IT1283574B1 - Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity - Google Patents
Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activityInfo
- Publication number
- IT1283574B1 IT1283574B1 ITMI960664A IT1283574B1 IT 1283574 B1 IT1283574 B1 IT 1283574B1 IT MI960664 A ITMI960664 A IT MI960664A IT 1283574 B1 IT1283574 B1 IT 1283574B1
- Authority
- IT
- Italy
- Prior art keywords
- activity
- beta
- preparation
- medicaments
- hydro
- Prior art date
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
- 206010064390 Tumour invasion Diseases 0.000 title abstract 2
- 230000002001 anti-metastasis Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1
Abstract
Use of beta -carboline derivatives of formula (I) and their enantiomers, reacemates, diastereomers and salts, for the preparation of pharmaceutical compositions having anti-metastatic activity or inhibitory activity of the tumour invasion process, is new. R = H, 1-5C alkyl, phenyl optionally substituted by 1-5C alkoxy, or (CH2)nCO2H; n = 1-3; R1 = H or CO2R4; R4 = H or 1-5C alkyl; R2 = H or CO2R4; and R3 = H, halo, 1-4C alkoxy or benzyloxy. Also claimed is use of (I) in compositions for treating or preventing conditions associated with the activity of the matrix metallo-proteinases.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI960664 IT1283574B1 (en) | 1996-04-04 | 1996-04-04 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
JP9535798A JP2000508302A (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-.BETA.-carboline derivatives as antimetastatic agents |
CA002250898A CA2250898A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
CN97193568A CN1113648C (en) | 1996-04-04 | 1997-03-27 | Use of derivativ |
PCT/EP1997/001582 WO1997037658A1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
AT97916410T ATE212549T1 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHYDROBETACARBOLINE DERIVATIVES TO PREVENT METASTASIS |
ES97916410T ES2169857T3 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHIDRO-BETA-CARBOLINAS DERIVATIVES AS ANTIMETASTATIC AGENTS. |
DE69710182T DE69710182T2 (en) | 1996-04-04 | 1997-03-27 | USE OF TETRAHYDROBETACARBOLIN DERIVATIVES FOR PREVENTING METASTASIS |
BR9708480A BR9708480A (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-cabolines derivatives as antimetastatic agents |
EP97916410A EP0891187B1 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
KR1019980707846A KR20000005175A (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
TR1998/01970T TR199801970T2 (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-carbolines as antimetastatic agents. |
AU25069/97A AU710079B2 (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
US09/142,058 US6069150A (en) | 1996-04-04 | 1997-03-27 | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
PT97916410T PT891187E (en) | 1996-04-04 | 1997-03-27 | USING TETRAHYDRO-BETA-CARBOLINOS DERIVATIVES AS ANTIMESTATIC AGENTS |
DK97916410T DK0891187T3 (en) | 1996-04-04 | 1997-03-27 | Use of tetrahydro-beta-carboline derivatives as antimetastatic agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI960664 IT1283574B1 (en) | 1996-04-04 | 1996-04-04 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI960664A0 ITMI960664A0 (en) | 1996-04-04 |
ITMI960664A1 ITMI960664A1 (en) | 1997-10-04 |
IT1283574B1 true IT1283574B1 (en) | 1998-04-22 |
Family
ID=11373883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI960664 IT1283574B1 (en) | 1996-04-04 | 1996-04-04 | Use of tetra:hydro-beta-carboline derivatives - for preparation of medicaments having anti-metastatic activity or tumour invasion or matrix metallo-proteinase inhibitory activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1283574B1 (en) |
-
1996
- 1996-04-04 IT ITMI960664 patent/IT1283574B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI960664A1 (en) | 1997-10-04 |
ITMI960664A0 (en) | 1996-04-04 |
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