IT1254254B - Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico - Google Patents
Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceuticoInfo
- Publication number
- IT1254254B IT1254254B ITMI920560A ITMI920560A IT1254254B IT 1254254 B IT1254254 B IT 1254254B IT MI920560 A ITMI920560 A IT MI920560A IT MI920560 A ITMI920560 A IT MI920560A IT 1254254 B IT1254254 B IT 1254254B
- Authority
- IT
- Italy
- Prior art keywords
- acid
- preparation
- purity
- iodesoxicolic
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimento per la preparazione dell'acido iodesossicolico ad elevata purezza a partire dalla bile suina consistente nel trattamento della bile suina con sodio idrato, isolamento degli acidi iodesossicolico, chenodesossicolico o iocolico per precipitazione dei loro sali di zinco e successiva precipitazione selettiva del sale di magnesio dell'acido iodesossicolico dal quale l'acido iodesossicolico viene liberato mediante acidificazione e poi cristallizzato.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920560A IT1254254B (it) | 1992-03-11 | 1992-03-11 | Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico |
US08/010,149 US5349074A (en) | 1992-03-11 | 1993-01-28 | Process for pharmaceutical grade high purity hyodeoxycholic acid preparation |
EP93101908A EP0564775A3 (en) | 1992-03-11 | 1993-02-08 | Process for pharmaceutical grade high purity iodeoxycholic acid preparation |
CA002091104A CA2091104A1 (en) | 1992-03-11 | 1993-03-05 | Process for pharmaceutical grade high purity iodeoxycholic acid preparation |
JP5049032A JPH069683A (ja) | 1992-03-11 | 1993-03-10 | 製薬等級高純度イオデオキシコール酸の製造法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920560A IT1254254B (it) | 1992-03-11 | 1992-03-11 | Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI920560A0 ITMI920560A0 (it) | 1992-03-11 |
ITMI920560A1 ITMI920560A1 (it) | 1993-09-11 |
IT1254254B true IT1254254B (it) | 1995-09-14 |
Family
ID=11362373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI920560A IT1254254B (it) | 1992-03-11 | 1992-03-11 | Procedimento per la preparazione di acido iodesossicolico ad elevata purezza per impiego farmaceutico |
Country Status (5)
Country | Link |
---|---|
US (1) | US5349074A (it) |
EP (1) | EP0564775A3 (it) |
JP (1) | JPH069683A (it) |
CA (1) | CA2091104A1 (it) |
IT (1) | IT1254254B (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670505B1 (en) | 2000-03-07 | 2003-12-30 | Eastman Chemical Company | Process for the recovery of organic acids from aqueous solutions |
US6320061B1 (en) | 2000-06-05 | 2001-11-20 | Eastman Chemical Company | Solvent exchange process |
ITMI20061735A1 (it) * | 2006-09-12 | 2008-03-13 | Dipharma Spa | Procedimento per la preparazione di acidi colanici |
EP2857414A1 (en) * | 2013-10-03 | 2015-04-08 | Prodotti Chimici E Alimentari Spa | Polymorphous form of sodium hyodeoxycholate (NaHDC) and preparation process thereof |
CN112656818A (zh) * | 2021-01-14 | 2021-04-16 | 四川菲德力制药有限公司 | 一种人工牛黄及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2758120A (en) * | 1953-02-27 | 1956-08-07 | Canada Packers Ltd | Preparation of hyodesoxycholic acid |
US2745849A (en) * | 1954-06-14 | 1956-05-15 | Armour & Co | Method of purifying bile acids |
US4079133A (en) * | 1976-02-06 | 1978-03-14 | Warren-Teed Laboratories, Inc. | Safer method for dissolving gallstones combining hyodeoxycholic acid with chenodeoxycholic acids |
US4186143A (en) * | 1977-06-20 | 1980-01-29 | Canada Packers Limited | Chenodeoxycholic acid recovery process |
US4163744A (en) * | 1978-02-10 | 1979-08-07 | Kaiser Emil T | Synthesis of steroids |
US4217279A (en) * | 1978-12-18 | 1980-08-12 | Kaiser Emil T | Synthesis of steroids |
IT1210874B (it) * | 1982-04-15 | 1989-09-29 | Istituto Chemioterapico | Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo. |
-
1992
- 1992-03-11 IT ITMI920560A patent/IT1254254B/it active
-
1993
- 1993-01-28 US US08/010,149 patent/US5349074A/en not_active Expired - Fee Related
- 1993-02-08 EP EP93101908A patent/EP0564775A3/en not_active Withdrawn
- 1993-03-05 CA CA002091104A patent/CA2091104A1/en not_active Abandoned
- 1993-03-10 JP JP5049032A patent/JPH069683A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ITMI920560A0 (it) | 1992-03-11 |
CA2091104A1 (en) | 1993-09-12 |
US5349074A (en) | 1994-09-20 |
JPH069683A (ja) | 1994-01-18 |
ITMI920560A1 (it) | 1993-09-11 |
EP0564775A3 (en) | 1995-12-20 |
EP0564775A2 (en) | 1993-10-13 |
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