JP2000034216A - Composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for external use useful for a cosmetic capable of maintaining a high moisture retaining effect for many hours, etc., without causing sense of use of greasiness. SOLUTION: This composition for external use is obtained by combining and formulating neotrehalose one of structural isomer of trehalose with a water- soluble polyhydric alcohol and is capable of continuing a high moisture retaining effect for many hours without causing sense of use of greasiness.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external composition. More specifically, the present invention relates to an external composition containing a humectant.

[0002]

2. Description of the Related Art In order to maintain healthy and fresh skin,
It is necessary to keep the skin sufficiently watery, and many cosmetics, pharmaceuticals and the like for moisturizing are commercially available. Research on humectants has also been actively conducted, and many types of humectants have been provided. In particular, water-soluble polyhydric alcohols represented by glycerin and propylene glycol have been widely used as humectants in cosmetics and pharmaceuticals because of their excellent water retention and hygroscopicity.

[0003]

However, external compositions such as cosmetics in which a water-soluble polyhydric alcohol is blended as a humectant have an excellent moisturizing effect, but tend to have a sticky feeling of use. There was a problem in terms of sex. In addition, there is a tendency that the moisturizing effect does not last for a long time, and it is desired to provide a means for maintaining the moisturizing effect for a long time in a composition for external use such as cosmetics.

[0004] Therefore, an object of the present invention is to provide a composition for external use such as cosmetics capable of maintaining a high moisturizing effect for a long time without a sticky feeling of use.

[0005]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by using a water-soluble polyhydric alcohol and neotrehalose, which is one of the isomers of trehalose, in combination, an external composition having no sticky feeling and having a high moisturizing effect for a long time is obtained. And found that the present invention was completed.

That is, the present invention provides an external composition containing neotrehalose and a water-soluble polyhydric alcohol. Incidentally, the `` external composition '' of the present invention means a composition applied to the outer skin for some purpose,
The specific form is not limited as long as the desired effect of the present invention can be exerted on the outer skin.

[0007]

Embodiments of the present invention will be described below. Neotrehalose blended in the composition for external use according to the present invention (hereinafter referred to as the composition for external use of the present invention)
Trehalose is one of the structural isomers.
It is a disaccharide represented by α-D-glucopyranosyl-β-D-glucopyranoside (see formula below), which is already a well-known disaccharide:

Embedded image Neotrehalose has a deep sweetness, is easily soluble in water, is non-reducing and stable in itself, and has an osmotic pressure adjusting property, shape forming property, shine imparting property, moisturizing property, viscosity, and other sugars. It is known to have properties such as crystallization prevention properties and fermentation resistance.

Neotrehalose produced by a known method can be used in the present invention. For example, according to the method for producing neotrehalose disclosed in Japanese Patent Application Laid-Open No. 5-252977, starch is converted into starch. α-
Those obtained by the action of amylase can be used as neotrehalose. Neotrehalose can be obtained as a commercial product and used in the present invention (for example, manufactured by Sigma, Inc.)
Hayashibara Biochemical Laboratory etc.).

The amount of neotrehalose in the composition for external use of the present invention is 0.1% based on the desired effect of the present invention, based on the effect of suppressing sticky feeling of use and the effect of maintaining moisturizing properties. It is preferably from 0001 to 20.0% by weight, and particularly preferably from 0.001 to 10.0% by weight. If the amount is less than 0.001% by weight based on the composition for external use, it is difficult to sufficiently exert the above-mentioned effects. Conversely, if the amount exceeds 20.0% by weight, the amount Not only does the enhancement of the effect commensurate with the increase in Nb is not recognized, but also the tendency to have a sticky feeling of use increases, which is not preferable.

The water-soluble polyhydric alcohol compounded with neotrehalose in the composition for external use of the present invention is not particularly limited as long as it has two or more hydroxyl groups in the molecule. Glycerin, diglycerin, polyglycerin, propylene glycol, dipropylene glycol, butylene glycol, polyethylene glycol, sucrose, trehalose other than neotrehalose (α, α-trehalose, β, β-trehalose), fructose, maltitol, xylitol, Polyhydric alcohols such as sorbitol, maltose, and maltotriose are exemplified.

[0011] These water-soluble polyhydric alcohols can be used alone or in combination of two or more in the composition for external use of the present invention together with the above-mentioned neotrehalose.

The amount of the water-soluble polyhydric alcohol in the composition for external use of the present invention should be appropriately selected according to the kind of the polyhydric alcohol to be selected, the amount of neotrehalose to be combined and combined, and the like. Although it is not particularly limited, it is generally 0.1-10.
0% by weight.

