IT1283256B1 - Derivati gem-difluoro di fenilacetammide e di acido fenilacetico e loro usi farmaceutici - Google Patents

Derivati gem-difluoro di fenilacetammide e di acido fenilacetico e loro usi farmaceutici

Info

Publication number
IT1283256B1
IT1283256B1 IT96MI000505A ITMI960505A IT1283256B1 IT 1283256 B1 IT1283256 B1 IT 1283256B1 IT 96MI000505 A IT96MI000505 A IT 96MI000505A IT MI960505 A ITMI960505 A IT MI960505A IT 1283256 B1 IT1283256 B1 IT 1283256B1
Authority
IT
Italy
Prior art keywords
phenylacetamide
gem
phenylacetic acid
pharmaceutical uses
difluoro derivatives
Prior art date
Application number
IT96MI000505A
Other languages
English (en)
Italian (it)
Inventor
Nubia Boechat
Cunha Pinto Angelo Da
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Publication of ITMI960505A0 publication Critical patent/ITMI960505A0/it
Publication of ITMI960505A1 publication Critical patent/ITMI960505A1/it
Application granted granted Critical
Publication of IT1283256B1 publication Critical patent/IT1283256B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT96MI000505A 1996-03-11 1996-03-15 Derivati gem-difluoro di fenilacetammide e di acido fenilacetico e loro usi farmaceutici IT1283256B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR9600975A BR9600975A (pt) 1996-03-11 1996-03-11 Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas

Publications (3)

Publication Number Publication Date
ITMI960505A0 ITMI960505A0 (enrdf_load_stackoverflow) 1996-03-15
ITMI960505A1 ITMI960505A1 (it) 1997-09-15
IT1283256B1 true IT1283256B1 (it) 1998-04-16

Family

ID=38353109

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI000505A IT1283256B1 (it) 1996-03-11 1996-03-15 Derivati gem-difluoro di fenilacetammide e di acido fenilacetico e loro usi farmaceutici

Country Status (10)

Country Link
JP (1) JP3947242B2 (enrdf_load_stackoverflow)
CN (1) CN1101806C (enrdf_load_stackoverflow)
BE (1) BE1010031A5 (enrdf_load_stackoverflow)
BR (1) BR9600975A (enrdf_load_stackoverflow)
CH (1) CH690722A5 (enrdf_load_stackoverflow)
DE (1) DE19610357C2 (enrdf_load_stackoverflow)
ES (1) ES2130923B1 (enrdf_load_stackoverflow)
FR (1) FR2745810B1 (enrdf_load_stackoverflow)
GB (1) GB2311066B (enrdf_load_stackoverflow)
IT (1) IT1283256B1 (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) 1999-09-27 1999-11-24 Novartis Ag Processes
JP5685384B2 (ja) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 ３，３−ジフルオロ−２，３−ジヒドロインドール−２−オン誘導体の製造方法
CN108299137B (zh) * 2018-04-09 2020-04-14 中南大学 一种靛红腙类化合物选择性氟化方法
GB201916600D0 (en) * 2019-11-14 2020-01-01 Syngenta Crop Protection Ag 81991-gb-reg-org-nat-1
CN113698308B (zh) * 2021-08-25 2024-06-21 山东辰龙药业有限公司 一种溴芬酸钠合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Also Published As

Publication number Publication date
GB9605407D0 (en) 1996-05-15
CN1159443A (zh) 1997-09-17
ES2130923A1 (es) 1999-07-01
DE19610357C2 (de) 1998-08-13
BR9600975A (pt) 1997-12-30
FR2745810A1 (fr) 1997-09-12
GB2311066A (en) 1997-09-17
ES2130923B1 (es) 2000-01-16
BE1010031A5 (fr) 1997-11-04
CH690722A5 (fr) 2000-12-29
FR2745810B1 (fr) 1998-06-19
JP3947242B2 (ja) 2007-07-18
CN1101806C (zh) 2003-02-19
ITMI960505A1 (it) 1997-09-15
JPH09323962A (ja) 1997-12-16
DE19610357A1 (de) 1997-09-18
GB2311066B (en) 1999-12-08
ITMI960505A0 (enrdf_load_stackoverflow) 1996-03-15

Similar Documents

Publication Publication Date Title
ITMI922006A0 (it) Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preprazione
EE200200666A (et) Meetod tsüklopropüülkarboksüülhappe estrite ja derivaatide valmistamiseks
FI20000677A7 (fi) Oksiimijohdannaiset ja niiden käyttö latentteina happoina
PL337698A1 (en) Derivatives of 4-bromo- or iodo-phenylaminobenzhydroxamic acid and their application as mek inhibitors
EE03765B1 (et) Propioonhappe derivaadid ja nende kasutamine
PL342207A1 (en) Derivatives of cyclic amines and their application as drugs
FI953968A7 (fi) Antraniiliset happojohdannaiset
FI20060617L (fi) Arakidonihappo ja menetelmä sen valmistamiseksi ja sen käyttö
EE04042B1 (et) Suure bioomastatavusega fenofibraatide ravimkoostis ja meetod selle valmistamiseks
BR9507374A (pt) Inhibidores da neuraminidase do vírus da gripe e processo de fabricação e uso dos mesmos
NO984878D0 (no) Fremstilling og anvendelse som medikamenter av 3-alkoksypyridin-2-karboksylsyreamidestere
EE9800425A (et) Uued aminohappe derivaadid ja nende kasutamine trombiini inhibiitoritena
IT1296689B1 (it) Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
ITMI920526A0 (it) Tassani di interesse oncologico, loro metodo di preparazione ed uso
ITMI951450A0 (it) Esteri acilici di amminoacidi achirali di gangiclovir e relativi derivati
FI961521L (fi) Lääkeformulaatioiden valmistusmenetelmä
FI962440A7 (fi) Vitamiini D:n amiini- ja amidijohdoksia
FI964482A7 (fi) Amidijohdannaisia ja niiden käyttö lääkkeenä
AR011441A1 (es) DERIVADOS ÉSTERES Y AMIDAS DE FENIL XANTINA ,PROCESOS PARA SU PREPARACIoN , FORMULACIONES FARMACÉUTICAS Y SU USO EN MEDICINA
IT1283256B1 (it) Derivati gem-difluoro di fenilacetammide e di acido fenilacetico e loro usi farmaceutici
FI943103L (fi) Puolikiinteä farmaseuttinen aine ja menetelmä sen valmistamiseksi
EE9800075A (et) Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
IT1227436B (it) Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci
FI971311A7 (fi) Menetelmiä syklopropaanikarboksyylihapon ja sen johdosten valmistamise ksi
PT1339723E (pt) Processo e derivados esteres uteis para a preparacao de cefalosporinas

Legal Events

Date Code Title Description
0001 Granted