IT1393985B1 - Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. - Google Patents
Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico.Info
- Publication number
- IT1393985B1 IT1393985B1 ITRM2009A000232A ITRM20090232A IT1393985B1 IT 1393985 B1 IT1393985 B1 IT 1393985B1 IT RM2009A000232 A ITRM2009A000232 A IT RM2009A000232A IT RM20090232 A ITRM20090232 A IT RM20090232A IT 1393985 B1 IT1393985 B1 IT 1393985B1
- Authority
- IT
- Italy
- Prior art keywords
- protein
- oncosoppressive
- mutata
- disassemble
- peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1758—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM2009A000232A IT1393985B1 (it) | 2009-05-11 | 2009-05-11 | Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. |
PCT/IT2010/000203 WO2010131283A1 (en) | 2009-05-11 | 2010-05-06 | Peptide able to disrupt the protein complex between the his273 mutaded p53 protein and the oncosuppressive p73 protein in tumour cells and therapeutic uses thereof |
EP10736805.2A EP2429563B1 (en) | 2009-05-11 | 2010-05-06 | Peptide able to disrupt the protein complex between the his273 mutated p53 protein and the oncosuppressive p73 protein in tumour cells and therapeutic uses thereof |
US13/319,682 US20120237614A1 (en) | 2009-05-11 | 2010-05-06 | Peptide able to disrupt the protein complex between the his273 mutaded p53 protein and the oncosuppressive p73 protein in tumor cells and therapeutic uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM2009A000232A IT1393985B1 (it) | 2009-05-11 | 2009-05-11 | Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITRM20090232A1 ITRM20090232A1 (it) | 2010-11-12 |
IT1393985B1 true IT1393985B1 (it) | 2012-05-17 |
Family
ID=41410415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM2009A000232A IT1393985B1 (it) | 2009-05-11 | 2009-05-11 | Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. |
Country Status (4)
Country | Link |
---|---|
US (1) | US20120237614A1 (it) |
EP (1) | EP2429563B1 (it) |
IT (1) | IT1393985B1 (it) |
WO (1) | WO2010131283A1 (it) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002327945A1 (en) * | 2001-09-17 | 2003-04-01 | Eirx Therapeutics Limited | Human delta-n p73 molecules and uses thereof |
ITMI20042227A1 (it) | 2004-11-19 | 2005-02-19 | Ist Fisioterap Ospitalroma | Peptide in grado di rompere il complesso m-p53-p63, m-p53-p73 e m-p53-relative proteine isoformi formatosi nelle cellule tumorali e relativi impieghi in campo farmacologico |
-
2009
- 2009-05-11 IT ITRM2009A000232A patent/IT1393985B1/it active
-
2010
- 2010-05-06 US US13/319,682 patent/US20120237614A1/en not_active Abandoned
- 2010-05-06 EP EP10736805.2A patent/EP2429563B1/en not_active Not-in-force
- 2010-05-06 WO PCT/IT2010/000203 patent/WO2010131283A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2429563A1 (en) | 2012-03-21 |
ITRM20090232A1 (it) | 2010-11-12 |
US20120237614A1 (en) | 2012-09-20 |
WO2010131283A1 (en) | 2010-11-18 |
EP2429563B1 (en) | 2014-07-09 |
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