IT1258143B - Compresse a cessione programmata contenenti naproxen - Google Patents
Compresse a cessione programmata contenenti naproxenInfo
- Publication number
- IT1258143B IT1258143B ITBO920315A ITBO920315A IT1258143B IT 1258143 B IT1258143 B IT 1258143B IT BO920315 A ITBO920315 A IT BO920315A IT BO920315 A ITBO920315 A IT BO920315A IT 1258143 B IT1258143 B IT 1258143B
- Authority
- IT
- Italy
- Prior art keywords
- naproxen
- time
- period
- allow
- sale
- Prior art date
Links
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 title abstract 5
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title abstract 5
- 229960002009 naproxen Drugs 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002895 emetic Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Compresse a cessione programmata, somministrabili per via orale, contenenti da 500 a 1200 mg di naproxen, preparate da miscele formate da un granulato a cessione immediata compattato a secco contenente dal 5% al 28% di naproxen, da un granulato a cessione controllata compattato a secco contenente dal 72% al 95% di naproxen e da un agente disgregante.Una parte di naproxen viene rilasciata in un breve periodo di tempo, in modo da consentire al farmaco di esplicare velocemente la sua azione terapeutica raggiungendo i livelli emetici necessari, mentre la rimanente parte viene ceduta in un intervallo di tempo più lungo, tale comunque da consentire la copertura terapeutica fino alla successiva somministrazione.L'effetto terapeutico è efficace per un periodo di tempo di 24 ore e pertanto le compresse oggetto della presente invenzione sono adatte per essere somministrate una sola volta al giorno.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITBO920315A IT1258143B (it) | 1992-09-11 | 1992-09-11 | Compresse a cessione programmata contenenti naproxen |
US08/115,897 US5480650A (en) | 1992-09-11 | 1993-09-01 | Programmed release tablets containing naproxen |
IS4069A IS1624B (is) | 1992-09-11 | 1993-09-01 | Forðaverkunar töflur sem innihalda Naproxen |
CZ931806A CZ279853B6 (cs) | 1992-09-11 | 1993-09-01 | Tablety s programovaně řízeným uvolňováním, obsahující naproxen |
ZA936445A ZA936445B (en) | 1992-09-11 | 1993-09-01 | Programmed release tablets containing naproxen |
NZ248574A NZ248574A (en) | 1992-09-11 | 1993-09-02 | Differential release tablet formulation containing naproxen prepared from a mixture of immediate-release granulate, a controlled release-granulate in admixture with retarding agents and a disintegrating agent |
DK93114151.9T DK0587065T3 (da) | 1992-09-11 | 1993-09-03 | Tabletter med programmeret afgivelse indeholdende naproxen |
ES93114151T ES2097952T3 (es) | 1992-09-11 | 1993-09-03 | Comprimidos de liberacion programada que contienen naproxeno. |
DE69307807T DE69307807T2 (de) | 1992-09-11 | 1993-09-03 | Naproxen-Tabletten mit gesteuerter Wirkstoffabgabe |
AT93114151T ATE148340T1 (de) | 1992-09-11 | 1993-09-03 | Naproxen-tabletten mit gesteuerter wirkstoffabgabe |
EP93114151A EP0587065B1 (en) | 1992-09-11 | 1993-09-03 | Programmed release tablets containing naproxen |
CA002105541A CA2105541C (en) | 1992-09-11 | 1993-09-03 | Programmed release tablets containing naproxen |
MX9305445A MX9305445A (es) | 1992-09-11 | 1993-09-06 | Tabletas farmaceuticas de liberacion programada. |
IL10694393A IL106943A (en) | 1992-09-11 | 1993-09-07 | Software release capsules containing naproxen |
NO933177A NO304260B1 (no) | 1992-09-11 | 1993-09-07 | Tablett for programmert avgivelse av naproksen |
CN93116664A CN1088091A (zh) | 1992-09-11 | 1993-09-08 | 含萘普生的程序化释放片剂 |
AU46202/93A AU669552B2 (en) | 1992-09-11 | 1993-09-08 | Programmed release tablets containing naproxen |
KR1019930018163A KR970008157B1 (ko) | 1992-09-11 | 1993-09-10 | 나프록센을 함유하는 계획 방출 정제 |
FI933975A FI933975A (fi) | 1992-09-11 | 1993-09-10 | Tabletter som kontrollerat avgiver naproxen |
GR970400110T GR3022434T3 (en) | 1992-09-11 | 1997-01-30 | Programmed release tablets containing naproxen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITBO920315A IT1258143B (it) | 1992-09-11 | 1992-09-11 | Compresse a cessione programmata contenenti naproxen |
Publications (3)
Publication Number | Publication Date |
---|---|
ITBO920315A0 ITBO920315A0 (it) | 1992-09-11 |
ITBO920315A1 ITBO920315A1 (it) | 1994-03-11 |
IT1258143B true IT1258143B (it) | 1996-02-20 |
Family
ID=11338458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITBO920315A IT1258143B (it) | 1992-09-11 | 1992-09-11 | Compresse a cessione programmata contenenti naproxen |
Country Status (20)
Country | Link |
---|---|
US (1) | US5480650A (it) |
EP (1) | EP0587065B1 (it) |
KR (1) | KR970008157B1 (it) |
CN (1) | CN1088091A (it) |
AT (1) | ATE148340T1 (it) |
AU (1) | AU669552B2 (it) |
CA (1) | CA2105541C (it) |
CZ (1) | CZ279853B6 (it) |
DE (1) | DE69307807T2 (it) |
DK (1) | DK0587065T3 (it) |
ES (1) | ES2097952T3 (it) |
FI (1) | FI933975A (it) |
GR (1) | GR3022434T3 (it) |
IL (1) | IL106943A (it) |
IS (1) | IS1624B (it) |
IT (1) | IT1258143B (it) |
MX (1) | MX9305445A (it) |
NO (1) | NO304260B1 (it) |
NZ (1) | NZ248574A (it) |
ZA (1) | ZA936445B (it) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5609884A (en) * | 1992-08-31 | 1997-03-11 | G. D. Searle & Co. | Controlled release naproxen sodium plus naproxen combination tablet |
US8022095B2 (en) * | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US6153225A (en) * | 1998-08-13 | 2000-11-28 | Elan Pharma International Limited | Injectable formulations of nanoparticulate naproxen |
US6165506A (en) * | 1998-09-04 | 2000-12-26 | Elan Pharma International Ltd. | Solid dose form of nanoparticulate naproxen |
EP1237544A1 (en) * | 1999-12-16 | 2002-09-11 | Trident Technologies, LLC | System and method for extended delivery of a therapeutic agent with its receptor loading dose |
ATE546134T1 (de) * | 2002-12-26 | 2012-03-15 | Pozen Inc | Mehrschichtige dosierformen enthaltend naproxen und triptane |
JP2008525313A (ja) | 2004-12-27 | 2008-07-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗痴呆薬の安定化方法 |
MX2010009704A (es) * | 2008-03-05 | 2010-12-20 | Panacea Biotec Ltd | Composiciones farmaceuticas de liberacion modifcada que comprenden micofenolato y procesos de estas. |
US20090252791A1 (en) * | 2008-04-02 | 2009-10-08 | Venkata Nookaraju Sreedharala | Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug |
US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
