IT1177974B - COMPOSITION INCLUDING REFINED DETOXIFIED ENDOTOXIN - Google Patents

COMPOSITION INCLUDING REFINED DETOXIFIED ENDOTOXIN

Info

Publication number
IT1177974B
IT1177974B IT48757/84A IT4875784A IT1177974B IT 1177974 B IT1177974 B IT 1177974B IT 48757/84 A IT48757/84 A IT 48757/84A IT 4875784 A IT4875784 A IT 4875784A IT 1177974 B IT1177974 B IT 1177974B
Authority
IT
Italy
Prior art keywords
composition including
detoxified endotoxin
refined detoxified
including refined
endotoxin
Prior art date
Application number
IT48757/84A
Other languages
Italian (it)
Other versions
IT8448757A0 (en
IT8448757A1 (en
Inventor
Edgar Ernst Ribi
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of IT8448757A0 publication Critical patent/IT8448757A0/en
Publication of IT8448757A1 publication Critical patent/IT8448757A1/en
Application granted granted Critical
Publication of IT1177974B publication Critical patent/IT1177974B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A composition which is capable of producing an effective adjuvant response or stimulating the immune response of a warm blooded animal which comprises an effective amount of a refined detoxified endotoxin material, in combination with a pharmaceutically acceptable carrier.
IT48757/84A 1983-08-26 1984-08-24 COMPOSITION INCLUDING REFINED DETOXIFIED ENDOTOXIN IT1177974B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52696783A 1983-08-26 1983-08-26

Publications (3)

Publication Number Publication Date
IT8448757A0 IT8448757A0 (en) 1984-08-24
IT8448757A1 IT8448757A1 (en) 1986-02-24
IT1177974B true IT1177974B (en) 1987-09-03

Family

ID=24099553

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48757/84A IT1177974B (en) 1983-08-26 1984-08-24 COMPOSITION INCLUDING REFINED DETOXIFIED ENDOTOXIN

Country Status (22)

Country Link
JP (1) JPS6072825A (en)
KR (1) KR880002223B1 (en)
AT (1) AT389228B (en)
AU (1) AU554039B2 (en)
BE (1) BE900377A (en)
CA (1) CA1225592A (en)
CH (1) CH660125A5 (en)
DE (2) DE3448164C2 (en)
DK (1) DK389384A (en)
ES (1) ES8606883A1 (en)
FI (1) FI843204L (en)
FR (1) FR2550945B1 (en)
GB (1) GB2147806B (en)
HU (1) HU191713B (en)
IL (1) IL72675A (en)
IN (1) IN157910B (en)
IT (1) IT1177974B (en)
NL (1) NL192326C (en)
NO (1) NO843243L (en)
NZ (1) NZ209233A (en)
SE (1) SE8404090L (en)
ZA (1) ZA846309B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
DE10115310A1 (en) * 2001-03-28 2002-10-10 Nodar A Daniela Bacteriophage preparation
KR100868443B1 (en) * 2002-05-27 2008-11-11 주식회사 포스코 Launch box manufacturing device with variable width and length

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (en) * 1971-11-19 1975-02-07 Anvar
BE793260A (en) * 1971-12-24 1973-06-22 Pasteur Institut IMMUNOSTIMULANT AGENT, MEDICINES CONTAINING IT AND METHOD FOR MANUFACTURING SUCH IMMUNOSTIMULANT AGENT
JPS5132794A (en) * 1974-06-20 1976-03-19 Anvar Koshuyokoirusu oyobi ajubantokatsuseiojusuru maikobakuteriumufurakushonnoseiseiho
FR2393065A1 (en) * 1977-05-31 1978-12-29 Merieux Inst PROCESS FOR SEPARATION OF LIPIDS FROM BACTERIAL ENDOTOXINS AND IN PARTICULAR FROM BORDETELLA PERTUSSIS ENDOTOXIN
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4435386A (en) * 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product

Also Published As

Publication number Publication date
IN157910B (en) 1986-07-19
JPH0556326B2 (en) 1993-08-19
ATA273384A (en) 1989-04-15
FI843204A7 (en) 1985-02-27
AU554039B2 (en) 1986-08-07
ES535124A0 (en) 1986-05-01
SE8404090L (en) 1985-02-27
FI843204L (en) 1985-02-27
JPS6072825A (en) 1985-04-24
ES8606883A1 (en) 1986-05-01
HUT34887A (en) 1985-05-28
NL8402515A (en) 1985-03-18
IL72675A (en) 1988-04-29
FI843204A0 (en) 1984-08-14
KR850001696A (en) 1985-04-01
SE8404090D0 (en) 1984-08-14
NZ209233A (en) 1987-11-27
DK389384D0 (en) 1984-08-13
ZA846309B (en) 1985-03-27
NL192326B (en) 1997-02-03
IT8448757A0 (en) 1984-08-24
FR2550945B1 (en) 1988-09-16
NL192326C (en) 1997-06-04
CH660125A5 (en) 1987-03-31
KR880002223B1 (en) 1988-10-20
GB2147806A (en) 1985-05-22
AT389228B (en) 1989-11-10
FR2550945A1 (en) 1985-03-01
DK389384A (en) 1985-02-27
CA1225592A (en) 1987-08-18
DE3448164C2 (en) 1987-06-25
NO843243L (en) 1985-02-27
IT8448757A1 (en) 1986-02-24
GB8420612D0 (en) 1984-09-19
DE3431058C2 (en) 1987-06-11
BE900377A (en) 1985-02-18
AU3221584A (en) 1985-02-28
DE3431058A1 (en) 1985-03-07
IL72675A0 (en) 1984-11-30
GB2147806B (en) 1986-10-22
HU191713B (en) 1987-03-30

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970828