IT1250653B - FIBRINOLYTIC ENZYMES AMID AND THEIR PRECURSORS, AND PROCESSES FOR THEIR PREPARATION. - Google Patents

FIBRINOLYTIC ENZYMES AMID AND THEIR PRECURSORS, AND PROCESSES FOR THEIR PREPARATION.

Info

Publication number
IT1250653B
IT1250653B ITMI911877A ITMI911877A IT1250653B IT 1250653 B IT1250653 B IT 1250653B IT MI911877 A ITMI911877 A IT MI911877A IT MI911877 A ITMI911877 A IT MI911877A IT 1250653 B IT1250653 B IT 1250653B
Authority
IT
Italy
Prior art keywords
amid
precursors
processes
preparation
fibrinolytic enzymes
Prior art date
Application number
ITMI911877A
Other languages
Italian (it)
Inventor
Luigia Gozzini
Carlo Visco
Rita Perego
Romeo Roncucci
Paolo Sarmientos
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ITMI911877A0 publication Critical patent/ITMI911877A0/en
Publication of ITMI911877A1 publication Critical patent/ITMI911877A1/en
Application granted granted Critical
Publication of IT1250653B publication Critical patent/IT1250653B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Vengono messi a disposizione enzimi fibrinolitici ammidati che sono derivati ammidati in posizione COOH-terminale della pro-urochinasi umana. Questi derivati hanno la formula generale P-CONH2 nella quale P rappresenta una porzione di pro-urochinasi umana, o una sua modificazione.Vengono anche messi a disposizione precursori di tali derivati di formula P-Gly-Yn nella quale Y è un residuo di amminoacido basico e n è 0 o un numero intero da 1 a 4.Amid fibrinolytic enzymes are made available which are amidated derivatives in the COOH-terminal position of the human pro-urokinase. These derivatives have the general formula P-CONH2 in which P represents a portion of human pro-urokinase, or a modification thereof. Precursors of these derivatives of formula P-Gly-Yn are also made available in which Y is an amino acid residue. basic en is 0 or an integer from 1 to 4.

ITMI911877A 1990-07-12 1991-07-08 FIBRINOLYTIC ENZYMES AMID AND THEIR PRECURSORS, AND PROCESSES FOR THEIR PREPARATION. IT1250653B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015369A GB9015369D0 (en) 1990-07-12 1990-07-12 Amidated fibrinolytic enzymes and their precursors,and processes for their preparation

Publications (3)

Publication Number Publication Date
ITMI911877A0 ITMI911877A0 (en) 1991-07-08
ITMI911877A1 ITMI911877A1 (en) 1993-01-08
IT1250653B true IT1250653B (en) 1995-04-21

Family

ID=10679005

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911877A IT1250653B (en) 1990-07-12 1991-07-08 FIBRINOLYTIC ENZYMES AMID AND THEIR PRECURSORS, AND PROCESSES FOR THEIR PREPARATION.

Country Status (4)

Country Link
JP (1) JPH04252185A (en)
DE (1) DE4122688A1 (en)
GB (2) GB9015369D0 (en)
IT (1) IT1250653B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0651761B1 (en) * 1992-07-13 2002-10-09 Bionebraska, Inc. Method for modification of recombinant polypeptides
US5656456A (en) * 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
AU4415796A (en) * 1994-12-07 1996-06-26 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
CA2426115A1 (en) * 2003-04-18 2004-10-18 Victor Gurewich Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8523156D0 (en) * 1985-09-19 1985-10-23 Celltech Ltd Polypeptide production
GB2220938B (en) * 1988-07-20 1992-01-29 Erba Carlo Spa Use of pam enzyme in solid phase peptide synthesis

Also Published As

Publication number Publication date
DE4122688A1 (en) 1992-01-16
GB9015369D0 (en) 1990-08-29
GB9114846D0 (en) 1991-08-28
JPH04252185A (en) 1992-09-08
ITMI911877A0 (en) 1991-07-08
GB2246133A (en) 1992-01-22
ITMI911877A1 (en) 1993-01-08

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Legal Events

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0001 Granted