IT1217344B - Farmaco per la cura delle sindrome di immunodeficienza acquisita - Google Patents
Farmaco per la cura delle sindrome di immunodeficienza acquisitaInfo
- Publication number
- IT1217344B IT1217344B IT19549/88A IT1954988A IT1217344B IT 1217344 B IT1217344 B IT 1217344B IT 19549/88 A IT19549/88 A IT 19549/88A IT 1954988 A IT1954988 A IT 1954988A IT 1217344 B IT1217344 B IT 1217344B
- Authority
- IT
- Italy
- Prior art keywords
- prodn
- melatonin
- methoxy
- reacting
- tryptamine
- Prior art date
Links
- JTEJPPKMYBDEMY-UHFFFAOYSA-N 5-methoxytryptamine Chemical compound COC1=CC=C2NC=C(CCN)C2=C1 JTEJPPKMYBDEMY-UHFFFAOYSA-N 0.000 title abstract 4
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 3
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 3
- 229940097276 5-methoxytryptamine Drugs 0.000 title abstract 2
- 229960003987 melatonin Drugs 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- XDGCOSMBEZEXSN-UHFFFAOYSA-N ethyl 2-acetyl-5-(1,3-dioxoisoindol-2-yl)pentanoate Chemical compound C1=CC=C2C(=O)N(CCCC(C(=O)OCC)C(C)=O)C(=O)C2=C1 XDGCOSMBEZEXSN-UHFFFAOYSA-N 0.000 abstract 3
- VKJCJJYNVIYVQR-UHFFFAOYSA-N 2-(3-bromopropyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCCBr)C(=O)C2=C1 VKJCJJYNVIYVQR-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 230000000397 acetylating effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- AGZWJQDJMAWCAW-UHFFFAOYSA-N ethyl 3-[2-(1,3-dioxoisoindol-2-yl)ethyl]-5-methoxy-1h-indole-2-carboxylate Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCC1=C(C(=O)OCC)NC2=CC=C(OC)C=C21 AGZWJQDJMAWCAW-UHFFFAOYSA-N 0.000 abstract 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 abstract 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19549/88A IT1217344B (it) | 1988-02-25 | 1988-02-25 | Farmaco per la cura delle sindrome di immunodeficienza acquisita |
| DE68925135T DE68925135T2 (de) | 1988-02-25 | 1989-02-16 | Verfahren zur totalen Synthese von einer Indol-Struktur-Verbindungsklasse des Tryptamin-Typs, insbesondere Melatonin- oder N-Acetyl-5-methoxytryptamin mit hoher Reinheit und Löslichkeit, verwendbar in der AIDS-Therapie |
| EP89830055A EP0330625B1 (en) | 1988-02-25 | 1989-02-16 | Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes |
| ES89830055T ES2083390T3 (es) | 1988-02-25 | 1989-02-16 | Procedimiento de sintesis total para preparar una clase de producto derivado de estructura indol, del tipo triptamina, en particular la melatonia o la n-acetil-5-metoxitriptamina, con un elevado grado de pureza y facilmente soluble, para uso terapeutico contra los sindromes de la |
| AT89830055T ATE131812T1 (de) | 1988-02-25 | 1989-02-16 | Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie |
| US07/312,627 US5122535A (en) | 1988-02-25 | 1989-02-17 | Method of solubilizing melatonine in water |
| JP1045068A JP2724493B2 (ja) | 1988-02-25 | 1989-02-23 | ５−メトキシトリプタミン及びトリプタミン誘導体の合成方法 |
| US08/252,905 USRE35631E (en) | 1988-02-25 | 1994-06-02 | Method of production of essentially pure melatonin and the method of solubilizing melatonin in water |
| GR960400765T GR3019365T3 (en) | 1988-02-25 | 1996-03-19 | Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19549/88A IT1217344B (it) | 1988-02-25 | 1988-02-25 | Farmaco per la cura delle sindrome di immunodeficienza acquisita |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8819549A0 IT8819549A0 (it) | 1988-02-25 |
| IT1217344B true IT1217344B (it) | 1990-03-22 |
Family
ID=11158960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19549/88A IT1217344B (it) | 1988-02-25 | 1988-02-25 | Farmaco per la cura delle sindrome di immunodeficienza acquisita |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1217344B (it) |
-
1988
- 1988-02-25 IT IT19549/88A patent/IT1217344B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| IT8819549A0 (it) | 1988-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940127 |