ITMI20051115A1 - Procedimento per l'ottenimento di cefotetan con resa elevata - Google Patents

Procedimento per l'ottenimento di cefotetan con resa elevata

Info

Publication number
ITMI20051115A1
ITMI20051115A1 IT001115A ITMI20051115A ITMI20051115A1 IT MI20051115 A1 ITMI20051115 A1 IT MI20051115A1 IT 001115 A IT001115 A IT 001115A IT MI20051115 A ITMI20051115 A IT MI20051115A IT MI20051115 A1 ITMI20051115 A1 IT MI20051115A1
Authority
IT
Italy
Prior art keywords
cefotetan
obtaining
procedure
high yield
tautomer
Prior art date
Application number
IT001115A
Other languages
English (en)
Inventor
Antonio Manca
Riccardo Monguzzi
Maurizio Zenoni
Original Assignee
Acs Dobfar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa
Priority to IT001115A priority Critical patent/ITMI20051115A1/it
Priority to US11/383,075 priority patent/US7560545B2/en
Priority to ES06113916T priority patent/ES2367367T3/es
Priority to EP06113916A priority patent/EP1734043B1/en
Priority to AT06113916T priority patent/ATE513835T1/de
Priority to KR1020060046640A priority patent/KR20060130491A/ko
Priority to CN2006100926462A priority patent/CN1880318B/zh
Publication of ITMI20051115A1 publication Critical patent/ITMI20051115A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT001115A 2005-06-14 2005-06-14 Procedimento per l'ottenimento di cefotetan con resa elevata ITMI20051115A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT001115A ITMI20051115A1 (it) 2005-06-14 2005-06-14 Procedimento per l'ottenimento di cefotetan con resa elevata
US11/383,075 US7560545B2 (en) 2005-06-14 2006-05-12 Process for obtaining cefotetan with high yield
ES06113916T ES2367367T3 (es) 2005-06-14 2006-05-15 Procedimiento para la preparación de cefotetán.
EP06113916A EP1734043B1 (en) 2005-06-14 2006-05-15 Process for the preparation of cefotetan
AT06113916T ATE513835T1 (de) 2005-06-14 2006-05-15 Verfahren zur herstellung von cefotetan
KR1020060046640A KR20060130491A (ko) 2005-06-14 2006-05-24 세포테탄을 고 수율로 수득하는 방법
CN2006100926462A CN1880318B (zh) 2005-06-14 2006-06-13 高收率制备头孢替坦的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001115A ITMI20051115A1 (it) 2005-06-14 2005-06-14 Procedimento per l'ottenimento di cefotetan con resa elevata

Publications (1)

Publication Number Publication Date
ITMI20051115A1 true ITMI20051115A1 (it) 2006-12-15

Family

ID=36838686

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001115A ITMI20051115A1 (it) 2005-06-14 2005-06-14 Procedimento per l'ottenimento di cefotetan con resa elevata

Country Status (7)

Country Link
US (1) US7560545B2 (it)
EP (1) EP1734043B1 (it)
KR (1) KR20060130491A (it)
CN (1) CN1880318B (it)
AT (1) ATE513835T1 (it)
ES (1) ES2367367T3 (it)
IT (1) ITMI20051115A1 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20051085A1 (it) * 2005-06-10 2006-12-11 Acs Dobfar Spa Metodo di purificazione del cefotetan
CN103044458A (zh) * 2012-12-25 2013-04-17 深圳华润九新药业有限公司 头孢替坦二钠纯化方法
CN107141307B (zh) * 2017-05-17 2019-09-17 华北制药河北华民药业有限责任公司 一种高纯度注射用头孢替坦二钠的制备方法
CN112745336B (zh) * 2020-12-27 2021-12-14 山东罗欣药业集团恒欣药业有限公司 一种抗感染类头孢药物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2824559C2 (de) * 1977-06-10 1985-01-10 Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo 7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
EP0290136A3 (en) * 1987-03-31 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. 7-beta-substituted-3-lower alkanoylacetoxymethyl-7-alpha-methoxy-3-cephem-4-carboxylic acid and process for production of same
ITMI20010964A1 (it) * 2001-05-10 2002-11-10 Acs Dobfar Spa Procedimento per l'ottenimento di composti utili per la produzione del cefotetan e nuovi composti cosi' ottenuti
ITMI20051085A1 (it) * 2005-06-10 2006-12-11 Acs Dobfar Spa Metodo di purificazione del cefotetan
ITMI20051991A1 (it) * 2005-10-20 2007-04-21 Acs Dobfar Spa Purificazione di prodotti beta-lattamici

Also Published As

Publication number Publication date
CN1880318A (zh) 2006-12-20
CN1880318B (zh) 2010-09-15
US20060281916A1 (en) 2006-12-14
KR20060130491A (ko) 2006-12-19
ES2367367T3 (es) 2011-11-02
EP1734043A1 (en) 2006-12-20
US7560545B2 (en) 2009-07-14
EP1734043B1 (en) 2011-06-22
ATE513835T1 (de) 2011-07-15

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