ITMI952614A0 - - Google Patents
Info
- Publication number
- ITMI952614A0 ITMI952614A0 ITMI952614A ITMI952614A ITMI952614A0 IT MI952614 A0 ITMI952614 A0 IT MI952614A0 IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A0 ITMI952614 A0 IT MI952614A0
- Authority
- IT
- Italy
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9426075A GB2296495B (en) | 1994-12-23 | 1994-12-23 | Anthracycline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI952614A0 true ITMI952614A0 (enExample) | 1995-12-13 |
| ITMI952614A1 ITMI952614A1 (it) | 1997-06-13 |
| IT1277073B1 IT1277073B1 (it) | 1997-11-04 |
Family
ID=10766488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95MI002614A IT1277073B1 (it) | 1994-12-23 | 1995-12-13 | Derivati antraciclinici |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4081148B2 (enExample) |
| DE (1) | DE19547958B4 (enExample) |
| GB (1) | GB2296495B (enExample) |
| IT (1) | IT1277073B1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2315067B (en) * | 1996-07-11 | 2000-02-16 | Pharmacia Spa | Morpholinyl anthracycline derivatives |
| EP1242438B1 (en) * | 1999-12-29 | 2006-11-08 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
| MXPA05009851A (es) * | 2003-03-18 | 2005-12-06 | Pharmacia Italia Spa | Como radiosensibilizador en combinacion con terapia con radiacion contra tumores. |
| CA2519310A1 (en) * | 2003-03-18 | 2004-09-30 | Maria Adele Pacciarini | Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor |
| ES2547552T3 (es) | 2008-02-01 | 2015-10-07 | Genentech, Inc. | Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos |
| US9115165B2 (en) | 2008-04-11 | 2015-08-25 | Tianjin Hemay Bio-Tech Co., Ltd. | Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof |
| ES2655243T3 (es) * | 2008-04-11 | 2018-02-19 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd | Derivados antibióticos de antraciclina con alta actividad, métodos de preparación y usos de los mismos |
| JP6067222B2 (ja) | 2008-07-15 | 2017-01-25 | ジェネンテック， インコーポレイテッド | アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途 |
| BR112013013127B1 (pt) | 2010-12-02 | 2021-06-22 | Nerviano Medical Sciences S.R.L. | Processo para a preparação de derivados de morfolinil antraciclina, compostos derivados de morfolinil antraciclina e composição farmacêutica compreendendo estes compostos |
| EP2824108B8 (en) * | 2012-03-06 | 2017-07-12 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd. | Tetracyclic anthraquinone derivatives |
| EP2991993B1 (en) * | 2013-04-29 | 2018-06-06 | Nerviano Medical Sciences S.r.l. | Morpholinyl anthracycline derivatives |
| KR102562864B1 (ko) | 2014-11-05 | 2023-08-04 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 관능화된 모르폴리닐 안트라사이클린 유도체 |
| CN110776501B (zh) * | 2019-08-22 | 2021-04-02 | 联宁（苏州）生物制药有限公司 | 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体 |
| WO2025092728A1 (zh) * | 2023-10-30 | 2025-05-08 | 上海皓元生物医药科技有限公司 | 一种pnu-159682的中间体及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4301277A (en) * | 1980-10-20 | 1981-11-17 | Sri International | 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin |
| JPS57163393A (en) * | 1981-03-27 | 1982-10-07 | Microbial Chem Res Found | Novel anthracyclin derivative and its preparation |
| JPS59212499A (ja) * | 1983-05-13 | 1984-12-01 | アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド | 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体 |
| US4585859A (en) * | 1983-05-24 | 1986-04-29 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
-
1994
- 1994-12-23 GB GB9426075A patent/GB2296495B/en not_active Expired - Lifetime
-
1995
- 1995-12-13 IT IT95MI002614A patent/IT1277073B1/it active IP Right Grant
- 1995-12-21 DE DE19547958.0A patent/DE19547958B4/de not_active Expired - Lifetime
- 1995-12-22 JP JP33521695A patent/JP4081148B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI952614A1 (it) | 1997-06-13 |
| DE19547958A1 (de) | 1996-06-27 |
| JP4081148B2 (ja) | 2008-04-23 |
| DE19547958B4 (de) | 2015-01-22 |
| JPH08231581A (ja) | 1996-09-10 |
| GB2296495A (en) | 1996-07-03 |
| GB2296495B (en) | 1998-04-15 |
| IT1277073B1 (it) | 1997-11-04 |
| GB9426075D0 (en) | 1995-02-22 |
Similar Documents
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |