ITMI20022535A1 - PROCEDURE FOR DIACEREIN PURIFICATION. - Google Patents

PROCEDURE FOR DIACEREIN PURIFICATION.

Info

Publication number
ITMI20022535A1
ITMI20022535A1 IT002535A ITMI20022535A ITMI20022535A1 IT MI20022535 A1 ITMI20022535 A1 IT MI20022535A1 IT 002535 A IT002535 A IT 002535A IT MI20022535 A ITMI20022535 A IT MI20022535A IT MI20022535 A1 ITMI20022535 A1 IT MI20022535A1
Authority
IT
Italy
Prior art keywords
sub
diacerein
purification
procedure
ppm
Prior art date
Application number
IT002535A
Other languages
Italian (it)
Inventor
Domenico Maggi
Original Assignee
Synteco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32448914&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ITMI20022535(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synteco Spa filed Critical Synteco Spa
Priority to IT002535A priority Critical patent/ITMI20022535A1/en
Priority to RU2005114743/04A priority patent/RU2344119C2/en
Priority to JP2004556176A priority patent/JP2006508157A/en
Priority to KR1020057009502A priority patent/KR101098366B1/en
Priority to CNB2003801042302A priority patent/CN100396659C/en
Priority to AU2003296594A priority patent/AU2003296594A1/en
Priority to SI200331445T priority patent/SI1567474T1/en
Priority to PT03812156T priority patent/PT1567474E/en
Priority to GEAP20038813A priority patent/GEP20074202B/en
Priority to AT03812156T priority patent/ATE411975T1/en
Priority to EP03812156A priority patent/EP1567474B1/en
Priority to PL377168A priority patent/PL216047B1/en
Priority to CA002507582A priority patent/CA2507582A1/en
Priority to ES03812156T priority patent/ES2316870T3/en
Priority to BR0316530-2A priority patent/BR0316530A/en
Priority to DE60324318T priority patent/DE60324318D1/en
Priority to US10/536,313 priority patent/US20060135797A1/en
Priority to PCT/EP2003/013194 priority patent/WO2004050601A2/en
Priority to DK03812156T priority patent/DK1567474T3/en
Priority to MXPA05005577A priority patent/MXPA05005577A/en
Publication of ITMI20022535A1 publication Critical patent/ITMI20022535A1/en
Priority to TNP2005000129A priority patent/TNSN05129A1/en
Priority to CO05050952A priority patent/CO5640078A2/en
Priority to IL168808A priority patent/IL168808A/en
Priority to ZA200504303A priority patent/ZA200504303B/en
Priority to MA28310A priority patent/MA27554A1/en
Priority to HK06103487.8A priority patent/HK1083488A1/en
Priority to CY20081101450T priority patent/CY1108654T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)

