JOP20210111A1 - نظائر عامل gdf15 وطرق استخدامه في تقليل وزن الجسم و/أو تخفيض امتصاص الطعام - Google Patents

نظائر عامل gdf15 وطرق استخدامه في تقليل وزن الجسم و/أو تخفيض امتصاص الطعام

Info

Publication number
JOP20210111A1
JOP20210111A1 JOP/2021/0111A JOP20210111A JOP20210111A1 JO P20210111 A1 JOP20210111 A1 JO P20210111A1 JO P20210111 A JOP20210111 A JO P20210111A JO P20210111 A1 JOP20210111 A1 JO P20210111A1
Authority
JO
Jordan
Prior art keywords
body weight
food intake
gdf15
methods
reducing food
Prior art date
Application number
JOP/2021/0111A
Other languages
Arabic (ar)
English (en)
Inventor
Songmao Zheng
Paul Rothenberg
Vedrana Stojanovic-Susulic
Elisa Fabbrini
Holly Kimko
Robert Hermann
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20210111A1 publication Critical patent/JOP20210111A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JOP/2021/0111A 2018-11-20 2021-05-19 نظائر عامل gdf15 وطرق استخدامه في تقليل وزن الجسم و/أو تخفيض امتصاص الطعام JOP20210111A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862769675P 2018-11-20 2018-11-20
PCT/IB2019/059945 WO2020104948A1 (en) 2018-11-20 2019-11-19 Gdf15 analogs and methods for use in decreasing body weight and/or reducing food intake

Publications (1)

Publication Number Publication Date
JOP20210111A1 true JOP20210111A1 (ar) 2021-05-19

Family

ID=70773869

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0111A JOP20210111A1 (ar) 2018-11-20 2021-05-19 نظائر عامل gdf15 وطرق استخدامه في تقليل وزن الجسم و/أو تخفيض امتصاص الطعام

Country Status (15)

Country Link
US (1) US20220315633A1 (https=)
EP (1) EP3883960A4 (https=)
JP (2) JP2022513098A (https=)
KR (1) KR20210094584A (https=)
CN (2) CN113474363A (https=)
AU (2) AU2019383019A1 (https=)
BR (1) BR112021009225A2 (https=)
CA (1) CA3120236A1 (https=)
EA (1) EA202191424A1 (https=)
IL (1) IL283189A (https=)
JO (1) JOP20210111A1 (https=)
MX (1) MX2021005908A (https=)
PH (1) PH12021551119A1 (https=)
SG (1) SG11202104952PA (https=)
WO (1) WO2020104948A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202191105A1 (ru) 2018-10-22 2021-08-03 Янссен Фармацевтика Нв Слитые белки, полученные из глюкагоноподобного пептида 1 (glp1) и ростового фактора дифференцировки 15 (gdf15), и их применение
EP4041281B1 (en) 2019-10-04 2025-11-26 Amgen Inc. Use of gdf15 for treating cardiometabolic syndrome and other conditions
WO2023154953A1 (en) 2022-02-14 2023-08-17 Ngm Biopharmaceuticals, Inc. Gdf15 polypeptides for treating and preventing autoimmune diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9131966B2 (en) * 2013-03-11 2015-09-15 DePuy Synthes Products, Inc. Vertebral manipulation assembly
EP3157947A1 (en) * 2014-06-23 2017-04-26 Novartis AG Hsa-gdf-15 fusion polypeptide and use thereof
JP6946304B2 (ja) * 2015-12-22 2021-10-06 ノバルティス アーゲー 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を処置するまたは軽快させる方法
US10336812B2 (en) * 2016-05-10 2019-07-02 Janssen Biotech, Inc. GDF15 fusion proteins and uses thereof
EA202191105A1 (ru) * 2018-10-22 2021-08-03 Янссен Фармацевтика Нв Слитые белки, полученные из глюкагоноподобного пептида 1 (glp1) и ростового фактора дифференцировки 15 (gdf15), и их применение

Also Published As

Publication number Publication date
CN121818901A (zh) 2026-04-10
BR112021009225A2 (pt) 2021-10-05
AU2019383019A1 (en) 2021-06-03
KR20210094584A (ko) 2021-07-29
JP2022513098A (ja) 2022-02-07
EP3883960A4 (en) 2022-11-09
WO2020104948A1 (en) 2020-05-28
MX2021005908A (es) 2021-09-08
PH12021551119A1 (en) 2021-11-22
AU2025202337A1 (en) 2025-04-24
US20220315633A1 (en) 2022-10-06
JP2025081388A (ja) 2025-05-27
EA202191424A1 (ru) 2021-08-24
IL283189A (en) 2021-06-30
EP3883960A1 (en) 2021-09-29
SG11202104952PA (en) 2021-06-29
CA3120236A1 (en) 2020-05-28
CN113474363A (zh) 2021-10-01

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