IT8424283A0 - Uso di derivati del tiofene nel trattamento dei tumori, composizioni farmaceutiche che licontengono e composti atti allo scopo. - Google Patents
Uso di derivati del tiofene nel trattamento dei tumori, composizioni farmaceutiche che licontengono e composti atti allo scopo.Info
- Publication number
- IT8424283A0 IT8424283A0 IT8424283A IT2428384A IT8424283A0 IT 8424283 A0 IT8424283 A0 IT 8424283A0 IT 8424283 A IT8424283 A IT 8424283A IT 2428384 A IT2428384 A IT 2428384A IT 8424283 A0 IT8424283 A0 IT 8424283A0
- Authority
- IT
- Italy
- Prior art keywords
- tumors
- treatment
- pharmaceutical compositions
- compositions containing
- compounds suitable
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8424283A IT1196390B (it) | 1984-12-28 | 1984-12-28 | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
EP85202136A EP0186252B1 (en) | 1984-12-28 | 1985-12-24 | use of thiophene compounds for the manufacture of a medicament against tumours |
AT85202136T ATE74270T1 (de) | 1984-12-28 | 1985-12-24 | Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore. |
DE8585202136T DE3585781D1 (de) | 1984-12-28 | 1985-12-24 | Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore. |
JP60299676A JPS61180784A (ja) | 1984-12-28 | 1985-12-27 | チオフエン誘導体及び該チオフエン誘導体を有効成分とする医薬組成物 |
US07/020,162 US4767758A (en) | 1984-12-28 | 1987-02-26 | Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8424283A IT1196390B (it) | 1984-12-28 | 1984-12-28 | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8424283A0 true IT8424283A0 (it) | 1984-12-28 |
IT1196390B IT1196390B (it) | 1988-11-16 |
Family
ID=11212932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8424283A IT1196390B (it) | 1984-12-28 | 1984-12-28 | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
Country Status (6)
Country | Link |
---|---|
US (1) | US4767758A (it) |
EP (1) | EP0186252B1 (it) |
JP (1) | JPS61180784A (it) |
AT (1) | ATE74270T1 (it) |
DE (1) | DE3585781D1 (it) |
IT (1) | IT1196390B (it) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196390B (it) * | 1984-12-28 | 1988-11-16 | Consiglio Nazionale Ricerche | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
US5112954A (en) * | 1988-02-26 | 1992-05-12 | Neorx Corporation | Method of enhancing the effect of cytotoxic agents |
DE3933573A1 (de) * | 1989-10-07 | 1991-04-18 | Basf Ag | Carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US5847007A (en) * | 1993-05-13 | 1998-12-08 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
ES2169773T3 (es) * | 1995-04-11 | 2002-07-16 | Mitsui Chemicals Inc | Derivados de tiofeno sustituido y fungicidas agricolas y horticolas que contienen dichos derivados como ingrediente activo. |
US6136984A (en) * | 1996-04-22 | 2000-10-24 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes |
WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
US6121202A (en) * | 1997-11-07 | 2000-09-19 | American Cyanamid Company | Thienyloxypyridines and-pyrimidines useful as herbicidal agents |
US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
WO2006040569A1 (en) * | 2004-10-14 | 2006-04-20 | Astex Therapeutics Limited | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2647120A (en) * | 1949-12-14 | 1953-07-28 | Du Pont | 5-nitro-2-thiophenecarboxamides |
US2680117A (en) * | 1951-05-18 | 1954-06-01 | Du Pont | 5-nitro-2-substituted thiophenes and process |
US2649461A (en) * | 1951-06-13 | 1953-08-18 | Du Pont | 5-nitro-2-thiophenecarboxaldehyde oxime |
BE545630A (it) * | 1955-03-02 | |||
US3639613A (en) * | 1968-08-28 | 1972-02-01 | Smith Kline French Lab | Composition and methods for controlling coccidiosis in poultry employing nitrothiophene derivatives |
US3707480A (en) * | 1968-08-28 | 1972-12-26 | Smith Kline French Lab | Nitrothiophene dicarboxamides |
US3839359A (en) * | 1970-09-23 | 1974-10-01 | Bayer Ag | 2-arylaminonitrothiophenes |
US3733319A (en) * | 1970-01-07 | 1973-05-15 | Us Army | Nitrothiophenes |
US3888986A (en) * | 1974-01-28 | 1975-06-10 | Schering Corp | Certain 1-(5-nitro-2-thienyl)-1-acylamidoalkanes for treating histomoniasis |
GB1560699A (en) * | 1975-11-14 | 1980-02-06 | Hoffmann La Roche | 2-or 3-thienyl-polyenes |
IT1140323B (it) * | 1981-12-09 | 1986-09-24 | Montedison Spa | Processo per la preparazione di composti carbossilati aromatici o etero-aromatici |
IT1196390B (it) * | 1984-12-28 | 1988-11-16 | Consiglio Nazionale Ricerche | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
-
1984
- 1984-12-28 IT IT8424283A patent/IT1196390B/it active
-
1985
- 1985-12-24 AT AT85202136T patent/ATE74270T1/de not_active IP Right Cessation
- 1985-12-24 DE DE8585202136T patent/DE3585781D1/de not_active Expired - Fee Related
- 1985-12-24 EP EP85202136A patent/EP0186252B1/en not_active Expired - Lifetime
- 1985-12-27 JP JP60299676A patent/JPS61180784A/ja active Pending
-
1987
- 1987-02-26 US US07/020,162 patent/US4767758A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4767758A (en) | 1988-08-30 |
DE3585781D1 (de) | 1992-05-07 |
IT1196390B (it) | 1988-11-16 |
EP0186252A3 (en) | 1987-05-06 |
EP0186252A2 (en) | 1986-07-02 |
JPS61180784A (ja) | 1986-08-13 |
ATE74270T1 (de) | 1992-04-15 |
EP0186252B1 (en) | 1992-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19951220 |