JO3197B1 - (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان - Google Patents
(مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطانInfo
- Publication number
- JO3197B1 JO3197B1 JOP/2010/0107A JOP20100107A JO3197B1 JO 3197 B1 JO3197 B1 JO 3197B1 JO P20100107 A JOP20100107 A JO P20100107A JO 3197 B1 JO3197 B1 JO 3197B1
- Authority
- JO
- Jordan
- Prior art keywords
- diazepin
- ribofuranosyl
- deoxy
- tetrahydro
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
.يتم في الطلب الحالي تقديم المركبات المستخدمة لتثبيط انزيم نزع المجموعة الأمينية المسئول عن تثبيط نشاط المركبات العلاجية , وطرق استخدامها.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16711209P | 2009-04-06 | 2009-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3197B1 true JO3197B1 (ar) | 2018-03-08 |
Family
ID=42126083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2010/0107A JO3197B1 (ar) | 2009-04-06 | 2010-04-06 | (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان |
Country Status (10)
Country | Link |
---|---|
US (1) | US8324180B2 (ar) |
EP (1) | EP2417146B1 (ar) |
JP (1) | JP5687687B2 (ar) |
AR (1) | AR076262A1 (ar) |
AU (2) | AU2010234637B2 (ar) |
CA (1) | CA2757743C (ar) |
ES (1) | ES2593088T3 (ar) |
JO (1) | JO3197B1 (ar) |
TW (1) | TWI477508B (ar) |
WO (1) | WO2010118006A1 (ar) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2778B1 (ar) | 2007-10-16 | 2014-03-15 | ايساي انك | مركبات وتركيبات وطرق معينة |
US8329666B2 (en) * | 2009-04-06 | 2012-12-11 | Eisai Inc. | Compositions and methods for treating cancer |
US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
CA2757745C (en) * | 2009-04-06 | 2018-02-13 | Eisai Inc. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
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US4017606A (en) * | 1973-10-04 | 1977-04-12 | The Upjohn Company | Organic compounds and process |
US4275057A (en) * | 1980-01-28 | 1981-06-23 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Seven-membered ring compounds as inhibitors of cytidine deaminase |
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
EP0160079B1 (en) | 1983-10-26 | 1990-01-31 | GREER, Sheldon B. | Method and materials for sensitizing neoplastic tissue to radiation |
EP0184365B1 (en) * | 1984-12-04 | 1993-08-04 | Eli Lilly And Company | Improvements in the treatment of tumors in mammals |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
US5223608A (en) * | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
WO1992018517A1 (en) | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
FR2682112B1 (fr) * | 1991-10-08 | 1993-12-10 | Commissariat A Energie Atomique | Procede de synthese d'acide ribonucleique (arn) utilisant un nouveau reactif de deprotection. |
US5594124A (en) * | 1992-06-22 | 1997-01-14 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof |
US5426183A (en) * | 1992-06-22 | 1995-06-20 | Eli Lilly And Company | Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
US5606048A (en) * | 1992-06-22 | 1997-02-25 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
US5821357A (en) * | 1992-06-22 | 1998-10-13 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides |
US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
AU664948B2 (en) * | 1993-02-23 | 1995-12-07 | City Of Hope | 4-ethoxy 5-fluoro 2'deoxyuridine |
AU6081294A (en) | 1993-05-14 | 1994-12-12 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
GB9311252D0 (en) | 1993-06-01 | 1993-07-21 | Hafslund Nycomed As | Cell growth regualtors |
US5637688A (en) * | 1994-12-13 | 1997-06-10 | Eli Lilly And Company | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
US5521294A (en) * | 1995-01-18 | 1996-05-28 | Eli Lilly And Company | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
US6001994A (en) | 1995-12-13 | 1999-12-14 | Eli Lilly And Company | Process for making gemcitabine hydrochloride |
