JOP20220027A1 - تركيبات من تروفينتايد - Google Patents

تركيبات من تروفينتايد

Info

Publication number
JOP20220027A1
JOP20220027A1 JOP/2022/0027A JOP20220027A JOP20220027A1 JO P20220027 A1 JOP20220027 A1 JO P20220027A1 JO P20220027 A JOP20220027 A JO P20220027A JO P20220027 A1 JOP20220027 A1 JO P20220027A1
Authority
JO
Jordan
Prior art keywords
compositions
compounds
products
methods
disclosure describes
Prior art date
Application number
JOP/2022/0027A
Other languages
Arabic (ar)
English (en)
Inventor
Clive Blower
Martin Bernard Catherine Bousmanne
James Anthony Bonnar
Mathew Peterson
Cecilia Betti
Karel Willy Luc Decroos
James Murray Shaw
Etienne David Frank Philippe Moniotte
Original Assignee
Neuren Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuren Pharmaceuticals Ltd filed Critical Neuren Pharmaceuticals Ltd
Publication of JOP20220027A1 publication Critical patent/JOP20220027A1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/06Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/18Carbon
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44Palladium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JOP/2022/0027A 2019-08-05 2022-02-01 تركيبات من تروفينتايد JOP20220027A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962882998P 2019-08-05 2019-08-05
PCT/US2020/044733 WO2021026066A1 (en) 2019-08-05 2020-08-03 Compositions of trofinetide

Publications (1)

Publication Number Publication Date
JOP20220027A1 true JOP20220027A1 (ar) 2023-01-30

Family

ID=74502416

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2022/0027A JOP20220027A1 (ar) 2019-08-05 2022-02-01 تركيبات من تروفينتايد

Country Status (16)

Country Link
US (3) US11370755B2 (https=)
EP (1) EP4009962A4 (https=)
JP (2) JP2022543391A (https=)
KR (1) KR20220059479A (https=)
CN (1) CN114667136A (https=)
AU (1) AU2020324396B2 (https=)
BR (1) BR112022002229A2 (https=)
CA (1) CA3149633A1 (https=)
CL (1) CL2022000301A1 (https=)
CO (1) CO2022002616A2 (https=)
IL (1) IL290324A (https=)
JO (1) JOP20220027A1 (https=)
MX (1) MX2022001505A (https=)
MY (1) MY206115A (https=)
SA (1) SA522431585B1 (https=)
WO (1) WO2021026066A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220059479A (ko) 2019-08-05 2022-05-10 뉴렌 파마슈티컬즈 리미티드 트로피네타이드의 조성물
MX2023014655A (es) * 2021-07-12 2024-01-12 Acadia Pharm Inc Formas cristalinas de trofinetida.
WO2025169163A1 (en) * 2024-02-10 2025-08-14 Teadus Pharma Private Limited Method for the synthesis of trofinetide and its analogues

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2573765B1 (fr) * 1984-11-23 1988-06-10 Solvay Procede pour la synthese de peptides
US8637567B2 (en) 2001-05-24 2014-01-28 Neuren Pharmaceuticals Ltd. Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid
US7714020B2 (en) 2001-05-24 2010-05-11 Neuren Pharmaceuticals Limited Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
US7605177B2 (en) 2001-05-24 2009-10-20 Neuren Pharmaceuticals Limited Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
ATE435852T1 (de) 2001-05-24 2009-07-15 Neuren Pharmaceuticals Ltd Gpe-analoga und peptidomimetika
US7863304B2 (en) 2001-05-24 2011-01-04 Neuren Pharmaceuticals Limited Analogs of glycyl-prolyl-glutamate
EP1888618A4 (en) * 2005-05-23 2009-07-15 Neuren Pharmaceuticals Ltd Analogs of glycyl-prolyl-glutamate
WO2007106555A2 (en) 2006-03-14 2007-09-20 Neuren Pharmaceuticals Limited Oral formulations of glycyl-2-methylprolyl-glutamate
EP2060580A1 (en) * 2007-11-19 2009-05-20 SOLVAY (Société Anonyme) Process for the manufacture of persilylated peptides
AU2012209466C1 (en) * 2011-01-27 2016-06-23 Neuren Pharmaceuticals Limited Treatment of Autism Spectrum Disorders using Glycyl-L-2-Methylprolyl-L-Glutamic Acid
US20150224164A1 (en) * 2013-11-26 2015-08-13 Neuren Pharmaceuticals Limited Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glumatic acid
KR20220059479A (ko) 2019-08-05 2022-05-10 뉴렌 파마슈티컬즈 리미티드 트로피네타이드의 조성물

