IT1265108B1 - Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono - Google Patents
Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengonoInfo
- Publication number
- IT1265108B1 IT1265108B1 IT93MI001657A ITMI931657A IT1265108B1 IT 1265108 B1 IT1265108 B1 IT 1265108B1 IT 93MI001657 A IT93MI001657 A IT 93MI001657A IT MI931657 A ITMI931657 A IT MI931657A IT 1265108 B1 IT1265108 B1 IT 1265108B1
- Authority
- IT
- Italy
- Prior art keywords
- bile acids
- preparation
- pharmaceutical compositions
- compositions containing
- new amides
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 239000003613 bile acid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 229910001410 inorganic ion Inorganic materials 0.000 abstract 1
- 125000003473 lipid group Chemical group 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
Sono presentate le nuove amidi degli acidi biliari aventi formula generale (FORMULA I) dove A1 può essere H o alfa-OH o ?-OH dove A2 può essere H o alfa-OH o ?-OH dove A3 può essere H o alfa-OH o ?-OH dove A4 può essere H o alfa-OH o ?-OH R rappresenta H, un metallo alcalino o alcalino terroso oppure una base organica o un aminoacido basico, od un suo sale organico con basi farmaceutiche attive, con aminoacidi (lisina o arginina) o con ioni inorganici (Na, Ca, ecc.) ed R1 rappresenta un alchile C1-C5 lineare o ramificato.I prodotti hanno potenziale utilità in condizioni patologiche quali calcolosi biliare, malattie del ricambio lipidico con effetto citoprotettivo sulle membrane cellulari.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001657A IT1265108B1 (it) | 1993-07-26 | 1993-07-26 | Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001657A IT1265108B1 (it) | 1993-07-26 | 1993-07-26 | Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI931657A0 ITMI931657A0 (it) | 1993-07-26 |
| ITMI931657A1 ITMI931657A1 (it) | 1995-01-26 |
| IT1265108B1 true IT1265108B1 (it) | 1996-10-30 |
Family
ID=11366681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT93MI001657A IT1265108B1 (it) | 1993-07-26 | 1993-07-26 | Amidi di acidi biliari, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1265108B1 (it) |
-
1993
- 1993-07-26 IT IT93MI001657A patent/IT1265108B1/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI931657A0 (it) | 1993-07-26 |
| ITMI931657A1 (it) | 1995-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |