IT1258143B - Compresse a cessione programmata contenenti naproxen - Google Patents

Compresse a cessione programmata contenenti naproxen

Info

Publication number
IT1258143B
IT1258143B ITBO920315A ITBO920315A IT1258143B IT 1258143 B IT1258143 B IT 1258143B IT BO920315 A ITBO920315 A IT BO920315A IT BO920315 A ITBO920315 A IT BO920315A IT 1258143 B IT1258143 B IT 1258143B
Authority
IT
Italy
Prior art keywords
naproxen
time
period
allow
sale
Prior art date
Application number
ITBO920315A
Other languages
English (en)
Inventor
Egidio Marchi
Leone Gabriele Rotini
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO920315A0 publication Critical patent/ITBO920315A0/it
Priority to ITBO920315A priority Critical patent/IT1258143B/it
Priority to CZ931806A priority patent/CZ279853B6/cs
Priority to ZA936445A priority patent/ZA936445B/xx
Priority to US08/115,897 priority patent/US5480650A/en
Priority to IS4069A priority patent/IS1624B/is
Priority to NZ248574A priority patent/NZ248574A/en
Priority to AT93114151T priority patent/ATE148340T1/de
Priority to DE69307807T priority patent/DE69307807T2/de
Priority to EP93114151A priority patent/EP0587065B1/en
Priority to DK93114151.9T priority patent/DK0587065T3/da
Priority to CA002105541A priority patent/CA2105541C/en
Priority to ES93114151T priority patent/ES2097952T3/es
Priority to MX9305445A priority patent/MX9305445A/es
Priority to NO933177A priority patent/NO304260B1/no
Priority to IL10694393A priority patent/IL106943A/en
Priority to CN93116664A priority patent/CN1088091A/zh
Priority to AU46202/93A priority patent/AU669552B2/en
Priority to FI933975A priority patent/FI933975L/fi
Priority to KR1019930018163A priority patent/KR970008157B1/ko
Publication of ITBO920315A1 publication Critical patent/ITBO920315A1/it
Application granted granted Critical
Publication of IT1258143B publication Critical patent/IT1258143B/it
Priority to GR970400110T priority patent/GR3022434T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compresse a cessione programmata, somministrabili per via orale, contenenti da 500 a 1200 mg di naproxen, preparate da miscele formate da un granulato a cessione immediata compattato a secco contenente dal 5% al 28% di naproxen, da un granulato a cessione controllata compattato a secco contenente dal 72% al 95% di naproxen e da un agente disgregante.Una parte di naproxen viene rilasciata in un breve periodo di tempo, in modo da consentire al farmaco di esplicare velocemente la sua azione terapeutica raggiungendo i livelli emetici necessari, mentre la rimanente parte viene ceduta in un intervallo di tempo più lungo, tale comunque da consentire la copertura terapeutica fino alla successiva somministrazione.L'effetto terapeutico è efficace per un periodo di tempo di 24 ore e pertanto le compresse oggetto della presente invenzione sono adatte per essere somministrate una sola volta al giorno.
ITBO920315A 1992-09-11 1992-09-11 Compresse a cessione programmata contenenti naproxen IT1258143B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITBO920315A IT1258143B (it) 1992-09-11 1992-09-11 Compresse a cessione programmata contenenti naproxen
CZ931806A CZ279853B6 (cs) 1992-09-11 1993-09-01 Tablety s programovaně řízeným uvolňováním, obsahující naproxen
ZA936445A ZA936445B (en) 1992-09-11 1993-09-01 Programmed release tablets containing naproxen
US08/115,897 US5480650A (en) 1992-09-11 1993-09-01 Programmed release tablets containing naproxen
IS4069A IS1624B (is) 1992-09-11 1993-09-01 Forðaverkunar töflur sem innihalda Naproxen
NZ248574A NZ248574A (en) 1992-09-11 1993-09-02 Differential release tablet formulation containing naproxen prepared from a mixture of immediate-release granulate, a controlled release-granulate in admixture with retarding agents and a disintegrating agent
CA002105541A CA2105541C (en) 1992-09-11 1993-09-03 Programmed release tablets containing naproxen
DE69307807T DE69307807T2 (de) 1992-09-11 1993-09-03 Naproxen-Tabletten mit gesteuerter Wirkstoffabgabe
EP93114151A EP0587065B1 (en) 1992-09-11 1993-09-03 Programmed release tablets containing naproxen
DK93114151.9T DK0587065T3 (da) 1992-09-11 1993-09-03 Tabletter med programmeret afgivelse indeholdende naproxen
AT93114151T ATE148340T1 (de) 1992-09-11 1993-09-03 Naproxen-tabletten mit gesteuerter wirkstoffabgabe
ES93114151T ES2097952T3 (es) 1992-09-11 1993-09-03 Comprimidos de liberacion programada que contienen naproxeno.
MX9305445A MX9305445A (es) 1992-09-11 1993-09-06 Tabletas farmaceuticas de liberacion programada.
NO933177A NO304260B1 (no) 1992-09-11 1993-09-07 Tablett for programmert avgivelse av naproksen
IL10694393A IL106943A (en) 1992-09-11 1993-09-07 Programmed release tablets containing naproxen
CN93116664A CN1088091A (zh) 1992-09-11 1993-09-08 含萘普生的程序化释放片剂
AU46202/93A AU669552B2 (en) 1992-09-11 1993-09-08 Programmed release tablets containing naproxen
FI933975A FI933975L (fi) 1992-09-11 1993-09-10 Tabletter som kontrollerat avgiver naproxen
KR1019930018163A KR970008157B1 (ko) 1992-09-11 1993-09-10 나프록센을 함유하는 계획 방출 정제
GR970400110T GR3022434T3 (en) 1992-09-11 1997-01-30 Programmed release tablets containing naproxen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO920315A IT1258143B (it) 1992-09-11 1992-09-11 Compresse a cessione programmata contenenti naproxen

