CY1110007T1 - Process for preparing crystals of zonisamide free of 1,2-dichloroethane and crystals of zonisamide having a very high purity - Google Patents

Process for preparing crystals of zonisamide free of 1,2-dichloroethane and crystals of zonisamide having a very high purity

Info

Publication number
CY1110007T1
CY1110007T1 CY20101100345T CY101100345T CY1110007T1 CY 1110007 T1 CY1110007 T1 CY 1110007T1 CY 20101100345 T CY20101100345 T CY 20101100345T CY 101100345 T CY101100345 T CY 101100345T CY 1110007 T1 CY1110007 T1 CY 1110007T1
Authority
CY
Cyprus
Prior art keywords
zonisamide
crystals
dichloroethane
ppm
preparing
Prior art date
Application number
CY20101100345T
Other languages
Greek (el)
Unknown language (xx)
Inventor
Yoshikazu Ueno
Yasujiro Kimura
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US34060103A priority Critical
Priority to EP03815138A priority patent/EP1583748B1/en
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32711361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110007(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of CY1110007T1 publication Critical patent/CY1110007T1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants

Abstract

Παρουσιάζεται μέθοδος παρασκευής κρυστάλλων ζονισαμίδης που περιέχουν υπολείμματα 1,2-διχλωροαιθανίου σε ποσότητα που δεν υπερβαίνει τα 5 ppm, η οποία μέθοδος περιλαμβάνει την προσθήκη υδατικού διαλύματος αλκοόλης C2-4 σε κρυστάλλους ζονισαμίδης που περιέχουν υπολείμματα 1,2-διχλωροαιθανίου σε ποσότητα πάνω από 5 ppm, την απομάκρυνση του εν λόγω 1,2-διχλωροαιθανίου με αζεοτροπική απόσταξη και την ακόλουθη συλλογή των καταβυθισθέντων κρυστάλλων ζονισαμίδης από το προκύπτον μίγμα καθώς και κρύσταλλοι ζονισαμίδης με πολύ υψηλό βαθμό καθαρότητας που περιέχουν υπολείμματα 1,2-διχλωροαιθανίου σε ποσότητα που δεν υπερβαίνει τα 5 ppm, 01 οποίοι είναι χρήσιμοι ως παράγοντες κατά της επιληψίας. Disclose methods for preparing crystals of zonisamide containing residual 1,2-dichloroethane of not more than 5 ppm, which method comprises adding an aqueous C2-4 alcohol solution in crystals of zonisamide containing residual 1,2-dichloroethane of more than 5 ppm, removing said 1,2-dichloroethane by azeotropic distillation and subsequent collection of precipitated crystals of zonisamide from the resulting mixture, and crystals of zonisamide having a very high degree of purity containing 1,2-dichloroethane residues in an amount not exceeding 5 ppm, 01 which are useful as agents against epilepsy.
CY20101100345T 2003-01-13 2010-04-16 Process for preparing crystals of zonisamide free of 1,2-dichloroethane and crystals of zonisamide having a very high purity CY1110007T1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US34060103A true 2003-01-13 2003-01-13
EP03815138A EP1583748B1 (en) 2003-01-13 2003-07-28 Process for the preparation of 1,2-dichloroethane free crystals of zonisamide and the highly pure crystals of zonisamide

Publications (1)

Publication Number Publication Date
CY1110007T1 true CY1110007T1 (en) 2015-01-14

Family

ID=32711361

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100345T CY1110007T1 (en) 2003-01-13 2010-04-16 Process for preparing crystals of zonisamide free of 1,2-dichloroethane and crystals of zonisamide having a very high purity

Country Status (16)

Country Link
US (3) US20050080269A1 (en)
EP (1) EP1583748B1 (en)
KR (1) KR101004187B1 (en)
CN (1) CN100528849C (en)
AT (1) AT457304T (en)
AU (1) AU2003249010A1 (en)
CY (1) CY1110007T1 (en)
DE (1) DE60331257D1 (en)
DK (1) DK1583748T3 (en)
ES (1) ES2338871T3 (en)
HK (1) HK1081555A1 (en)
IL (1) IL169451A (en)
PT (1) PT1583748E (en)
SI (1) SI1583748T1 (en)
TW (1) TWI331035B (en)
WO (1) WO2004063174A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1913935A1 (en) * 2005-01-21 2008-04-23 Teva Pharmaceutical Industries Ltd Stable pharmaceutical formulations of zonisamide and methods for their manufacture
ES2344574T3 (en) * 2005-01-21 2010-08-31 Teva Pharmaceutical Industries Ltd Stable pharmaceutical formulations of zonisamide and procedures for preparation.
US7268234B2 (en) * 2005-09-16 2007-09-11 Dainippon Sumitomo Pharma Co., Ltd. Method for sulfonation of 1,2-benzisoxazole-3-acetic acid
CN104059120A (en) * 2014-05-27 2014-09-24 上海新华联制药有限公司 Preparation process of high-purity betamethasone acetate

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033114B2 (en) 1976-12-16 1985-08-01 Dainippon Pharmaceutical Co
US4172896A (en) * 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
FR2428033B1 (en) 1978-06-09 1980-11-21 Dainippon Pharmaceutical Co
JPS6159308B2 (en) 1978-06-12 1986-12-16 Dainippon Pharmaceutical Co
JPS6159288B2 (en) 1978-06-12 1986-12-16 Dainippon Pharmaceutical Co
US4533764A (en) * 1984-03-29 1985-08-06 The Dow Chemical Company Purification of bisphenols by removing residual solvent
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
JPS63150220A (en) 1986-12-15 1988-06-22 Dainippon Pharmaceut Co Ltd Preparation of solid drug for oral administration
US5082669A (en) * 1989-07-20 1992-01-21 Dainippon Pharmaceutical Co., Ltd. Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
US5811547A (en) * 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
TW350757B (en) * 1994-11-03 1999-01-21 Ciba Geigy Ag Benzisoxazole derivatives and pesticidal compositions containing them
WO2001078725A2 (en) * 2000-04-13 2001-10-25 Synthon B.V. Modified release formulations containing a hypnotic agent
US20030036556A1 (en) * 2001-06-29 2003-02-20 Jennings Julianne E. Zonisamide use in headache
IL158239D0 (en) 2001-08-30 2004-05-12 Teva Pharma Zonisamide intermediate and synthesis
IL163593D0 (en) 2002-02-22 2005-12-18 Teva Pharma Preparation of paroxetine involving novel intermediates

Also Published As

Publication number Publication date
US20040138473A1 (en) 2004-07-15
HK1081555A1 (en) 2010-06-11
PT1583748E (en) 2010-03-03
TW200412341A (en) 2004-07-16
SI1583748T1 (en) 2010-03-31
DK1583748T3 (en) 2010-04-19
EP1583748A1 (en) 2005-10-12
ES2338871T3 (en) 2010-05-13
US20050080269A1 (en) 2005-04-14
KR101004187B1 (en) 2010-12-24
AU2003249010A1 (en) 2004-08-10
KR20050098862A (en) 2005-10-12
EP1583748A4 (en) 2006-12-06
WO2004063174A1 (en) 2004-07-29
EP1583748B1 (en) 2010-02-10
CN1720239A (en) 2006-01-11
IL169451A (en) 2010-12-30
US6900333B2 (en) 2005-05-31
DE60331257D1 (en) 2010-03-25
TWI331035B (en) 2010-10-01
US20040138474A1 (en) 2004-07-15
AT457304T (en) 2010-02-15
CN100528849C (en) 2009-08-19

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