IT1222367B - Amminoacil derivati di 4(5)-imidazolodinoni adattivita' nootropica:loro preparazione ed uso farmaceutico - Google Patents
Amminoacil derivati di 4(5)-imidazolodinoni adattivita' nootropica:loro preparazione ed uso farmaceuticoInfo
- Publication number
- IT1222367B IT1222367B IT21236/85A IT2123685A IT1222367B IT 1222367 B IT1222367 B IT 1222367B IT 21236/85 A IT21236/85 A IT 21236/85A IT 2123685 A IT2123685 A IT 2123685A IT 1222367 B IT1222367 B IT 1222367B
- Authority
- IT
- Italy
- Prior art keywords
- branched
- straight
- alkyl
- optionally substituted
- different
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title abstract 6
- 230000001777 nootropic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002664 nootropic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21236/85A IT1222367B (it) | 1985-06-21 | 1985-06-21 | Amminoacil derivati di 4(5)-imidazolodinoni adattivita' nootropica:loro preparazione ed uso farmaceutico |
| FI862422A FI862422A7 (fi) | 1985-06-21 | 1986-06-06 | Kemiska blandningar. |
| ZA864446A ZA864446B (en) | 1985-06-21 | 1986-06-13 | Imidazolidinones and imidazolidines,process for the preparation and their use |
| NZ216552A NZ216552A (en) | 1985-06-21 | 1986-06-16 | Imidazoles and pharmaceutical compositions |
| IL79138A IL79138A (en) | 1985-06-21 | 1986-06-17 | Substituted imidazolidinones,their preparation and pharmaceutical compositions containing them |
| DE8686304650T DE3673709D1 (de) | 1985-06-21 | 1986-06-17 | Chemische verbindungen. |
| AT86304650T ATE56020T1 (de) | 1985-06-21 | 1986-06-17 | Chemische verbindungen. |
| EP86304650A EP0207680B1 (en) | 1985-06-21 | 1986-06-17 | Chemical compounds |
| GR861578A GR861578B (en) | 1985-06-21 | 1986-06-18 | Chemical compounds and preparation process therefor |
| AU58917/86A AU590283B2 (en) | 1985-06-21 | 1986-06-20 | 4(5)-imidazolidinone derivatives with nootropic activity |
| KR1019860004922A KR870000305A (ko) | 1985-06-21 | 1986-06-20 | 신규의 화학적 화합물의 제조방법 |
| PH33924A PH23229A (en) | 1985-06-21 | 1986-06-20 | Imidazolidinone and imidazolidine acetamide derivatives |
| NO862487A NO166409C (no) | 1985-06-21 | 1986-06-20 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive oksadiazol-forbindelser. |
| HU862610A HUT41741A (en) | 1985-06-21 | 1986-06-20 | Process for preparing new imidazolidinones and pharmaceutical compositions containing the new compounds |
| DK290386A DK290386A (da) | 1985-06-21 | 1986-06-20 | Imidazolidinforbindelse og fremgangsmaade til fremstilling deraf |
| US06/876,946 US4703054A (en) | 1985-06-21 | 1986-06-20 | Nootropic imidazolidinones |
| JP61144688A JPH0688979B2 (ja) | 1985-06-21 | 1986-06-20 | 化合物 |
| CA000512111A CA1273450A (en) | 1985-06-21 | 1986-06-20 | Nootropic imidazolidinomes |
| PH35708A PH24336A (en) | 1985-06-21 | 1987-08-20 | Process for preparing imidazolidine acetamide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21236/85A IT1222367B (it) | 1985-06-21 | 1985-06-21 | Amminoacil derivati di 4(5)-imidazolodinoni adattivita' nootropica:loro preparazione ed uso farmaceutico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8521236A0 IT8521236A0 (it) | 1985-06-21 |
| IT1222367B true IT1222367B (it) | 1990-09-05 |
Family
ID=11178826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21236/85A IT1222367B (it) | 1985-06-21 | 1985-06-21 | Amminoacil derivati di 4(5)-imidazolodinoni adattivita' nootropica:loro preparazione ed uso farmaceutico |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4703054A (it) |
