IT1256702B - Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale. - Google Patents

Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale.

Info

Publication number
IT1256702B
IT1256702B ITRM920900A ITRM920900A IT1256702B IT 1256702 B IT1256702 B IT 1256702B IT RM920900 A ITRM920900 A IT RM920900A IT RM920900 A ITRM920900 A IT RM920900A IT 1256702 B IT1256702 B IT 1256702B
Authority
IT
Italy
Prior art keywords
treatment
prevention
protein formulation
microbial
microorganisms
Prior art date
Application number
ITRM920900A
Other languages
English (en)
Inventor
Giovanni Antonini
Original Assignee
Giovanni Antonini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giovanni Antonini filed Critical Giovanni Antonini
Publication of ITRM920900A0 publication Critical patent/ITRM920900A0/it
Priority to ITRM920900A priority Critical patent/IT1256702B/it
Priority to JP6513809A priority patent/JPH08506098A/ja
Priority to AU58123/94A priority patent/AU690533B2/en
Priority to CA002151909A priority patent/CA2151909A1/en
Priority to EP94903801A priority patent/EP0688226B1/en
Priority to DE69324046T priority patent/DE69324046T2/de
Priority to US08/448,535 priority patent/US5830489A/en
Priority to DK94903801T priority patent/DK0688226T3/da
Priority to PCT/EP1993/003571 priority patent/WO1994013318A1/en
Priority to AT94903801T priority patent/ATE177646T1/de
Priority to ES94903801T priority patent/ES2129624T3/es
Publication of ITRM920900A1 publication Critical patent/ITRM920900A1/it
Priority to FI952949A priority patent/FI952949A0/fi
Application granted granted Critical
Publication of IT1256702B publication Critical patent/IT1256702B/it
Priority to GR990401092T priority patent/GR3030011T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La capacità dei microorganismi di causare parodontiti ed altre affezioni legate alla colonizzazione microbica del cavo orale è in relazione alla loro possibilità di aderire alla superficie dei denti, di colonizzarla e di invadere i tessuti. Le sostanze attualmente in uso per la prevenzione e cura di tali patologie, adoperate come coadiuvanti il trattamento odontoiatrico, appartengono per la maggior parte alla categoria dei disinfettanti; questi ultimi, oltre e presentare tossicità sistemica, in genere, non impediscono il legame dei microorganismi ai denti, né inibiscono l'invasione dei tessuti. Viene qui descritta una formulazione proteica contenente le proteine nei seguenti rapporti in peso: Albumina 75%, Transferrina 17%, Lisozima 5% ed Inibitori della Tripsina e della Chimotripsina 3%. Tale formulazione, inibisce la crescita microbica (attività antibatterica), inibisce l'adesione di microorganismi alla idrossiapatite, sostanza che simula la superficie dentale (attività antiadesiva) e conseguentemente diminuisce sia la colonizzazione che l'invasione dei tessuti (attività antiinvasiva). La presenza degli inibitori della Tripsina e della Chimotripsina rende la formulazione proteica resistente all'attacco delle proteasi microbiche. La tossicità della formulazione è praticamente assente per uso topico negli organismi animali. Per tali motivi la formulazione proteica oggetto del presente brevetto, è da considerarsi un valido coadiuvante per la prevenzione e cura della affezioni microbiche del cavo orale, avente caratteristiche migliori rispetto ai coadiuvanti attualmente esistenti.
ITRM920900A 1992-12-16 1992-12-17 Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale. IT1256702B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITRM920900A IT1256702B (it) 1992-12-17 1992-12-17 Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale.
US08/448,535 US5830489A (en) 1992-12-16 1993-12-15 Protein preparation for the prevention and therapy of periodontitis
PCT/EP1993/003571 WO1994013318A1 (en) 1992-12-17 1993-12-15 Protein preparation for the prevention and therapy of periodontitis or other bacterial pathologies of the oral cavity
CA002151909A CA2151909A1 (en) 1992-12-17 1993-12-15 Protein preparation for the prevention and therapy of periodontitis or other bacterial pathologies of the oral cavity
EP94903801A EP0688226B1 (en) 1992-12-17 1993-12-15 Protein preparation for the prevention and therapy of periodontitis or other bacterial pathologies of the oral cavity
DE69324046T DE69324046T2 (de) 1992-12-17 1993-12-15 Protein präparate zur verhütung und behandlung van periodontitis und sonstigen bakteriellen erkrankungen der mundhöhle
JP6513809A JPH08506098A (ja) 1992-12-17 1993-12-15 歯周炎及び他の細菌性口腔疾患の予防及び治療用の蛋白製剤
DK94903801T DK0688226T3 (da) 1992-12-17 1993-12-15 Proteinpræparat til forebyggelse og terapi af periodontitis eller andre bakterielle patologier i mundhulen
AU58123/94A AU690533B2 (en) 1992-12-17 1993-12-15 Protein preparation for the prevention and therapy of periodontitis or other bacterial pathologies of the oral cavity
AT94903801T ATE177646T1 (de) 1992-12-17 1993-12-15 Protein präparate zur verhütung und behandlung van periodontitis und sonstigen bakteriellen erkrankungen der mundhöhle
ES94903801T ES2129624T3 (es) 1992-12-17 1993-12-15 Preparacion de proteinas para la prevencion y terapia de periodontitis y otras patologias bacterianas de la cavidad bucal.
FI952949A FI952949A0 (fi) 1992-12-17 1995-06-15 Proteiinivalmiste periodontiitiksen ja muiden suuontelon bakteerisairauksien ehkäisyyn ja terapiaan
GR990401092T GR3030011T3 (en) 1992-12-17 1999-04-20 Protein preparation for the prevention and therapy of periodontitis or other bacterial pathologies of the oral cavity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920900A IT1256702B (it) 1992-12-17 1992-12-17 Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale.

Publications (3)

Publication Number Publication Date
ITRM920900A0 ITRM920900A0 (it) 1992-12-17
ITRM920900A1 ITRM920900A1 (it) 1994-06-17
IT1256702B true IT1256702B (it) 1995-12-12

Family

ID=11401331

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920900A IT1256702B (it) 1992-12-16 1992-12-17 Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale.

Country Status (13)

Country Link
US (1) US5830489A (it)
EP (1) EP0688226B1 (it)
JP (1) JPH08506098A (it)
AT (1) ATE177646T1 (it)
AU (1) AU690533B2 (it)
CA (1) CA2151909A1 (it)
DE (1) DE69324046T2 (it)
DK (1) DK0688226T3 (it)
ES (1) ES2129624T3 (it)
FI (1) FI952949A0 (it)
GR (1) GR3030011T3 (it)
IT (1) IT1256702B (it)
WO (1) WO1994013318A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0776163A4 (en) * 1994-09-09 1999-11-24 Univ Maryland ENZYMES ENCODED BY BACTERIOPHAGES, FOR THE TREATMENT AND PREVENTION OF DENTAL CARIES AND PERIODONTOLYSIS
JPH08217693A (ja) * 1995-02-17 1996-08-27 Yoshihisa Naito 新規医薬組成物
US5834424A (en) * 1995-07-12 1998-11-10 Gambit International Limited Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
JP4082782B2 (ja) * 1998-04-30 2008-04-30 雪印乳業株式会社 歯周病予防及び改善剤
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6482396B1 (en) 2001-05-15 2002-11-19 Campina Melkunie B.V. Methods for treating or preventing diseases of the oral cavity
US7087228B2 (en) * 2002-07-03 2006-08-08 University Of Southern California Preventing tooth decay and infective endocarditis using natural oligopeptides
WO2004089187A2 (en) * 2003-04-01 2004-10-21 University Of Southern California Caries risk test for predicting and assessing the risk of disease
WO2004100884A2 (en) * 2003-05-07 2004-11-25 Dmi Biosciences, Inc. Oral care methods and products
US20050019317A1 (en) * 2003-07-22 2005-01-27 Cheng Bridget Qiuying Composition for human immunostimulation containing Lysozyme and Lactal Bumin
US9127045B2 (en) * 2005-11-17 2015-09-08 University Of Southern California Method of inhibiting bacterial growth and biofilm formation with natural quorum sensing peptides
US20110206749A1 (en) * 2010-02-19 2011-08-25 J.M. Huber Corporation Silica materials for reducing oral malador
CN107115565B (zh) * 2017-06-28 2020-10-16 陕西师范大学 一种羟基磷灰石/相转变溶菌酶涂层杂化材料及其制备方法
CN108251482B (zh) * 2018-02-28 2021-01-22 安徽精准医疗产业研究院有限公司 三酶一酵鸡胚肽的生产方法
KR102441460B1 (ko) * 2020-04-01 2022-09-06 김종길 치주 질환 예방 및 개선을 위한 반려동물용 영양제 조성물 및 그로부터 제조되는 영양제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651433B1 (fr) * 1989-09-07 1994-01-14 Dominique Dana Complexe enzymatique a activite sur le tartre et la carie dentaire.
US5202113A (en) * 1990-04-30 1993-04-13 The United States Of America As Represented By The Department Of Health And Human Services Plaque-inhibiting protein from bacteroides loeschei and methods for using the same
US5422108A (en) * 1991-09-19 1995-06-06 Smart Plants International Inc. Protection of plants against plant pathogens

Also Published As

Publication number Publication date
DK0688226T3 (da) 1999-10-11
EP0688226A1 (en) 1995-12-27
DE69324046D1 (de) 1999-04-22
FI952949A (fi) 1995-06-15
GR3030011T3 (en) 1999-07-30
EP0688226B1 (en) 1999-03-17
ATE177646T1 (de) 1999-04-15
ES2129624T3 (es) 1999-06-16
CA2151909A1 (en) 1994-06-23
JPH08506098A (ja) 1996-07-02
DE69324046T2 (de) 1999-10-21
US5830489A (en) 1998-11-03
ITRM920900A0 (it) 1992-12-17
ITRM920900A1 (it) 1994-06-17
AU690533B2 (en) 1998-04-30
WO1994013318A1 (en) 1994-06-23
AU5812394A (en) 1994-07-04
FI952949A0 (fi) 1995-06-15

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970527