG. 3 is a conceptual diagram illustrating the hair matrix activity of the hair matrix active hair restorer of the present invention from three viewpoints.

FIG. 4 is an explanatory view showing the state of the scalp before and after use of the hair matrix active hair restorer of the present invention, wherein (a) shows a state before treatment and (b) shows a state after treatment for 220 days.

FIG. 5 is an explanatory view showing the state of the scalp before and after using both the scalp improving agent and the hair matrix active hair restorer of the present invention, wherein (a) shows the state before treatment and (b) shows the state after treatment for 185 days.

Claims (2)

[Claims] 1. A testosterone inhibitory substance, a lipase inhibitor, a lipid peroxide inhibitor, a sebum secretion inhibitor,
A hair restorer comprising a substance that improves the action on the scalp surface and contains at least three or more isoelectric point normalizing substances 2. A hair restorer comprising a testosterone-inhibiting substance and a substance that improves the action on hair mother cells.