IT1256699B - METHOXYMETHYL ESTER SALTS OF AMPHOTERICIN B. - Google Patents
METHOXYMETHYL ESTER SALTS OF AMPHOTERICIN B.Info
- Publication number
- IT1256699B IT1256699B ITRM920896A ITRM920896A IT1256699B IT 1256699 B IT1256699 B IT 1256699B IT RM920896 A ITRM920896 A IT RM920896A IT RM920896 A ITRM920896 A IT RM920896A IT 1256699 B IT1256699 B IT 1256699B
- Authority
- IT
- Italy
- Prior art keywords
- amphotericin
- methoxymethyl ester
- ester salts
- salts
- mono
- Prior art date
Links
- -1 METHOXYMETHYL Chemical class 0.000 title abstract 4
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 title abstract 2
- 229960003942 amphotericin b Drugs 0.000 title abstract 2
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical class O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 150000002763 monocarboxylic acids Chemical class 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Sono stati preparati alcuni sali dell'estere metossimetilico dell'anfotericina B facendolo reagire con amminoacidi mono e dicarbossilici (es. acido aspartico, glutammico o piroglutammico), con acidi idrossi carbossilici (es. acido lattico), con acidi mono e dicarbossilici (es. acido acetico, succinico).E' stato trovato che detti sali sono in generale facilmente idrosolubili e almeno altrettanto stabili ed attivi dell'estere di base.Some salts of the amphotericin B methoxymethyl ester were prepared by reacting it with mono and dicarboxylic amino acids (e.g. aspartic, glutamic or pyroglutamic acid), with hydroxy carboxylic acids (e.g. lactic acid), with mono and dicarboxylic acids (e.g. acetic, succinic acid) It has been found that said salts are generally easily water-soluble and at least as stable and active as the base ester.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920896A IT1256699B (en) | 1992-12-17 | 1992-12-17 | METHOXYMETHYL ESTER SALTS OF AMPHOTERICIN B. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920896A IT1256699B (en) | 1992-12-17 | 1992-12-17 | METHOXYMETHYL ESTER SALTS OF AMPHOTERICIN B. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM920896A0 ITRM920896A0 (en) | 1992-12-17 |
| ITRM920896A1 ITRM920896A1 (en) | 1994-06-17 |
| IT1256699B true IT1256699B (en) | 1995-12-12 |
Family
ID=11401329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM920896A IT1256699B (en) | 1992-12-17 | 1992-12-17 | METHOXYMETHYL ESTER SALTS OF AMPHOTERICIN B. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1256699B (en) |
-
1992
- 1992-12-17 IT ITRM920896A patent/IT1256699B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM920896A1 (en) | 1994-06-17 |
| ITRM920896A0 (en) | 1992-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961223 |