Publications (3)

Publication Number Publication Date
ITBO920315A0 ITBO920315A0 (it) 1992-09-11
ITBO920315A1 ITBO920315A1 (it) 1994-03-11
IT1258143B true IT1258143B (it) 1996-02-20

Family

ID=11338458

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO920315A IT1258143B (it) 1992-09-11 1992-09-11 Compresse a cessione programmata contenenti naproxen

Country Status (20)

Country Link
US (1) US5480650A (it)
EP (1) EP0587065B1 (it)
KR (1) KR970008157B1 (it)
CN (1) CN1088091A (it)
AT (1) ATE148340T1 (it)
AU (1) AU669552B2 (it)
CA (1) CA2105541C (it)
CZ (1) CZ279853B6 (it)
DE (1) DE69307807T2 (it)
DK (1) DK0587065T3 (it)
ES (1) ES2097952T3 (it)
FI (1) FI933975L (it)
GR (1) GR3022434T3 (it)
IL (1) IL106943A (it)
IS (1) IS1624B (it)
IT (1) IT1258143B (it)
MX (1) MX9305445A (it)
NO (1) NO304260B1 (it)
NZ (1) NZ248574A (it)
ZA (1) ZA936445B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5609884A (en) * 1992-08-31 1997-03-11 G. D. Searle & Co. Controlled release naproxen sodium plus naproxen combination tablet
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6153225A (en) * 1998-08-13 2000-11-28 Elan Pharma International Limited Injectable formulations of nanoparticulate naproxen
US6165506A (en) * 1998-09-04 2000-12-26 Elan Pharma International Ltd. Solid dose form of nanoparticulate naproxen
AU785372B2 (en) * 1999-12-16 2007-03-01 Trident Technologies, Llc System and method for extended delivery of a therapeutic agent with its receptor loading dose
DK1575566T3 (da) * 2002-12-26 2012-03-26 Pozen Inc Flerlagsdoseringsformer indeholdende naproxen og triptaner
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
BRPI0909030A2 (pt) * 2008-03-05 2018-03-13 Panacea Biotec Ltd composições farmacêuticas de liberação modificada compreendendo micofenolato e processos para as mesmas.
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
EP2306998A4 (en) * 2008-06-20 2011-06-15 Alphapharm Pty Ltd PHARMACEUTICAL FORMULATION
ES2821528T3 (es) 2012-11-14 2021-04-26 Grace W R & Co Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200178B (it) * 1986-07-23 1989-01-05 Alfa Farmaceutici Spa Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica
IT1215726B (it) * 1988-01-18 1990-02-22 Alfa Wassermann Spa Formulazioni galeniche a cessione programmata.
US5232705A (en) * 1990-08-31 1993-08-03 Alza Corporation Dosage form for time-varying patterns of drug delivery
US5204116A (en) * 1991-05-01 1993-04-20 Alza Corporation Dosage form providing immediate therapy followed by prolonged therapy

Also Published As

Publication number Publication date
CA2105541C (en) 1999-01-05
MX9305445A (es) 1994-05-31
IL106943A (en) 1998-09-24
ITBO920315A0 (it) 1992-09-11
ES2097952T3 (es) 1997-04-16
CN1088091A (zh) 1994-06-22
CA2105541A1 (en) 1994-03-12
NO933177D0 (no) 1993-09-07
ITBO920315A1 (it) 1994-03-11
DE69307807T2 (de) 1997-05-15
EP0587065B1 (en) 1997-01-29
US5480650A (en) 1996-01-02
KR970008157B1 (ko) 1997-05-21
FI933975A7 (fi) 1994-03-12
IS1624B (is) 1996-10-18
CZ180693A3 (en) 1994-03-16
CZ279853B6 (cs) 1995-07-12
DK0587065T3 (da) 1997-06-09
KR940006577A (ko) 1994-04-25
ATE148340T1 (de) 1997-02-15
ZA936445B (en) 1995-01-31
GR3022434T3 (en) 1997-04-30
NZ248574A (en) 1995-04-27
AU4620293A (en) 1994-03-17
AU669552B2 (en) 1996-06-13
DE69307807D1 (de) 1997-03-13
EP0587065A1 (en) 1994-03-16
FI933975A0 (fi) 1993-09-10
FI933975L (fi) 1994-03-12
IS4069A (is) 1994-03-12
NO933177L (no) 1994-03-14
NO304260B1 (no) 1998-11-23

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970716