IT1400072B1 - Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato. - Google Patents

Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato.

Info

Publication number
IT1400072B1
IT1400072B1 ITME2010A000011A ITME20100011A IT1400072B1 IT 1400072 B1 IT1400072 B1 IT 1400072B1 IT ME2010A000011 A ITME2010A000011 A IT ME2010A000011A IT ME20100011 A ITME20100011 A IT ME20100011A IT 1400072 B1 IT1400072 B1 IT 1400072B1
Authority
IT
Italy
Prior art keywords
chromatography
equipment
balanced flow
flow micro
multidimensional separation
Prior art date
Application number
ITME2010A000011A
Other languages
English (en)
Inventor
Luigi Mondello
Original Assignee
Mondello
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITME2010A000011A priority Critical patent/IT1400072B1/it
Application filed by Mondello filed Critical Mondello
Priority to PT117227835T priority patent/PT2577287T/pt
Priority to ES11722783.5T priority patent/ES2683031T3/es
Priority to PL11722783T priority patent/PL2577287T3/pl
Priority to PCT/EP2011/058404 priority patent/WO2011147801A1/en
Priority to US13/699,068 priority patent/US9067167B2/en
Priority to EP18170961.9A priority patent/EP3376221A1/en
Priority to DK11722783.5T priority patent/DK2577287T3/en
Priority to TR2018/11105T priority patent/TR201811105T4/tr
Priority to EP11722783.5A priority patent/EP2577287B1/en
Priority to HUE11722783A priority patent/HUE039548T2/hu
Publication of ITME20100011A1 publication Critical patent/ITME20100011A1/it
Application granted granted Critical
Publication of IT1400072B1 publication Critical patent/IT1400072B1/it

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/02—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by adsorption, e.g. preparative gas chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G01N30/6039—Construction of the column joining multiple columns in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3084—Control of physical parameters of the fluid carrier of temperature ovens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
ITME2010A000011A 2010-05-27 2010-05-27 Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato. IT1400072B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITME2010A000011A IT1400072B1 (it) 2010-05-27 2010-05-27 Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato.
ES11722783.5T ES2683031T3 (es) 2010-05-27 2011-05-24 Método e instrumentación para separaciones por cromatografía multidimensional integral mediante un modulador de microflujo
PL11722783T PL2577287T3 (pl) 2010-05-27 2011-05-24 Sposób i aparatura do kompletnego rozdzielania metodą chromatografii wielowymiarowej z użyciem mikro modulatora strumienia
PCT/EP2011/058404 WO2011147801A1 (en) 2010-05-27 2011-05-24 Method and instrumentation for comprehensive multidimensional chromatography separations using a micro flow modulator
PT117227835T PT2577287T (pt) 2010-05-27 2011-05-24 Método e instrumentação para separações por cromatografia multidimensional compreensiva utilizando um micromodulador de fluxo
US13/699,068 US9067167B2 (en) 2010-05-27 2011-05-24 Method and instrumentation for comprehensive multidimensional chromatography separations using a micro flow modulator
EP18170961.9A EP3376221A1 (en) 2010-05-27 2011-05-24 Method and instrumentation for comprehensive multidimensional chromatography separations using a micro flow modulator
DK11722783.5T DK2577287T3 (en) 2010-05-27 2011-05-24 METHOD AND INSTRUMENTS FOR COMPREHENSIVE MULTI-DIMENSIONAL CHROMATOGRAPHIC SEPARATIONS USING A MICRO-FLOW MODULATOR
TR2018/11105T TR201811105T4 (tr) 2010-05-27 2011-05-24 Bir mikro akış modülatörü kullanarak kapsamlı çok boyutlu kromatografi ayrımlarına yönelik yöntem ve enstrümantasyon.
EP11722783.5A EP2577287B1 (en) 2010-05-27 2011-05-24 Method and instrumentation for comprehensive multidimensional chromatography separations using a micro flow modulator
HUE11722783A HUE039548T2 (hu) 2010-05-27 2011-05-24 Eljárás és berendezés átfogó multidimenziós kromatográfia elválasztásra egy "micro flow" modulátor használatával

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITME2010A000011A IT1400072B1 (it) 2010-05-27 2010-05-27 Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato.

