IT1283574B1 - Uso di derivati beta-carbolinici come agenti antimetastatici - Google Patents
Uso di derivati beta-carbolinici come agenti antimetastaticiInfo
- Publication number
- IT1283574B1 IT1283574B1 ITMI960664A IT1283574B1 IT 1283574 B1 IT1283574 B1 IT 1283574B1 IT MI960664 A ITMI960664 A IT MI960664A IT 1283574 B1 IT1283574 B1 IT 1283574B1
- Authority
- IT
- Italy
- Prior art keywords
- activity
- beta
- preparation
- medicaments
- hydro
- Prior art date
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
- 206010064390 Tumour invasion Diseases 0.000 title abstract 2
- 230000002001 anti-metastasis Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI960664 IT1283574B1 (it) | 1996-04-04 | 1996-04-04 | Uso di derivati beta-carbolinici come agenti antimetastatici |
| JP9535798A JP2000508302A (ja) | 1996-04-04 | 1997-03-27 | 抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用 |
| EP97916410A EP0891187B1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
| AU25069/97A AU710079B2 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
| US09/142,058 US6069150A (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
| TR1998/01970T TR199801970T2 (xx) | 1996-04-04 | 1997-03-27 | Tetrahidro-beta-karbolinlerin antimetastatik ajanlar olarak kullan�m�. |
| DE69710182T DE69710182T2 (de) | 1996-04-04 | 1997-03-27 | Verwendung von tetrahydrobetacarbolin-derivaten zur vorbeugung der metastasenbildung |
| KR1019980707846A KR20000005175A (ko) | 1996-04-04 | 1997-03-27 | 테트라하이드로-베타-카르볼린 유도체의 항전이제로서의 용도 |
| DK97916410T DK0891187T3 (da) | 1996-04-04 | 1997-03-27 | Anvendelse af tetrahydro-beta-carbolin-derivater som antimetastatiske midler |
| AT97916410T ATE212549T1 (de) | 1996-04-04 | 1997-03-27 | Verwendung von tetrahydrobetacarbolin-derivaten zur vorbeugung der metastasenbildung |
| PCT/EP1997/001582 WO1997037658A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
| BR9708480A BR9708480A (pt) | 1996-04-04 | 1997-03-27 | Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos |
| ES97916410T ES2169857T3 (es) | 1996-04-04 | 1997-03-27 | Uso de derivados de tetrahidro-beta-carbolinas como agentes antimetastaticos. |
| PT97916410T PT891187E (pt) | 1996-04-04 | 1997-03-27 | Utilizacao de derivados de tetrahidro-beta-carbolinos como agentes antimestaticos |
| CN97193568A CN1113648C (zh) | 1996-04-04 | 1997-03-27 | 四氢－β－咔啉衍生物作为抗转移瘤剂的用途 |
| CA002250898A CA2250898A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI960664 IT1283574B1 (it) | 1996-04-04 | 1996-04-04 | Uso di derivati beta-carbolinici come agenti antimetastatici |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI960664A0 ITMI960664A0 (nl) | 1996-04-04 |
| ITMI960664A1 ITMI960664A1 (it) | 1997-10-04 |
| IT1283574B1 true IT1283574B1 (it) | 1998-04-22 |
Family
ID=11373883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI960664 IT1283574B1 (it) | 1996-04-04 | 1996-04-04 | Uso di derivati beta-carbolinici come agenti antimetastatici |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1283574B1 (nl) |
-
1996
- 1996-04-04 IT ITMI960664 patent/IT1283574B1/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI960664A1 (it) | 1997-10-04 |
| ITMI960664A0 (nl) | 1996-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |