JOP20220031A1 - أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين - Google Patents

أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين

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Publication number
JOP20220031A1
JOP20220031A1 JOP/2022/0031A JOP20220031A JOP20220031A1 JO P20220031 A1 JOP20220031 A1 JO P20220031A1 JO P20220031 A JOP20220031 A JO P20220031A JO P20220031 A1 JOP20220031 A1 JO P20220031A1
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JO
Jordan
Prior art keywords
triazol
making
orexin receptor
synthetic methods
receptor modulators
Prior art date
Application number
JOP/2022/0031A
Other languages
English (en)
Inventor
Kiran Matcha
Cheng Yi Chen
Dominique Paul M Depre
Florian Damien Medina
Pieter Westerduin
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Janssen Pharmaceutica Nv
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Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20220031A1 publication Critical patent/JOP20220031A1/ar

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/74Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/74Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/78Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/061,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28Nitrogen atoms
    • C07D295/30Nitrogen atoms non-acylated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

وصف لعملية تحضير (((3aR,6aS)-5-(4,6-ثنائي ميثيل بيريميدين-2-يل)سداسي هيدروبيرولو[3,4-c]بيرول-2(1H)-يل)(2-فلورو-6-(2H-1,2,3-تريازول-2-يل)فينيل)ميثانون ، وهي عملية مفيدة للتصنيع التجاري. المركب المذكور عبارة عن مُعدِّل لمستقبل الأوركسين وربما يكون مفيدًا في التركيبات الصيدلانية وطرق علاج الحالات المرضية، والاضطرابات، والحالات التي يتوسطها نشاط الأوركسين، مثل الأرق والاكتئاب.
JOP/2022/0031A 2019-08-07 2020-08-06 أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين JOP20220031A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962883857P 2019-08-07 2019-08-07
US202062971265P 2020-02-07 2020-02-07
PCT/EP2020/072192 WO2021023843A1 (en) 2019-08-07 2020-08-06 Improved synthetic methods of making (2h-1,2,3-triazol-2-yl)phenyl compounds as orexin receptor modulators

Publications (1)

Publication Number Publication Date
JOP20220031A1 true JOP20220031A1 (ar) 2023-01-30

Family

ID=72139573

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2022/0031A JOP20220031A1 (ar) 2019-08-07 2020-08-06 أساليب اصطناعية مُحسَّنة لإعداد مركبات (2h-1,2,3-تريازول-2-يل) فينيل كمُعدِّلات لمستقبلات الأوريكسين

Country Status (15)

Country Link
US (1) US20220289754A1 (ar)
EP (1) EP4010325A1 (ar)
JP (1) JP2022543286A (ar)
KR (1) KR20220044323A (ar)
CN (1) CN114555603A (ar)
AU (1) AU2020324552A1 (ar)
BR (1) BR112022002128A2 (ar)
CA (1) CA3149689A1 (ar)
CR (1) CR20220050A (ar)
EC (1) ECSP22016630A (ar)
IL (1) IL290362A (ar)
JO (1) JOP20220031A1 (ar)
MX (1) MX2022001615A (ar)
PE (1) PE20220842A1 (ar)
WO (1) WO2021023843A1 (ar)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
KR20120105449A (ko) * 2009-10-23 2012-09-25 얀센 파마슈티카 엔.브이. 오렉신 수용체 조절제로서의 이치환된 옥타하이드로피롤로[3,4-c]피롤
US8299117B2 (en) * 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
ES2861589T3 (es) * 2014-04-01 2021-10-06 Bayer Cropscience Ag Uso de compuestos heterocíclicos para controlar nematodos

Also Published As

Publication number Publication date
EP4010325A1 (en) 2022-06-15
CN114555603A (zh) 2022-05-27
KR20220044323A (ko) 2022-04-07
PE20220842A1 (es) 2022-05-24
ECSP22016630A (es) 2022-04-29
MX2022001615A (es) 2022-05-26
BR112022002128A2 (pt) 2022-06-07
JP2022543286A (ja) 2022-10-11
CA3149689A1 (en) 2021-02-11
IL290362A (en) 2022-04-01
AU2020324552A1 (en) 2022-03-24
WO2021023843A1 (en) 2021-02-11
CR20220050A (es) 2022-04-20
US20220289754A1 (en) 2022-09-15

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