IT1283574B1 - Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity - Google Patents

Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity

Info

Publication number
IT1283574B1
IT1283574B1 ITMI960664A IT1283574B1 IT 1283574 B1 IT1283574 B1 IT 1283574B1 IT MI960664 A ITMI960664 A IT MI960664A IT 1283574 B1 IT1283574 B1 IT 1283574B1
Authority
IT
Italy
Prior art keywords
activity
beta
preparation
medicaments
hydro
Prior art date
Application number
Other languages
Italian (it)
Inventor
Silvano Spinelli
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ITMI960664A0 publication Critical patent/ITMI960664A0/it
Priority to ITMI960664 priority Critical patent/IT1283574B1/en
Priority to BR9708480A priority patent/BR9708480A/en
Priority to KR1019980707846A priority patent/KR20000005175A/en
Priority to CN97193568A priority patent/CN1113648C/en
Priority to PCT/EP1997/001582 priority patent/WO1997037658A1/en
Priority to AT97916410T priority patent/ATE212549T1/en
Priority to ES97916410T priority patent/ES2169857T3/en
Priority to DE69710182T priority patent/DE69710182T2/en
Priority to JP9535798A priority patent/JP2000508302A/en
Priority to EP97916410A priority patent/EP0891187B1/en
Priority to CA002250898A priority patent/CA2250898A1/en
Priority to TR1998/01970T priority patent/TR199801970T2/en
Priority to AU25069/97A priority patent/AU710079B2/en
Priority to US09/142,058 priority patent/US6069150A/en
Priority to PT97916410T priority patent/PT891187E/en
Priority to DK97916410T priority patent/DK0891187T3/en
Publication of ITMI960664A1 publication Critical patent/ITMI960664A1/en
Application granted granted Critical
Publication of IT1283574B1 publication Critical patent/IT1283574B1/en

Links

Abstract

Use of beta -carboline derivatives of formula (I) and their enantiomers, reacemates, diastereomers and salts, for the preparation of pharmaceutical compositions having anti-metastatic activity or inhibitory activity of the tumour invasion process, is new. R = H, 1-5C alkyl, phenyl optionally substituted by 1-5C alkoxy, or (CH2)nCO2H; n = 1-3; R1 = H or CO2R4; R4 = H or 1-5C alkyl; R2 = H or CO2R4; and R3 = H, halo, 1-4C alkoxy or benzyloxy. Also claimed is use of (I) in compositions for treating or preventing conditions associated with the activity of the matrix metallo-proteinases.
ITMI960664 1996-04-04 1996-04-04 Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity IT1283574B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ITMI960664 IT1283574B1 (en) 1996-04-04 1996-04-04 Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity
JP9535798A JP2000508302A (en) 1996-04-04 1997-03-27 Use of tetrahydro-.BETA.-carboline derivatives as antimetastatic agents
CA002250898A CA2250898A1 (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
CN97193568A CN1113648C (en) 1996-04-04 1997-03-27 Use of derivativ
PCT/EP1997/001582 WO1997037658A1 (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
AT97916410T ATE212549T1 (en) 1996-04-04 1997-03-27 USE OF TETRAHYDROBETACARBOLINE DERIVATIVES TO PREVENT METASTASIS
ES97916410T ES2169857T3 (en) 1996-04-04 1997-03-27 USE OF TETRAHIDRO-BETA-CARBOLINAS DERIVATIVES AS ANTIMETASTATIC AGENTS.
DE69710182T DE69710182T2 (en) 1996-04-04 1997-03-27 USE OF TETRAHYDROBETACARBOLIN DERIVATIVES FOR PREVENTING METASTASIS
BR9708480A BR9708480A (en) 1996-04-04 1997-03-27 Use of tetrahydro-beta-cabolines derivatives as antimetastatic agents
EP97916410A EP0891187B1 (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
KR1019980707846A KR20000005175A (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
TR1998/01970T TR199801970T2 (en) 1996-04-04 1997-03-27 Use of tetrahydro-beta-carbolines as antimetastatic agents.
AU25069/97A AU710079B2 (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
US09/142,058 US6069150A (en) 1996-04-04 1997-03-27 Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
PT97916410T PT891187E (en) 1996-04-04 1997-03-27 USING TETRAHYDRO-BETA-CARBOLINOS DERIVATIVES AS ANTIMESTATIC AGENTS
DK97916410T DK0891187T3 (en) 1996-04-04 1997-03-27 Use of tetrahydro-beta-carboline derivatives as antimetastatic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI960664 IT1283574B1 (en) 1996-04-04 1996-04-04 Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity

Publications (3)

Publication Number Publication Date
ITMI960664A0 ITMI960664A0 (en) 1996-04-04
ITMI960664A1 ITMI960664A1 (en) 1997-10-04
IT1283574B1 true IT1283574B1 (en) 1998-04-22

Family

ID=11373883

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI960664 IT1283574B1 (en) 1996-04-04 1996-04-04 Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity

Country Status (1)

Country Link
IT (1) IT1283574B1 (en)

Also Published As

Publication number Publication date
ITMI960664A1 (en) 1997-10-04
ITMI960664A0 (en) 1996-04-04

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