JP2000069935A - Health food capable of preventing atopic dermatitis - Google Patents
Health food capable of preventing atopic dermatitisInfo
- Publication number
- JP2000069935A JP2000069935A JP10287208A JP28720898A JP2000069935A JP 2000069935 A JP2000069935 A JP 2000069935A JP 10287208 A JP10287208 A JP 10287208A JP 28720898 A JP28720898 A JP 28720898A JP 2000069935 A JP2000069935 A JP 2000069935A
- Authority
- JP
- Japan
- Prior art keywords
- atopic dermatitis
- food
- health food
- preventing
- preventing atopic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【0001】[0001]
【発明の属する技術分野】この発明は、アトピー性皮膚
炎になりやすい子供がアトピー性皮膚炎になるのを予防
するための保健食品の作り方に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method of preparing a health food for preventing a child susceptible to atopic dermatitis from developing atopic dermatitis.
【0002】[0002]
【従来の技術】アトピー性皮膚炎にかかる恐れの有る子
供が毎日食べ続けることでアトピー性皮膚炎にかかりに
くくなるアトピー性皮膚炎発病予防効果のある保健食品
には、従来より米や牛乳などの食品に加水分解処理を加
えて蛋白質を変化させてアレルギーの原因となる蛋白質
の抗原性を低下させた低アレルゲン食品が有ったが、製
造コストが高く、製品の風味・味覚が著しく損なわれる
欠点が有った。2. Description of the Related Art Health foods for preventing the onset of atopic dermatitis, which are less likely to be affected by atopic dermatitis when a child who is susceptible to atopic dermatitis eats daily, include rice and milk. Some low-allergen foods have reduced the antigenicity of proteins that cause allergies by changing the protein by hydrolyzing the food, but the manufacturing cost is high and the flavor and taste of the product are significantly impaired. There was.
【0003】[0003]
【発明が解決しようとする課題】本発明では、食品を加
水分解で低アレルゲン化する事なくアトピー性皮膚炎の
発症を予防する効果のある保健食品を作った。従来より
乳幼児や子供の食べるものは衛生的で無菌であるべきと
の見解が強く納豆・ヨーグルト等の一部の食品を例外と
して、子供用の食品に生きた細菌類を添加する事は避け
られていた。乳酸菌を用いた食品であるヨーグルトが便
秘の改善に有用との認識は既に有ったが、ヨーグルトは
牛乳の蛋白質を豊富に含むために逆にアレルギーを引き
起こす可能性が有る為、アトピー性皮膚炎の予防の目的
では使用できなかった。SUMMARY OF THE INVENTION According to the present invention, a health food having an effect of preventing the onset of atopic dermatitis without hydrolyzing the food to reduce the allergen is produced. There has been a strong view that infants and children eat foods that should be sanitary and sterile, and the addition of live bacteria to foods for children has been avoided, with the exception of some foods such as natto and yogurt. I was Although it was already recognized that yogurt, a food containing lactic acid bacteria, is useful for improving constipation, atopic dermatitis because yogurt may cause allergies due to its high protein content in milk Could not be used for the purpose of prevention.
【0004】[0004]
【課題を解決するための手段】請求項1、の育児用粉ミ
ルク中に生きた乳酸桿菌属乾燥抽出物を配合して作るア
トピー性皮膚炎を防ぐ保健食品とは、乳酸桿菌属を人工
的に培養増殖させて生きたままで乾燥させた物を、一般
に使われている粉末の育児用粉ミルク200g当たりに
ビフィズス菌を概数で100億個から10億個、アシド
フィルス菌を10億個から1億個程度含むように配合し
た育児用の粉ミルクの事である。The health food for preventing atopic dermatitis, which is prepared by blending a live extract of Lactobacillus in infant formula milk powder according to claim 1, is a Lactobacillus spp. Cultured, grown and dried alive, approximately 10 to 1 billion Bifidobacteria and 1 to 100 million Acidophilus bacteria per 200 g of commonly used powdered infant milk powder It is a powdered milk for childcare formulated to contain.
【0005】請求項2、の離乳食等の食品中に生きた乳
酸桿菌属乾燥抽出物を配合して作るアトピー性皮膚炎を
防ぐ保健食品とは、離乳食などの幼児用の食品やその他
の食品中に、前記と同様に製造した乳酸桿菌属乾燥抽出
物を混合して食事毎にビフィズス菌を概数で100億個
から10億個、アシドフィルス菌を10億個から1億個
程度含むように混合して作る保健食品の事である。The health food for preventing atopic dermatitis produced by blending a live extract of a lactobacillus with a food such as a baby food according to claim 2 is intended to be used in foods for infants such as baby food and other foods. Then, the dried extract of Lactobacillus genus produced in the same manner as above was mixed and mixed so as to contain approximately 10 to 1 billion bifidobacteria and about 1 to 100 million acidophilus for each meal. Health food.
【0006】請求項3、の食品中に配合して使用するた
めの乳酸桿菌属乾燥抽出物から成るアトピー性皮膚炎を
防ぐ保健食品とは、あらかじめ混入する食品を限定せず
にビフィズス菌、アシドフィルス菌などの乳酸桿菌属を
人工的に培養増殖させて、ビフィズス菌を概数で100
億個から10億個、アシドフィルス菌を10億個から1
億個程度含むように生きたままで乾燥させてドライパウ
ダー、固形等の形状にした製品で、食事と同様に摂取す
る事でアトピー性皮膚炎を防ぐ効果を発揮する保健食品
の事である。こうして作られた製品では食品が本来持つ
味や風味がほとんど損なわれる事がなく、また製造コス
トも比較的に安価で、従来から行われていた食品中の蛋
白質を加水分解して低アレルゲン化処理することの持つ
欠点を解決できた。[0006] The health food for preventing atopic dermatitis comprising a dried extract of Lactobacillus for use in the food according to claim 3 is a bifidobacterium, an acidophilus, without limiting the food to be mixed in advance. Lactobacillus genus such as bacteria is artificially cultured and grown, and the number of bifidobacteria is approximately 100.
From 1 billion to 1 billion, and from 1 billion to 1
It is a health food that is dried alive to contain about 100 million pieces and is made into a form such as dry powder or solid. It is effective in preventing atopic dermatitis when ingested in the same manner as a meal. Products made in this way have little impairment of the original taste and flavor of the food, are relatively inexpensive to manufacture, and have been conventionally processed to hydrolyze proteins in foods to reduce allergens. The disadvantages of doing were solved.
【0007】[0007]
【発明の実施の形態】本発明の実施の方法について、発
明者の勤務する皮膚科・小児科医院での実際のアレルギ
ー予防用保健食品としての使用実験を基に説明する。静
岡県焼津市でアトピー性皮膚炎の治療を専門としている
『西焼津こどもクリニック』で、両親あるいは兄弟にア
レルギー歴が有る事から将来かなり高い確率でアトピー
性皮膚炎を発症すると予想された乳児湿疹を持つ2歳未
満の子どもの対象群に、育児用粉ミルクを調整する時に
先に述べたように粉ミルク200g中にビフィズス菌を
概数で100億個から10億個、アシドフィルス菌を1
0億個から1億個程度含むようにドライパウダーにした
ヒト腸内細菌類を配合して毎日続けて飲用させた。同様
に家族歴・病歴から高率にアトピー性皮膚炎を発症する
と予想された幼児の食べる食品の中に前項の2)で述べ
たように生きた乳酸桿菌属の乾燥抽出物を混入させて毎
日食べさせ続けた。母乳栄養を行っている場合には前項
の3)で述べたような乳酸桿菌属乾燥抽出物を授乳時に
直接乳首に付けて毎日与えた。与える量は1日量換算で
ビフィズス菌を500億個、アシドフィルス菌を50億
個程度摂取するようにした。BEST MODE FOR CARRYING OUT THE INVENTION A method for carrying out the present invention will be described based on an experiment of using it as a health food for preventing allergies at a dermatology / pediatric clinic where the inventor works. Nishi-Yaizu Child Clinic specializes in the treatment of atopic dermatitis in Yaizu City, Shizuoka Prefecture. As described above, when preparing infant formula for infants under 2 years old, approximately 200 to 1 billion bifidobacteria and 1 billion acidophilus bacteria per 200 g of milk powder were prepared.
