JOP20220031A1 - أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين - Google Patents

أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين

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Publication number
JOP20220031A1
JOP20220031A1 JOP/2022/0031A JOP20220031A JOP20220031A1 JO P20220031 A1 JOP20220031 A1 JO P20220031A1 JO P20220031 A JOP20220031 A JO P20220031A JO P20220031 A1 JOP20220031 A1 JO P20220031A1
Authority
JO
Jordan
Prior art keywords
triazol
making
orexin receptor
synthetic methods
receptor modulators
Prior art date
Application number
JOP/2022/0031A
Other languages
English (en)
Inventor
Kiran Matcha
Cheng Yi Chen
Dominique Paul M Depre
Florian Damien Medina
Pieter Westerduin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20220031A1 publication Critical patent/JOP20220031A1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/78—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/30—Nitrogen atoms non-acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

وصف لعملية تحضير (((3aR,6aS)-5-(4,6-ثنائي ميثيل بيريميدين-2-يل)سداسي هيدروبيرولو[3,4-c]بيرول-2(1H)-يل)(2-فلورو-6-(2H-1,2,3-تريازول-2-يل)فينيل)ميثانون ، وهي عملية مفيدة للتصنيع التجاري. المركب المذكور عبارة عن مُعدِّل لمستقبل الأوركسين وربما يكون مفيدًا في التركيبات الصيدلانية وطرق علاج الحالات المرضية، والاضطرابات، والحالات التي يتوسطها نشاط الأوركسين، مثل الأرق والاكتئاب.
JOP/2022/0031A 2019-08-07 2020-08-06 أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين JOP20220031A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962883857P 2019-08-07 2019-08-07
US202062971265P 2020-02-07 2020-02-07
PCT/EP2020/072192 WO2021023843A1 (en) 2019-08-07 2020-08-06 Improved synthetic methods of making (2h-1,2,3-triazol-2-yl)phenyl compounds as orexin receptor modulators

Publications (1)

Publication Number Publication Date
JOP20220031A1 true JOP20220031A1 (ar) 2023-01-30

Family

ID=72139573

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2022/0031A JOP20220031A1 (ar) 2019-08-07 2020-08-06 أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين

Country Status (15)

Country Link
US (1) US20220289754A1 (ar)
EP (1) EP4010325A1 (ar)
JP (1) JP2022543286A (ar)
KR (1) KR20220044323A (ar)
CN (1) CN114555603A (ar)
AU (1) AU2020324552A1 (ar)
BR (1) BR112022002128A2 (ar)
CA (1) CA3149689A1 (ar)
CR (1) CR20220050A (ar)
EC (1) ECSP22016630A (ar)
IL (1) IL290362A (ar)
JO (1) JOP20220031A1 (ar)
MX (1) MX2022001615A (ar)
PE (1) PE20220842A1 (ar)
WO (1) WO2021023843A1 (ar)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
JP5759470B2 (ja) * 2009-10-23 2015-08-05 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての二置換オクタヒドロピロロ［３，４−ｃ］ピロール
US8299117B2 (en) * 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
US10258038B2 (en) * 2014-04-01 2019-04-16 Bayer Cropscience Aktiengesellschaft Use of heterocyclic compounds for controlling nematodes

Also Published As

Publication number Publication date
US20220289754A1 (en) 2022-09-15
ECSP22016630A (es) 2022-04-29
KR20220044323A (ko) 2022-04-07
EP4010325A1 (en) 2022-06-15
JP2022543286A (ja) 2022-10-11
CR20220050A (es) 2022-04-20
WO2021023843A1 (en) 2021-02-11
CN114555603A (zh) 2022-05-27
CA3149689A1 (en) 2021-02-11
MX2022001615A (es) 2022-05-26
AU2020324552A1 (en) 2022-03-24
BR112022002128A2 (pt) 2022-06-07
IL290362A (en) 2022-04-01
PE20220842A1 (es) 2022-05-24

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JOP20220031A1 (ar) أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين