IT1170286B - Derivati del labdano, procedimento per la loro preparazione, e composizioni farmaceutiche contenenti derivati del labdano - Google Patents

Derivati del labdano, procedimento per la loro preparazione, e composizioni farmaceutiche contenenti derivati del labdano

Info

Publication number
IT1170286B
IT1170286B IT24392/83A IT2439283A IT1170286B IT 1170286 B IT1170286 B IT 1170286B IT 24392/83 A IT24392/83 A IT 24392/83A IT 2439283 A IT2439283 A IT 2439283A IT 1170286 B IT1170286 B IT 1170286B
Authority
IT
Italy
Prior art keywords
labdano
derivatives
procedure
preparation
pharmaceutical compositions
Prior art date
Application number
IT24392/83A
Other languages
English (en)
Other versions
IT8324392A0 (it
Inventor
William Kreutner
Michael J Green
Anil K Saksena
Ho-Jane Shune
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IT8324392A0 publication Critical patent/IT8324392A0/it
Application granted granted Critical
Publication of IT1170286B publication Critical patent/IT1170286B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
IT24392/83A 1982-12-27 1983-12-27 Derivati del labdano, procedimento per la loro preparazione, e composizioni farmaceutiche contenenti derivati del labdano IT1170286B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45343682A 1982-12-27 1982-12-27
US06/542,825 US4517200A (en) 1982-12-27 1983-10-17 Method for treating allergic reactions with forskolin

Publications (2)

Publication Number Publication Date
IT8324392A0 IT8324392A0 (it) 1983-12-27
IT1170286B true IT1170286B (it) 1987-06-03

Family

ID=27037108

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24392/83A IT1170286B (it) 1982-12-27 1983-12-27 Derivati del labdano, procedimento per la loro preparazione, e composizioni farmaceutiche contenenti derivati del labdano

Country Status (5)

Country Link
US (1) US4517200A (it)
EP (1) EP0116713A1 (it)
JP (1) JPS59152380A (it)
DE (1) DE3346869A1 (it)
IT (1) IT1170286B (it)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751224A (en) * 1983-07-21 1988-06-14 Brown University Research Foundation Treatment of metastasis
WO1985002616A1 (en) * 1983-12-14 1985-06-20 Brown University Research Foundation Treatment of metastasis
DE3502685A1 (de) * 1985-01-26 1986-09-04 Hoechst Ag, 6230 Frankfurt Forskolin, seine analoge und derivate, verfahren zu deren herstellung mittels mikrobieller umwandlungen und die anwendung dieser verbindungen als arzneimittel
US4639446A (en) * 1984-12-14 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmaceutical compositions and use
DE3502686A1 (de) * 1985-01-26 1986-08-14 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von labdan-derivaten und ihre verwendung als arzneimittel
US4666904A (en) * 1984-12-14 1987-05-19 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmacuetical compositions and use
DE3678736D1 (de) * 1985-03-01 1991-05-23 Hoechst Roussel Pharma Labdanderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel.
US4963537A (en) * 1985-03-01 1990-10-16 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
JPS6310783A (ja) * 1985-11-15 1988-01-18 Nippon Kayaku Co Ltd 新規フオルスコリン誘導体
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives
US4734513A (en) * 1986-03-31 1988-03-29 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US5008407A (en) * 1986-03-31 1991-04-16 Hoechst-Roussel Pharmaceuticals Inc. Method of synthesizing forskolin from 9-deoxyforskolin
US5247097A (en) * 1986-08-28 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Oxolabdanes
US4740522A (en) * 1986-08-28 1988-04-26 Hoechst-Roussel Pharmaceuticals Inc. Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure
US5130332A (en) * 1986-08-28 1992-07-14 Hoechst Roussel Pharmaceuticals Inc. Oxolabdanes
US4978678A (en) * 1986-11-20 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 12-halogenated forskolin derivatives
US4871764A (en) * 1986-11-20 1989-10-03 Hoechst-Roussel Pharmaceuticals, Inc. 12-Halogenated forskolin derivatives
US4920146A (en) * 1986-12-29 1990-04-24 Hoechst Roussel Pharmaceuticals Inc. Carbamoyloxylabdane compounds useful in reducing intraocular pressure
US5646175A (en) * 1987-12-28 1997-07-08 Hoechst Marion Roussel, Inc. Carbamoyloxylabdane compounds
TR27832A (tr) * 1987-04-29 1995-08-31 Monsanto Co Zararli ucucu hasarata mukavim bitkiler.
FR2614891B1 (fr) * 1987-05-04 1991-05-24 Roussel Uclaf Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation
US5302730A (en) * 1987-06-29 1994-04-12 Nippon Kayaku Kk Process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives
DE3740625A1 (de) * 1987-12-01 1989-06-15 Hoechst Ag Neue labdanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AT389114B (de) * 1987-10-08 1989-10-25 Hoechst Ag 7-acyloxy-6-aminoacyloxypolyoxylabdane und verfahren zu ihrer herstellung
IN168181B (it) * 1987-12-01 1991-02-16 Hoechst India
US5252598A (en) * 1987-12-01 1993-10-12 Hoechst Aktiengesellschaft Labdane derivatives, a process for their preparation, and their use as medicaments
US4883793A (en) * 1988-05-09 1989-11-28 Hoechst-Roussel Pharmaceuticals Inc. Hydrazinocarbonyloxylabdanes for treating cardiac failure
US5177207A (en) * 1989-01-11 1993-01-05 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
US4999351A (en) * 1989-01-11 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 7-aryl and heteroaryl ethers of desacetylforskolin
IL89530A0 (en) * 1989-03-08 1989-09-10 Jeffrey J Feigenbaum Compositions containing forskolin
US5051132A (en) * 1989-06-15 1991-09-24 Nippon Kayaku Kabushiki Kaisha Lyophilized preparation of 6-(3-dimethylaminopropionyl)forskolin
US5093336A (en) * 1989-07-06 1992-03-03 Hoechat-Roussel Pharmaceuticals, Inc. 6- and 7-deoxyforskolin and derivatives thereof
US5145855A (en) * 1989-07-06 1992-09-08 Hoechst Roussel Pharmaceuticals, Inc. 6- and 7-deoxyforskolin and derivatives thereof
EP0447962A1 (en) * 1990-03-17 1991-09-25 Hoechst Aktiengesellschaft Labdanes and process for their preparation
US20060004090A1 (en) * 2004-07-01 2006-01-05 Roberts William J Forskolin compositions and methods for administration
US20110077292A1 (en) * 2004-07-01 2011-03-31 Biotest Laboratories, Llc. Forskolin carbonates and uses thereof
US20060024341A1 (en) * 2004-08-02 2006-02-02 Roberts William J Microemulsion composition and related method
WO2008157205A2 (en) * 2007-06-15 2008-12-24 Duke University Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2640275A1 (de) * 1976-09-08 1978-03-09 Hoechst Ag Pharmakologisch wirksame substanz aus labiaten
AU2717777A (en) * 1976-07-21 1979-01-25 Hoechst Ag Pharmacologically effective substance from plants belonging to the family of labiatae
DE2654796A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Polyoxygenierte labdan-derivate

Also Published As

Publication number Publication date
DE3346869A1 (de) 1984-07-12
JPS59152380A (ja) 1984-08-31
US4517200A (en) 1985-05-14
IT8324392A0 (it) 1983-12-27
JPH0576447B2 (it) 1993-10-22
EP0116713A1 (en) 1984-08-29

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Effective date: 19941130