Human powdered intestinal bacteria in a dry powder form was added so as to contain about 100 million to 100 million pieces, and the drink was continuously taken every day. Similarly, a live extract of Lactobacillus spp. As described in 2) in the previous section is mixed with foods to be eaten by infants who are expected to develop atopic dermatitis at a high rate based on family history and medical history. I continued to eat. When breastfeeding was carried out, a dry extract of the genus Lactobacillus as described in 3) above was directly attached to the nipple during lactation and given daily. The amount given was such that about 50 billion bifidobacteria and about 5 billion acidophilus bacteria were ingested on a daily basis.
【0008】実験で用いたヒト腸内細菌類は、概ね上記
のような配合比率の生きた乳酸桿菌を混合してドライパ
ウダーの形状で乾燥させて保管しておき、使用の直前に
開封してミルクあるいは離乳食中に混合して、あるいは
母親の乳首に授乳時に付着させて使用した。[0008] The human intestinal bacteria used in the experiments were mixed with live lactobacilli having the above-described composition ratio, dried and stored in the form of dry powder, and opened immediately before use. Used in milk or baby food, or applied to mother's nipples during lactation.
【0009】[0009]
【発明の効果】家族中にアレルギー疾患の病歴を持つ人
の数が多いほど次に生まれた子どもがアレルギー疾患を
発病する確率が高くなることは既に広く認められてい
る。両親のいずれか一人にアレルギー疾患を経験した人
がいる場合に子どもがアレルギー疾患を発病する確率は
およそ40%程度、両親の両方にアレルギー疾患を認め
る場合には子どもがアレルギー疾患を発病する確率はお
よそ50%程度との認識が一般的である。今回実験対象
とされた子どもの群は、両親兄弟のいずれか一名以上に
アレルギー疾患を有する人がいる場合と、乳児期早期に
全身性に重症の湿疹病変を認めており、しかも2週間の
ステロイド剤を含む外用療法で症状の改善を認めなかっ
た2歳未満の乳児で、体の顔面頭部、胸腹部、背臀部、
上肢、下肢の5カ所のうち最低2カ所以上の皮膚に左右
対称性の湿疹病変を有する子どもの集団であった。この
集団中の将来のアトピー性皮膚炎発病確率を40%以上
と予測することには十分な妥当性がある。It has been widely accepted that the greater the number of people in the family who have a history of allergic disease, the higher the probability that the next child will develop the allergic disease. The probability of a child developing an allergic disease is about 40% if one of the parents has experienced an allergic disease, and the probability of a child developing an allergic disease if both parents have an allergic disease It is generally recognized that it is about 50%. The group of children studied in this study included one or more of the parents and siblings who had an allergic disease, and one who had systemic severe eczema lesions early in infancy and had a two-week period. Infants under 2 years of age who did not improve their symptoms with topical therapy including steroids, face head, thoracoabdomen, back hips,
This group consisted of children with bilaterally symmetric eczema lesions on at least two or more of the five upper and lower limb skins. Predicting the future probability of developing atopic dermatitis in this population at 40% or more is well-validated.
