IT1244538B - Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativi - Google Patents
Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativiInfo
- Publication number
- IT1244538B IT1244538B ITMI910237A ITMI910237A IT1244538B IT 1244538 B IT1244538 B IT 1244538B IT MI910237 A ITMI910237 A IT MI910237A IT MI910237 A ITMI910237 A IT MI910237A IT 1244538 B IT1244538 B IT 1244538B
- Authority
- IT
- Italy
- Prior art keywords
- acyl
- procedure
- preparation
- kanamycin
- acylamino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title 1
- 229960004821 amikacin Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 229960000318 kanamycin Drugs 0.000 abstract 3
- 229930182823 kanamycin A Natural products 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- 239000004411 aluminium Substances 0.000 abstract 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000536 complexating effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
Si descrive un procedimento per la preparazione di una 3,6'- di - N - acil - l - (L - ( - ) - 4 acilamino -2 -idrossibutirril) kanamicina A, in cui l'acile è un gruppo N - protettore, a partire dalla corrispondente 3,6' - di - N - acilkanamina A che consiste nell proteggere selettivamente il gruppo 3" - NH2 mediante formazione di un complesso con alluminio in un solvente organico inerte, successivo trattamento dell'intermedio così ottenuto con un derivato reattivo dell'acido L - ( - ) - 4 - acilamino -2 - idrossibutirrrico, in cui l'acile è un gruppo N - protettore preferibilmente identico a quello che protegge i gruppi amminici in 3 e6' della kanamicina A di partenza, e rimozione finale dell'alluminio complessante in ambiente basico.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910237A IT1244538B (it) | 1991-01-31 | 1991-01-31 | Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910237A IT1244538B (it) | 1991-01-31 | 1991-01-31 | Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI910237A0 ITMI910237A0 (it) | 1991-01-31 |
| ITMI910237A1 ITMI910237A1 (it) | 1992-07-31 |
| IT1244538B true IT1244538B (it) | 1994-07-15 |
Family
ID=11358348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI910237A IT1244538B (it) | 1991-01-31 | 1991-01-31 | Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativi |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1244538B (it) |
-
1991
- 1991-01-31 IT ITMI910237A patent/IT1244538B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI910237A0 (it) | 1991-01-31 |
| ITMI910237A1 (it) | 1992-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2118566A1 (fr) | Compositions de revetement anti-abrasion a base d'hydrolysats de silanes et de composes de l'aluminium, et articles revetus correspondants resistants a l'abrasion et aux chocs | |
| UA43331C2 (uk) | Спосіб асиметричного одержання флорфеніколу, спосіб регіовибіркового розкриття хірального епоксиду та спосіб одержання r, s- ізомеру флорфеніколу | |
| GR3021087T3 (en) | Compositions for treating ischemia-related neuronal damage. | |
| HUT63567A (en) | Process for producing composition suitable for treating infections caused by organisms sensitive to beta-lactam antibiotics | |
| CA2157114A1 (en) | Process for the preparation of 9-desoxotaxanes | |
| HUT68166A (en) | Process for preparing substituted piperidines | |
| GB8822726D0 (en) | Compositions & process for treatment of textiles | |
| EP0504431A4 (en) | Method of removing organic coating | |
| GB1530201A (en) | Process for the preparation of aminoglycoside antibiotics and intermediates therefor | |
| HUT47430A (en) | Process for producing pharmaceutical compositions containing 2-pyrimidinyl-1-piperazine derivatives for treating alcoholizmus | |
| IT1244538B (it) | Procedimento per la preparazione di precursori dell'amikacina ed intermedi relativi | |
| DE69104092T2 (de) | Verfahren zur Herstellung von Amikacin-Vorläufern. | |
| HRP930014A2 (en) | 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates | |
| GB8804701D0 (en) | Process & apparatus for spraying plant protective solutions/dispersions | |
| JPS5488241A (en) | Novel fortimicin a derivative | |
| PT71801A (en) | Process for coating reactors using organic compound vapor application | |
| ES469303A1 (es) | Un procedimiento para la preparacion de una 1-n-( amino- - hidroxialcanoil)kanamicina a o b | |
| IN167403B (it) | ||
| AU5102490A (en) | Process of treating alcoholic beverages by vapor-arbitrated pervaporisation | |
| CA2132829A1 (en) | Novel derivatives of 2,3-dihydro-benzofuranols | |
| IT1243380B (it) | Procedimento per la preparazione di precursori di amikacina | |
| NO942964L (no) | Fremgangsmåte ved fremstilling av kiralt etyl-(5-amino-1,2-dihydro-2-metyl-3-fenylpyrido[3,4-bÅ-pyrazin-7-yl)-karbamat | |
| EP0284863A3 (en) | (meth)acrylic-acid-ester-modified organic polysiloxanes, process for their preparation and their use as abhesive coatings | |
| SG47459A1 (en) | Process for preparing enantiomerically pure imidazo(4,5,1)(1,4)benzodiazepin-2(1H)-thiones | |
| AU3438193A (en) | Method for the treatment of plant parts to improve quality |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960130 |