ITUB20152058A1 - Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci - Google Patents

Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci

Info

Publication number
ITUB20152058A1
ITUB20152058A1 ITUB2015A002058A ITUB20152058A ITUB20152058A1 IT UB20152058 A1 ITUB20152058 A1 IT UB20152058A1 IT UB2015A002058 A ITUB2015A002058 A IT UB2015A002058A IT UB20152058 A ITUB20152058 A IT UB20152058A IT UB20152058 A1 ITUB20152058 A1 IT UB20152058A1
Authority
IT
Italy
Prior art keywords
avidin
nano
drugs
transport
nucleic acids
Prior art date
Application number
ITUB2015A002058A
Other languages
English (en)
Inventor
Margherita Morpurgo
Original Assignee
Jointherapeutics S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jointherapeutics S R L filed Critical Jointherapeutics S R L
Priority to ITUB2015A002058A priority Critical patent/ITUB20152058A1/it
Priority to US15/743,486 priority patent/US10940208B2/en
Priority to PL16759685T priority patent/PL3319692T3/pl
Priority to EP16759685.7A priority patent/EP3319692B1/en
Priority to DK16759685.7T priority patent/DK3319692T3/da
Priority to PT167596857T priority patent/PT3319692T/pt
Priority to HUE16759685A priority patent/HUE055342T2/hu
Priority to ES16759685T priority patent/ES2875459T3/es
Priority to PCT/EP2016/066240 priority patent/WO2017009215A1/en
Priority to CA2991803A priority patent/CA2991803A1/en
Publication of ITUB20152058A1 publication Critical patent/ITUB20152058A1/it
Priority to HRP20210962TT priority patent/HRP20210962T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ITUB2015A002058A 2015-07-10 2015-07-10 Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci ITUB20152058A1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITUB2015A002058A ITUB20152058A1 (it) 2015-07-10 2015-07-10 Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci
PT167596857T PT3319692T (pt) 2015-07-10 2016-07-08 Complexos nanomontados de ácidos nucleicos, avidina e compostos biotinilados para uso como transportadores de fármacos
PL16759685T PL3319692T3 (pl) 2015-07-10 2016-07-08 Nanozłożone kompleksy kwasów nuklejowych, awidyny i biotynylowanych związków do wykorzystania jako nośniki leków
EP16759685.7A EP3319692B1 (en) 2015-07-10 2016-07-08 Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as drug carriers
DK16759685.7T DK3319692T3 (da) 2015-07-10 2016-07-08 Nanosamlede komplekser af nukleinsyrer, avidin og biotinylerede forbindelser til anvendelse som lægemiddelbærere
US15/743,486 US10940208B2 (en) 2015-07-10 2016-07-08 Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as drug carriers
HUE16759685A HUE055342T2 (hu) 2015-07-10 2016-07-08 Nukleinsavak, avidin és biotinilált vegyületek nanoszerkezetû komplexei gyógyszerhordozóként való felhasználásra
ES16759685T ES2875459T3 (es) 2015-07-10 2016-07-08 Complejos nanoensamblados de ácidos nucleicos, avidina y compuestos biotinilados para el uso como portadores de fármacos
PCT/EP2016/066240 WO2017009215A1 (en) 2015-07-10 2016-07-08 Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as drug carriers
CA2991803A CA2991803A1 (en) 2015-07-10 2016-07-08 Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as drug carriers
HRP20210962TT HRP20210962T1 (hr) 2015-07-10 2021-06-16 Nanosastavljeni kompleksi nukleinskih kiselina, avidina i biotiniliranih spojeva za uporabu kao nositelja lijekova

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUB2015A002058A ITUB20152058A1 (it) 2015-07-10 2015-07-10 Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci

Publications (1)

Publication Number Publication Date
ITUB20152058A1 true ITUB20152058A1 (it) 2017-01-10

Family

ID=54364469

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUB2015A002058A ITUB20152058A1 (it) 2015-07-10 2015-07-10 Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati impiegabili per il trasporto di farmaci

Country Status (11)

Country Link
US (1) US10940208B2 (it)
EP (1) EP3319692B1 (it)
CA (1) CA2991803A1 (it)
DK (1) DK3319692T3 (it)
ES (1) ES2875459T3 (it)
HR (1) HRP20210962T1 (it)
HU (1) HUE055342T2 (it)
IT (1) ITUB20152058A1 (it)
PL (1) PL3319692T3 (it)
PT (1) PT3319692T (it)
WO (1) WO2017009215A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900002679A1 (it) * 2019-02-25 2020-08-25 Livera S R L Complessi nanoassemblati di acidi nucleici, avidina e composti biotinilati per l’uso nel trattamento patologie epatiche

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003951A1 (en) * 2007-06-29 2009-01-08 Universita' Degli Studi Di Padova Nanoassembled complexes of nucleic acids, avidin and polymers, use and preparation thereof
WO2015011675A1 (en) * 2013-07-26 2015-01-29 Ananas Nanotech S.R.L. Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as carriers for intracellular delivery

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10012120A1 (de) * 2000-03-13 2001-09-27 Ktb Tumorforschungs Gmbh Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003951A1 (en) * 2007-06-29 2009-01-08 Universita' Degli Studi Di Padova Nanoassembled complexes of nucleic acids, avidin and polymers, use and preparation thereof
WO2015011675A1 (en) * 2013-07-26 2015-01-29 Ananas Nanotech S.R.L. Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds for use as carriers for intracellular delivery

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRANCESCO RONCATO: "Preparation and characterization of ananas/antibody/drug complexes: a first comparative investigation on Nanoparticle-based vs Antibody conjugate solutions for targeted drug delivery.", 19 February 2015 (2015-02-19), XP055259628, Retrieved from the Internet <URL:http://tesi.cab.unipd.it/48700/> [retrieved on 20160318] *
GREG T HERMANSON: "Bioconjugate Techniques (3rd Edition): Chapter 11 - (Strept)avidin-Biotin Systems", PROQUEST EBRARY. WEB. 21, 1 November 2013 (2013-11-01), XP055259971, Retrieved from the Internet <URL:http://site.ebrary.com/lib/epo/reader.action?docID=10738880&ppg=484> [retrieved on 20160321] *
GREG T HERMANSON: "Bioconjugate Techniques (3rd Edition): Chapter 18 - PEGylation and Synthetic Polymer Modification", PROQUEST EBRARY. WEB. 21, 1 November 2013 (2013-11-01), XP055259996, Retrieved from the Internet <URL:http://site.ebrary.com/lib/epo/reader.action?docID=10738880&ppg=806> [retrieved on 20160321] *

Also Published As

Publication number Publication date
HRP20210962T1 (hr) 2021-09-17
PT3319692T (pt) 2021-06-21
EP3319692B1 (en) 2021-03-24
CA2991803A1 (en) 2017-01-19
PL3319692T3 (pl) 2021-10-04
WO2017009215A1 (en) 2017-01-19
US20180200376A1 (en) 2018-07-19
DK3319692T3 (da) 2021-06-21
EP3319692A1 (en) 2018-05-16
ES2875459T3 (es) 2021-11-10
US10940208B2 (en) 2021-03-09
HUE055342T2 (hu) 2021-11-29

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