【0010】この将来40%以上の確率でアトピー性皮
膚炎を発病すると予想された子どもの群に対して請求項
目1、2、3の食品を発明の実施の形態のところで述べ
た方法で毎日与えて観察を続けたところ、半年以上の観
察期間で、対象群105中でわずか9名8.6%の子供
の皮膚にアトピー性皮膚炎の症状が見られただけで、他
の大多数の子供のアトピー性皮膚炎の発病を予防でき
た。本発明では食品に加水分解等の処理を加える事な
く、子供のアトピー性皮膚炎の発症を予防する食品を作
る事ができた。子供のアトピー性皮膚炎の発症の原因に
ついては食品の影響が大であることは既に指摘されてい
たが、現在まで有効な解決策は知られていない。本発明
は従来のアトピー性皮膚炎予防用食品の持つ欠点を解決
して、食品の風味・味覚を損なう事なく安価かつ大量に
アトピー性皮膚炎を防ぐ食品を製造する事を可能にし
た。この事は現在まだ治療法さえ確立されていない子供
のアトピー性皮膚炎を発症以前に予防することで医療費
の抑制・薬剤使用量の削減等の経済的効果を始め、教育
的効果、産業振興的効果、保健的効果が期待できる。[0010] The group of children expected to develop atopic dermatitis with a probability of 40% or more in the future are given the foods of claims 1, 2 and 3 daily by the method described in the embodiment of the invention. In the observation group for more than half a year, only 8.6% of the children in the control group 105 showed symptoms of atopic dermatitis on the skin, and the majority of other children Was able to prevent the onset of atopic dermatitis. According to the present invention, it is possible to produce a food which prevents the development of atopic dermatitis in children without adding a treatment such as hydrolysis to the food. It has already been pointed out that the effects of food on the cause of the development of atopic dermatitis in children have been identified, but no effective solution has been known to date. The present invention has solved the drawbacks of conventional foods for preventing atopic dermatitis, and has made it possible to produce foods that prevent atopic dermatitis at low cost and in large quantities without impairing the flavor and taste of the food. This can be achieved by preventing the development of atopic dermatitis in children, for whom the treatment has not yet been established, before the onset of the disease, including economic effects such as reduction of medical expenses and reduction of drug use, educational effects, and industrial promotion. And health benefits can be expected.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI テーマコート゛(参考) A61K 35/74 A61K 35/74 A ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 35/74 A61K 35/74 A
Claims (3)
抽出物を配合して作るアトピー性皮膚炎を防ぐ保健食
品。1. A health food for preventing atopic dermatitis, which is prepared by mixing a live extract of Lactobacillus sp. In powdered milk for childcare.
抽出物を配合して作るアトピー性皮膚炎を防ぐ保健食
品。2. A health food for preventing atopic dermatitis, which is prepared by mixing a live Lactobacillus dry extract with food such as baby food.
属乾燥抽出物から成るアトピー性皮膚炎を防ぐ保健食
品。3. A health food for preventing atopic dermatitis comprising a dried extract of Lactobacillus for use in a food.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28720898A JP4010062B2 (en) | 1998-09-02 | 1998-09-02 | Health food to prevent atopic dermatitis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28720898A JP4010062B2 (en) | 1998-09-02 | 1998-09-02 | Health food to prevent atopic dermatitis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000069935A true JP2000069935A (en) | 2000-03-07 |
JP4010062B2 JP4010062B2 (en) | 2007-11-21 |
Family
ID=17714463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP28720898A Expired - Lifetime JP4010062B2 (en) | 1998-09-02 | 1998-09-02 | Health food to prevent atopic dermatitis |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4010062B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010520850A (en) * | 2006-09-14 | 2010-06-17 | フィート,ラインホルト,ダブリュ | Vitamin D composition and method for administration to humans |
JP2011500016A (en) * | 2007-10-10 | 2011-01-06 | ユン リム,ビュング | Infant infant formula containing green tea and lactic acid bacteria |
EP2206507B1 (en) * | 2000-06-20 | 2019-03-13 | Nestec S.A. | Probiotics for use in primary prevention of atopic diseases |
-
1998
- 1998-09-02 JP JP28720898A patent/JP4010062B2/en not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2206507B1 (en) * | 2000-06-20 | 2019-03-13 | Nestec S.A. | Probiotics for use in primary prevention of atopic diseases |
EP2201955B1 (en) * | 2000-06-20 | 2019-08-14 | Société des Produits Nestlé S.A. | Bifidobacterium lactis Bb-12 in primary prevention of atopic diseases |
JP2010520850A (en) * | 2006-09-14 | 2010-06-17 | フィート,ラインホルト,ダブリュ | Vitamin D composition and method for administration to humans |
JP2011500016A (en) * | 2007-10-10 | 2011-01-06 | ユン リム,ビュング | Infant infant formula containing green tea and lactic acid bacteria |
Also Published As
Publication number | Publication date |
---|---|
JP4010062B2 (en) | 2007-11-21 |
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