IT1255472B - Procedimento per la preparazione di (-)-eseretolo da miscele di (-) e (+)- eseretolo - Google Patents
Procedimento per la preparazione di (-)-eseretolo da miscele di (-) e (+)- eseretoloInfo
- Publication number
- IT1255472B IT1255472B ITMI921861A ITMI921861A IT1255472B IT 1255472 B IT1255472 B IT 1255472B IT MI921861 A ITMI921861 A IT MI921861A IT MI921861 A ITMI921861 A IT MI921861A IT 1255472 B IT1255472 B IT 1255472B
- Authority
- IT
- Italy
- Prior art keywords
- hexeretol
- eseretol
- mixtures
- preparation
- procedure
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Si descrive un procedimento per la preparazione di (-)-eseretolo, di formula (I) (FORMULA I) a partire dal (?)-eseretolo, o da miscele di (+)- e (-)-eseretolo con prevalenza di quest'ultimo enantiomero, mediante trattamento di (±)-eseretolo o di miscele di (+)- e (-)-eseretolo arricchite in quest'ultimo enantiomero, con 0,5-0,7 moli (per mole di miscela dei due enantiomeri) di un agente risolvente che fornì un sale di (-)- eseretolo meno solubile del corrispondente sale di (+)-eseretolo.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921861A IT1255472B (it) | 1992-07-30 | 1992-07-30 | Procedimento per la preparazione di (-)-eseretolo da miscele di (-) e (+)- eseretolo |
EP93915956A EP0652881A1 (en) | 1992-07-30 | 1993-07-20 | A process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole |
PCT/EP1993/001908 WO1994003457A1 (en) | 1992-07-30 | 1993-07-20 | A process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole |
CA002141456A CA2141456C (en) | 1992-07-30 | 1993-07-20 | A process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole |
JP6504937A JPH08506084A (ja) | 1992-07-30 | 1993-07-20 | (−)および(+)−エセレトールの混合物から(−)−エセレトールを製造する方法 |
US08/379,536 US5610316A (en) | 1992-07-30 | 1993-07-20 | Process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921861A IT1255472B (it) | 1992-07-30 | 1992-07-30 | Procedimento per la preparazione di (-)-eseretolo da miscele di (-) e (+)- eseretolo |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI921861A0 ITMI921861A0 (it) | 1992-07-30 |
ITMI921861A1 ITMI921861A1 (it) | 1994-01-30 |
IT1255472B true IT1255472B (it) | 1995-11-02 |
Family
ID=11363783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI921861A IT1255472B (it) | 1992-07-30 | 1992-07-30 | Procedimento per la preparazione di (-)-eseretolo da miscele di (-) e (+)- eseretolo |
Country Status (6)
Country | Link |
---|---|
US (1) | US5610316A (it) |
EP (1) | EP0652881A1 (it) |
JP (1) | JPH08506084A (it) |
CA (1) | CA2141456C (it) |
IT (1) | IT1255472B (it) |
WO (1) | WO1994003457A1 (it) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB899023A (en) * | 1960-09-06 | 1962-06-20 | Pfizer & Co C | Resolving optically active ª--phenoxy alkanoic acids |
-
1992
- 1992-07-30 IT ITMI921861A patent/IT1255472B/it active IP Right Grant
-
1993
- 1993-07-20 WO PCT/EP1993/001908 patent/WO1994003457A1/en not_active Application Discontinuation
- 1993-07-20 EP EP93915956A patent/EP0652881A1/en not_active Withdrawn
- 1993-07-20 CA CA002141456A patent/CA2141456C/en not_active Expired - Fee Related
- 1993-07-20 US US08/379,536 patent/US5610316A/en not_active Expired - Fee Related
- 1993-07-20 JP JP6504937A patent/JPH08506084A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2141456C (en) | 2004-04-13 |
WO1994003457A1 (en) | 1994-02-17 |
ITMI921861A1 (it) | 1994-01-30 |
ITMI921861A0 (it) | 1992-07-30 |
EP0652881A1 (en) | 1995-05-17 |
CA2141456A1 (en) | 1994-02-17 |
US5610316A (en) | 1997-03-11 |
JPH08506084A (ja) | 1996-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970729 |