IT1196363B - Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici - Google Patents
Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologiciInfo
- Publication number
- IT1196363B IT1196363B IT23965/84A IT2396584A IT1196363B IT 1196363 B IT1196363 B IT 1196363B IT 23965/84 A IT23965/84 A IT 23965/84A IT 2396584 A IT2396584 A IT 2396584A IT 1196363 B IT1196363 B IT 1196363B
- Authority
- IT
- Italy
- Prior art keywords
- denotes
- atoms
- functions
- hydroxyalkyl
- alkylene
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 17
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000002947 alkylene group Chemical group 0.000 abstract 8
- -1 alkali metal salt Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- KRNGCUVYNDDIBX-UHFFFAOYSA-N 2,4,5-tribromobenzene-1,3-dicarboxamide Chemical class NC(=O)C1=CC(Br)=C(Br)C(C(N)=O)=C1Br KRNGCUVYNDDIBX-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- 241000534944 Thia Species 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical group 0.000 abstract 2
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 239000011630 iodine Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23965/84A IT1196363B (it) | 1984-12-10 | 1984-12-10 | Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici |
| EP85103121A EP0185130B1 (de) | 1984-12-10 | 1985-03-18 | Neue Derivate der 5-Alkoxy-2,4,6-trijod- und tribrom-isophthalsäure, Verfahren zu ihrer Herstellung und diese enthaltende Röntgenkontrastmittel |
| DE8585103121T DE3561724D1 (en) | 1984-12-10 | 1985-03-18 | 5-alkoxy-2,4,6-triodo or tribromo-isophthalic-acid derivatives, process for their preparation and x-ray contrast agents containing them |
| AT85103121T ATE32713T1 (de) | 1984-12-10 | 1985-03-18 | Neue derivate der 5-alkoxy-2,4,6-trijod- und tribrom-isophthalsaeure, verfahren zu ihrer herstellung und diese enthaltende roentgenkontrastmittel. |
| JP60167840A JPS61140555A (ja) | 1984-12-10 | 1985-07-31 | ５−アルコキシ−２，４，６−トリヨ−ド−及びトリブロム−イソフタ−ル酸の新規誘導体、その製造法及びこれを含有するレントゲン造影剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23965/84A IT1196363B (it) | 1984-12-10 | 1984-12-10 | Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8423965A0 IT8423965A0 (it) | 1984-12-10 |
| IT1196363B true IT1196363B (it) | 1988-11-16 |
Family
ID=11211185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT23965/84A IT1196363B (it) | 1984-12-10 | 1984-12-10 | Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0185130B1 (en, 2012) |
| JP (1) | JPS61140555A (en, 2012) |
| AT (1) | ATE32713T1 (en, 2012) |
| DE (1) | DE3561724D1 (en, 2012) |
| IT (1) | IT1196363B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8630594D0 (en) * | 1986-12-22 | 1987-02-04 | Exxon Chemical Patents Inc | Chemical compositions |
| US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
| US5227455A (en) * | 1989-12-14 | 1993-07-13 | Basf Aktiengesellschaft | Polymer granules having improved processability |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| FR2687669B1 (fr) * | 1992-02-24 | 1997-12-19 | Guerbet Sa | Composes utilisables dans des produits de contraste pour la radiographie. |
| IL113142A0 (en) * | 1995-03-27 | 1995-06-29 | Icl Israel Chemical Ltd | Process for the preparation of 5-hydroxyisophthalic acids |
| IT1277339B1 (it) * | 1995-07-25 | 1997-11-10 | Bracco Spa | Processo per la produzione di agenti contrastografici iodurati |
| IT1303797B1 (it) * | 1998-11-27 | 2001-02-23 | Bracco Spa | Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide. |
| EP2394984A1 (en) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Process for the iodination of phenolic derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3914294A (en) * | 1972-06-01 | 1975-10-21 | Squibb & Sons Inc | 3,5-Disubstituted-2,4,6-triiodobenzoic acids |
-
1984
- 1984-12-10 IT IT23965/84A patent/IT1196363B/it active
-
1985
- 1985-03-18 AT AT85103121T patent/ATE32713T1/de not_active IP Right Cessation
- 1985-03-18 DE DE8585103121T patent/DE3561724D1/de not_active Expired
- 1985-03-18 EP EP85103121A patent/EP0185130B1/de not_active Expired
- 1985-07-31 JP JP60167840A patent/JPS61140555A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0433786B2 (en, 2012) | 1992-06-04 |
| EP0185130A1 (de) | 1986-06-25 |
| IT8423965A0 (it) | 1984-12-10 |
| JPS61140555A (ja) | 1986-06-27 |
| EP0185130B1 (de) | 1988-03-02 |
| DE3561724D1 (en) | 1988-04-07 |
| ATE32713T1 (de) | 1988-03-15 |
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