US5760208A (en) * | 1996-08-14 | 1998-06-02 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Process to prepare pyrimidine nucleosides |
TW466112B (en) | 1998-04-14 | 2001-12-01 | Lilly Co Eli | Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same |
AP2001002109A0 (en) | 1998-09-25 | 2001-03-31 | Warner Lambert Co | Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin. |
DE60030842T2 (de) | 1999-03-01 | 2007-05-10 | Halogenetics Inc., Aventura | VERWENDUNG VON ZUSAMMENSETZUNGEN ENTHALTEND CldC ALS STRAHLUNGSSENSIBILISATOREN IN DER BEHANDLUNG VON NEOPLASTISCHEN ERKRANKUNGEN |
US6933287B1 (en) * | 1999-03-01 | 2005-08-23 | Sheldon B. Greer | Dramatic simplification of a method to treat neoplastic disease by radiation |
US6462191B1 (en) * | 2000-07-13 | 2002-10-08 | Air Products And Chemicals, Inc. | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
DE60144573D1 (de) | 2000-11-29 | 2011-06-16 | Mitsui Chemicals Inc | Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin |
WO2002056912A2 (en) * | 2001-01-16 | 2002-07-25 | Glaxo Group Limited | Pharmaceutical combination for the treatment of cancer containing a 4-quinazolineamine and another anti-neoplastic agent |
US7589077B2 (en) | 2001-05-18 | 2009-09-15 | Rakesh Kumar | Antiviral nucleosides |
JP2006507255A (ja) | 2002-09-24 | 2006-03-02 | コローニス ファーマシューティカルズ インコーポレイテッド | ウイルス疾患の治療のための1,3,5−トリアジン |
WO2005115410A2 (en) | 2004-05-06 | 2005-12-08 | University Of Rochester | Context dependent inhibitors of cytidine deaminases and uses thereof |
US20060014949A1 (en) | 2004-07-13 | 2006-01-19 | Supergen Inc. | Compositions and formulations of decitabine polymorphs and methods of use thereof |
EP1812457A1 (en) | 2004-07-30 | 2007-08-01 | Pharmaessentia Corp. | STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES |
JP2007522151A (ja) | 2004-12-08 | 2007-08-09 | シコール インコーポレイティド | ジフルオロヌクレオシド及びその調製方法 |
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JO2778B1 (ar) * | 2007-10-16 | 2014-03-15 | ايساي انك | مركبات وتركيبات وطرق معينة |
WO2010047698A1 (en) | 2008-10-22 | 2010-04-29 | University Of Alabama At Birmingham | Activation-induced cytidine deaminase inhibitor suppression of autoimmune diseases |
CA2757745C (en) * | 2009-04-06 | 2018-02-13 | Eisai Inc. | Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
US8329666B2 (en) * | 2009-04-06 | 2012-12-11 | Eisai Inc. | Compositions and methods for treating cancer |
-
2010
- 2010-04-06 CA CA2757743A patent/CA2757743C/en active Active
- 2010-04-06 EP EP10713754.9A patent/EP2417146B1/en active Active
- 2010-04-06 ES ES10713754.9T patent/ES2593088T3/es active Active
- 2010-04-06 AR ARP100101142A patent/AR076262A1/es active IP Right Grant
- 2010-04-06 WO PCT/US2010/030073 patent/WO2010118006A1/en active Application Filing
- 2010-04-06 US US12/755,106 patent/US8324180B2/en active Active
- 2010-04-06 AU AU2010234637A patent/AU2010234637B2/en active Active
- 2010-04-06 TW TW099110581A patent/TWI477508B/zh active
- 2010-04-06 JP JP2012504771A patent/JP5687687B2/ja active Active
- 2010-04-06 JO JOP/2010/0107A patent/JO3197B1/ar active
-
2016
- 2016-08-12 AU AU2016213881A patent/AU2016213881B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TWI477508B (zh) | 2015-03-21 |
EP2417146B1 (en) | 2016-07-13 |
AU2010234637B2 (en) | 2016-05-12 |
AR076262A1 (es) | 2011-06-01 |
WO2010118006A1 (en) | 2010-10-14 |
TW201102397A (en) | 2011-01-16 |
US20100279966A1 (en) | 2010-11-04 |
AU2016213881B2 (en) | 2018-03-22 |
CA2757743C (en) | 2017-10-10 |
ES2593088T3 (es) | 2016-12-05 |
JP5687687B2 (ja) | 2015-03-18 |
AU2016213881A1 (en) | 2016-09-01 |
JP2012522840A (ja) | 2012-09-27 |
EP2417146A1 (en) | 2012-02-15 |
US8324180B2 (en) | 2012-12-04 |
CA2757743A1 (en) | 2010-10-14 |
AU2010234637A1 (en) | 2011-11-10 |
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