IT1210604B - 2-Oxo-alkyl sulphonate ester(s) - Google Patents
2-Oxo-alkyl sulphonate ester(s)Info
- Publication number
- IT1210604B IT1210604B IT8167106A IT6710681A IT1210604B IT 1210604 B IT1210604 B IT 1210604B IT 8167106 A IT8167106 A IT 8167106A IT 6710681 A IT6710681 A IT 6710681A IT 1210604 B IT1210604 B IT 1210604B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- oxo
- substd
- cycloalkyl
- halogen
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New sulphonate esters (I) are of formula R1SO3CH2CO(CH2)nR2 (where R1 is 1-4C alkyl, 2-6C alkoxyalkyl, aralkyl, cycloalkyl or aryl opt. substd. by 1-12C alkyl, lower alkoxy, halogen, OH, COOH, acetamido, NO2 or 1,3-dioxolan-2-yl; R2 is 1-15C alkyl, 2-15C alkenyl, halogen, OH, lower alkoxy, lower alkoxycarbonyl, acyloxy, carbobenzoxyamino, 3-6C cycloalkyl, a 2-5C cyclic alkyl or alkenyl ether gp. or aryl opt. substd. by alkyl; n is 0-6). (I) are esterase and chymotrypsin inhibitors useful as hypolipaemic, anti-inflammatory and immunity-controlling agents. They have higher hypolipaemic activity than, e.g., nicotinic acid, dextran sulphate and clofibrate, and very low toxicity (LD50 often more than 3000 mg/kg).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1121480A JPS6059904B2 (en) | 1980-01-31 | 1980-01-31 | Sulfonate derivative and method for producing the same |
JP55137026A JPS5759854A (en) | 1980-09-30 | 1980-09-30 | Sulfonate derivative and its preparation |
JP55180852A JPS57102858A (en) | 1980-12-19 | 1980-12-19 | Sulfonate derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8167106A0 IT8167106A0 (en) | 1981-01-28 |
IT1210604B true IT1210604B (en) | 1989-09-14 |
Family
ID=27279328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8167106A IT1210604B (en) | 1980-01-31 | 1981-01-28 | 2-Oxo-alkyl sulphonate ester(s) |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1210604B (en) |
-
1981
- 1981-01-28 IT IT8167106A patent/IT1210604B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8167106A0 (en) | 1981-01-28 |
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