WO2012021475A3 - ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF - Google Patents

ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF Download PDF

Info

Publication number
WO2012021475A3
WO2012021475A3 PCT/US2011/047002 US2011047002W WO2012021475A3 WO 2012021475 A3 WO2012021475 A3 WO 2012021475A3 US 2011047002 W US2011047002 W US 2011047002W WO 2012021475 A3 WO2012021475 A3 WO 2012021475A3
Authority
WO
WIPO (PCT)
Prior art keywords
amyloid beta
beta peptide
peptide antibodies
n3pglu amyloid
n3pglu
Prior art date
Application number
PCT/US2011/047002
Other languages
French (fr)
Other versions
WO2012021475A2 (en
Inventor
Ying Tang
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of WO2012021475A2 publication Critical patent/WO2012021475A2/en
Publication of WO2012021475A3 publication Critical patent/WO2012021475A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Abstract

Anti-N3pGlu amyloid beta antibodies useful in the treatment of Alzheimer's Disease are provided.
PCT/US2011/047002 2010-08-12 2011-08-09 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF WO2012021475A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37301610P 2010-08-12 2010-08-12
US61/373,016 2010-08-12

Publications (2)

Publication Number Publication Date
WO2012021475A2 WO2012021475A2 (en) 2012-02-16
WO2012021475A3 true WO2012021475A3 (en) 2012-07-05

Family

ID=45568152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/047002 WO2012021475A2 (en) 2010-08-12 2011-08-09 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF

Country Status (1)

Country Link
WO (1) WO2012021475A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20170004B1 (en) * 2016-01-15 2022-09-15 Lilly Co Eli ANTl-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
TW201740954A (en) * 2016-03-16 2017-12-01 美國禮來大藥廠 Combination therapy
TWI798751B (en) * 2016-07-01 2023-04-11 美商美國禮來大藥廠 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
CN109562167A (en) * 2016-08-09 2019-04-02 伊莱利利公司 Combination therapy
TW201827467A (en) 2016-11-03 2018-08-01 比利時商健生藥品公司 Antibodies to pyroglutamate amyloid-[beta] and uses thereof
JOP20190247A1 (en) * 2017-04-20 2019-10-20 Lilly Co Eli ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
EA202192606A1 (en) 2019-03-26 2022-01-24 Янссен Фармацевтика Нв ANTIBODIES TO PYROGLUTAMATE-AMYLOID AND THEIR APPLICATIONS
MX2023000949A (en) 2020-07-23 2023-02-22 Othair Prothena Ltd Anti-abeta antibodies.
TW202243690A (en) * 2021-01-11 2022-11-16 美商美國禮來大藥廠 Anti-n3pglu amyloid beta antibodies and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122374B1 (en) * 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
US20080050370A1 (en) * 2006-03-17 2008-02-28 Scott Glaser Stabilized polypeptide compositions
US20100021478A1 (en) * 2008-07-21 2010-01-28 Probiodrug Ag Diagnostic antibody assay

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122374B1 (en) * 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
US20080050370A1 (en) * 2006-03-17 2008-02-28 Scott Glaser Stabilized polypeptide compositions
US20100021478A1 (en) * 2008-07-21 2010-01-28 Probiodrug Ag Diagnostic antibody assay

Also Published As

Publication number Publication date
WO2012021475A2 (en) 2012-02-16

Similar Documents

Publication Publication Date Title
WO2012021475A3 (en) ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
BRPI1012853A2 (en) protofibrillar beta-amyloid peptide-specific humanized antibodies
HRP20180230T8 (en) Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies
IL254157B (en) 14-3-3eta antibodies and uses thereof for the diagnosis and treatment of arthritis
UA107600C2 (en) ANTIBODY AGAINST N3pGlu BETA-AMYLOID PAPIDE AND ITS APPLICATION
CA2883095C (en) Antibody and protein formulations
IL231201B (en) Isolated antibody for therapy and diagnosis of tau-mediated pathology in alzheimer's disease
AU2018256498A1 (en) Antibodies to amyloid beta
EP2558493A4 (en) Antibodies for the treatment of clostridium difficile-associated infection and disease
LT2498620T (en) Protein concentrates and isolates, and processes for the production thereof
IL232325A0 (en) 18-methyl-6'7-methylene-3-oxo-17-pregn-4-ene-21,17b-carbolactones, pharmaceutical preparations comprising said compounds and use thereof in the treatment of endometriosis
EP2519234A4 (en) Anaplerotic therapy for alzheimer's disease and the aging brain
WO2013059530A3 (en) Peptidomimetic macrocycles
SG179095A1 (en) Novel assay for the detection of amyloid beta peptides
AP2957A (en) New antibodies specific of the Beta-amyloid peptides and their uses as diagnostic agents or drugs
EP2651965A4 (en) Cyclosporine analogue molecules modified at amino acid 1 and 3
IL210364A (en) Cyclic peptide analogue of the ß-amyloid peptide and uses thereof in the treatment or diagnosis of neurodegenerative diseases or conditions
WO2011072257A3 (en) Amyloid binding agents
EP2182978A4 (en) Tissue kallikrein for the treatment of diseases associated with amyloid protein
EP3558340A4 (en) Methods of using gm6 in diagnosing and treating alzheimer's disease
EP3086846A4 (en) Diagnosing and treating alzheimer's disease
HK1151241A1 (en) Enhancement of the efficacy of therapeutic proteins
BR112012006005A2 (en) "peptides in the treatment of oxidative stress disorder"
GB2458868B (en) Fluphenazine based combination for use in the treatment of protein aggregation diseases
GB201220630D0 (en) Kissorphin peptides for use in the treatment of alzheimer's disease, creutzfeldtjakob disease or diabetes mellitus

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11816897

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11816897

Country of ref document: EP

Kind code of ref document: A2