The compounding ratio of neotrehalose to water-soluble polyhydric alcohol (neotrehalose: water-soluble polyhydric alcohol) in the composition for external use of the present invention is approximately 1: 1 by weight.
1000 to 10: 1 is preferable, and 1: 100 to 1: 1 for the same.
Is particularly preferred. If the blending amount of neotrehalose is relatively excessive, it tends to be accompanied by a sticky feeling, which is not preferable. The effects of the invention cannot be sufficiently exhibited, which is not preferable.

[0014] By combining neotrehalose and a water-soluble polyhydric alcohol in an external composition in this way, surprisingly, the moisturizing effect, especially without a sticky feeling, can be obtained. An external composition having an excellent moisturizing effect over time is provided. Of course, such an effect due to the combined use of neotrehalose and a water-soluble polyhydric alcohol has not been known at all.

In addition to the above-mentioned essential components neotrehalose and water-soluble polyhydric alcohol, the composition for external use of the present invention contains
Ingredients usually blended in an external composition such as cosmetics, for example, alcohols, oils, surfactants, antioxidants, water-soluble polymers or thickeners other than the above essential components, and the above essential components other than the above essential components Other humectants, pigments, ultraviolet absorbers, whitening agents, various chemicals, pigments, fragrances, preservatives, and the like can be appropriately compounded within a range that does not impair the intended effects of the present invention.

Specific examples of these general components include alcohols such as cetyl alcohol, stearyl alcohol, and behenyl alcohol.

Examples of the oil component include higher fatty acids, solid paraffin, liquid paraffin, silicone oil, high molecular silicone and its derivatives, squalane, petrolatum, ester oil and the like.

Among the surfactants, examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyalkylene alkyl sulfate, alkyl sulfate, olefin sulfonate, alkyl phosphate, polyoxyalkylene alkyl ether. Phosphates,
Examples include dialkyl sulfosuccinates and fatty acid salts. Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyhydric alcohol fatty acid partial ester, polyoxyethylene polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. Derivatives, fatty acid diethanolamide and the like. Examples of the cationic surfactant include a tertiary aliphatic amine salt, an alkyltrimethylammonium halide, a dialkyldimethylammonium halide and the like. Examples of the amphoteric surfactant include an amidobetaine type, an imidazolinium betaine type, and a sulfobetaine type.

Examples of the antioxidant include ascorbic acid, succinic acid, and tocopherols.

Examples of the water-soluble polymer or thickener include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, cannan, quince seed (quince), alge colloid (gassou extract), starch (rice, rice, Plant macromolecules such as corn, potato, wheat), glycyrrhizic acid, microbial macromolecules such as xanthan gum, dextran, succino glugan, burlan, collagen,
Casein, albumin, animal polymers such as gelatin, carboxymethyl starch, starch polymers such as methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, Sodium carboxymethylcellulose (CMC),
Crystalline cellulose, cellulosic polymers such as cellulose powder,
Alginate polymers such as sodium alginate and propylene glycol alginate; vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone and carboxyvinyl polymer (Carbopol); polyethylene glycol 2000, 4000, 60
Polyoxyethylene polymer such as 00, polyoxyethylene polyoxypropylene copolymer copolymer polymer, acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethylene imine, cationic polymer, bentonite , AlMg silicate
(Veegum), laponite, hectorite, silicic anhydride and the like.

As the humectant, for example, sodium lactate,
And sodium 2-pyrrolidone-5-carboxylate.

Examples of pigments include talc, kaolin, calcium carbonate, fine particle titanium dioxide, titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, red iron oxide,
Sintered pigment, Gunjo Pink, chromium hydroxide, yellow iron oxide, chromium oxide, aluminum cobalt oxide, navy blue, carbon black, silicic anhydride, magnesium silicate, zinc oxide, titanium oxide, light calcium carbonate, heavy calcium carbonate And light magnesium carbonate, heavy magnesium carbonate, calamine, nylon powder, polymer resin powder, and natural polymer powder.

Examples of the ultraviolet absorber include benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, and para-aminobenzo such as para-aminobenzoic acid and ethyl para-aminobenzoate. Acid derivatives, methoxycinnamic acid derivatives such as ethyl paramethoxycinnamate and isopropyl paramethoxycinnamate, salicylic acid derivatives such as octyl salicylate and phenyl salicylate, urocanic acid, ethyl urocanate and the like.

Examples of the whitening agent include arbutin, kojic acid, vitamin C and the like.

