JO3197B1 - (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان - Google Patents

(مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان

Info

Publication number
JO3197B1
JO3197B1 JOP/2010/0107A JOP20100107A JO3197B1 JO 3197 B1 JO3197 B1 JO 3197B1 JO P20100107 A JOP20100107 A JO P20100107A JO 3197 B1 JO3197 B1 JO 3197B1
Authority
JO
Jordan
Prior art keywords
diazepin
ribofuranosyl
deoxy
tetrahydro
derivatives
Prior art date
Application number
JOP/2010/0107A
Other languages
English (en)
Inventor
Duvall Bridget
Hamilton Gregory
Ferraris Dana
Belyakov Sergei
Vaal Mark
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of JO3197B1 publication Critical patent/JO3197B1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

.يتم في الطلب الحالي تقديم المركبات المستخدمة لتثبيط انزيم نزع المجموعة الأمينية المسئول عن تثبيط نشاط المركبات العلاجية , وطرق استخدامها.
JOP/2010/0107A 2009-04-06 2010-04-06 (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان JO3197B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16711209P 2009-04-06 2009-04-06

Publications (1)

Publication Number Publication Date
JO3197B1 true JO3197B1 (ar) 2018-03-08

Family

ID=42126083

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2010/0107A JO3197B1 (ar) 2009-04-06 2010-04-06 (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان

Country Status (10)

Country Link
US (1) US8324180B2 (ar)
EP (1) EP2417146B1 (ar)
JP (1) JP5687687B2 (ar)
AR (1) AR076262A1 (ar)
AU (2) AU2010234637B2 (ar)
CA (1) CA2757743C (ar)
ES (1) ES2593088T3 (ar)
JO (1) JO3197B1 (ar)
TW (1) TWI477508B (ar)
WO (1) WO2010118006A1 (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2778B1 (ar) 2007-10-16 2014-03-15 ايساي انك مركبات وتركيبات وطرق معينة
US8329666B2 (en) * 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
CA2757745C (en) * 2009-04-06 2018-02-13 Eisai Inc. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer

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Also Published As

Publication number Publication date
TWI477508B (zh) 2015-03-21
EP2417146B1 (en) 2016-07-13
AU2010234637B2 (en) 2016-05-12
AR076262A1 (es) 2011-06-01
WO2010118006A1 (en) 2010-10-14
TW201102397A (en) 2011-01-16
US20100279966A1 (en) 2010-11-04
AU2016213881B2 (en) 2018-03-22
CA2757743C (en) 2017-10-10
ES2593088T3 (es) 2016-12-05
JP5687687B2 (ja) 2015-03-18
AU2016213881A1 (en) 2016-09-01
JP2012522840A (ja) 2012-09-27
EP2417146A1 (en) 2012-02-15
US8324180B2 (en) 2012-12-04
CA2757743A1 (en) 2010-10-14
AU2010234637A1 (en) 2011-11-10

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