IT1210604B - 2-Oxo-alkyl sulphonate ester(s) - Google Patents

2-Oxo-alkyl sulphonate ester(s)

Info

Publication number
IT1210604B
IT1210604B IT8167106A IT6710681A IT1210604B IT 1210604 B IT1210604 B IT 1210604B IT 8167106 A IT8167106 A IT 8167106A IT 6710681 A IT6710681 A IT 6710681A IT 1210604 B IT1210604 B IT 1210604B
Authority
IT
Italy
Prior art keywords
alkyl
oxo
substd
cycloalkyl
halogen
Prior art date
Application number
IT8167106A
Other languages
Italian (it)
Other versions
IT8167106A0 (en
Inventor
Setsuro Fujii Toshihi Hamakawa
Kazuo Ogawa Yoshiyuki Muranaka
Sadao Hashimoto
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1121480A external-priority patent/JPS6059904B2/en
Priority claimed from JP55137026A external-priority patent/JPS5759854A/en
Priority claimed from JP55180852A external-priority patent/JPS57102858A/en
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of IT8167106A0 publication Critical patent/IT8167106A0/en
Application granted granted Critical
Publication of IT1210604B publication Critical patent/IT1210604B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New sulphonate esters (I) are of formula R1SO3CH2CO(CH2)nR2 (where R1 is 1-4C alkyl, 2-6C alkoxyalkyl, aralkyl, cycloalkyl or aryl opt. substd. by 1-12C alkyl, lower alkoxy, halogen, OH, COOH, acetamido, NO2 or 1,3-dioxolan-2-yl; R2 is 1-15C alkyl, 2-15C alkenyl, halogen, OH, lower alkoxy, lower alkoxycarbonyl, acyloxy, carbobenzoxyamino, 3-6C cycloalkyl, a 2-5C cyclic alkyl or alkenyl ether gp. or aryl opt. substd. by alkyl; n is 0-6). (I) are esterase and chymotrypsin inhibitors useful as hypolipaemic, anti-inflammatory and immunity-controlling agents. They have higher hypolipaemic activity than, e.g., nicotinic acid, dextran sulphate and clofibrate, and very low toxicity (LD50 often more than 3000 mg/kg).
IT8167106A 1980-01-31 1981-01-28 2-Oxo-alkyl sulphonate ester(s) IT1210604B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1121480A JPS6059904B2 (en) 1980-01-31 1980-01-31 Sulfonate derivative and method for producing the same
JP55137026A JPS5759854A (en) 1980-09-30 1980-09-30 Sulfonate derivative and its preparation
JP55180852A JPS57102858A (en) 1980-12-19 1980-12-19 Sulfonate derivative

Publications (2)

Publication Number Publication Date
IT8167106A0 IT8167106A0 (en) 1981-01-28
IT1210604B true IT1210604B (en) 1989-09-14

Family

ID=27279328

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8167106A IT1210604B (en) 1980-01-31 1981-01-28 2-Oxo-alkyl sulphonate ester(s)

Country Status (1)

Country Link
IT (1) IT1210604B (en)

Also Published As

Publication number Publication date
IT8167106A0 (en) 1981-01-28

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