As the drug, for example, plant extract such as carrot extract; vitamins such as vitamin B6 and biotin; pantothenic acid and its derivatives, glycyrrhizic acid and its derivatives; amino acids such as serine and methionine;
Various drugs such as female hormones such as nicorandil, cyclosporins, and estradiol.

Examples of the preservative include ethyl paraben, methyl paraben and the like.

The form of the composition for external use of the present invention is not particularly limited as long as it takes a form as a composition which can be applied to the skin. For example, ointments, creams, emulsions, lotions, gels, packs, etc. Of course, various makeup products such as foundations and lipsticks, as well as hair tonics,
Examples include hair cosmetics such as shampoo and rinse, and body cosmetics such as body lotion and body shampoo.

The specific formulation of the composition for external use of the present invention is described in the Examples section.

EXAMPLES The present invention will be described below in detail with reference to examples, but the technical scope of the present invention is not limited by these examples. In addition, the compounding amount in this example is
Unless otherwise specified, it is% by weight based on the compounded compound. In this example, neotrehalose (manufactured by Hayashibara Biochemical Laboratory Co., Ltd.) produced by reacting starch with α-amylase was used in accordance with the description in JP-A-5-252973.

Test Methods Tests for clarifying whether or not a composition for external use exhibits the intended effects of the present invention include (1) a water evaporation rate test, (2) a skin water retention test, and ( 3) Usability (stickiness) test was performed.

(1) Moisture Evaporation Rate Test 10 μL of each sample solution was dropped on a 2 cm × 2 cm piece of filter paper (No. 2), and the mass was measured over time in a thermostatic chamber at 25 ° C. and 50% relative humidity. It was measured. Since the weight of the sample solution decreases in proportion to time when left for a certain period of time, the weight of the test sample is plotted against the standing time, and the moisture retention is determined from the slope -k (moisture evaporation rate constant) of the approximate straight line. evaluated. That is, the smaller the value of k, the higher the moisture retention.

(2) Skin Surface Moisture Retention Test Using 10 healthy subjects as subjects, a measurement point was marked with an oil-based magic pen on the inner part of the forearm washed with soap, and a constant temperature and humidity chamber at 25 ° C. and 50% relative humidity was applied. 20 minutes after entering the room, a high-frequency current conductivity measuring device (SKICON-200, IBS
(Manufactured by K.K.), the skin conductivity (conductance) at the same measurement point was measured seven times, and the average of the five points from which the minimum value and the maximum value were removed was defined as the conductance before dropping the sample. Next, 0.2 mL of the sample solution was dropped at the measurement point, and one minute later, the sample solution was blotted with cotton, and the conductance was measured seven times each after 10, 30, 60, and 120 minutes. The average value of the five points from which the minimum value and the maximum value were removed was defined as the conductance after dropping the sample, and the amount of water contained in the skin surface was evaluated by the ratio to the conductance before dropping the sample solution. That is, the larger the conductance ratio value, the higher the skin surface water retention.

(3) Usability (Stickiness and Moisturizing Property) Test The usability (sticky and moist feeling) of the composition for external use to be tested was determined by the actual use test using 50 healthy panelists. Judgment and evaluation were made based on criteria.

(Judgment criteria: sticky feeling of use) Significant effect: no sticky feeling of use is recognized at all. Invalid: Sticky feeling is observed

(Criteria: Moist feeling) Excellent effect: Moist feeling is maintained. Effective: Moist feeling is recognized. Slightly effective: Some moist feeling is recognized. Invalid: Moist feeling. No feeling at all

(Evaluation: Both of the above items) ◎: 8 panels evaluated to be extremely effective, effective and slightly effective
0% or more ：: 5 panels evaluated as excellent, effective, and slightly effective
0 or more and less than 80% Δ: 3 panels evaluated as excellent, effective, and slightly effective
0 or more and less than 50% ×: 3 panels evaluated as excellent, effective, and slightly effective
Less than 0%

The lotions of Example 1 and Comparative Example 1 were prepared in the usual manner according to the following formulation, and (1) water evaporation rate test,
(2) Skin surface moisture retention test and (3) usability test were performed to evaluate the moisture retention and usability.

[Example 1] Composition amount (wt%) of lotion component Neotrehalose 5.0 Glycerin 5.0 Purified water 90.0

COMPARATIVE EXAMPLE 1 Lotion Component (Wt%) Trehalose 5.0 Glycerin 5.0 Purified Water 90.0

FIGS. 1 and 2 show (1) a water evaporation rate test (FIG. 1: the vertical axis is a water evaporation rate constant) and (2) a skin surface water retention test (FIG. 2: vertical). The axis of abscissa indicates the conductance ratio, and the axis of abscissa indicates the elapsed time (minutes).
From the results shown in FIGS. 1 and 2, the lotion of Example 1 was superior to the lotion of Comparative Example 1 in terms of the moisturizing effect and the moisturizing effect and the sustainability thereof.

