JO2541B1 - N-Acylamino Benzyl Ether Derivatives - Google Patents
N-Acylamino Benzyl Ether DerivativesInfo
- Publication number
- JO2541B1 JO2541B1 JO200358A JOP20030058A JO2541B1 JO 2541 B1 JO2541 B1 JO 2541B1 JO 200358 A JO200358 A JO 200358A JO P20030058 A JOP20030058 A JO P20030058A JO 2541 B1 JO2541 B1 JO 2541B1
- Authority
- JO
- Jordan
- Prior art keywords
- alkyl
- halogen
- hydrogen
- alkoxy
- independently
- Prior art date
Links
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
This invention relates to N-acylamino aryl derivatives of the general formula (I), wherein R<1> is halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy; R<21>, R<22>, R<23> and R<24> independently from each other are selected from the group consisting of hydrogen, (C1-C6)-alkyl, halogen, halogen-(C1-C6)-alkyl, hydroxy, C1-C6-alkoxy or -CHO; R<3> is hydrogen or C1-C3-alkyl; R<4>, R<5> independently from each other are selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy or -COO(C1-C6)alkyl; or R<4> and R<5> form together with the C-atom to which they are attach a C3-C7-cycloalkyl ring; R<6> is -CO-NR<7>R<8>; -COO(C1-C6)-alkyl, -CN, -NR2 or -NHC(O)R; R<7> and R<8> independently from each other are selected from the group consisting of hydrogen, C1-C6-alkyl, NH2 or hydroxy; R is hydrogen or C1-C6-alkyl; n is 0, 1, 2 or 3. X is -CHRO, -OCHR, -CH2S-, -SCH2-, -CH2CH2-, -CH=CH- or -C=C-; and to pharmaceutically active acid addition salts thereof. It has been found that the compounds of general formula (I) are selective monoamine oxidase B inhibitors and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B inhibitors, for example for the treatment of Alzheimer's disease or senile dementia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20116398 | 2002-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO2541B1 true JO2541B1 (en) | 2010-09-05 |
Family
ID=48040998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO200358A JO2541B1 (en) | 2002-05-29 | 2003-05-28 | N-Acylamino Benzyl Ether Derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JO (1) | JO2541B1 (en) |
-
2003
- 2003-05-28 JO JO200358A patent/JO2541B1/en active
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