IT1393985B1 - Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. - Google Patents

Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico.

Info

Publication number
IT1393985B1
IT1393985B1 ITRM2009A000232A ITRM20090232A IT1393985B1 IT 1393985 B1 IT1393985 B1 IT 1393985B1 IT RM2009A000232 A ITRM2009A000232 A IT RM2009A000232A IT RM20090232 A ITRM20090232 A IT RM20090232A IT 1393985 B1 IT1393985 B1 IT 1393985B1
Authority
IT
Italy
Prior art keywords
protein
oncosoppressive
mutata
disassemble
peptide
Prior art date
Application number
ITRM2009A000232A
Other languages
English (en)
Inventor
Giovanni Blandino
Gennaro Citro
Sabrina Strano
Agostino Silvia Di
Original Assignee
Ist Fisioterap Ospitalroma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Fisioterap Ospitalroma filed Critical Ist Fisioterap Ospitalroma
Priority to ITRM2009A000232A priority Critical patent/IT1393985B1/it
Priority to PCT/IT2010/000203 priority patent/WO2010131283A1/en
Priority to EP10736805.2A priority patent/EP2429563B1/en
Priority to US13/319,682 priority patent/US20120237614A1/en
Publication of ITRM20090232A1 publication Critical patent/ITRM20090232A1/it
Application granted granted Critical
Publication of IT1393985B1 publication Critical patent/IT1393985B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1758—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITRM2009A000232A 2009-05-11 2009-05-11 Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico. IT1393985B1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITRM2009A000232A IT1393985B1 (it) 2009-05-11 2009-05-11 Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico.
PCT/IT2010/000203 WO2010131283A1 (en) 2009-05-11 2010-05-06 Peptide able to disrupt the protein complex between the his273 mutaded p53 protein and the oncosuppressive p73 protein in tumour cells and therapeutic uses thereof
EP10736805.2A EP2429563B1 (en) 2009-05-11 2010-05-06 Peptide able to disrupt the protein complex between the his273 mutated p53 protein and the oncosuppressive p73 protein in tumour cells and therapeutic uses thereof
US13/319,682 US20120237614A1 (en) 2009-05-11 2010-05-06 Peptide able to disrupt the protein complex between the his273 mutaded p53 protein and the oncosuppressive p73 protein in tumor cells and therapeutic uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2009A000232A IT1393985B1 (it) 2009-05-11 2009-05-11 Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico.

Publications (2)

Publication Number Publication Date
ITRM20090232A1 ITRM20090232A1 (it) 2010-11-12
IT1393985B1 true IT1393985B1 (it) 2012-05-17

Family

ID=41410415

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM2009A000232A IT1393985B1 (it) 2009-05-11 2009-05-11 Peptide capace di disassemblare i complessi proteici fra la proteina p53 mutata his 273 e la proteina oncosoppressiva p73 in cellule tumorali e suoi usi in campo medico.

Country Status (4)

Country Link
US (1) US20120237614A1 (it)
EP (1) EP2429563B1 (it)
IT (1) IT1393985B1 (it)
WO (1) WO2010131283A1 (it)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002327945A1 (en) * 2001-09-17 2003-04-01 Eirx Therapeutics Limited Human delta-n p73 molecules and uses thereof
ITMI20042227A1 (it) 2004-11-19 2005-02-19 Ist Fisioterap Ospitalroma Peptide in grado di rompere il complesso m-p53-p63, m-p53-p73 e m-p53-relative proteine isoformi formatosi nelle cellule tumorali e relativi impieghi in campo farmacologico

Also Published As

Publication number Publication date
EP2429563A1 (en) 2012-03-21
ITRM20090232A1 (it) 2010-11-12
US20120237614A1 (en) 2012-09-20
WO2010131283A1 (en) 2010-11-18
EP2429563B1 (en) 2014-07-09

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