Table 1 shows the results of the (3) usability test. Table 1 Example 1 Comparative Example 1評 価 Evaluation of usability (sticky feeling of use) ◎ × ───────────── ────────────────────

As shown in Table 1, the skin lotion of Example 1 did not clearly have a sticky feeling in use compared to the skin lotion of Comparative Example 1. From these results, it is clear that by combining neotrehalose and a water-soluble polyhydric alcohol in an external composition, the moisturizing effect, the durability thereof, and the usability (existence of sticky feeling) are excellent. Was.

The external compositions of Examples 2 to 4 and Comparative Examples 2 and 3 were prepared according to the following formulation by a conventional method, and the above-mentioned tests were performed on each of them.

Example 2 Emulsion Formulation Component Content (% by Weight) Dipropylene glycol 5.0 Glycerin 8.0 Carboxyvinyl polymer 0.1 Triethanolamine 1.0 Stearic acid 2.0 Sorbitan monooleate 2 0.0 Neotrehalose 1.0 Stearyl alcohol 1.5 Vaseline 4.0 Squalane 5.0 Glycerol tri-2-ethylhexanoate 2.0 Ethylparaben 0.2 Fragrance 0.05 Purified water 68.15

[Example 3] Ingredients of foundation ingredients (% by weight) Cetyl alcohol 3.0 Vaseline 5.0 Glyceryl monostearate 2.5 Stearic acid 3.0 Butylparaben 2.0 Polyoxyethylene (10EO) ..) Stearyl ether 1.0 Sorbitol 10.0 1,3-butylene glycol 12.0 Neotrehalose 1.0 Compound powder 15.0 Sodium cetyl sulfate 1.2 Purified water 44.3

Example 4 Cream Ingredients Ingredients (Weight%) 1,3-butylene glycol 9.5 Neotrehalose 0.5 Polyoxyethylene (25EO) cetyl ether 3.0 Glyceryl monostearate 2 2.0 Cetyl alcohol 3.0 Solid paraffin 2.0 Vaseline 5.0 Squalane 15.0 Butylparaben 0.2 Chondroitin sulfate 0.05 Fragrance 0.1 Purified water 59.65

[Comparative Example 2] Emulsion formulation components blending amount (% by weight) dipropylene glycol 5.0 glycerin 8.0 carboxyvinyl polymer 0.1 triethanolamine 1.0 stearic acid 2.0 sorbitan monooleate 2 2.0 Stearyl alcohol 1.5 Vaseline 4.0 Squalane 5.0 Glycerol tri-2-ethylhexanoate 2.0 Ethyl paraben 0.2 Perfume 0.05 Purified water 69.15

[Comparative Example 3] Emulsion compounding amount (% by weight) Carboxyvinyl polymer 0.1 Triethanolamine 1.0 Stearic acid 2.0 Sorbitan monooleate 2.0 Neotrehalose 1.0 Stearyl alcohol 1 5.5 Vaseline 4.0 Squalane 5.0 Glycerol tri-2-ethylhexanoate 2.0 Ethylparaben 0.2 Perfume 0.05 Purified water 81.15

In the (1) moisture evaporation rate test and (2) skin surface moisture retention test, Examples 2 and 3 were more than equal in comparison with Comparative Examples 2 and 3 in moisture retention effect and Excellent in its sustainability. Also in Example 4, the moisturizing effect and its durability were excellent.

(3) The results of the usability test are shown in Table 2 (sticky usability and moist usability are separately expressed). Table 2 Example 2 Example 3 Example 3 Example 4 Comparative Example 2 Comparative Example 3 感 Sticky feeling ◎ ◎ ◎ × ○ Moist use Feeling ◎ ◎ ◎ ○ × ───────────────────────────────────

As shown in Table 2, the sticky feeling of the composition for external use of Example was not clearly recognized as compared with the composition for external use of Comparative Example.

[0051]

Industrial Applicability According to the present invention, there is provided an external composition such as a cosmetic which can maintain a high moisturizing effect for a long time without sticky feeling.

[Brief description of the drawings]

FIG. 1 is a drawing showing the results of a water evaporation rate test of a test product.

FIG. 2 is a view showing the results of a skin surface moisture retention test of a test sample.

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Claims (1)

[Claims] An external composition comprising neotrehalose and a water-soluble polyhydric alcohol.