ITRM20050094A1 - Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari. - Google Patents

Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari.

Info

Publication number
ITRM20050094A1
ITRM20050094A1 IT000094A ITRM20050094A ITRM20050094A1 IT RM20050094 A1 ITRM20050094 A1 IT RM20050094A1 IT 000094 A IT000094 A IT 000094A IT RM20050094 A ITRM20050094 A IT RM20050094A IT RM20050094 A1 ITRM20050094 A1 IT RM20050094A1
Authority
IT
Italy
Prior art keywords
methyl
methylpyzine
pyrrols
chlorophenyl
tubular
Prior art date
Application number
IT000094A
Other languages
English (en)
Inventor
Mariangela Biava
Maurizio Botta
Delia Deidda
Fabrizio Manetti
Raffaello Pompei
Giulio Cesare Porretta
Original Assignee
Univ Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Siena filed Critical Univ Siena
Priority to IT000094A priority Critical patent/ITRM20050094A1/it
Priority to PCT/IT2006/000131 priority patent/WO2006092822A2/en
Priority to EP06711446A priority patent/EP1866283A2/en
Priority to US11/817,678 priority patent/US7910581B2/en
Priority to EP09176606A priority patent/EP2172451A3/en
Publication of ITRM20050094A1 publication Critical patent/ITRM20050094A1/it
Priority to US13/033,117 priority patent/US8012970B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT000094A 2005-03-04 2005-03-04 Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari. ITRM20050094A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT000094A ITRM20050094A1 (it) 2005-03-04 2005-03-04 Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari.
PCT/IT2006/000131 WO2006092822A2 (en) 2005-03-04 2006-03-03 4-fluorophenyl-derivatives of 1-{[1,5 -bis (4-chloro phenyl) -2-methyl-1h-pyrrol-3-yl]methyl} -4- methylpi pεrazine, synthesis process and uses thereof
EP06711446A EP1866283A2 (en) 2005-03-04 2006-03-03 4-fluorophenyl-derivatives of 1-{[1,5 -bis (4-chlorophenyl) -2-methyl-1h-pyrrol-3-yl]methyl} -4- methylpiperazine, synthesis process and uses thereof
US11/817,678 US7910581B2 (en) 2005-03-04 2006-03-03 Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl] methyl}-4-methylpiperazine, synthesis process and uses thereof
EP09176606A EP2172451A3 (en) 2005-03-04 2006-03-03 Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis and use thereof
US13/033,117 US8012970B2 (en) 2005-03-04 2011-02-23 Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000094A ITRM20050094A1 (it) 2005-03-04 2005-03-04 Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari.

Publications (1)

Publication Number Publication Date
ITRM20050094A1 true ITRM20050094A1 (it) 2006-09-05

Family

ID=36734526

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000094A ITRM20050094A1 (it) 2005-03-04 2005-03-04 Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari.

Country Status (4)

Country Link
US (2) US7910581B2 (it)
EP (2) EP1866283A2 (it)
IT (1) ITRM20050094A1 (it)
WO (1) WO2006092822A2 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2045237A1 (en) 2007-09-26 2009-04-08 Universita'Degli Studi di Roma "La Sapienza" Pyrrole compounds as inhibitors of mycrobacteria, synthesis thereof and intermediates thereto

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0725754B2 (ja) 1986-01-30 1995-03-22 富山化学工業株式会社 新規なチアゾール化合物またはその塩
DE3819037A1 (de) * 1988-06-04 1989-12-14 Hoechst Ag 2,4-disubstituierte oxazol-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als therapiemittel gegen krankheiten, die durch rhinoviren verursacht werden
US6610723B2 (en) * 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
US7691837B2 (en) 2002-09-20 2010-04-06 Lupin Limited Pyrrole derivatives as antimycobacterial compounds

Also Published As

Publication number Publication date
EP2172451A3 (en) 2010-07-07
EP1866283A2 (en) 2007-12-19
WO2006092822A2 (en) 2006-09-08
WO2006092822A3 (en) 2007-04-05
US8012970B2 (en) 2011-09-06
US20110144109A1 (en) 2011-06-16
EP2172451A2 (en) 2010-04-07
US20090281094A1 (en) 2009-11-12
US7910581B2 (en) 2011-03-22

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