IT8521041A0 - Decapeptidi ad azione ipotensiva eprocedimento per la loro preparazione. - Google Patents

Decapeptidi ad azione ipotensiva eprocedimento per la loro preparazione.

Info

Publication number
IT8521041A0
IT8521041A0 IT8521041A IT2104185A IT8521041A0 IT 8521041 A0 IT8521041 A0 IT 8521041A0 IT 8521041 A IT8521041 A IT 8521041A IT 2104185 A IT2104185 A IT 2104185A IT 8521041 A0 IT8521041 A0 IT 8521041A0
Authority
IT
Italy
Prior art keywords
decapeptides
procedure
preparation
hypotensive action
hypotensive
Prior art date
Application number
IT8521041A
Other languages
English (en)
Other versions
IT1186732B (it
Inventor
Valerio Caciagli
Antonio Silvio Verdini
Giovanna De Luca
Giovanni Di Stazio
Vincenzo Politi
Original Assignee
Roma Eniricerche S P A A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roma Eniricerche S P A A filed Critical Roma Eniricerche S P A A
Priority to IT21041/85A priority Critical patent/IT1186732B/it
Publication of IT8521041A0 publication Critical patent/IT8521041A0/it
Priority to EP86200944A priority patent/EP0205209B1/en
Priority to DE8686200944T priority patent/DE3667176D1/de
Priority to US06/870,161 priority patent/US4810779A/en
Priority to JP61129341A priority patent/JPS61293998A/ja
Application granted granted Critical
Publication of IT1186732B publication Critical patent/IT1186732B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT21041/85A 1985-06-05 1985-06-05 Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione IT1186732B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT21041/85A IT1186732B (it) 1985-06-05 1985-06-05 Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione
EP86200944A EP0205209B1 (en) 1985-06-05 1986-05-30 Decapeptides having hypotensive action and process for their preparation
DE8686200944T DE3667176D1 (de) 1985-06-05 1986-05-30 Dekapeptide mit hypotensiver wirksamkeit und verfahren zu deren herstellung.
US06/870,161 US4810779A (en) 1985-06-05 1986-06-03 Decapeptides having hypotensive action and process for their preparation
JP61129341A JPS61293998A (ja) 1985-06-05 1986-06-05 デカペプチド

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21041/85A IT1186732B (it) 1985-06-05 1985-06-05 Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IT8521041A0 true IT8521041A0 (it) 1985-06-05
IT1186732B IT1186732B (it) 1987-12-16

Family

ID=11175818

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21041/85A IT1186732B (it) 1985-06-05 1985-06-05 Decapeptidi ad azione ipotensiva e procedimento per la loro preparazione

Country Status (5)

Country Link
US (1) US4810779A (it)
EP (1) EP0205209B1 (it)
JP (1) JPS61293998A (it)
DE (1) DE3667176D1 (it)
IT (1) IT1186732B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2782142B2 (ja) * 1992-07-23 1998-07-30 カルピス株式会社 アンジオテンシン変換酵素阻害剤及びその製造法
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562244A (en) * 1963-09-12 1971-02-09 Squibb & Sons Inc 8-l-ornithine vasotocin and intermediates therefor
US3546198A (en) * 1968-03-26 1970-12-08 Searle & Co Process for the synthesis of bradykinin and other arginine containing peptides
US3832337A (en) * 1970-07-28 1974-08-27 Squibb & Sons Inc Peptide enzyme inhibitors
US4108846A (en) * 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
US4591648A (en) * 1981-04-01 1986-05-27 National Research Development Corp. Histidine protection
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens

Also Published As

Publication number Publication date
EP0205209A2 (en) 1986-12-17
IT1186732B (it) 1987-12-16
US4810779A (en) 1989-03-07
JPS61293998A (ja) 1986-12-24
DE3667176D1 (de) 1990-01-04
EP0205209A3 (en) 1987-07-15
EP0205209B1 (en) 1989-11-29

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