AU2009260166B2 (en) * | 2008-06-20 | 2014-10-09 | Alphapharm Pty Ltd | Pharmaceutical formulation |
WO2014078435A1 (en) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1200178B (it) * | 1986-07-23 | 1989-01-05 | Alfa Farmaceutici Spa | Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica |
IT1215726B (it) * | 1988-01-18 | 1990-02-22 | Alfa Wassermann Spa | Formulazioni galeniche a cessione programmata. |
US5232705A (en) * | 1990-08-31 | 1993-08-03 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
US5204116A (en) * | 1991-05-01 | 1993-04-20 | Alza Corporation | Dosage form providing immediate therapy followed by prolonged therapy |
-
1992
- 1992-09-11 IT ITBO920315A patent/IT1258143B/it active IP Right Grant
-
1993
- 1993-09-01 ZA ZA936445A patent/ZA936445B/xx unknown
- 1993-09-01 US US08/115,897 patent/US5480650A/en not_active Expired - Fee Related
- 1993-09-01 CZ CZ931806A patent/CZ279853B6/cs not_active IP Right Cessation
- 1993-09-01 IS IS4069A patent/IS1624B/is unknown
- 1993-09-02 NZ NZ248574A patent/NZ248574A/en unknown
- 1993-09-03 DK DK93114151.9T patent/DK0587065T3/da active
- 1993-09-03 CA CA002105541A patent/CA2105541C/en not_active Expired - Fee Related
- 1993-09-03 AT AT93114151T patent/ATE148340T1/de not_active IP Right Cessation
- 1993-09-03 ES ES93114151T patent/ES2097952T3/es not_active Expired - Lifetime
- 1993-09-03 EP EP93114151A patent/EP0587065B1/en not_active Expired - Lifetime
- 1993-09-03 DE DE69307807T patent/DE69307807T2/de not_active Expired - Fee Related
- 1993-09-06 MX MX9305445A patent/MX9305445A/es not_active IP Right Cessation
- 1993-09-07 NO NO933177A patent/NO304260B1/no not_active IP Right Cessation
- 1993-09-07 IL IL10694393A patent/IL106943A/en not_active IP Right Cessation
- 1993-09-08 CN CN93116664A patent/CN1088091A/zh active Pending
- 1993-09-08 AU AU46202/93A patent/AU669552B2/en not_active Ceased
- 1993-09-10 FI FI933975A patent/FI933975A/fi not_active Application Discontinuation
- 1993-09-10 KR KR1019930018163A patent/KR970008157B1/ko not_active IP Right Cessation
-
1997
- 1997-01-30 GR GR970400110T patent/GR3022434T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69307807T2 (de) | 1997-05-15 |
ES2097952T3 (es) | 1997-04-16 |
AU669552B2 (en) | 1996-06-13 |
FI933975A (fi) | 1994-03-12 |
GR3022434T3 (en) | 1997-04-30 |
ITBO920315A1 (it) | 1994-03-11 |
EP0587065A1 (en) | 1994-03-16 |
IS4069A (is) | 1994-03-12 |
ATE148340T1 (de) | 1997-02-15 |
AU4620293A (en) | 1994-03-17 |
CZ180693A3 (en) | 1994-03-16 |
IS1624B (is) | 1996-10-18 |
CA2105541C (en) | 1999-01-05 |
FI933975A0 (fi) | 1993-09-10 |
DE69307807D1 (de) | 1997-03-13 |
NZ248574A (en) | 1995-04-27 |
KR940006577A (ko) | 1994-04-25 |
CN1088091A (zh) | 1994-06-22 |
IL106943A (en) | 1998-09-24 |
CZ279853B6 (cs) | 1995-07-12 |
MX9305445A (es) | 1994-05-31 |
CA2105541A1 (en) | 1994-03-12 |
DK0587065T3 (da) | 1997-06-09 |
NO933177D0 (no) | 1993-09-07 |
ZA936445B (en) | 1995-01-31 |
ITBO920315A0 (it) | 1992-09-11 |
EP0587065B1 (en) | 1997-01-29 |
NO304260B1 (no) | 1998-11-23 |
NO933177L (no) | 1994-03-14 |
US5480650A (en) | 1996-01-02 |
KR970008157B1 (ko) | 1997-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970716 |