JO2526B1 - substituted 1,4-di-piperidin-4-yl-piperizine derivatives and their use as neurokinin antagonists - Google Patents
substituted 1,4-di-piperidin-4-yl-piperizine derivatives and their use as neurokinin antagonistsInfo
- Publication number
- JO2526B1 JO2526B1 JO2003131A JOP20030131A JO2526B1 JO 2526 B1 JO2526 B1 JO 2526B1 JO 2003131 A JO2003131 A JO 2003131A JO P20030131 A JOP20030131 A JO P20030131A JO 2526 B1 JO2526 B1 JO 2526B1
- Authority
- JO
- Jordan
- Prior art keywords
- disorders
- neurokinin
- diseases
- piperidin
- emesis
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depression, pain, pancreatitis and IBS. The compounds according to the invention can be represented by general Formula (I), and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1. In view of their capability to antagonize the actions of neurokinins by blocking the neurokinin receptors, and in particular antagonizing the actions of substance P by blocking the NK1 receptor, the compounds according to the invention are useful as a medicine, in particular in the prophylactic and therapeutic treatment of neurokinin-mediated conditions, such as, for instance CNS disorders, in particular depression, anxiety disorders, stress-related disorders, sleep disorders, cognitive disorders, personality disorders, schizoaffective disorders, eating disorders, neurodegenerative diseases, addiction disorders, mood disorders, sexual dysfunction, pain and other CNS-related conditions; inflammation; allergic disorders; emesis; gastrointestinal disorders, in particular irritable bowel syndrome (IBS); skin disorders; vasospastic diseases; fibrosing and collagen diseases; disorders related to immune enhancement or suppression and rheumatic diseases and body weight control
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0211328 | 2002-10-08 | ||
EP0214836 | 2002-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO2526B1 true JO2526B1 (en) | 2010-03-17 |
Family
ID=48040996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JO2003131A JO2526B1 (en) | 2002-10-08 | 2003-10-05 | substituted 1,4-di-piperidin-4-yl-piperizine derivatives and their use as neurokinin antagonists |
Country Status (1)
Country | Link |
---|---|
JO (1) | JO2526B1 (en) |
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2003
- 2003-10-05 JO JO2003131A patent/JO2526B1/en active
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