Abstract

A process for obtaining diacerein with an aloe-emodine content lower thatn 100 ppm, prefereably of 0-5 ppm, is herein disclosed. The process comprises subjecting an an aqueous-organic solution of a diacerein salt with a weak base to extraction with a water immiscible or sparingly water-miscible solvent, such as toluene, aetates of C<SUB>2</SUB>-C<SUB>4 </SUB>alcohols, halohydrocarbons and the like.
IT002535A 2002-11-29 2002-11-29 PROCEDURE FOR DIACEREIN PURIFICATION. ITMI20022535A1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
IT002535A ITMI20022535A1 (en) 2002-11-29 2002-11-29 PROCEDURE FOR DIACEREIN PURIFICATION.
MXPA05005577A MXPA05005577A (en) 2002-11-29 2003-11-24 Process for purifying diacerein.
CA002507582A CA2507582A1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
BR0316530-2A BR0316530A (en) 2002-11-29 2003-11-24 Process to purify diacereìna
KR1020057009502A KR101098366B1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
CNB2003801042302A CN100396659C (en) 2002-11-29 2003-11-24 Process for purifying diacerein
AU2003296594A AU2003296594A1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
SI200331445T SI1567474T1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
PT03812156T PT1567474E (en) 2002-11-29 2003-11-24 Process for purifying diacerein
GEAP20038813A GEP20074202B (en) 2002-11-29 2003-11-24 Process for purifying diacerein
AT03812156T ATE411975T1 (en) 2002-11-29 2003-11-24 METHOD FOR PURIFYING DIACEREIN
EP03812156A EP1567474B1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
PL377168A PL216047B1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
RU2005114743/04A RU2344119C2 (en) 2002-11-29 2003-11-24 Diacerein refining process
ES03812156T ES2316870T3 (en) 2002-11-29 2003-11-24 DIACEREIN PURIFICATION PROCEDURE.
JP2004556176A JP2006508157A (en) 2002-11-29 2003-11-24 Purification method of diacerein
DE60324318T DE60324318D1 (en) 2002-11-29 2003-11-24 METHOD FOR PURIFYING DIACEREIN
US10/536,313 US20060135797A1 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
PCT/EP2003/013194 WO2004050601A2 (en) 2002-11-29 2003-11-24 Process for purifying diacerein
DK03812156T DK1567474T3 (en) 2002-11-29 2003-11-24 Process for the purification of diacerein
TNP2005000129A TNSN05129A1 (en) 2002-11-29 2005-05-10 Process for purifying diacerein
CO05050952A CO5640078A2 (en) 2002-11-29 2005-05-25 PROCEDURE TO PURIFY DIACEREIN
IL168808A IL168808A (en) 2002-11-29 2005-05-26 Process for purifying diacerein
ZA200504303A ZA200504303B (en) 2002-11-29 2005-05-26 Process for purifying diacerein
MA28310A MA27554A1 (en) 2002-11-29 2005-06-01 PROCESS FOR THE PURIFICATION OF DIACEREIN.
HK06103487.8A HK1083488A1 (en) 2002-11-29 2006-03-20 Process for purifying diacerein
CY20081101450T CY1108654T1 (en) 2002-11-29 2008-12-16 METHOD OF CLEANING THE INTERIOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002535A ITMI20022535A1 (en) 2002-11-29 2002-11-29 PROCEDURE FOR DIACEREIN PURIFICATION.

Publications (1)

Publication Number Publication Date
ITMI20022535A1 true ITMI20022535A1 (en) 2004-05-30

Family

ID=32448914

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002535A ITMI20022535A1 (en) 2002-11-29 2002-11-29 PROCEDURE FOR DIACEREIN PURIFICATION.

Country Status (27)