| EP (1) | EP0207680B1 (it) |
| JP (1) | JPH0688979B2 (it) |
| KR (1) | KR870000305A (it) |
| AT (1) | ATE56020T1 (it) |
| AU (1) | AU590283B2 (it) |
| CA (1) | CA1273450A (it) |
| DE (1) | DE3673709D1 (it) |
| DK (1) | DK290386A (it) |
| FI (1) | FI862422A7 (it) |
| GR (1) | GR861578B (it) |
| HU (1) | HUT41741A (it) |
| IL (1) | IL79138A (it) |
| IT (1) | IT1222367B (it) |
| NO (1) | NO166409C (it) |
| NZ (1) | NZ216552A (it) |
| PH (2) | PH23229A (it) |
| ZA (1) | ZA864446B (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| FR2677984B1 (fr) * | 1991-06-21 | 1994-02-25 | Elf Sanofi | Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant. |
| JP2606026B2 (ja) * | 1991-07-09 | 1997-04-30 | コクヨ株式会社 | フォルダー |
| RU2142470C1 (ru) * | 1998-12-22 | 1999-12-10 | Анохина Ирина Петровна | Тетрапептид trp-nle-asp-phenh-ch(ch3)2, обладающий антиалкогольной активностью |
| WO2001053269A1 (en) * | 2000-01-18 | 2001-07-26 | The Regents Of The University Of California | Acid addition salts of imidazolidinones as reaction catalysts |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH470396A (de) * | 1963-08-12 | 1969-03-31 | Hoffmann La Roche | Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
-
1985
- 1985-06-21 IT IT21236/85A patent/IT1222367B/it active
-
1986
- 1986-06-06 FI FI862422A patent/FI862422A7/fi not_active Application Discontinuation
- 1986-06-13 ZA ZA864446A patent/ZA864446B/xx unknown
- 1986-06-16 NZ NZ216552A patent/NZ216552A/xx unknown
- 1986-06-17 EP EP86304650A patent/EP0207680B1/en not_active Expired - Lifetime
- 1986-06-17 AT AT86304650T patent/ATE56020T1/de not_active IP Right Cessation
- 1986-06-17 DE DE8686304650T patent/DE3673709D1/de not_active Expired - Lifetime
- 1986-06-17 IL IL79138A patent/IL79138A/xx unknown
- 1986-06-18 GR GR861578A patent/GR861578B/el unknown
- 1986-06-20 JP JP61144688A patent/JPH0688979B2/ja not_active Expired - Lifetime
- 1986-06-20 US US06/876,946 patent/US4703054A/en not_active Expired - Lifetime
- 1986-06-20 NO NO862487A patent/NO166409C/no unknown
- 1986-06-20 PH PH33924A patent/PH23229A/en unknown
- 1986-06-20 HU HU862610A patent/HUT41741A/hu unknown
- 1986-06-20 AU AU58917/86A patent/AU590283B2/en not_active Ceased
- 1986-06-20 CA CA000512111A patent/CA1273450A/en not_active Expired - Fee Related
- 1986-06-20 KR KR1019860004922A patent/KR870000305A/ko not_active Ceased
- 1986-06-20 DK DK290386A patent/DK290386A/da not_active Application Discontinuation
-
1987
- 1987-08-20 PH PH35708A patent/PH24336A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0207680A2 (en) | 1987-01-07 |
| JPH0688979B2 (ja) | 1994-11-09 |
| NO862487L (no) | 1986-12-22 |
| US4703054A (en) | 1987-10-27 |
| PH24336A (en) | 1990-06-13 |
| AU5891786A (en) | 1986-12-24 |
| ATE56020T1 (de) | 1990-09-15 |
| NO166409B (no) | 1991-04-08 |
| KR870000305A (ko) | 1987-02-17 |
| IL79138A (en) | 1991-04-15 |
| FI862422A7 (fi) | 1986-12-22 |
| DK290386D0 (da) | 1986-06-20 |
| EP0207680A3 (en) | 1989-01-18 |
| FI862422A0 (fi) | 1986-06-06 |
| HUT41741A (en) | 1987-05-28 |
| DK290386A (da) | 1987-02-11 |
| AU590283B2 (en) | 1989-11-02 |
| GR861578B (en) | 1986-10-21 |
| ZA864446B (en) | 1987-03-25 |
| CA1273450A (en) | 1990-08-28 |
| IT8521236A0 (it) | 1985-06-21 |
| JPS6230763A (ja) | 1987-02-09 |
| EP0207680B1 (en) | 1990-08-29 |
| DE3673709D1 (de) | 1990-10-04 |
| NO862487D0 (no) | 1986-06-20 |
| PH23229A (en) | 1989-06-06 |
| NO166409C (no) | 1991-07-24 |
| NZ216552A (en) | 1989-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950630 |