Publications (2)

Publication Number Publication Date
ITME20100011A1 ITME20100011A1 (it) 2011-11-28
IT1400072B1 true IT1400072B1 (it) 2013-05-17

Family

ID=42813413

Family Applications (1)

Application Number Title Priority Date Filing Date
ITME2010A000011A IT1400072B1 (it) 2010-05-27 2010-05-27 Metodo e apparecchiatura per cromatografia a separazione multidimensionale completa con micro modulatore a flusso bilanciato.

Country Status (10)

Country Link
US (1) US9067167B2 (it)
EP (2) EP3376221A1 (it)
DK (1) DK2577287T3 (it)
ES (1) ES2683031T3 (it)
HU (1) HUE039548T2 (it)
IT (1) IT1400072B1 (it)
PL (1) PL2577287T3 (it)
PT (1) PT2577287T (it)
TR (1) TR201811105T4 (it)
WO (1) WO2011147801A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150369781A1 (en) * 2014-06-06 2015-12-24 The Penn State Research Foundation Mems flow control chip for gas chromatography
WO2015198096A1 (en) * 2014-06-25 2015-12-30 Agilent Technologies, Inc. Secondary stage fluid separation device detachably connectable with primary stage fluid separation device
JP6672781B2 (ja) * 2015-12-22 2020-03-25 株式会社島津製作所 流路機構及びこれを備えた液体クロマトグラフ
DE112017006319T5 (de) 2016-12-15 2019-09-19 Leco Corporation Chromatographiesystem
CN109580852B (zh) * 2019-02-03 2022-04-22 南京九岚纹仪器科技有限公司 一种全二维气相色谱仪及调制方法
GB2590418B (en) * 2019-12-17 2024-04-10 Agilent Technologies Inc Fluid separation with sampling unit selectively coupling upstream and downstream of separation unit
CN111239062B (zh) * 2020-02-04 2021-01-01 中国计量科学研究院 气体定量检测设备及方法
WO2024194405A1 (en) * 2023-03-23 2024-09-26 Universita' Di Pisa Method and apparatus for the selective isolation of single or multiple compounds from complex mixtures

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135549A (en) 1991-01-30 1992-08-04 The Board Of Trustees Of Southern Illinois University Chromatographic technique and apparatus
WO2002039106A1 (en) 2000-12-19 2002-05-16 Thermo Finnigan Italia S.P.A. Modulator for gas chromatography
US6632268B2 (en) 2001-02-08 2003-10-14 Oakland University Method and apparatus for comprehensive two-dimensional gas chromatography
WO2003021251A1 (en) * 2001-08-28 2003-03-13 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimentional liquid chromatography
US6998095B2 (en) * 2003-08-15 2006-02-14 Metara, Inc. Loop dilution system
ITMI20020549A1 (it) 2002-03-15 2003-09-15 Thermo Finnigan Italia S P A Modulatore criogenico per gascromatografia
US7247189B2 (en) * 2003-05-19 2007-07-24 Oakland University Device for combining two fluid streams
US7451634B2 (en) * 2005-02-22 2008-11-18 Systeme Analytique Inc. Chromatographic methods for measuring impurities in a gas sample
IL176724A (en) * 2006-07-06 2010-06-16 Aviv Amirav Method and apparatus for pulsed flow modulation gas chromatography mass spectrometry with supersonic molecular beams
JP4826570B2 (ja) * 2007-10-19 2011-11-30 株式会社島津製作所 ガス流路切替装置
CA2725537C (en) * 2008-05-27 2016-07-19 Perkinelmer Health Sciences, Inc. Chromatography systems and methods using them
JP5509087B2 (ja) * 2008-10-03 2014-06-04 アークレイ株式会社 分析装置およびその制御方法
US8603833B2 (en) * 2010-06-03 2013-12-10 University Of South Florida Germania-silica-based sol-gel monolith and uses thereof
EP2618913B1 (en) * 2010-09-22 2019-07-03 PerkinElmer Health Sciences, Inc. Backflush methods and devices for chromatography

Also Published As

Publication number Publication date
ES2683031T3 (es) 2018-09-24
PT2577287T (pt) 2018-09-28
EP3376221A1 (en) 2018-09-19
EP2577287B1 (en) 2018-05-09
TR201811105T4 (tr) 2018-08-27
ITME20100011A1 (it) 2011-11-28
US9067167B2 (en) 2015-06-30
US20130068100A1 (en) 2013-03-21
DK2577287T3 (en) 2018-08-13
WO2011147801A1 (en) 2011-12-01
HUE039548T2 (hu) 2019-01-28
PL2577287T3 (pl) 2018-12-31
EP2577287A1 (en) 2013-04-10

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