ITMI20121232A1 - Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati - Google Patents

Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati Download PDF

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Publication number
ITMI20121232A1
ITMI20121232A1 IT001232A ITMI20121232A ITMI20121232A1 IT MI20121232 A1 ITMI20121232 A1 IT MI20121232A1 IT 001232 A IT001232 A IT 001232A IT MI20121232 A ITMI20121232 A IT MI20121232A IT MI20121232 A1 ITMI20121232 A1 IT MI20121232A1
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IT
Italy
Prior art keywords
benzyl
trityl
equal
phenyl
compound
Prior art date
Application number
IT001232A
Other languages
English (en)
Italian (it)
Inventor
Laura Bigini
Elios Giannini
Edoardo Gianolli
Oreste Piccolo
Daniele Vigo
Original Assignee
Cambrex Profarmaco Milano Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambrex Profarmaco Milano Srl filed Critical Cambrex Profarmaco Milano Srl
Priority to IT001232A priority Critical patent/ITMI20121232A1/it
Priority to PCT/EP2013/064607 priority patent/WO2014012832A1/fr
Publication of ITMI20121232A1 publication Critical patent/ITMI20121232A1/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT001232A 2012-07-16 2012-07-16 Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati ITMI20121232A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT001232A ITMI20121232A1 (it) 2012-07-16 2012-07-16 Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
PCT/EP2013/064607 WO2014012832A1 (fr) 2012-07-16 2013-07-10 Procédé pour la préparation de 2-(3-n,n-diisopropylamino-1-phénylpropyl)-4-hydroxyméthylphénol et de ses dérivés

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001232A ITMI20121232A1 (it) 2012-07-16 2012-07-16 Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati

Publications (1)

Publication Number Publication Date
ITMI20121232A1 true ITMI20121232A1 (it) 2014-01-17

Family

ID=46982675

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001232A ITMI20121232A1 (it) 2012-07-16 2012-07-16 Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati

Country Status (2)

Country Link
IT (1) ITMI20121232A1 (fr)
WO (1) WO2014012832A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (fr) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Dérivés de 3,3-diphénylpropylamines
US20110152227A1 (en) * 2008-04-09 2011-06-23 Concert Pharmaceuticals Inc. Deuterium labelled derivatives of 3-(2-hydroxy-5-methyphenyl)-n,n-diisopropyl-3-phenylpropylamine and methods of use thereof
EP2364966A1 (fr) * 2010-03-09 2011-09-14 LEK Pharmaceuticals d.d. Procédé pour la préparation de 3-(2-hydroxy-5-substitue phényl)-3-phénylpropylamines, intermédiaires pour la préparation de tolterodine
EP2463267A1 (fr) * 2010-12-09 2012-06-13 Dipharma Francis S.r.l. Processus pour la préparation de la fésotérodine ou sel correspondant
WO2012098560A2 (fr) * 2011-01-17 2012-07-26 Msn Laboratories Limited Procédé de préparation de l'antagoniste du récepteur muscarinique

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
DE29923134U1 (de) 1999-11-16 2000-06-29 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen
DE10028443C1 (de) 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
WO2005012227A2 (fr) 2003-08-05 2005-02-10 Ranbaxy Laboratories Limited Procede de preparation de 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, un metabolite de la tolterodine
ES2268987B1 (es) 2005-08-05 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de 3,3-difenilpropilaminas.
ATE480531T1 (de) 2006-05-24 2010-09-15 Pfizer Ltd Verfahren zur herstellung von benzopyran-2- olderivaten
CN101454273B (zh) 2006-05-31 2013-08-21 施瓦茨制药有限公司 取代的羟甲基苯酚的合成方法
EP2027103B1 (fr) 2006-06-12 2014-02-26 UCB Pharma GmbH Nouvel intermédiaire chiral, son procédé de fabrication et son utilisation dans la fabrication de toltérodine, fésotérodine, ou de son métabolite actif
WO2007147547A1 (fr) 2006-06-20 2007-12-27 Lek Pharmaceuticals D.D. Procédé de préparation de 3-(2-hydroxy-5-(phényle substitué))-n-alkyl-3-phénylpropylamines
WO2009037569A2 (fr) 2007-09-21 2009-03-26 Actavis Group Ptc Ehf Procédé amélioré de préparation de fésotérodine
WO2010018484A1 (fr) 2008-08-14 2010-02-18 Pfizer Limited Nouvelles utilisations de dérivés de diisopropylamine
WO2011128294A1 (fr) 2010-04-14 2011-10-20 Bayer Cropscience Ag Dérivés de dithiinopyridazindione
WO2011145019A1 (fr) 2010-05-17 2011-11-24 Orchid Chemicals And Pharmaceuticals Limited Procédé amélioré pour des dérivés de la diphénylpropylamine
IT1401451B1 (it) 2010-06-10 2013-07-26 Chemi Spa Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (fr) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Dérivés de 3,3-diphénylpropylamines
US20110152227A1 (en) * 2008-04-09 2011-06-23 Concert Pharmaceuticals Inc. Deuterium labelled derivatives of 3-(2-hydroxy-5-methyphenyl)-n,n-diisopropyl-3-phenylpropylamine and methods of use thereof
EP2364966A1 (fr) * 2010-03-09 2011-09-14 LEK Pharmaceuticals d.d. Procédé pour la préparation de 3-(2-hydroxy-5-substitue phényl)-3-phénylpropylamines, intermédiaires pour la préparation de tolterodine
EP2463267A1 (fr) * 2010-12-09 2012-06-13 Dipharma Francis S.r.l. Processus pour la préparation de la fésotérodine ou sel correspondant
WO2012098560A2 (fr) * 2011-01-17 2012-07-26 Msn Laboratories Limited Procédé de préparation de l'antagoniste du récepteur muscarinique

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WO2014012832A1 (fr) 2014-01-23

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