Country Link
US (1) US20060135797A1 (en)
EP (1) EP1567474B1 (en)
JP (1) JP2006508157A (en)
KR (1) KR101098366B1 (en)
CN (1) CN100396659C (en)
AT (1) ATE411975T1 (en)
AU (1) AU2003296594A1 (en)
BR (1) BR0316530A (en)
CA (1) CA2507582A1 (en)
CO (1) CO5640078A2 (en)
CY (1) CY1108654T1 (en)
DE (1) DE60324318D1 (en)
DK (1) DK1567474T3 (en)
ES (1) ES2316870T3 (en)
GE (1) GEP20074202B (en)
HK (1) HK1083488A1 (en)
IL (1) IL168808A (en)
IT (1) ITMI20022535A1 (en)
MA (1) MA27554A1 (en)
MX (1) MXPA05005577A (en)
PL (1) PL216047B1 (en)
PT (1) PT1567474E (en)
RU (1) RU2344119C2 (en)
SI (1) SI1567474T1 (en)
TN (1) TNSN05129A1 (en)
WO (1) WO2004050601A2 (en)
ZA (1) ZA200504303B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03008622A (en) * 2003-09-23 2005-03-30 Interquim S A De C V Method for the purification of crude diacerein by means of toluene.
WO2008092221A2 (en) * 2007-01-30 2008-08-07 União Brasileira De Educacão E Assistência - Sponsor Of Da Pucrs Process for obtaining trans-resveratrol and composition containing the same
KR100885677B1 (en) * 2007-05-22 2009-02-25 주식회사 엔지켐 Process for purification of Diacerein
ITMI20080011A1 (en) * 2008-01-04 2009-07-05 Chimico Internaz S P A PROCEDURE FOR THE PREPARATION OF DIACEREIN
WO2009106909A1 (en) * 2008-02-29 2009-09-03 Laboratoire Medidom S.A. Process for the purification of diacerein
US8423852B2 (en) * 2008-04-15 2013-04-16 Qualcomm Incorporated Channel decoding-based error detection
CN102264683B (en) * 2008-12-09 2014-07-09 Evultis公司 Process for the preparation of non-genotoxic diacetylrhein (diacerein) and formulations comprising non-genotoxic diacetylrhein
EP2196450A1 (en) 2008-12-09 2010-06-16 Evultis S.A. Process for the preparation of pure diacetylrhein (diacerein)
EP2218707A1 (en) 2009-02-16 2010-08-18 Evultis S.A. Process for the preparation of non-genotoxic Diacetylrhein (Diacerein)
WO2011030350A1 (en) 2009-09-08 2011-03-17 Lupin Limited Eco-friendly method for catalytic aerial oxidation of aloe-emodin to rheinal
ITTO20110120A1 (en) 2011-02-11 2012-08-12 Icrom Spa A NEW PURIFICATION PROCESS FOR ANTHRACHINON DERIVATIVES
WO2013038424A2 (en) * 2011-07-13 2013-03-21 Glenmark Generics Limited Process for purifying diacerein
CN103058865B (en) * 2013-01-01 2014-07-09 李友香 Crystal form and medicine composition of carboxylic acid derivative
TWI757350B (en) 2016-10-04 2022-03-11 紐西蘭商艾克福特士技術有限公司 A thermo-responsive solution, and method of use therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4120989C2 (en) * 1991-06-25 1995-07-27 Madaus Ag Process for the preparation of diacetylrhein
IT1264545B1 (en) * 1993-07-30 1996-10-02 Medidom Lab PROCEDURE FOR THE PREPARATION OF DIACEREIN
CH689279A5 (en) * 1995-02-07 1999-01-29 Steba Beheer Bv A method for purifying diacetylrhein.
US5641462A (en) * 1995-07-12 1997-06-24 University Of Utah Continuous solvent extraction with bottom gas injection
IT1312309B1 (en) * 1999-05-07 2002-04-15 Synteco Spa PROCEDURE FOR PURIFYING DIACEREIN
JP4030253B2 (en) * 2000-07-10 2008-01-09 株式会社トクヤマ Method for producing triazine compound

Also Published As

Publication number Publication date
MA27554A1 (en) 2005-10-03
US20060135797A1 (en) 2006-06-22
SI1567474T1 (en) 2009-02-28
CN1717386A (en) 2006-01-04
PL216047B1 (en) 2014-02-28
PT1567474E (en) 2009-01-30
ZA200504303B (en) 2006-07-26
WO2004050601A2 (en) 2004-06-17
TNSN05129A1 (en) 2007-05-14
CA2507582A1 (en) 2004-06-17
CO5640078A2 (en) 2006-05-31
KR101098366B1 (en) 2011-12-23
EP1567474B1 (en) 2008-10-22
DE60324318D1 (en) 2008-12-04
KR20050086864A (en) 2005-08-30
ATE411975T1 (en) 2008-11-15
IL168808A (en) 2012-02-29
HK1083488A1 (en) 2006-07-07
GEP20074202B (en) 2007-09-25
CN100396659C (en) 2008-06-25
JP2006508157A (en) 2006-03-09
RU2005114743A (en) 2006-01-20
RU2344119C2 (en) 2009-01-20
DK1567474T3 (en) 2009-01-12
EP1567474A2 (en) 2005-08-31
MXPA05005577A (en) 2005-07-27
AU2003296594A1 (en) 2004-06-23
ES2316870T3 (en) 2009-04-16
WO2004050601A3 (en) 2004-08-19
BR0316530A (en) 2005-10-04
PL377168A1 (en) 2006-01-23
CY1108654T1 (en) 2014-04-09

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