Also Published As

Publication number Publication date
MY206115A (en) 2024-11-29
US12297172B2 (en) 2025-05-13
CA3149633A1 (en) 2021-02-11
EP4009962A1 (en) 2022-06-15
JP2022543391A (ja) 2022-10-12
US11866406B2 (en) 2024-01-09
MX2022001505A (es) 2022-03-11
US20240109841A1 (en) 2024-04-04
KR20220059479A (ko) 2022-05-10
EP4009962A4 (en) 2023-08-09
CO2022002616A2 (es) 2022-06-10
US20220324799A1 (en) 2022-10-13
CL2022000301A1 (es) 2022-09-20
JP2026063085A (ja) 2026-04-10
BR112022002229A2 (pt) 2022-04-19
SA522431585B1 (ar) 2025-02-13
AU2020324396B2 (en) 2025-07-03
US20220055987A1 (en) 2022-02-24
AU2020324396A1 (en) 2022-03-10
IL290324A (en) 2022-04-01
CN114667136A (zh) 2022-06-24
US11370755B2 (en) 2022-06-28
WO2021026066A1 (en) 2021-02-11

Similar Documents

Publication Publication Date Title
PH12020551062A1 (en) 1,2,4-oxadiazole compounds as inhibitors of cd47 signalling pathways
WO2020160193A3 (en) Compounds and uses thereof
PH12019501985A1 (en) Fused imidazo-piperidine jak inhibitors
JOP20220027A1 (ar) تركيبات من تروفينتايد
MX388682B (es) Compuestos agonistas de gpr119 y metodo para tratar enfermedades y afecciones mediado a traves de gpr119.
MX380907B (es) Compuestos útiles como inhibidores de cinasa.
PH12019500196A1 (en) Compounds and compositions and uses thereof
EA201100311A1 (ru) Амидные производные гетероарилов и их применение в качестве активаторов глюкокиназы
EA201400624A1 (ru) Замещенные 4-фенилпиридины для лечения болезней, связанных с рецептором nk-1
NZ759764A (en) Glucuronide prodrugs of janus kinase inhibitors
EP4356969A3 (en) Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections
MX2017014035A (es) Formas solidas novedosas.
SA519410320B1 (ar) مركبات فينيل -2-هيدروكسي-أسيتيل أمينو -2-ميثيل-فينيل
EA202090414A1 (ru) Соединения и их применение
PH12021551058A1 (en) Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof
EA202190272A1 (ru) Дополнительно замещенные производные триазолохиноксалина
EA202190271A1 (ru) Замещенные триазолохиноксалиновые производные
PH12019500198A1 (en) Compounds and compositions and uses thereof
MX2021008510A (es) Derivados de tiazolopiridina como antagonistas del receptor de adenosina.
PH12016501393A1 (en) Substituted bicyclic heteroaryl compounds as rxr agonists
ZA202001295B (en) Thiazolopyridine derivatives as adenosine receptor antagonists
JOP20210332A1 (ar) عقاقير أولية لمعدلات المستقبل nmda
MX385475B (es) Derivados de piridoquinazolina eficaces como inhibidores de proteina quinasa
MX2019000276A (es) Nuevos derivados ciclopropílicos.
EA201992397A1 (ru) Соединения для лечения эпилепсии, нейродегенеративных нарушений и других нарушений цнс